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1. 发明申请

US20050054009A1 Agents that bind to and inhibit human cytochrome P450 2C19 有权
公开(公告)号：US20050054009A1
公开(公告)日：2005-03-10
申请号：US10941285
申请日：2004-09-14
申请人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
发明人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
IPC分类号： G01N33/573 , G01N33/53
CPC分类号： G01N33/5735 , G01N33/573 , G01N2333/80 , G01N2333/90245 , Y10T436/105831
摘要： The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C19 levels in individuals relative to P450 2C19 levels in a control population.

2. 发明申请

US20070154971A1 AGENTS THAT BIND TO AND INHIBIT HUMAN CYTOCHROME P450 2C19 有权
标题翻译：与人体细胞色素P450 2C19相结合的药剂
公开(公告)号：US20070154971A1
公开(公告)日：2007-07-05
申请号：US11683229
申请日：2007-03-07
申请人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
发明人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
IPC分类号： G01N33/53 , C12Q1/26
CPC分类号： G01N33/5735 , G01N33/573 , G01N2333/80 , G01N2333/90245 , Y10T436/105831
摘要： The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C19, and in methods of measuring P450 2C19 levels in individuals relative to P450 2C19 levels in a control population.
摘要翻译：本发明提供了具有有利性质的人细胞色素P450 2C19的单克隆抗体和其他结合剂，其包括基本上抑制人细胞色素P450 2C19的酶活性和缺乏与其它人细胞色素P450的特异性结合的能力。本发明的结合剂特别可用于筛选细胞色素P450 2C19代谢药物的方法，以及测量个体相对于对照群体中P450 2C19水平的P450 2C19水平的方法。

3. 发明申请

US20050075487A1 Agents that bind to and inhibit human cytochrome P450 2C8, 2C9, 2C18 and 2C19 有权
标题翻译：与人细胞色素P450 2C8,2C9,2C18和2C19结合并抑制人体的药剂
公开(公告)号：US20050075487A1
公开(公告)日：2005-04-07
申请号：US10616760
申请日：2003-07-09
申请人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
发明人： Harry Gelboin , Kristopher Krausz , Frank Gonzalez
IPC分类号： C07K16/40 , C12N5/20 , C07K16/42 , C07H21/04 , C12N5/06
CPC分类号： C07K16/40 , C12N2799/023 , C12N2799/026 , G01N2333/90245
摘要： The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C8, 2C9, 2C18, and 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of the various human cytochrome P450 2C family members and lack of specific binding to other human cytochromes P450. The binding agents of the invention are useful inter alia in methods for screening drugs for metabolism by cytochrome P450 2C family members, and in methods of screening individuals for a poor metabolizing individual human P450 2C family phenotypes.
摘要翻译：本发明提供了具有有利性质的人细胞色素P450 2C8,2C9,2C18和2C19的单克隆抗体和其他结合剂，其包括基本上抑制各种人细胞色素P450 2C家族成员的酶活性的能力，以及缺乏与其他人细胞色素的特异性结合 P450。本发明的结合剂尤其可用于筛选细胞色素P450 2C家族成员的代谢药物的方法，以及筛选个体对于代谢不良的人P450 2C家族表型的方法。

