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1. 发明授权

US5267564A Pacemaker lead for sensing a physiologic parameter of the body 失效
标题翻译：起搏器导线用于感测身体的生理参数
公开(公告)号：US5267564A
公开(公告)日：1993-12-07
申请号：US716032
申请日：1991-06-14
申请人： James E. Barcel , Alvin H. Weinberg , Shahram Moaddeb , James R. Thacker
发明人： James E. Barcel , Alvin H. Weinberg , Shahram Moaddeb , James R. Thacker
IPC分类号： A61B5/145 , A61B5/1459 , A61N1/05 , A61N1/365 , A61N1/37 , H01R43/00 , A61B5/0205
CPC分类号： A61N1/056 , A61N1/36557 , A61N1/3702 , Y10T29/49117
摘要： The present invention includes a body implantable lead having a multi-polar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having glass frit sealing rings are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the glass frit such that the glass frit reflows between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.

2. 发明授权

US5490323A Method for making a body implantable sensor 失效
标题翻译：制造人体植入式传感器的方法
公开(公告)号：US5490323A
公开(公告)日：1996-02-13
申请号：US380764
申请日：1995-01-30
申请人： James R. Thacker , Alvin H. Weinberg , Shahram Moaddeb
发明人： James R. Thacker , Alvin H. Weinberg , Shahram Moaddeb
IPC分类号： A61B5/145 , A61B5/1459 , A61N1/05 , A61N1/365 , A61N1/37 , H01R43/00
CPC分类号： A61N1/056 , A61N1/36557 , A61N1/3702 , Y10T29/49117
摘要： The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.
摘要翻译：本发明包括具有多极近端连接器的主体可植入引线，至少一个耦合到至少一个刺激电极的第一导体，用于感测身体的至少一个生理参数的传感器，以及耦合到该主体的第二和第三导体传感器。传感器密封在D形外壳中。传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。用密封环（玻璃料或金属）的端盖用于密封外壳的端部。通过加热密封材料直到它们在端盖和壳体之间再流动，容易实现气密密封。有利地，传感器端子的尺寸设计成紧密地配合在端盖的窄孔内，然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。有利地，D形壳体将需要被密封的面积减少一半以上，从而减小了导线的总直径。有利地，耦合到传感器的导体独立于刺激导体起作用，从而防止对起搏器的基本操作的干扰。

3. 发明授权

US5438987A Implantable lead for sensing a physiologic parameter of the body 失效
标题翻译：用于感测身体生理参数的植入性铅
公开(公告)号：US5438987A
公开(公告)日：1995-08-08
申请号：US68454
申请日：1993-05-28
申请人： James R. Thacker , Alvin H. Weinberg , Shahram Moaddeb
发明人： James R. Thacker , Alvin H. Weinberg , Shahram Moaddeb
IPC分类号： A61B5/145 , A61B5/1459 , A61N1/05 , A61N1/365 , A61N1/37 , H01R43/00 , A61B5/0205
CPC分类号： A61N1/056 , A61N1/36557 , A61N1/3702 , Y10T29/49117
摘要： The present invention includes a body implantable lead having a multipolar proximal connector, at least a first conductor coupled to at least one stimulating electrode, a sensor for sensing at least one physiologic parameter of the body, and a second and a third conductor coupled to the sensor. The sensor is hermetically sealed in a D-shaped housing. Sensor components are mounted onto a microelectronic substrate which is advantageously placed on an inner flat portion of the D-shaped housing. End caps having sealing rings, either glass frit or metal, are used to seal the ends of the shell. A hermetic seal is easily achieved by heating the sealing material until they re-flow between the end caps and the shell. Advantageously, the sensor terminals are sized to fit snugly within a narrow bore of the end cap which is then circumferentially welded closed. The D-shaped sensor is placed on a carrier having at least two lumens. At least the first and second conductors pass through the lumens for connection with the stimulating electrode and the distal end of the sensor. Advantageously, the D-shaped housing reduces the area that needs to be hermetically sealed by more than half, and thus reduces the overall diameter of the lead. Advantageously, the conductors coupled to the sensor function independently from the stimulation conductors so that interference with basic operation of the pacemaker is prevented.
摘要翻译：本发明包括具有多极近端连接器的主体可植入引线，至少一个耦合到至少一个刺激电极的第一导体，用于感测身体的至少一个生理参数的传感器，以及耦合到该主体的第二和第三导体传感器。传感器密封在D形外壳中。传感器组件安装在有利地放置在D形壳体的内部平坦部分上的微电子衬底上。用密封环（玻璃料或金属）的端盖用于密封外壳的端部。通过加热密封材料直到它们在端盖和壳体之间再流动，容易实现气密密封。有利地，传感器端子的尺寸设计成紧密地配合在端盖的窄孔内，然后圆形焊接封闭。 D形传感器放置在具有至少两个流明的载体上。至少第一和第二导体穿过腔以便与刺激电极和传感器的远端连接。有利地，D形壳体将需要被密封的面积减少一半以上，从而减小了导线的总直径。有利地，耦合到传感器的导体独立于刺激导体起作用，从而防止对起搏器的基本操作的干扰。

