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1. 发明申请

US20150366889A1 PROTON-MOTIVE FORCE STIMULATION TO POTENTIATE AMINOGLYCOSIDE ANTIBIOTICS AGAINST PERSISTENT BACTERIA 有权
标题翻译：原始动力学刺激阻止氨基甲酸酯抗生素对抗细菌性细菌
公开(公告)号：US20150366889A1
公开(公告)日：2015-12-24
申请号：US14115528
申请日：2012-05-04
申请人： Mark P. Brynildsen , James J. Collins , Kyle R. Allison
发明人： Mark P. Brynildsen , James J. Collins , Kyle R. Allison
IPC分类号： A61K31/7036 , A61K31/7004 , A61K31/047
CPC分类号： A61K31/7036 , A61K9/0019 , A61K31/047 , A61K31/19 , A61K31/7004 , A61K45/06 , Y02A50/473 , A61K2300/00
摘要： Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more PMF stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. These approaches and therapeutic methods are also useful with non-metabolic chemicals that induce proton-motive force in bacteria.
摘要翻译：本文提供了使用氨基糖苷类抗生素的特定组合以及一种或多种PMF刺激化合物的高定量浓度来改善慢性感染治疗并减少，延迟或抑制生物膜形成的组合物和方法。这些新颖的方法很容易适应于临床环境，因为所用的抗生素和代谢物的毒性和功效已经在体内进行了研究，并且因为抗生素和代谢物的给药都是已知的。这些方法和治疗方法对于在细菌中诱导质子运动力的非代谢化学物质也是有用的。

2. 发明授权

US08306752B1 Method to determine transcriptional regulation pathways in organisms 有权
标题翻译：确定生物体内转录调控途径的方法
公开(公告)号：US08306752B1
公开(公告)日：2012-11-06
申请号：US12271944
申请日：2008-11-17
申请人： Timothy S. Gardner , James J. Collins , Boris Hayete , Jeremiah Faith
发明人： Timothy S. Gardner , James J. Collins , Boris Hayete , Jeremiah Faith
IPC分类号： G06F7/00
CPC分类号： G06F19/24 , G06F19/20
摘要： The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
摘要翻译：本发明涉及用于鉴定表达的调节多肽与这些调节多肽的调节活性的靶标之间的调节关系的计算机实现的方法和系统。更具体地，本发明提供了用于鉴定细胞中生物化学物质之间的调节依赖性的新方法。在特定实施方案中，提供了用于鉴定转录因子与转录因子的转录因子和基因靶标之间或转录因子与转录因子的一组基因靶标之间的调节相互作用的计算机实现的方法。还提供了用于预测一组转录因子与其相应的一组转录靶标底物之间的调节相互作用的基因组大小的方法。

3. 发明授权

US5388591A Method and apparatus for analyzing the human postural control system 失效
标题翻译：人体姿态控制系统分析方法及装置
公开(公告)号：US5388591A
公开(公告)日：1995-02-14
申请号：US987715
申请日：1992-12-09
申请人： Carlo J. De Luca , James J. Collins
发明人： Carlo J. De Luca , James J. Collins
IPC分类号： A61B5/103
CPC分类号： A61B5/1036 , A61B5/4023
摘要： A method and an apparatus for analyzing the human postural control system includes computing the mean square displacement of the center of pressure beneath a subject's feet vs. the time interval. The result is plotted as a stabilogram diffusion plot. The stabilogram diffusion plot, since reproducible, provides physiologically meaningful information from which an assessment of the subject's postural control system can be made. A Brownian diffusion coefficient, which is indicative of the level of stochastic activity of the center of pressure, can be calculated from the slope of the stabilogram diffusion plot. Also, from the slope of the log-log stabilogram diffusion plot, a determination can be made as to whether the system is moving closer to or away from a state of relative equilibrium. Finally, a short term open-loop postural control scheme, which operates before a long term closed-loop feedback postural control scheme activates, can be studied from the stabilogram diffusion plot. Also, from the stabilogram diffusion plot, a determination can be made as to when the postural control system switches from open-loop control to closed-loop control.
摘要翻译：用于分析人类姿态控制系统的方法和装置包括计算受试者脚下的压力中心与时间间隔的均方位移。结果绘制为稳态扩散图。稳定的扩散图，由于可重现，提供了生理上有意义的信息，从而可以对主体的姿势控制系统进行评估。可以从稳态扩散图的斜率计算表示压力中心的随机活动水平的布朗扩散系数。此外，从对数 - 对数稳态扩散图的斜率可以确定系统是否移动更靠近或远离相对平衡状态。最后，在稳定的闭环反馈姿势控制方案激活之前运行的短期开环姿态控制方案可以从稳态扩散图进行研究。此外，从稳态扩散图可以确定姿势控制系统何时从开环控制切换到闭环控制。