4. 发明授权

US5851221A Attachment apparatus and method for an implantable medical device 失效
标题翻译：一种植入式医疗装置的附着装置及方法
公开(公告)号：US5851221A
公开(公告)日：1998-12-22
申请号：US905093
申请日：1997-08-01
申请人： Eric M. Rieder , Frank Gonzalez , Randal C. Schulhauser , Bryan Zart
发明人： Eric M. Rieder , Frank Gonzalez , Randal C. Schulhauser , Bryan Zart
IPC分类号： A61N1/375
CPC分类号： A61N1/375
摘要： An implantable medical device of the type formed of a hermetically sealed enclosure attached on a enclosure attachment surface thereof to a module attachment surface of a pre-formed header module is disclosed. The pre-formed header module is attached to the enclosure attachment surface through use of a retention structure extending away from the enclosure surface into proximity with a portion of the pre-formed header module when the enclosure and module attachment surfaces are aligned with respect to one another. The retention structure comprises a bendable member that is bent from an initial position allowing the pre-formed header module to be seated with respect to the hermetically sealed enclosure to a retention position making an attachment against a bend engaging portion of the pre-formed header module. The bendable member is the free end portion of an attachment tab having a tab base attached at a predetermined location of the hermetically sealed enclosure such that the upstanding attachment tab extends in a predetermined direction away from the enclosure surface and the free end of the attachment tab is bendable laterally with respect to the predetermined direction against the bend engaging portion. Adhesive is then applied to the retention mechanism and the space between the enclosure attachment surface and the module attachment surface.
摘要翻译：公开了一种由安装在其外壳附接表面上的密封外壳形成的可植入式医疗装置，其中预先形成的头部模块的模块附接表面。当外壳和模块附接表面相对于一个对准时，通过使用延伸远离外壳表面的保持结构与预成型的头部模块的一部分相接合，预形成的头模块附接到外壳附接表面另一个。保持结构包括弯曲构件，该弯曲构件从初始位置弯曲，允许预成型的头部模块相对于密封的壳体就座到保持位置，该保持位置抵靠预成型的头部模块的弯曲接合部分。可弯曲构件是附接突片的自由端部，其具有附接在密封外壳的预定位置处的突片底座，使得直立的附接突片沿着预定的方向延伸远离封闭表面，并且附接突片的自由端相对于预定方向横向地弯曲弯曲接合部分。然后将粘合剂施加到保持机构以及外壳附接表面和模块附接表面之间的空间。

5. 发明授权

US5141524A Catalytic clean combustion promoter compositions for liquid fuels used in internal combustion engines 失效
标题翻译：用于内燃机的液体燃料的催化清洁助燃剂组合物
公开(公告)号：US5141524A
公开(公告)日：1992-08-25
申请号：US608526
申请日：1990-11-02
申请人： Frank Gonzalez
发明人： Frank Gonzalez
IPC分类号： C10L1/14 , C10L1/16 , C10L1/18 , C10L1/22 , C10L10/00 , F02B3/06
CPC分类号： C10L10/04 , C10L1/14 , C10L10/02 , C10L10/06 , C10L10/10 , C10L10/12 , C10L1/1616 , C10L1/1824 , C10L1/1852 , C10L1/1857 , C10L1/223 , C10L1/231 , F02B3/06
摘要： The incorporation of these catalytic clean combustion promoters compositions to liquid fuels for internal combustion engines, improve their combustion properties; thus, reducing their air polluting emissions as nitrogen oxides (NO.sub.x), carbon monoxide (CO), and unburned hydrocarbons (HC). Also, these fuel activators reduce smoke and particulate matter exhaust emissions. Moreover, the addition of these fuel activators, reduce the corrosion properties of fuels, clean the whole fuel systems of gums and varnishes, clean and prevent carbon deposits on injectors, valves and on the combustion chamber parts.The composition of these catalytic clean combustion promoters additives includes aromatic and aliphatic hydrocarbon solvents with and without oxygenated functional groups, aromatic amines, a catalytic agent in chemical reactions, nitroparaffin solvents, aliphatic ether as an octaine assistant, and/or Kerosene as a cetane assistant.These chemical compositions can be incorporated to liquid fuels derivated from petroleum oils in micro-volumetric concentrations ranging from 400 to 2,500 parts per million (ppm.) by volume of engine fuel.
摘要翻译：将这些催化清洁燃烧促进剂组合物掺入用于内燃机的液体燃料中，改善其燃烧性能; 从而减少其作为氮氧化物（NOx），一氧化碳（CO）和未燃碳氢化合物（HC）的空气污染排放。此外，这些燃料活化剂减少了烟雾和颗粒物质的废气排放。此外，添加这些燃料活化剂，降低燃料的腐蚀性能，清洁牙龈和清漆的整个燃料系统，清洁并防止喷射器，阀门和燃烧室部件上的碳沉积。这些催化清洁助燃剂添加剂的组成包括具有和不具有氧化官能团的芳族和脂族烃溶剂，芳族胺，化学反应中的催化剂，硝基链烷烃溶剂，脂肪族醚作为辛基助剂，和/或煤油作为十六烷助剂。这些化学成分可以掺入石油中的液体燃料，其微量体积浓度范围为发动机燃料的体积的400至2,500ppm（ppm）。