4. 发明申请

US20130006238A1 CATHETER WITH VARIABLE ARCUATE DISTAL SECTION 有权
标题翻译：具有可变电极远程部分的导管
公开(公告)号：US20130006238A1
公开(公告)日：2013-01-03
申请号：US13174742
申请日：2011-06-30
申请人： Tom Allen Ditter , Diana Gallardo , Shahram Moaddeb , Michael Olen Zirkle
发明人： Tom Allen Ditter , Diana Gallardo , Shahram Moaddeb , Michael Olen Zirkle
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B5/0422 , A61B5/0538 , A61B5/062 , A61B5/6857 , A61B2017/00867 , A61B2018/00029 , A61B2018/00214 , A61B2018/00351 , A61B2018/00357 , A61B2018/00375 , A61B2018/00577 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/1407 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2034/2051 , A61B2034/2063 , A61B2090/065 , A61B2217/007
摘要： A catheter includes an elongated body, a distal assembly with a shape-memory member defining a generally circular form, and a control handle adapted to actuate a deflection puller wire for deflecting a portion of the elongated body, and a contraction wire for contracting the generally circular form. The generally circular form which carries at least one ring electrode has an off-edge configuration relative to the elongated body such that a longitudinal axis of the elongated body does not intersect the circumference of the circular form and the generally circular form spirals about the longitudinal axis of the elongated body. Moreover, the circular form can have an on-axis configuration such that the longitudinal axis of the elongated body is axially aligned with a central longitudinal axis of the circular form, or an off-axis configuration such that these axes are axially offset from each other. In a more detailed embodiment, the catheter has a distal assembly with a helical form or a crescent form carrying a plurality of irrigated ablation ring electrodes and a plurality of smaller ring electrodes adapted for impedance recording or PV potential recording. A support member with shape memory extends through the distal assembly to provide the helical or crescent form. The support member has a varying stiffness along its length, for example, a decreasing stiffness toward a distal end of the support member. The support member can also be hollow so that it can receive a mandrel whose stiffness is greater than that of the support member.
摘要翻译：导管包括细长体，具有限定大致圆形形状的形状记忆构件的远端组件和适于致动用于偏转细长体的一部分的偏转牵引线的控制手柄，以及用于收缩一般的收缩线圆形承载至少一个环形电极的大致圆形形状具有相对于细长主体的非边缘构造，使得细长主体的纵向轴线不与圆形的圆周相交，并且大致圆形的形状围绕纵向轴线螺旋的细长的身体。此外，圆形形状可以具有轴上构造，使得细长体的纵向轴线与圆形的中心纵向轴线轴向对齐，或者离轴构造使得这些轴线彼此轴向偏移。在更详细的实施例中，导管具有远端组件，其具有螺旋形式或月牙形，其携带多个灌溉消融环电极和适于阻抗记录或PV电位记录的多个较小环形电极。具有形状记忆的支撑构件延伸穿过远端组件以提供螺旋形或新月形。支撑构件沿其长度具有变化的刚度，例如朝向支撑构件的远端的刚度的降低。支撑构件也可以是中空的，使得其可以容纳其刚度大于支撑构件的刚度的心轴。

