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    • 6. 发明授权
    • Process for the preparation of glycidylesters of branched carboxylic acids
    • 制备支链羧酸的缩水甘油酯的方法
    • US06570028B1
    • 2003-05-27
    • US09703158
    • 2000-10-31
    • Denis Marie Charles HeymansLeo Wim Van NoortJozef Jacobus Titus SmitsHendrik Stichter
    • Denis Marie Charles HeymansLeo Wim Van NoortJozef Jacobus Titus SmitsHendrik Stichter
    • C07D30124
    • C07D303/16
    • Process for the manufacture of diglycidylesters of &agr;,&agr;′-branched dicarboxylic acids, comprising (a) the reaction of the &agr;,&agr;′-branched dicarboxylic acid with a halo substituted monoepoxide such as an epihalohydrin, in a 1.1-20 acid equivalent ratio relative to the &agr;,&agr;′-branched aliphatic dicarboxylic acid, optionally in the presence of water and water-miscible solvent, and in the presence of a catalyst in an amount of at most 45 mol % of the acid equivalent amount of the &agr;,&agr;′-branched aliphatic dicarboxylic acid, at a temperature in the range of from 30 to 110° C., during a period in the range of from 0.5 to 2.5 hr, (b) addition of alkali metal hydroxide or alkali metal alkanolate up to an acid equivalent ratio as to the &agr;,&agr;′-branched aliphatic dicarboxylic acid in the range of from 0.9:1 to 1.2:1, and reaction at a temperature of from 0 to 80° C., (c) distillation of the obtained reaction mixture to remove the excess halo substituted monoepoxide and the solvent and water formed, and (d) removal of alkali metal halide salt, preferably by washing the obtained diglycidylester with water mixed with an inert organic solvent, after optionally treating the residual product with a concentrated aqueous alkali metal hydroxide solution, in order to complete the dehydrohalogenation.
    • 制备α,α'-支链二羧酸的二缩水甘油酯的方法,包括(a)α,α'-支链二羧酸与卤代取代的单环氧化物如表卤代醇以1.1-20酸当量比的反应 相对于α,α'-支链脂族二羧酸,任选地在水和水混溶性溶剂的存在下,并且在催化剂存在下,所述催化剂的量为所述α的酸当量的至多45摩尔% α-支链脂族二羧酸,温度范围为30至110℃,时间范围为0.5至2.5小时,(b)加入碱金属氢氧化物或碱金属链烷醇酯直到 相对于α,α'-支链脂族二羧酸的酸当量比为0.9:1至1.2:1,在0至80℃的温度下进行反应,(c)将所得到的 反应混合物以除去过量的卤素取代的单环氧化物a 和(d)除去碱金属卤化物盐,优选通过用与惰性有机溶剂混合的水洗涤得到的二缩水甘油酯,在任选地用浓碱碱金属氢氧化物水溶液处理残留物之后,依次 完成脱卤化氢。