6. 发明申请

US20100058485A1 CONTENT PROTECTION AND DIGITAL RIGHTS MANAGEMENT (DRM) 有权
标题翻译：内容保护和数字权限管理（DRM）
公开(公告)号：US20100058485A1
公开(公告)日：2010-03-04
申请号：US12548420
申请日：2009-08-26
申请人： Frank Gonzalez
发明人： Frank Gonzalez
IPC分类号： H04N7/16
CPC分类号： G06F21/10
摘要： An end to end content protection system that includes enhanced digital rights management (DRM). The system provides content delivery to devices over a managed multimedia home network. The system includes a domain manager for receiving content, wherein the domain manager includes a cable card, conditional access component and a MSO security application and a managed client device, coupled to and registered with the domain manager, the managed client device running a security DRM application client, the managed client device communicates with the MSO security application in the domain manager, wherein the MSO security application of the domain manager and the security DRM application client of the managed client instantiate a preferred DRM as an overlay on top of any other content protection scheme.
摘要翻译：包括增强型数字版权管理（DRM）的端到端内容保护系统。该系统通过被管理的多媒体家庭网络向设备提供内容传送。该系统包括用于接收内容的域管理器，其中域管理器包括耦合到域管理器并且向域管理器注册的有线卡，条件访问组件和MSO安全应用以及被管理客户端设备，运行安全DRM 应用客户端，被管理客户端设备与域管理器中的MSO安全应用进行通信，其中域管理器的MSO安全应用和被管理客户端的安全DRM应用客户端将优选的DRM实例化为任何其他内容之上的覆盖保护方案。

7. 发明申请

US20050266695A1 Novel aqueous based metal etchant 审中-公开
标题翻译：新型含水基金属蚀刻剂
公开(公告)号：US20050266695A1
公开(公告)日：2005-12-01
申请号：US11173788
申请日：2005-07-01
申请人： Frank Gonzalez , Emil Kneer , Michelle Elderkin , Vince Leon
发明人： Frank Gonzalez , Emil Kneer , Michelle Elderkin , Vince Leon
IPC分类号： C23F1/20 , C23F1/44 , H01L21/3213 , H01L21/60 , H01L21/302 , H01L21/461
CPC分类号： H01L21/32134 , C23F1/20 , C23F1/44 , H01L24/11 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01022 , H01L2924/01023 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01042 , H01L2924/01047 , H01L2924/01067 , H01L2924/01072 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/19041
摘要： The present invention provides an aluminum etchant solution for etching an aluminum surface in the presence of solder bumps. The etchant solution includes about 42% to about 80% phosphoric acid; about 0.1% to about 6% nitric acid; about 5% to about 40% acetic acid; about 0.005% to about 5% of an amine oxide surfactant; about 0.1% to about 8% of a Pb solubilizing additive; and about 5 to about 25% de-ionized water; wherein the solder bumps are substantially phosphate free after the etching. Also provided is a process for etching an exposed aluminum surface in a semiconductor structure in the presence of solder bumps including the steps of: contacting the exposed aluminum surface with the etchant solution; rinsing the semiconductor structure with de-ionized water; and drying the semiconductor structure to remove residual water; wherein the solder bumps are substantially phosphate free after the etching.
摘要翻译：本发明提供了一种用于在存在焊料凸块的情况下蚀刻铝表面的铝蚀刻剂溶液。蚀刻剂溶液包括约42％至约80％的磷酸; 约0.1％至约6％的硝酸; 约5％至约40％乙酸; 约0.005％至约5％的氧化胺表面活性剂; 约0.1％至约8％的Pb增溶添加剂; 和约5至约25％的去离子水; 其中在蚀刻之后，焊料凸块基本上不含磷酸盐。还提供了一种用于在存在焊料凸块的情况下蚀刻半导体结构中的暴露的铝表面的方法，包括以下步骤：使暴露的铝表面与蚀刻剂溶液接触; 用去离子水冲洗半导体结构; 并干燥半导体结构以除去残留水; 其中在蚀刻之后，焊料凸块基本上不含磷酸盐。

