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1. 发明申请

WO2022169720A1 ACCOUNT FOR PRELOAD CHANGES IN THE LEFT VENTRICLE 审中-公开
公开(公告)号：WO2022169720A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/014645
申请日：2022-02-01
申请人： HEARTWARE, INC.
发明人： VASUDEVAN JALAJA, Neethu Lekshmi , REYES, Carlos
IPC分类号： A61M60/122 , A61M60/403 , A61M60/546
摘要： A method of estimating a patient's cardiac preload in a patient having an implantable blood pump. The method includes generating a current waveform from operation of the implanted blood pump. A beat-to-beat pump filling index (PFI) is calculated, the PFI is calculated by dividing a current amplitude component by a time component, the amplitude component being calculated by subtracting a trough of the current waveform from an inflection point divided by an amplitude difference of peak to trough of the waveform, the time component being calculated by dividing a time between the trough and the inflection point by a time between the peak and the trough. An alert is generated if the PFI deviates from predetermined thresholds.

2. 发明申请

WO2019152363A1 AXIAL BLOOD PUMP WITH IMPELLER RINSE OPERATION 审中-公开
公开(公告)号：WO2019152363A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/015561
申请日：2019-01-29
申请人： HEARTWARE, INC.
发明人： CASAS, Fernando , REYES, Carlos , WOLMAN, Justin , JOHNSON, Thomas R.
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1029 , A61M1/1012 , A61M1/1086 , A61M1/122 , A61M2205/50
摘要： A method of controlling a blood pump including executing a control command to temporarily displace an impeller of the blood pump within a pump housing from a first axial position relative to the pump housing to a second axial position a distance away from the first axial position using a vector control method, and causing the impeller to move from the second axial position to a third axial position, the third axial position including a positive and a negative displacement of the impeller relative to the first axial position.

3. 发明申请

WO2018026655A2 HEART RATE DETERMINATION BASED ON VAD CURRENT WAVEFORM 审中-公开
标题翻译：基于VAD电流波形的心率测定
公开(公告)号：WO2018026655A2
公开(公告)日：2018-02-08
申请号：PCT/US2017/044459
申请日：2017-07-28
申请人： HEARTWARE, INC.
发明人： REYES, Carlos , CASAS, Fernando , WOLMAN, Justin
IPC分类号： A61M1/10
摘要： The present disclosure provides for methods and systems for determining heart rate of a patient. Based on motor current signals of a ventricular assist device (VAD), each of first, second and third events in the measured current signal may be detected, the first event being indicative of a rise or fall in the current signal, the second event being indicative of a rise or fall in the current signal in the opposite direction as the first event, and the third event being indicative of a rise or fall in the current signal in the same direction as the first event. A timer counter may be initiated upon detection of the first event, and an elapsed time may be measured upon detection of the third event. Heart rate may be determined based on the elapsed time of the timer counter.
摘要翻译：本公开提供了用于确定患者的心率的方法和系统。基于心室辅助装置（VAD）的电机电流信号，可以检测测量的电流信号中的第一事件，第二事件和第三事件中的每一个事件，第一事件指示电流信号的上升或下降，第二事件是指示电流信号在与第一事件相反的方向上的上升或下降，并且第三事件指示电流信号在与第一事件相同的方向上的上升或下降。定时器计数器可以在检测到第一事件时启动，并且可以在检测到第三事件时测量流逝的时间。心率可以基于计时器计数器的经过时间来确定。

4. 发明申请

WO2016089693A1 MEAN ARTERIAL PRESSURE ESTIMATION 审中-公开
标题翻译：平均压力估计
公开(公告)号：WO2016089693A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/062617
申请日：2015-11-25
申请人： HEARTWARE, INC.
发明人： BROWN, Michael, C. , REYES, Carlos
IPC分类号： A61M1/10
CPC分类号： A61B5/7278 , A61B5/0215 , A61M1/101 , A61M1/1031 , A61M1/1036 , A61M1/1086 , A61M1/122 , A61M2205/33 , A61M2205/3303 , A61M2205/3334 , A61M2205/35
摘要： The present disclosure provides for a method (600) of monitoring the mean arterial pressure of a patient having a blood pump (101). The method may involve identifying a segment of time associated with diastole of the patient's cardiac cycle (604), determining a first parameter of the blood pump corresponding to the identified segment of time (606, 608), and estimating the mean arterial pressure of the patient based at least in part on the first parameter (610).
摘要翻译：本公开提供了监测具有血液泵（101）的患者的平均动脉压的方法（600）。该方法可以包括识别与患者的心动周期的舒张相关的时间段（604），确定对应于所识别的时间段（606,608）的血液泵的第一参数，以及估计所述时间段的平均动脉压所述患者至少部分地基于所述第一参数（610）。

5. 发明申请

WO2021101822A1 METHOD TO EXTRACT AND QUANTIFY THE CARDIAC END DIASTOLIC POINT/MITRAL VALVE CLOSING POINT FROM THE HVAD ESTIMATED FLOW WAVEFORM 审中-公开
公开(公告)号：WO2021101822A1
公开(公告)日：2021-05-27
申请号：PCT/US2020/060661
申请日：2020-11-16
申请人： HEARTWARE, INC.
发明人： REYES, Carlos , VASUDEVAN JALAJA, Neethu Lekshmi
IPC分类号： A61M60/178 , A61M60/232 , A61M60/216 , A61M60/422 , A61M60/538 , A61M60/546
摘要： A control circuit for a sensorless implantable blood pump configured to determine mitral valve regurgitation includes processing circuitry configured to generate an estimated blood flow waveform from the sensorless implanted blood pump and generate an alert if between an end period of diastole and a beginning period of systole a measured amplitude of the estimated blood flow waveform does not include an inflection point.

