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1. 发明申请

WO2016200337A1 COATING COMPOSITIONS COMPRISING ADHESION PROMOTING BASE LAYER 审中-公开
标题翻译：涂料组合物包含粘合促进基层
公开(公告)号：WO2016200337A1
公开(公告)日：2016-12-15
申请号：PCT/SG2016/050266
申请日：2016-06-08
申请人： JMEDTECH PTE LTD
发明人： LUO, Jingnan , WANG, Honglei
IPC分类号： A61L29/08 , A61L29/14 , B32B7/00 , B32B7/12 , C09J133/00 , C09J153/00 , C09J159/00 , C09J201/02
CPC分类号： C10M107/28 , A61L29/085 , A61L29/14 , A61L2400/10 , B05D3/067 , C08F290/061 , C09D4/06 , C09D5/002 , C09D129/14 , C09D171/02 , C09D187/005 , C10M177/00 , C10M2209/0845 , C10N2070/00 , C10N2240/66 , C08F226/10 , C08F265/06
摘要： Described herein are coatings and formulations thereof for coating a substrate for use in producing a lubricious coating on a substrate surface that is to be inserted into the body lumen of a subject. Said coatings all contain an adhesion promoting coating formulation for applying to a substrate material that is formed from a polymeric adhesion promoter, a monomeric or polymeric crosslinking agent and a photoinitiator, where the polymeric adhesion promoter is a block copolymer comprising hydrophobic and hydrophilic polymer blocks and/or a hydrophilic polymer comprising hydrophilic functional groups, where from 10% to 100% of the hydrophilic functional groups are capped with a hydrophobic functional group and the formulations thereof further contain a solvent to enable the coating to be applied to a substrate surface.
摘要翻译：本文描述的是用于涂覆基材以用于在要插入到受试者的体腔中的基底表面上制备光滑涂层的涂层及其制剂。所述涂层都含有粘附促进涂料配方，用于施加到由聚合物粘合促进剂，单体或聚合物交联剂和光引发剂形成的基底材料，其中聚合物粘合促进剂是包含疏水和亲水聚合物嵌段的嵌段共聚物， /或包含亲水性官能团的亲水性聚合物，其中10％至100％的亲水性官能团用疏水性官能团封端，并且其制剂还含有溶剂以使涂层施加于基材表面。

2. 发明申请

WO2017007430A1 DRUG-COATED MEDICAL DEVICES 审中-公开
标题翻译：药物包装医疗器械
公开(公告)号：WO2017007430A1
公开(公告)日：2017-01-12
申请号：PCT/SG2016/050318
申请日：2016-07-08
申请人： JMEDTECH PTE LTD
发明人： LUO, Jingnan , LEE, Qian Yi, Michele , WANG, Honglei
IPC分类号： A61L29/08 , A61M25/10 , A61L33/00 , A61K31/00 , A61K47/30
CPC分类号： A61L29/16 , A61K31/337 , A61K31/436 , A61L29/085 , A61L2300/416 , A61L2300/62 , A61L2300/622 , A61L2300/624 , A61L2420/02 , A61M25/1029 , A61M2025/1004 , A61M2025/1031 , A61M2025/105 , A61M2025/1075
摘要： Disclosed herein is a drug-coated medical device in the form of a balloon having an inner surface and an outer hydrophobic surface, an adhesion balance layer directly on the outer hydrophobic surface of the balloon, comprising a hydrophilic polymer and/or a hydrophilic compound where the hydrophilic compound has a molecular weight of less than 1,000 Daltons, and a therapeutic layer directly on the adhesion balance layer comprising a therapeutic agent and a pharmaceutically acceptable carrier, wherein the therapeutic agent is a hydrophobic therapeutic agent with one or more hydrogen-bonding groups and is provided as discrete drug particles in the therapeutic layer, the drug particles have at least one dimension that is less than 25 μηι and are uniformly distributed on the surface of the balloon, and the pharmaceutically acceptable carrier is hydrophilic and has a molecular weight of less than 1,000 Daltons. A process to make the drug-coated medical device and uses thereof are also disclosed.
摘要翻译：本文公开了一种具有内表面和外疏水表面的气囊形式的药物涂覆的医疗装置，直接在气囊的外疏水表面上的粘附平衡层，包括亲水性聚合物和/或亲水性化合物，其中亲水性化合物的分子量小于1,000道尔顿，直接在包含治疗剂和药学上可接受的载体的粘附平衡层上的治疗层，其中治疗剂是具有一个或多个氢键基团的疏水性治疗剂并且作为治疗层中的离散药物颗粒提供，药物颗粒具有至少一个小于25微米的尺寸并且均匀分布在球囊的表面上，并且药学上可接受的载体是亲水性的并且具有小于1,000道尔顿。还公开了制备药物包被的医疗装置及其用途的方法。

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