8. 发明授权

US5433756A Chemical clean combustion promoter compositions for liquid fuels used in compression ignition engines and spark ignition engines 失效
标题翻译：用于压燃式发动机和火花点火发动机的液体燃料的化学清洁助燃剂组合物
公开(公告)号：US5433756A
公开(公告)日：1995-07-18
申请号：US199948
申请日：1994-02-22
申请人： Frank Gonzalez
发明人： Frank Gonzalez
IPC分类号： C10L1/14 , C10L1/16 , C10L1/18 , C10L1/22 , C10L10/00 , F02B3/06
CPC分类号： C10L1/14 , C10L10/02 , C10L10/04 , C10L10/10 , C10L10/12 , C10L1/1616 , C10L1/1824 , C10L1/1852 , C10L1/1857 , C10L1/223 , C10L1/231 , F02B3/06
摘要： Catalytic clean-combustion-promoter compositions for use with finished gasoline or diesel fuels in compression ignition engines and spark ignition engines improve fuel efficiency and reduce air polluting emissions. The compositions utilize ketones as solvents, alcohols as cosolvents, nitroparaffin compounds as combustion supporters, and, to promote the chemical reactions, a catalytic medium is used. When the additive compositions are employed in microvolumetric concentrations ranging from 670 to 1,350 parts per million by volume of engine fuel, the chemical bonding of the carbon molecules with the oxygen molecules is increased during the combustion process, thus, producing a synergistic effect, which increases the combustion characteristic of the fuels to be burned and reduces the tendency of the fuel to create deposits, and therefore reduces the CO.sub.2 and NO.sub.X emissions, and increases the fuel economy. Engines operating with the present compositions added to the fuel do not require the use of fuels with a high cetane or octane number for maximum performance. The present chemical clean-combustion-promoter compounds meet the standards of the EPA "Clean Air Act" as amended in 1990 for emissions from liquid hydrocarbon fuels.
摘要翻译：用于压燃式发动机和火花点火发动机的成品汽油或柴油燃料的催化清洁助燃剂组合物提高燃料效率并减少空气污染排放。组合物使用酮作为溶剂，醇作为共溶剂，硝基石蜡化合物作为燃烧载体，并且为了促进化学反应，使用催化介质。当添加剂组合物以体积浓度为670至1350ppm的发动机燃料的微量浓度使用时，在燃烧过程中碳分子与氧分子的化学键合增加，从而产生协同效应，其增加要燃烧的燃料的燃烧特性，并降低燃料产生沉积物的倾向，从而减少二氧化碳和氮氧化物的排放，并提高燃料经济性。以本添加到燃料中的组合物运行的发动机不需要使用具有高十六烷值或辛烷值的燃料以获得最大性能。目前的化学清洁助燃剂化合物符合1990年修订的EPA“清洁空气法案”中关于液体碳氢燃料排放的标准。