6. 发明申请

WO2019194976A1 MULTI-INPUT SPEED RESPONSE ALGORITHM FOR A BLOOD PUMP 审中-公开
公开(公告)号：WO2019194976A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/023181
申请日：2019-03-20
申请人： HEARTWARE, INC.
发明人： REYES, Carlos , CHORPENNING, Katherine , FERREIRA, Antonio Luiz Silva , VASUDEVAN JALAJA, Neethu Lekshmi , WOLMAN, Justin , CASAS, Fernando
IPC分类号： A61M1/10 , A61M1/12
摘要： A method of responding to an adverse event associated with an implantable blood pump including detecting the adverse event, reducing a pump speed of the blood pump relative to a set pump speed in response to the detected adverse event, and determining whether at least one of a group consisting of the adverse event and a second adverse event is present following the reducing of the pump speed of the blood pump. If the at least one of the group consisting of the adverse event and a second adverse event is not present, the method includes increasing the pump speed to the set pump speed and if the at least one of the group consisting of the adverse event and a second adverse event is present while increasing the pump speed to the set pump speed, the method includes reducing the pump speed to a maximum safe operating speed.

7. 发明申请

WO2019125999A1 HEART RATE MEASUREMENT USING BLOOD PUMP IMPELLER LOCATION 审中-公开
公开(公告)号：WO2019125999A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/065936
申请日：2018-12-17
申请人： HEARTWARE, INC.
发明人： WOLMAN, Justin , CASAS, Fernando , REYES, Carlos
IPC分类号： A61M1/12 , A61M1/10
CPC分类号： A61M1/12 , A61M1/1012 , A61M1/1031 , A61M1/1086 , A61M1/122 , A61M2205/3334
摘要： A method of determining a heart rate of a patient having an implanted blood pump including applying a voltage to a plurality of coils of a stator of the blood pump to produce an electromagnetic force to rotate a rotor in communication with the plurality of coils; displaying a waveform associated with a back electromotive force in the plurality of coils of the blood pump, the waveform being proportional to an axial position of the rotor relative to the stator; determining a time interval between a first alteration in the waveform relative to a baseline and a second alteration in the waveform relative to the baseline; and determining the heart rate of the patient based on the time interval.

8. 发明申请

WO2018026716A1 VAD WITH AORTIC VALVE OPENING DETECTION 审中-公开
标题翻译：带有主动阀开启检测的VAD
公开(公告)号：WO2018026716A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/044698
申请日：2017-07-31
申请人： HEARTWARE, INC.
发明人： DEMOU, Zoe , REYES, Carlos , GRAVE DE PERALTA, Pedro E.
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1086 , A61M1/1036 , A61M1/122 , A61M2205/3334 , A61M2205/3365 , A61M2205/50 , A61M2230/04
摘要： The present disclosure provides for methods and devices for determining the probability of a patient's aortic valve being open or closed. In one embodiment, a plurality of flow rate data points are obtained from a blood pump, a portion of the flow rate data points are identified, first and second index values characterizing properties of at least part of the identified portion of the flow rate data points determined using only arithmetic and/or exponentiation operations, and a probability is determined of whether the patient's aortic valve is open or closed based on the first and second index values.
摘要翻译：本公开提供用于确定患者的主动脉瓣打开或关闭的可能性的方法和装置。在一个实施例中，从血泵获得多个流率数据点，识别流率数据点的一部分，表征流率数据点的至少部分识别部分的属性的第一和第二索引值仅使用算术和/或求幂运算来确定，并且基于第一和第二指标值确定患者的主动脉瓣是打开还是关闭的概率。

9. 发明申请

WO2018026655A3 HEART RATE DETERMINATION BASED ON VAD CURRENT WAVEFORM 审中-公开
公开(公告)号：WO2018026655A3
公开(公告)日：2018-02-08
申请号：PCT/US2017/044459
申请日：2017-07-28
申请人： HEARTWARE, INC.
发明人： REYES, Carlos , CASAS, Fernando , WOLMAN, Justin
IPC分类号： A61M1/10
摘要： The present disclosure provides for methods and systems for determining heart rate of a patient. Based on motor current signals of a ventricular assist device (VAD), each of first, second and third events in the measured current signal may be detected, the first event being indicative of a rise or fall in the current signal, the second event being indicative of a rise or fall in the current signal in the opposite direction as the first event, and the third event being indicative of a rise or fall in the current signal in the same direction as the first event. A timer counter may be initiated upon detection of the first event, and an elapsed time may be measured upon detection of the third event. Heart rate may be determined based on the elapsed time of the timer counter.

10. 发明申请

WO2017173217A1 AXIAL FLOW BLOOD PUMP WITH RADIALLY OFFSET ROTOR 审中-公开
标题翻译：带放射性偏转转子的轴流式血泵
公开(公告)号：WO2017173217A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025283
申请日：2017-03-31
申请人： HEARTWARE, INC.
发明人： LAROSE, Jeffrey A. , REYES, Carlos , SHAMBAUGH, Charles R.
IPC分类号： A61M1/10 , A61M1/12
摘要： A blood pump including a housing defining a proximal end, a distal end, and a first axis extending from the proximal end to the distal end. A ferromagnetic rotor is disposed within the housing and configured pump blood in a direction along the first axis. A stator is disposed within housing and around the ferromagnetic rotor, the stator is configured to apply a magnetic force causing rotation of the ferromagnetic rotor, the stator being eccentric to the rotor.
摘要翻译：一种血泵，包括限定近端，远端和从近端延伸到远端的第一轴线的壳体。铁磁转子设置在壳体内并且沿着第一轴线的方向配置泵血。定子设置在壳体内并围绕铁磁转子，定子构造成施加引起铁磁转子旋转的磁力，定子相对于转子偏心。

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