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1. 发明申请

US20020146770A1 RAS proteins 审中-公开
标题翻译： RAS蛋白
公开(公告)号：US20020146770A1
公开(公告)日：2002-10-10
申请号：US10051986
申请日：2002-01-15
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Y. Tom Tang , Preeti Lal , Karl J. Guegler , Neil C. Corley , Chandra Patterson , Sajeev Batra , Mariah R. Baughn
IPC分类号： C12Q001/68 , G01N033/53 , C07H021/04 , C12N009/10 , C12P021/02 , C12N005/06
CPC分类号： C07K14/4722 , A61K38/00
摘要： The invention provides seven human Ras proteins (RASP) and polynucleotides which identify and encode RASP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of RASP.
摘要翻译：本发明提供了七种人类Ras蛋白（RASP）和识别和编码RASP的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与RASP表达相关的疾病的方法。

2. 发明申请

US20020127689A1 Novel human galectins 审中-公开
标题翻译：新型人类galectins
公开(公告)号：US20020127689A1
公开(公告)日：2002-09-12
申请号：US09894526
申请日：2001-06-27
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Surya K. Goli , Olga Bandman , Phillip R. Hawkins , Joanne R. Petithory
IPC分类号： C12N009/24 , C07H021/04 , C12P021/02 , C12N005/06 , A01K067/00 , C12N001/21
CPC分类号： C07K14/4726 , A61K38/00
摘要： The present invention provides two novel human galectins (designated individually as GAL-5HA and GAL-5HB, and collectively as GAL-5H) and polynucleotides which identify and encode GAL-5H. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding GAL-5H and a method for producing GAL-5H. The invention also provides for use of GAL-5H and agonists, antibodies, or antagonists specifically binding GAL-5H, in the prevention and treatment of diseases associated with expression of GAL-5H. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding GAL-5H for the treatment of diseases associated with the expression of GAL-5H. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding GAL-5H.
摘要翻译：本发明提供两种新型人半乳凝素（单独命名为GAL-5HA和GAL-5HB，统称为GAL-5H）和识别和编码GAL-5H的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码GAL-5H的核酸序列和产生GAL-5H的方法。本发明还提供使用GAL-5H和特异性结合GAL-5H的激动剂，抗体或拮抗剂来预防和治疗与GAL-5H表达相关的疾病。另外，本发明提供了反义分子用于编码GAL-5H的多核苷酸用于治疗与GAL-5H表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合GAL-5H的抗体的诊断测定法。

3. 发明申请

US20020127225A1 New annexin binding protein 审中-公开
标题翻译：新膜联蛋白
公开(公告)号：US20020127225A1
公开(公告)日：2002-09-12
申请号：US09808885
申请日：2001-03-14
申请人： Incyte Pharmaceuticals, Inc
发明人： Jennifer L. Hillman , Neil C. Corley , Purvi Shah
IPC分类号： G01N033/53 , A61K039/395 , A61K039/40 , A61K039/42 , A61K039/00 , C07K005/00 , C07K007/00 , C07K016/00 , C07K017/00 , A61K038/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human annexin binding protein (NABP-1) and polynucleotides which identify and encode NABP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NABP-1.
摘要翻译：本发明提供人类膜联蛋白结合蛋白（NABP-1）和识别和编码NABP-1的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与NABP-1表达相关的疾病的方法。

4. 发明申请

US20020106737A1 Human SQM1 protein homolog 审中-公开
标题翻译：人类SQM1蛋白同源物
公开(公告)号：US20020106737A1
公开(公告)日：2002-08-08
申请号：US09962021
申请日：2001-09-21
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07H021/04 , C12P021/02 , C12N005/06 , C07K014/78
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human SQM2. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding human SQM2. The invention also provides for the use of purified SQM2 and its agonists in the production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. Additionally, the invention provides for the use of SQM2 antagonists and inhibitors, including antisense molecules to SQM2 polynucleotides (i.e., gene sequences) in pharmaceutical compositions for the treatment of diseases associated with the expression of SQM2. The invention also describes diagnostic assays which utilize the polynucleotide to hybridize with the transcripts and/or genomic DNA encoding SQM2 and anti-human SQM2 antibodies which specifically bind to SQM2.
摘要翻译：本发明提供鉴定和编码新型人SQM2的多核苷酸。本发明提供了包含编码人SQM2的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供纯化的SQM2及其激动剂在生产重组蛋白质和用于治疗与SQM2表达相关的疾病的药物组合物中的用途。另外，本发明提供SQM2拮抗剂和抑制剂的用途，包括用于治疗与SQM2表达相关的疾病的药物组合物中的SQM2多核苷酸（即基因序列）的反义分子。本发明还描述了利用多核苷酸与编码SQM2的转录物和/或基因组DNA和特异性结合SQM2的抗人SQM2抗体杂交的诊断测定法。

5. 发明申请

US20020102649A1 Human transport protein homologs 审中-公开
标题翻译：人类运输蛋白质同系物
公开(公告)号：US20020102649A1
公开(公告)日：2002-08-01
申请号：US09953688
申请日：2001-09-12
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Henry Yue , Roopa M. Reddy , Gina A. Gorgone , Neil C. Corley , Yalda Azimzai , Chandra Patterson , Mariah R. Baughn
IPC分类号： A01K067/00 , C07H021/04 , C12N009/00 , C12P021/02 , C07K014/435 , C12N005/06
CPC分类号： C07K14/705 , A61K38/00
摘要： The invention provides a human transport protein homologs (HTPH) and polynucleotides which identify and encode HTPH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HTPH.
摘要翻译：本发明提供了识别和编码HTPH的人类转运蛋白同系物（HTPH）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与HTPH表达相关的障碍的方法。