5. 发明申请

US20110257741A1 IMPLANTS AND METHODS FOR RESHAPING HEART VALVES 审中-公开
标题翻译：用于修复心脏瓣膜的植入物和方法
公开(公告)号：US20110257741A1
公开(公告)日：2011-10-20
申请号：US13088189
申请日：2011-04-15
申请人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
发明人： Shahram Moaddeb , Emanuel Shaoulian , Samuel M. Shaolian , Michael R. Henson , Richard S. Rhee , Steven C. Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/3468 , A61B2017/00243 , A61F2/2451 , A61F2002/249 , A61F2210/0076
摘要： Tissue shaping methods and devices are provided for reinforcing and/or remodeling heart valves. In certain embodiments, magnetic tissue shaping devices are implanted in tissue adjacent heart valve leaflets. The devices are mutually attractive or repulsive so as to remodel the heart tissue and improve heart valve function. In certain other embodiments, one or more tissue shaping devices including shape memory material are implanted in a patient's body within or on tissue adjacent a heart valve leaflet. The shape memory material can be activated within the patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. The shape memory tissue shaping devices are implanted in a first configuration and then activated to remember a second configuration that displaces tissue so as to remodel the heart valve geometry and improve heart valve function. In certain other embodiments, a brace is crimped to the base of a heart valve leaflet to support the leaflet and improve valve closure.
摘要翻译：提供组织成形方法和装置用于加强和/或改造心脏瓣膜。在某些实施例中，将磁组织成形装置植入在心脏瓣膜小叶附近的组织中。这些装置是相互吸引或排斥的，以便改造心脏组织并改善心脏瓣膜功能。在某些其他实施例中，包括形状记忆材料的一个或多个组织成形装置植入在心脏瓣膜附近的组织内或组织附近的患者体内。形状记忆材料可以以较少侵入性或非侵入性方式在患者体内被激活，例如通过经皮或外部施加能量到患者身体。形状记忆组织成形装置以第一配置植入，然后被激活以记住置换组织的第二配置，以便改造心脏瓣膜几何形状并改善心脏瓣膜功能。在某些其他实施例中，支架卷曲到心脏瓣膜小叶的底部以支撑小叶并改善瓣膜关闭。

6. 发明申请

US20080183285A1 ADJUSTABLE CARDIAC VALVE IMPLANT WITH SELECTIVE DIMENSIONAL ADJUSTMENT 审中-公开
标题翻译：可调节心脏瓣膜植入物，具有选择性的尺寸调整
公开(公告)号：US20080183285A1
公开(公告)日：2008-07-31
申请号：US12031652
申请日：2008-02-14
申请人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
发明人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb , Richard S. Rhee
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2448 , A61F2210/0014 , A61F2210/0023 , A61F2210/009 , A61F2250/0001 , A61F2250/0004
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。该变换被配置为减小前部和后部之间的距离超过两个侧向部分之间的距离。

7. 发明申请

US20070118215A1 Magnetic engagement of catheter to implantable device 审中-公开
标题翻译：导管与植入式装置的磁接合
公开(公告)号：US20070118215A1
公开(公告)日：2007-05-24
申请号：US11600470
申请日：2006-11-16
申请人： Shahram Moaddeb
发明人： Shahram Moaddeb
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/009 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： An annuloplasty device for supporting a heart valve is described. The system includes a body member having a proximal end, a distal end, and a length extending therebetween. The body member is configured to be implanted within a patient's heart at or near a base of a heart valve. The body member includes a first portion, including a shape memory material and being transformable from a first configuration to a second configuration in response to an activation energy. The body member also includes a second portion coupled to the first portion. The second portion includes a magnetic material that is responsive to a magnetic field. When in position at or near the base of the heart valve and when the body member transforms from the first configuration to the second configuration, the body member reshapes a tissue of the heart so as to exert a force on the heart valve base.
摘要翻译：描述了用于支撑心脏瓣膜的瓣环成形术装置。该系统包括具有近端，远端以及在它们之间延伸的长度的本体构件。身体构件被构造成植入患者心脏内心脏瓣膜的基部或附近。身体构件包括第一部分，包括形状记忆材料，并且可响应于活化能从第一构型转变为第二构型。主体构件还包括联接到第一部分的第二部分。第二部分包括响应于磁场的磁性材料。当在心脏瓣膜的基部处或附近的位置处，并且当身体构件从第一构造变换到第二构造时，身体构件重新形成心脏的组织，以便对心脏瓣膜基底施加力。