4. 发明授权

US09284562B2 Biological circuit chemotactic converters 有权
标题翻译：生物电路趋化转换器
公开(公告)号：US09284562B2
公开(公告)日：2016-03-15
申请号：US13512453
申请日：2010-11-30
申请人： James J. Collins , Timothy Kuan-Ta Lu
发明人： James J. Collins , Timothy Kuan-Ta Lu
IPC分类号： C12N15/00 , C12N15/09 , C07H21/04 , C12Q1/68 , H03M1/66 , H03M1/12 , C12N15/63
CPC分类号： C12N15/63 , C12N15/635
摘要： Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis in cellular systems. Flexibility in these biological circuit chemotactic converter is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create network systems that regulate chemotactic responses based on the combination and nature of input signals received.
摘要翻译：这里描述的是利用诸如遗传拨动开关和单一转换存储器模块（SIMM）等模块化组件的新型生物电路趋化转换器，用于检测和转换诸如化学引诱剂的外部输入到允许在细胞系统中自主趋化的输出。这些生物电路趋化转换器的灵活性通过将各个模块化组件即SIMM和遗传拨动开关组合在一起来提供。这些生物转换器开关可以组合在各种网络拓扑中，以创建基于所接收的输入信号的组合和性质来调节趋化反应的网络系统。

5. 发明授权

US08308665B2 Method and apparatus for improving human balance and gait and preventing foot injury 有权
标题翻译：改善人体平衡和步态，防止脚部受伤的方法和装置
公开(公告)号：US08308665B2
公开(公告)日：2012-11-13
申请号：US10793729
申请日：2004-03-08
申请人： Jason D. Harry , James J. Collins , James B. Niemi , Atilla A. Priplata , Stephen J. Kleshinski
发明人： Jason D. Harry , James J. Collins , James B. Niemi , Atilla A. Priplata , Stephen J. Kleshinski
IPC分类号： A61H1/00 , A61B5/103
CPC分类号： A61H1/00 , A43B3/0005 , A43B7/00 , A43B7/1465 , A43B13/00 , A43B17/00 , A43B19/00 , A61F5/0111 , A61F5/14 , A61H39/002 , A61H2205/125 , A61N1/0456 , A61N1/0468 , A61N1/0476 , A61N1/0484 , A61N1/0492 , A61N1/20 , A61N1/32 , A61N2/06
摘要： A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns. The controller optionally includes a communication port for interfacing with an external computer for purposes of optimizing and programming the controller. The wearable system is powered by a power source.
摘要翻译：一种方法和可穿戴系统，用于通过脚和脚踝的神经刺激来增强人的平衡和步态并防止脚部受伤。通过经由电极或振动致动器或其组合的电极或振动致动器或其组合来提供用于神经感觉增强的亚阈值刺激，其设置在可佩戴的平台上，例如鞋垫，袜子鞋，可移除的鞋插入件中，或者没有平台的支撑施加到皮肤一个人的表面用于治疗目的的超阈值刺激，例如改善血流量，也由振动致动器提供。致动器和电极由耦合到控制器的偏置信号发生器产生的偏置信号驱动。在控制器的控制下的信号发生器适于产生非确定性随机信号，重复模式或一系列模式。控制器可选地包括用于与外部计算机接口的通信端口，用于优化和编程控制器。可穿戴系统由电源供电。