6. 发明申请

US20020086830A1 Human apoptosis-related calcium-binding protein 审中-公开
标题翻译：人类凋亡相关钙结合蛋白
公开(公告)号：US20020086830A1
公开(公告)日：2002-07-04
申请号：US09969836
申请日：2001-10-01
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A01K067/00 , A61K038/17 , C07H021/04 , C12N009/64 , C12P021/02 , C12N005/06 , C12N001/21
CPC分类号： C07K14/4747 , A61K38/00 , C07K14/4702
摘要： The present invention provides a human apoptosis-related calcium-binding protein (HARC) and polynucleotides which identify and encode HARC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HARC and a method for producing HARC. The invention also provides for agonists, antibodies, or antagonists specifically binding HARC, and their use, in the prevention and treatment of diseases associated with expression of HARC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HARC for the treatment of diseases associated with the expression of HARC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HARC.
摘要翻译：本发明提供了人凋亡相关的钙结合蛋白（HARC）和识别和编码HARC的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码HARC的核酸序列和用于产生HARC的方法。本发明还提供了特异性结合HARC的激动剂，抗体或拮抗剂及其在预防和治疗与HARC表达相关的疾病中的用途。另外，本发明提供反义分子用于编码HARC的多核苷酸用于治疗与HARC表达相关的疾病。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HARC的抗体的诊断测定法。

7. 发明申请

US20020086406A1 Human ubiquitin-conjugating enzyme homologs 失效
标题翻译：人泛素结合酶同源物
公开(公告)号：US20020086406A1
公开(公告)日：2002-07-04
申请号：US09930026
申请日：2001-08-14
申请人： Incyte Pharmaceuticals, Inc.
发明人： Preeti Lal , Jennifer L. Hillman , Karl J. Guegler , Neil C. Corley , Mariah Baughn , Yalda Azimzai
IPC分类号： C12N009/64 , C12Q001/68 , A01K067/00 , C12N005/06 , C12N001/21 , C12P021/02
CPC分类号： C12N9/93
摘要： The invention provides human ubiquitin-conjugating enzyme homologs (UCEH) and polynucleotides which identify and encode UCEH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of UCEH.
摘要翻译：本发明提供了人泛素缀合酶同源物（UCEH）和识别和编码UCEH的多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供用于诊断，治疗或预防与UCEH表达相关的障碍的方法。

8. 发明申请

US20020081290A1 Protein kinase homologs 审中-公开
标题翻译：蛋白激酶同源物
公开(公告)号：US20020081290A1
公开(公告)日：2002-06-27
申请号：US09870962
申请日：2001-05-30
申请人： Incyte Pharmaceuticals, Inc.
发明人： Olga Bandman , Y. Tom Tang , Jennifer L. Hillman , Henry Yue , Karl J. Guegler , Neil C. Corley , Gina A. Gorgone , Yalda Azimzai , Dyung Aina M. Lu
IPC分类号： A01K067/00 , A61K038/53 , C07H021/04 , C12P021/02 , C12N005/06 , C12N009/12 , C12N001/21
CPC分类号： C12N9/1205 , C12Q1/6883 , C12Q2600/158
摘要： The invention provides human protein kinase homologs (PKH) and polynucleotides which identify and encode PKH. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of PKH.
摘要翻译：本发明提供鉴定和编码PKH的人类蛋白激酶同源物（PKH）和多核苷酸。本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。本发明还提供了用于诊断，治疗或预防与PKH表达相关的障碍的方法。

9. 发明申请

US20020068341A1 Human kallikrein 失效
公开(公告)号：US20020068341A1
公开(公告)日：2002-06-06
申请号：US09764762
申请日：2001-01-16
申请人： Incyte Pharmaceuticals, Inc.
发明人： Jennifer L. Hillman , Preeti Lal
IPC分类号： C12N009/00 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C12N9/6424 , A61K38/00 , C12N9/6445
摘要： The present invention provides a human tumor suppressor (HKALL) and polynucleotides which identify and encode HKALL. The invention also provides expression vectors and host cells, agonists, antibodies, or antagonists. The invention provides methods for treating diseases associated with expression of HKALL.

10. 发明申请

US20030147893A1 Novel human transmembrane 4 superfamily protein 审中-公开
标题翻译：新型人类跨膜4超家族蛋白
公开(公告)号：US20030147893A1
公开(公告)日：2003-08-07
申请号：US09970424
申请日：2001-10-02
申请人： Incyte Pharmaceuticals, Inc
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A01K067/00 , C12Q001/68 , G01N033/574 , A61K039/395 , C12P021/02 , C12N005/06 , C07K014/47 , C07H021/04
CPC分类号： C07K14/70596 , A61K38/00
摘要： The present invention provides a novel human integral membrane (TMP-1) and polynucleotides which identify and encode TMP-1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TMP-1 and a method for producing TMP-1. The invention also provides for agonists, antibodies, or antagonists specifically binding TMP-1, and their use, in the prevention and treatment of diseases associated with expression of TMP-1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TMP-1 for the treatment of diseases associated with the expression of TMP-1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TMP-1.
摘要翻译：本发明提供一种新型人体内膜（TMP-1）和识别和编码TMP-1的多核苷酸。本发明还提供了包含编码TMP-1的核酸序列的基因工程表达载体和宿主细胞以及产生TMP-1的方法。本发明还提供了特异性结合TMP-1的激动剂，抗体或拮抗剂及其在预防和治疗与TMP-1表达相关的疾病中的用途。此外，本发明提供了将反义分子用于编码TMP-1的多核苷酸用于治疗与TMP-1表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TMP-1的抗体的诊断测定法。

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