8. 发明申请

US20070067027A1 Left atrial balloon catheter 审中-公开
标题翻译：左心房球囊导管
公开(公告)号：US20070067027A1
公开(公告)日：2007-03-22
申请号：US11520981
申请日：2006-09-13
申请人： Shahram Moaddeb , Richard Rhee , Steve Anderson
发明人： Shahram Moaddeb , Richard Rhee , Steve Anderson
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/2466 , A61F2250/0004
摘要： Systems, methods and devices are provided for activation of an adjustable annuloplasty device. The devices may include a catheter system for percutaneously activating an adjustable annuloplasty device, including a handle assembly, a shaft assembly having at least one fluid lumen, and a distal element. The shaft assembly extends between the handle assembly and the distal element, the distal element being in fluid communication with the handle assembly via the at least one fluid lumen. The distal element includes an elongated core having a first port and an expandable member. The core extends through the expandable member and the expandable member is movable between a collapsed position and an inflated position. The distal element has a preset shape in the inflated position, having a long axis that is curvilinear. A surface of the distal element extends along the long axis and is configured to conform to a curvilinear surface of the annuloplasty device. In some arrangements, the annuloplasty device includes a ring, and the circumference of the annuloplasty device is a circumference of the ring.
摘要翻译：提供了用于激活可调节瓣环成形术装置的系统，方法和装置。装置可以包括用于经皮激活可调节瓣环成形术装置的导管系统，包括手柄组件，具有至少一个流体腔的轴组件和远端元件。轴组件在手柄组件和远侧元件之间延伸，远端元件通过至少一个流体腔与手柄组件流体连通。远侧元件包括具有第一端口和可扩张构件的细长芯。芯延伸穿过可膨胀构件，并且可膨胀构件可在折叠位置和膨胀位置之间移动。远侧元件在充气位置具有预设的形状，具有曲线的长轴。远侧元件的表面沿着长轴延伸并且构造成符合瓣环成形术装置的曲线表面。在一些布置中，瓣环成形术装置包括环，并且瓣环成形术装置的圆周是环的圆周。

9. 发明申请

US20060100669A1 Method and system for atrial defibrillation 审中-公开
公开(公告)号：US20060100669A1
公开(公告)日：2006-05-11
申请号：US11319250
申请日：2005-12-27
申请人： Kristine Fuimaono , Shahram Moaddeb
发明人： Kristine Fuimaono , Shahram Moaddeb
IPC分类号： A61N1/39
CPC分类号： A61N1/0563
摘要： A method and system for atrial defibrillation in a patient are provided. The method comprises introducing into the patient a catheter comprising an elongated catheter body having proximal and distal ends and at least one lumen therethrough, and a basket-shaped electrode assembly at the distal end of the catheter body. The electrode assembly has proximal and distal ends and comprises a plurality of spines connected at their proximal and distal ends, each spine comprising an elongated spine electrode along its length. The electrode assembly has an expanded arrangement wherein the spines bow radially outwardly and a collapsed arrangement wherein the spines are arranged generally along the axis of the catheter body. The method further comprises introducing the electrode assembly into the heart of the patient and applying defibrillation energy to the tissue through one or more of the elongated electrodes. The system comprises a catheter as described above in combination with an external defibrillator electrically connected to the catheter.

10. 发明申请

US20050288776A1 Adjustable cardiac valve implant with coupling mechanism 有权
标题翻译：可调节心脏瓣膜植入物与联接机构
公开(公告)号：US20050288776A1
公开(公告)日：2005-12-29
申请号：US11123851
申请日：2005-05-06
申请人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb
发明人： Emanuel Shaoulian , Samuel Shaolian , Shahram Moaddeb
IPC分类号： A61F2/00 , A61F2/02 , A61F2/24
CPC分类号： A61F2/2448 , A61F2/2445 , A61F2210/0014 , A61F2210/0023 , A61F2250/0001 , A61F2250/0004 , A61F2250/0082
摘要： Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.
摘要翻译：提供了用于支撑身体结构的方法和装置。可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。能量可以包括例如声能，射频能量，光能和磁能。因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。在某些实施例中，这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。管状构件包括容置端和插入端，所述插入端构造成与管状构件的容置端相连，使得管状构件基本上形成环的形状。插入端构造成相对于插座端移动以改变环的圆周。

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