9. 发明授权

US5316558A Catalytic clean-combustion-promoter compositions for liquid hydrocarbon fuels used in internal combustion engines 失效
标题翻译：用于内燃机中的液体烃燃料的催化清洁助燃剂组合物
公开(公告)号：US5316558A
公开(公告)日：1994-05-31
申请号：US932063
申请日：1992-08-19
申请人： Frank Gonzalez
发明人： Frank Gonzalez
IPC分类号： C10L1/14 , C10L1/16 , C10L1/18 , C10L1/22 , C10L10/00 , F02B3/06
CPC分类号： C10L10/02 , C10L1/14 , C10L10/04 , C10L10/06 , C10L10/10 , C10L10/12 , C10L1/1616 , C10L1/1824 , C10L1/1852 , C10L1/1857 , C10L1/223 , C10L1/231 , F02B3/06
摘要： Petroleum derived fuel compositions of improved efficiency for use with finished gasoline and diesel fuels in compression ignition engines and spark ignition engines include a catalytic clean-combustion-promoter composition to improve fuel efficiency and reduce their air polluting effects. The catalytic clean-combustion-promoter compositions utilize ketones as solvents, alcohols as cosolvents, ethers as octane supporters, nitroparaffin compounds as combustion supporters, and, to promote the chemical reactions a catalytic medium is used in combination with aromatic amines. When all the compounds are combined in the recited quantities, the molecular structure and surface tension of the fuel is transformed through chemical bonding to produce a synergistic effect, which increases the combustion characteristic of the fuels to be burned and reduces the tendency of the fuel to create deposits, and therefore reduces the exhaust emissions. Engines operating with the catalytic clean-combustion-promoter compositions added to the fuel do not require the use of fuels with a high cetane or octane number for maximum performance. Such compositions may be employed in micro-amount ranging from 400 to 2,500 parts per million relative to the volume of the basic liquid of engine fuel. The present catalytic clean-combustion-promoter compounds meet the standards of the EPA "Clean Air Act" as amended in 1990.
摘要翻译：用于压燃式发动机和火花点火发动机的成品汽油和柴油燃料使用的提高效率的石油衍生燃料组合物包括提高燃料效率并降低其空气污染效应的催化清洁助燃剂组合物。催化清洁助燃剂组合物使用酮作为溶剂，醇作为助溶剂，作为辛烷撑子的醚，作为燃烧载体的硝基石蜡化合物，以及为了促进化学反应，将催化介质与芳族胺组合使用。当所有化合物以所述量组合时，通过化学键合转化燃料的分子结构和表面张力以产生协同效应，这增加燃烧燃料的燃烧特性并降低燃料的趋势造成沉积物，从而减少废气排放。加入到燃料中的催化清洁助燃剂组合物运行的发动机不需要使用具有高十六烷值或辛烷值的燃料以达到最佳性能。相对于发动机燃料的碱性液体的体积，这种组合物可以以400至2500份/百万的微量使用。本催化清洁助燃剂化合物符合1990年修订的EPA“清洁空气法案”的标准。

10. 发明授权

US07147798B2 Aqueous based metal etchant 失效
标题翻译：水性金属蚀刻剂
公开(公告)号：US07147798B2
公开(公告)日：2006-12-12
申请号：US10921785
申请日：2004-08-19
申请人： Frank Gonzalez , Emil Kneer , Michelle Elderkin , Vince Leon
发明人： Frank Gonzalez , Emil Kneer , Michelle Elderkin , Vince Leon
IPC分类号： C09K13/00 , H01L21/302
CPC分类号： H01L21/32134 , C23F1/20 , C23F1/44 , H01L24/11 , H01L2224/13099 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01019 , H01L2924/01022 , H01L2924/01023 , H01L2924/01024 , H01L2924/01029 , H01L2924/01033 , H01L2924/01042 , H01L2924/01047 , H01L2924/01067 , H01L2924/01072 , H01L2924/01074 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/14 , H01L2924/19041
摘要： The present invention provides an aluminum etchant solution for etching an aluminum surface in the presence of solder bumps. The etchant solution includes about 42% to about 80% phosphoric acid; about 0.1% to about 6% nitric acid; about 5% to about 40% acetic acid; about 0.005% to about 5% of an amine oxide surfactant; about 0.1% to about 8% of a Pb solubilizing additive; and about 5 to about 25% de-ionized water; wherein the solder bumps are substantially phosphate free after the etching. Also provided is a process for etching an exposed aluminum surface in a semiconductor structure in the presence of solder bumps including the steps of: contacting the exposed aluminum surface with the etchant solution; rinsing the semiconductor structure with de-ionized water; and drying the semiconductor structure to remove residual water; wherein the solder bumps are substantially phosphate free after the etching.
摘要翻译：本发明提供了一种用于在存在焊料凸块的情况下蚀刻铝表面的铝蚀刻剂溶液。蚀刻剂溶液包括约42％至约80％的磷酸; 约0.1％至约6％的硝酸; 约5％至约40％乙酸; 约0.005％至约5％的氧化胺表面活性剂; 约0.1％至约8％的Pb增溶添加剂; 和约5至约25％的去离子水; 其中在蚀刻之后，焊料凸块基本上不含磷酸盐。还提供了一种用于在存在焊料凸块的情况下蚀刻半导体结构中的暴露的铝表面的方法，包括以下步骤：使暴露的铝表面与蚀刻剂溶液接触; 用去离子水冲洗半导体结构; 并干燥半导体结构以除去残留水; 其中在蚀刻之后，焊料凸块基本上不含磷酸盐。

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