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1. 发明授权

US08389567B2 Compounds that modulate intracellular calcium 失效
标题翻译：调节细胞内钙的化合物
公开(公告)号：US08389567B2
公开(公告)日：2013-03-05
申请号：US12747604
申请日：2008-12-10
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
IPC分类号： A61K31/381
CPC分类号： C07D403/04 , A61K31/381 , A61K31/415 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/456 , C07D213/55 , C07D213/80 , C07D231/38 , C07D231/40 , C07D261/18 , C07D333/38 , C07D333/68 , C07D333/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。

2. 发明申请

US20100305200A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 失效
标题翻译：调节细胞内钙的化合物
公开(公告)号：US20100305200A1
公开(公告)日：2010-12-02
申请号：US12747604
申请日：2008-12-10
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
IPC分类号： A61K31/381 , C07D261/18 , C07D413/14 , C07D231/38 , C07D413/04 , C07D401/04 , C07D403/04 , C07D401/14 , C07D207/50 , C07D333/36 , A61P29/00 , A61P13/12 , A61P1/16 , A61P11/00 , A61P1/00 , A61P17/00 , A61P19/10 , A61P3/10 , A61P7/06 , A61P11/02 , A61P37/08 , A61P37/02 , A61P27/02 , A61P17/06 , A61P25/00
CPC分类号： C07D403/04 , A61K31/381 , A61K31/415 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/456 , C07D213/55 , C07D213/80 , C07D231/38 , C07D231/40 , C07D261/18 , C07D333/38 , C07D333/68 , C07D333/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。

3. 发明申请

US20130123265A1 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM 审中-公开
标题翻译：调节细胞内钙的化合物
公开(公告)号：US20130123265A1
公开(公告)日：2013-05-16
申请号：US13734827
申请日：2013-01-04
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Frank King , Yazhong Pei , Jeffrey P. Whitten
IPC分类号： C07D403/04 , A61K31/506 , A61K31/444 , A61K31/4436 , A61K31/4439 , A61K31/415 , A61K31/381 , C07D495/04 , C07D401/14 , C07D401/04 , C07D409/12 , C07D231/38 , C07D333/68 , C07D333/38 , A61K45/06 , A61K31/5025
CPC分类号： C07D403/04 , A61K31/381 , A61K31/415 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/5025 , A61K31/506 , A61K45/06 , C07D207/456 , C07D213/55 , C07D213/80 , C07D231/38 , C07D231/40 , C07D261/18 , C07D333/38 , C07D333/68 , C07D333/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/04 , C07D413/14 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译：本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。

4. 发明申请

US20080140576A1 METHOD AND APPARATUS FOR EVALUATING FRAUD RISK IN AN ELECTRONIC COMMERCE TRANSACTION 有权
标题翻译：用于评估电子商务交易中风险的方法和装置
公开(公告)号：US20080140576A1
公开(公告)日：2008-06-12
申请号：US12034447
申请日：2008-02-20
申请人： Michael LEWIS , Frank King , Thomas Arnold , William Wright , John Pettit
发明人： Michael LEWIS , Frank King , Thomas Arnold , William Wright , John Pettit
IPC分类号： G06Q10/00 , G06Q20/00 , H04L9/32 , G06F17/00
CPC分类号： G06Q20/12 , G06Q10/0635 , G06Q20/10 , G06Q20/3674 , G06Q20/3829 , G06Q20/40 , G06Q20/4016 , G06Q30/0185 , G06Q30/02 , G06Q40/00 , G06Q40/025
摘要： A method and system for evaluating fraud risk in an electronic commerce transaction between consumer and a merchant over a network is disclosed. The merchant requests service from the system over the network using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned to the merchant. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used to examine numerous factors to calculate fraud risk. The fraud screening system performs analysis that utilizes data elements submitted with the order, and includes data integrity checks and correlation analyses based on the characteristics of the transaction. Other analysis includes a comparative comparison of the current transaction against past known fraudulent transactions, and a search of a transaction history database to identify abnormal velocity patterns, name and address changes, and known defrauders. A risk score is generated and compared to the merchant's specified risk threshold. The result is returned to the merchant for order disposition. In one alternative, scoring algorithms are regularly refined through the use of a closed-loop risk modeling process that enables the service provided by the system to be fine-tuned to adapt to new or changing fraud patterns.
摘要翻译：公开了一种通过网络来评估消费者和商家之间的电子商务交易中的欺诈风险的方法和系统。商家通过安全的，开放的消息传递协议通过网络从系统请求服务。从商家收到电子商务交易或电子采购订单，测量与每个订单相关的风险级别，并向商家返回风险分数。在一个实施例中，使用数据验证，高度预测的人工智能模式匹配，网络数据聚合和负文件检查来检查多种因素来计算欺诈风险。欺诈筛选系统执行利用按订单提交的数据元素的分析，并且包括基于交易特征的数据完整性检查和相关性分析。其他分析包括当前交易与过去已知的欺诈交易的对比比较，以及搜索交易历史数据库以识别异常速度模式，名称和地址变化以及已知的欺诈者。产生风险分数，并将其与商家的指定风险阈值进行比较。结果返回给商人进行订单处理。在一个替代方案中，通过使用闭环风险建模过程来定期评估评分算法，使得系统提供的服务被微调以适应新的或变化的欺诈模式。