6. 发明申请

US20120003630A1 MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC 有权
标题翻译：用于计数器，二进制运算，存储器和逻辑的基于核酸的基于电路的电路
公开(公告)号：US20120003630A1
公开(公告)日：2012-01-05
申请号：US13141165
申请日：2009-12-22
申请人： James J. Collins , Timothy Lu
发明人： James J. Collins , Timothy Lu
IPC分类号： C12Q1/68 , C12N15/63
CPC分类号： C12Q1/6897 , C12N15/63 , C12N15/635 , C12Q2521/507
摘要： We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for encoding memory in cells and cellular systems. Our designs are easily extended to compute to high numbers, by utilizing the >100 known recombinases to create subsequent modules. Flexibility in our engineered genetic counter designs is provided by daisy-chaining individual modular components, i.e., SIMMs together. These modular components of the engineered genetic counters can be combined in other network topologies to create circuits that perform, amongst other things, logic and memory. Our novel engineered genetic counter designs allow for the maintenance of memory and provide the ability to count between discrete states by expressing the recombinases between their cognate recognition sites.
摘要翻译：我们已经创建了新颖的遗传算法设计及其使用方法，其利用DNA重组酶来提供称为单一转换酶存储器模块（SIMM）的模块化系统，用于对细胞和细胞系统中的存储器进行编码。通过使用> 100个已知重组酶来创建后续模块，我们的设计可以轻松扩展到高数量计算。我们设计的基因计数器设计中的灵活性是通过菊花链连接单个模块化组件（即SIMM）来提供的。设计的遗传计数器的这些模块化组件可以组合在其他网络拓扑中，以创建执行逻辑和存储器的电路。我们的新颖设计的基因计数器设计允许维持记忆，并提供通过在其同源识别位点之间表达重组酶来提供离散状态之间的计数能力。

7. 发明申请

US20110097721A1 IN VIVO GENE SENSORS 有权
标题翻译： VIVO基因传感器
公开(公告)号：US20110097721A1
公开(公告)日：2011-04-28
申请号：US12867537
申请日：2009-02-17
申请人： James J. Collins , Timothy Kuan-Ta Lu
发明人： James J. Collins , Timothy Kuan-Ta Lu
IPC分类号： C12Q1/68 , C12N15/00
CPC分类号： C12N15/1086 , C12N15/111 , C12N15/63 , C12N2310/111 , C12N2320/50
摘要： Described are methods and compositions for the detection of target genes. The inventors have developed a synthetic nucleic acid sensor-effector gene circuit. In cells without a target gene, the circuit suppresses e.g., effector production, but in the presence of the target gene the suppression is subject to competition, such that the synthetic sensor is de-repressed and permits expression of the effector gene. The methods and compositions described further permit the selective expression of an effector gene in those cells expressing the target gene. In this manner, cells expressing a target gene can be selectively targeted for treatment or elimination. In certain aspects, the methods and compositions described permit the selective expression of an agent such as a therapeutic gene product, in a specifically targeted population of cells in an organism.
摘要翻译：描述了用于检测靶基因的方法和组合物。本发明人开发了合成核酸传感器 - 效应子基因电路。在没有靶基因的细胞中，电路抑制例如效应子产生，但是在靶基因的存在下，抑制受到竞争，使得合成传感器被去抑制并且允许效应基因的表达。所描述的方法和组合物进一步允许在表达靶基因的那些细胞中选择性表达效应基因。以这种方式，表达靶基因的细胞可以选择性地靶向用于治疗或消除。在某些方面，所描述的方法和组合允许在生物体中的特定靶细胞群中选择性地表达诸如治疗性基因产物的试剂。

