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    • 2. 发明授权
    • Quantitative analysis of nuclear magnetic resonance spectra having
solvent peaks
    • 具有溶剂峰的核磁共振谱的定量分析
    • US4081742A
    • 1978-03-28
    • US755271
    • 1976-12-29
    • Donald C. HoferVincent N. KahwatyCarl R. Valentino
    • Donald C. HoferVincent N. KahwatyCarl R. Valentino
    • G01N24/08G01R33/46G01R33/00
    • G01R33/46
    • A method is described for the quantitative analysis of a solution in which the solvent produces a nuclear magnetic resonant (NMR) spectral peak that dominates the system. A first spectrum containing the peak is made by operation of a nuclear magnetic resonant spectrometer at a first gain setting. The NMR apparatus is a pulse-modulated, Fourier-transform type spectrometer. A second spectrum is produced in which a 180.degree. pulse is applied to invert the spectral component magnetization followed after a period of time by a 90.degree. pulse. The period of time is sufficient to allow the solvent or component producing the unwanted peak to relax from the inverted state to a point where there is minimum magnetization along the longitudinal axis. At this point, in many solutions the other components have completely relaxed so that the 90.degree. pulse produces a free induction decay signal which, after undergoing the Fourier-transformation, yields a spectrum that does not include any significant peak due to the solvent. Thereafter, the quantitative analysis is performed by measuring the areas under the respective component peaks and simultaneously solving a series of equations in which the weight of the various components is proportional to the respective areas under the peaks and to the gain settings of the spectrometer.
    • 描述了一种溶液的定量分析方法,其中溶剂产生支配系统的核磁共振(NMR)光谱峰。 通过在第一增益设置下的核磁共振光谱仪的操作来进行含有峰的第一光谱。 NMR装置是脉冲调制的傅里叶变换型光谱仪。 产生第二个频谱,其中施加180°脉冲以在一段时间之后90分钟脉冲将频谱分量磁化反转。 这段时间足以使得产生不需要的峰的溶剂或组分从反转状态松弛到沿着纵向轴线具有最小磁化强度的点。 此时,在许多解决方案中,其他组分已经完全松弛,因此90°脉冲产生一个自由感应衰减信号,在经历傅里叶变换之后,产生不包括由溶剂引起的任何明显峰值的光谱。 此后,通过测量各个分量峰值下的面积并同时求解一系列方程式来进行定量分析,其中各种分量的重量与峰值下的各个区域以及分光计的增益设置成比例。
    • 5. 发明授权
    • NMR field frequency lock system
    • NMR场频锁系统
    • US4110681A
    • 1978-08-29
    • US769142
    • 1977-02-16
    • Donald C. HoferVincent N. KahwatyCarl R. Valentino
    • Donald C. HoferVincent N. KahwatyCarl R. Valentino
    • G05F7/00G01R33/389G01R33/46G01R33/08
    • G01R33/46G01R33/389
    • An NMR (nuclear magnetic resonance) spectrometer has a permanent magnet provided with a field coil. A lock system cyclically pulses a deuterium lock sample to produce a FID (free induction decay) signal that is analyzed by measuring the time interval during which the FID signal crosses the zero axis a predetermined number of times. The measured interval is compared to a predetermined interval or set point, and the current through the field coil is adjusted in the direction tending to correct the field strength so as to maintain the measured interval equal to the preset interval. Such measurement, comparison and adjustment are done several times each second. When the sample is removed, the lock system retains the last field setting achieved with the sample.
    • NMR(核磁共振)光谱仪具有设置有场线圈的永磁体。 锁定系统周期性地脉冲氘锁定样本以产生FID(自由感应衰减)信号,该信号通过测量FID信号跨过零轴预定次数的时间间隔来分析。 将测量的间隔与预定的间隔或设定点进行比较,并且在趋向于校正场强的方向上调整通过励磁线圈的电流,以便将测量的间隔保持为预设间隔。 这样的测量,比较和调整每秒进行几次。 当样品被取出时,锁定系统保留用样品实现的最后一个场设置。