5. 发明授权

US5041408A Catalyst comprising calcium aluminate cement and at least one oxide of nickel or cobalt 失效
标题翻译：催化剂包括铝酸钙水泥和至少一种镍或钴的氧化物
公开(公告)号：US5041408A
公开(公告)日：1991-08-20
申请号：US519690
申请日：1990-05-07
申请人： Frank King , Martin E. Fakley
发明人： Frank King , Martin E. Fakley
IPC分类号： B01J23/74 , B01J23/78 , B01J35/10 , B01J37/00 , C02F1/58 , C02F1/72 , C02F1/76
CPC分类号： C02F1/725 , B01J23/78 , B01J35/10 , B01J35/108 , B01J37/0009 , C02F2303/185
摘要： Shaped particles suitable for use as a catalyst, or precursor thereto, particularly for the decomposition of hypohalite ions in aqueous solution, comprising a calcium aluminate cement and at least one oxide of a Group VIII metal M selected from nickel and cobalt, said particles containing 10 to 70% by weight of said Group VIII metal oxide (expressed as the divalent oxide, MO) and having a porosity in the range 25 to 50%, in which at least 30% of the pore volume is in the form of pores of size in the range 15 to 35 nm and less than 40% of the pore volume is in the form of pores of diameter greater than 35 nm.

6. 发明授权

US4501685A Catalytic selective hydrogenation of aliphatic unsaturation in copolymers 失效
标题翻译：共聚物中脂族不饱和度的催化选择性氢化
公开(公告)号：US4501685A
公开(公告)日：1985-02-26
申请号：US530360
申请日：1983-09-08
申请人： Alasdair I. Thomson , Frank King
发明人： Alasdair I. Thomson , Frank King
IPC分类号： C08C19/02 , C08F8/04 , C08G69/26
CPC分类号： C08C19/02 , C08F8/04
摘要： A catalyst system and process for the selective hydrogenation of aliphatic unsaturation in copolymers containing aromatic groups for example styrene-butadiene copolyers, the catalyst system comprising palladium supported on non-porous carbon black poisoned by a Lewis base containing nitrogen, phosphorus or sulphur moiety.
摘要翻译：用于在含有芳族基团的共聚物（例如苯乙烯 - 丁二烯共聚物）中选择性氢化脂族不饱和基团的催化剂体系和方法，所述催化剂体系包含负载在由含有氮，磷或硫部分的路易斯碱中毒的无孔碳黑上的钯。

7. 发明申请

US20110276468A1 Method And Apparatus For Evaluating Fraud Risk In An Electronic Commerce Transaction 有权
标题翻译：电子商务交易中欺诈风险评估的方法与装置
公开(公告)号：US20110276468A1
公开(公告)日：2011-11-10
申请号：US13168795
申请日：2011-06-24
申请人： Michael Lewis , Frank King , Thomas Arnold , William Wright , John Pettit
发明人： Michael Lewis , Frank King , Thomas Arnold , William Wright , John Pettit
IPC分类号： G06Q40/00
CPC分类号： G06Q20/12 , G06Q10/0635 , G06Q20/10 , G06Q20/3674 , G06Q20/3829 , G06Q20/40 , G06Q20/4016 , G06Q30/0185 , G06Q30/02 , G06Q40/00 , G06Q40/025
摘要： Evaluating fraud risk in a transaction between consumer and a merchant over a network is disclosed. The merchant requests service over the network using a secure, open messaging protocol. An e-commerce transaction or electronic purchase order is received from the merchant, the level of risk associated with each order is measured, and a risk score is returned to the merchant. In one embodiment, data validation, highly predictive artificial intelligence pattern matching, network data aggregation and negative file checks are used to examine numerous factors to calculate fraud risk. A risk score is generated and compared to the merchant's specified risk threshold. The result is returned to the merchant for order disposition.
摘要翻译：公开了通过网络对消费者和商家之间的交易中的欺诈风险进行评估。商家使用安全的，开放的消息传递协议通过网络请求服务。从商家收到电子商务交易或电子采购订单，测量与每个订单相关的风险级别，并向商家返回风险分数。在一个实施例中，使用数据验证，高度预测的人工智能模式匹配，网络数据聚合和负文件检查来检查多种因素来计算欺诈风险。产生风险分数，并将其与商家的指定风险阈值进行比较。结果返回给商人进行订单处理。