8. 发明申请

US20100175141A1 TUNABLE GENETIC SWITCH FOR REGULATING GENE EXPRESSION 有权
标题翻译：用于调节基因表达的可调节遗传开关（TUNABLE GENETIC SWITCH FOR REGULATING GENE EXPRESSION）
公开(公告)号：US20100175141A1
公开(公告)日：2010-07-08
申请号：US12446300
申请日：2007-10-19
申请人： James J. Collins , Tara L. Deans
发明人： James J. Collins , Tara L. Deans
IPC分类号： A01K67/00 , C12N15/74 , C12N5/071 , A61K45/00 , G01N33/53 , A61P43/00
CPC分类号： C12N15/85 , C12N15/111 , C12N15/63 , C12N2310/14 , C12N2320/30 , C12N2800/30 , C12N2830/005 , C12N2830/006 , C12N2830/50 , C12N2840/102
摘要： The present invention relates generally the field of genetics, in particular methods, compositions and systems for controlling the inducible expression of transgenes, while eliminating background expression of transgene expression. The present invention relates to methods of use of the compositions and systems as disclosed herein for controlling the inducible expression of transgenes while eliminating background expression of transgene expression, such as use in, for example, the in generation of transgenic animals, use in therapeutic application and use in assays. In some embodiments, the present invention relates to a system of controlled expression of RNAi molecules which target binding sites in the untranslated regions of transgene, thereby the expression of the transgene is modulated and leakiness is reduced. The compositions and methods of the present invention can be used to for therapy, prophylaxis, research and diagnostics in diseases and disorders which afflict mammalian species, generation of transgenic animals, in the study of biological processes as well as for enhance performance of agricultural crops.
摘要翻译：本发明一般涉及遗传学领域，特别是用于控制转基因诱导表达的方法，组合物和系统，同时消除转基因表达的背景表达。本发明涉及如本文所公开的用于控制转基因诱导表达同时消除转基因表达的背景表达的用途的方法，例如在例如转基因动物的产生中的用途，在治疗应用中的用途并用于测定。在一些实施方案中，本发明涉及靶向转基因非翻译区中的结合位点的RNAi分子的受控表达系统，由此调节转基因的表达并降低渗透性。本发明的组合物和方法可用于治疗，预防，研究和诊断在影响哺乳动物物种的疾病和病症中，产生转基因动物，研究生物过程以及增强农作物的性能。

9. 发明授权

US10676721B2 Bacteriophages expressing antimicrobial peptides and uses thereof 有权
公开(公告)号：US10676721B2
公开(公告)日：2020-06-09
申请号：US13224776
申请日：2011-09-02
申请人： James J. Collins , Michael Koeris , Timothy Kuan-Ta Lu , Gregory Stephanopoulos , Christopher Jongsoo Yoon
发明人： James J. Collins , Michael Koeris , Timothy Kuan-Ta Lu , Tanguy My Chau , Gregory Stephanopoulos , Christopher Jongsoo Yoon
IPC分类号： C12N7/00 , A61K35/76 , A61K38/17 , C07K14/435 , C07K14/46 , C12N9/50
摘要： The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.

10. 发明申请

US20130034907A1 BIOLOGICAL CIRCUIT CHEMOTACTIC CONVERTERS 有权
标题翻译：生物电路化学转换器
公开(公告)号：US20130034907A1
公开(公告)日：2013-02-07
申请号：US13512453
申请日：2010-11-30
申请人： James J. Collins , Kuan-Ta Lu Timothy
发明人： James J. Collins , Kuan-Ta Lu Timothy
IPC分类号： C12N15/63 , C12N15/87
CPC分类号： C12N15/63 , C12N15/635
摘要： Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis in cellular systems. Flexibility in these biological circuit chemotactic converter is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a variety of network topologies to create network systems that regulate chemotactic responses based on the combination and nature of input signals received.
摘要翻译：这里描述的是利用诸如遗传拨动开关和单一转换存储器模块（SIMM）等模块化组件的新型生物电路趋化转换器，用于检测和转换诸如化学引诱剂的外部输入到允许在细胞系统中自主趋化的输出。这些生物电路趋化转换器的灵活性通过将各个模块化组件即SIMM和遗传拨动开关组合在一起来提供。这些生物转换器开关可以组合在各种网络拓扑中，以创建基于所接收的输入信号的组合和性质来调节趋化反应的网络系统。

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