8. 发明申请

US20060269991A1 T cell protein and nucleotides encoding the same 审中-公开
标题翻译： T细胞蛋白和编码相同的核苷酸
公开(公告)号：US20060269991A1
公开(公告)日：2006-11-30
申请号：US11262688
申请日：2005-10-31
申请人： Jianfei Yang , Frank King , Jun Li , Zhen Qi , Ming Xue
发明人： Jianfei Yang , Frank King , Jun Li , Zhen Qi , Ming Xue
IPC分类号： C07K14/74 , C07H21/02 , C12P21/06
CPC分类号： C12Q1/6883 , C07K14/52 , C12Q2600/158 , G01N2500/02
摘要： The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The polypeptides and/or antibodies described herein can be used in methods for detection and treatment of certain autoimmune and inflammatory diseases including asthma.
摘要翻译：本发明涉及小鼠和人J12多核苷酸，多肽和抗J12抗体分子。 J12是优先在Th2细胞中表达的细胞因子。本文所述的多肽和/或抗体可用于检测和治疗某些自身免疫性和炎性疾病（包括哮喘）的方法中。

9. 发明授权

US06827917B1 Process for oxidation of ammonia 失效
标题翻译：氨氧化工艺
公开(公告)号：US06827917B1
公开(公告)日：2004-12-07
申请号：US09334986
申请日：1999-06-17
申请人： Andrew Mark Ward , Brett Albert Wolfindale , Frank King , Bernard John Crewdson
发明人： Andrew Mark Ward , Brett Albert Wolfindale , Frank King , Bernard John Crewdson
IPC分类号： C01B2126
CPC分类号： B01J23/83 , C01B21/265
摘要： A catalyst for oxidation reactions, particularly the oxidation of ammonia comprises oxides of (a) at least one element A selected from rare earths and yttrium, and (b) cobalt and element A being in such proportions that the element A to cobalt atomic ratio is in the range 0.8 to 1.2, at least some of said cobalt and element A oxides being present as a mixed oxide phase with less than 25% of the cobalt (by atoms) being present as free cobalt oxides, is disclosed. The catalyst may be supported on a secondary support in the form of an alkali-free alumina or lanthana wash coat on a primary support in the form of a mesh, gauze, pad, or monolith formed from a high temperature iron/aluminum alloy or a mesh, gauze, pad, monolith, or foam of a ceramic material.
摘要翻译：用于氧化反应的催化剂，特别是氨的氧化包括（a）至少一种选自稀土和钇的元素A的氧化物，和（b）钴和元素A的比例使得元素A与钴的原子比为在0.8至1.2的范围内，所述钴和元素A氧化物中的至少一些以作为游离钴氧化物存在的小于25％的钴（原子）存在的混合氧化物相存在。催化剂可以以不含碱的氧化铝或氧化镧洗涤剂的形式负载在主要载体上，形式为网状，纱布，垫，或由高温铁/铝合金或由网，纱布，垫，整料或泡沫。

10. 发明授权

US5220110A Catalysts 失效
标题翻译：催化剂
公开(公告)号：US5220110A
公开(公告)日：1993-06-15
申请号：US711053
申请日：1991-06-06
申请人： Frank King , Martin E. Fakley
发明人： Frank King , Martin E. Fakley
IPC分类号： B01J23/78 , B01J35/10 , C02F1/72 , C02F1/76
CPC分类号： C02F1/725 , B01J23/78 , B01J35/10 , B01J35/1014 , B01J35/1061 , B01J35/108 , C02F2303/185
摘要： Shaped particles, comprising a calcium aluminate cement and at least one oxide of a Group VIII metal M selected from nickel and cobalt, said particles containing 10 to 70% by weight of said Group VIII metal oxide (expressed as the divalent oxide, MO) and having a porosity in the range 25 to 50%, in which at least 30% of the pore volume is in the form of pores of size in the range 15 to 35 nm and less than 40% of the pore volume is in the form of pores of diameter greater than 35 nm. These particles are used to catalytically decompose oxidizing agents including hypohalites.
摘要翻译：包含铝酸钙水泥和选自镍和钴的Ⅷ族金属M的至少一种氧化物的成形颗粒，所述颗粒含有10至70重量％的所述VIII族金属氧化物（以二价氧化物MO表示）和其孔隙率在25至50％的范围内，其中至少30％的孔体积为15至35nm范围内的孔隙的形式，小于孔体积的40％为孔的形式直径大于35nm的孔。这些颗粒用于催化分解氧化剂，包括次卤酸盐。

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