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1. 发明申请

US20080119371A1 ANTIREFLECTIVE COATINGS FOR HIGH-RESOLUTION PHOTOLITHOGRAPHIC SYNTHESIS OF DNA ARRAYS 有权
标题翻译：用于DNA阵列高分辨光谱合成的抗反射涂层
公开(公告)号：US20080119371A1
公开(公告)日：2008-05-22
申请号：US12014879
申请日：2008-01-16
申请人： Mark TRULSON , Glenn McGall , Bei-Shen Sywe , Lisa Kajisa , Dana Truong
发明人： Mark TRULSON , Glenn McGall , Bei-Shen Sywe , Lisa Kajisa , Dana Truong
IPC分类号： C40B40/06 , C40B40/14 , C40B40/10
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00711 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , G03F7/091 , C12Q2545/101
摘要： The present invention provides an array of polymers and methods of forming arrays of polymers by providing a substrate having a first layer including one or more dielectric coatings on a solid support and a second layer including a plurality of polymers disposed on the first layer. The invention also provides methods for forming an array of polymers on a substrate using light-directed synthesis by providing a substrate having a first layer including one or more dielectric coatings on a solid support, derivatizing the first layer by contacting the first layer with a silanation reagent, and a second layer disposed on said first layer wherein the second layer includes functional groups protected with a photolabile protecting group.
摘要翻译：本发明提供了一种聚合物阵列和通过提供一种具有第一层的衬底来形成聚合物阵列的方法，所述第一层包括在固体载体上的一个或多个电介质涂层和包含设置在第一层上的多个聚合物的第二层。本发明还提供了使用光导合成法在基底上形成聚合物阵列的方法，该方法是通过提供具有第一层的基底，该第一层包含固体支持物上的一个或多个电介质涂层，通过使第一层与硅烷化接触来衍生第一层试剂和设置在所述第一层上的第二层，其中所述第二层包括用光不稳定保护基团保护的官能团。

2. 发明授权

US07144700B1 Photolithographic solid-phase polymer synthesis 有权
标题翻译：光刻固相聚合物合成
公开(公告)号：US07144700B1
公开(公告)日：2006-12-05
申请号：US09620780
申请日：2000-07-21
申请人： Glenn McGall , Daniel E. Falvey , Jacqueline A. Fidanza , Brian M. Feldman
发明人： Glenn McGall , Daniel E. Falvey , Jacqueline A. Fidanza , Brian M. Feldman
IPC分类号： C12Q1/68 , C12M1/34 , C07H21/00 , G01N33/543
CPC分类号： C07H21/00 , Y02P20/55 , Y10T436/17 , Y10T436/23
摘要： Methods, employing a polycyclic hydrocarbon or a polycyclic heteroaromatic compound as sensitizers, are provided to increase the efficiency of removing, by irradiation, photolabile protecting groups that mask reactive sites on synthesis intermediaries. Preferred groups of photolabile protecting moieties include: ((α-methyl-2-nitropiperonyl)-oxy)carbonyl (MeNPOC), ((Phenacyl)-oxy)carbonyl (PAOC), O-(9-phenylxanthen-9-yl) (PIXYL), and ((2-methylene-9,10-anthraquinone)-oxy)carbonyl (MAQOC). In conjunction with using the sensitizers and protecting groups described above, a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support is provided. These resulting solid-phase arrays are useful, for example, to assay for the presence of biochemical products in biological samples.
摘要翻译：提供了使用多环烃或多环杂芳族化合物作为敏化剂的方法，以提高通过照射去除掩蔽合成中间体上反应性位点的光不稳定保护基的效率。优选的光不稳定保护基团包括：（（α-甲基-2-硝基吡喃基） - 氧基）羰基（MeNPOC），（（苯甲酰基） - 氧基）羰基（PAOC），O-（9-苯基呫吨-9-基） PIXYL）和（（2-亚甲基-9,10-蒽醌） - 氧基）羰基（MAQOC）。结合使用上述敏化剂和保护基团，提供了从组分分子在载体上形成多种化合物的方法，每种化合物占据支持体的单独的预定区域。这些所得到的固相阵列可用于例如测定生物样品中生化产物的存在。

3. 发明授权

US07129307B2 Functionalized silicon compounds and methods for their synthesis and use 有权
公开(公告)号：US07129307B2
公开(公告)日：2006-10-31
申请号：US10853378
申请日：2004-05-25
申请人： Glenn McGall , Jonathan Eric Forman
发明人： Glenn McGall , Jonathan Eric Forman
IPC分类号： C08G77/00 , C08G77/04
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

4. 发明申请

US20060147981A1 Methods for array preparation using substrate rotation 审中-公开
标题翻译：使用基片旋转的阵列制备方法
公开(公告)号：US20060147981A1
公开(公告)日：2006-07-06
申请号：US11365770
申请日：2006-02-28
申请人： Glenn McGall , Lisa Kajisa , Bradley Kreger
发明人： Glenn McGall , Lisa Kajisa , Bradley Kreger
IPC分类号： C12Q1/68 , B05D3/02 , C12M1/34
CPC分类号： C07H21/04
摘要： Methods are provided for the preparation of polymer arrays on wafers wherein the wafers are rotated between synthesis steps to provide more uniform results across the entire wafer.
摘要翻译：提供了用于在晶片上制备聚合物阵列的方法，其中晶片在合成步骤之间旋转以在整个晶片上提供更均匀的结果。

5. 发明申请

US20060147971A1 Parallel preparation of high fidelity probes in an array format 有权
标题翻译：以阵列格式并行准备高保真探头
公开(公告)号：US20060147971A1
公开(公告)日：2006-07-06
申请号：US11324834
申请日：2006-01-03
申请人： Robert Kuimelis , Glenn McGall
发明人： Robert Kuimelis , Glenn McGall
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01J19/0046 , B01J2219/00427 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B40/06 , C40B50/14 , C40B80/00
摘要： The present invention provides massively parallel oligonucleotide synthesis and purification for applications that utilize large collections of defined high-fidelity oligonucleotides (e.g., from about 101 to about 105 different sequences, generally between 25-160 bases in length).
摘要翻译：本发明提供大规模并行的寡核苷酸合成和纯化，用于使用定义的高保真寡核苷酸的大集合（例如，约10个至约10个不同序列）的应用，一般在25-160个碱基之间）。

6. 发明申请

US20060147963A1 Detection of polynucleotides on nucleic acid arrays using azido-modified triphosphate nucleotide analogs 审中-公开
标题翻译：使用叠氮基修饰的三磷酸核苷酸类似物检测核酸阵列上的多核苷酸
公开(公告)号：US20060147963A1
公开(公告)日：2006-07-06
申请号：US11313480
申请日：2005-12-20
申请人： Anthony Barone , Handong Li , Glenn McGall
发明人： Anthony Barone , Handong Li , Glenn McGall
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12N15/1096 , C12Q1/6806 , C12Q1/6837 , C12Q2600/158 , C12Q2525/113 , C12Q2565/501 , C12Q2521/107 , C12Q2525/143 , C12Q2525/117
摘要： Methods are provided for detecting hybridization of a polynucleotide to a nucleic acid array by chemically modifying the polynucleotide to contain a detectable label. According to one aspect of the present invention, a method is provided for detecting the presence of a mRNA in a nucleic acid sample, the method having the steps of providing a mRNA sample and azido modified nucleotides, hybridizing a primer to the mRNA, reversed transcribing the mRNA to provide azido modified DNA, followed by reacting the azido groups with a detectable label, hybridizing the labeled RNA to a nucleic acid array and detecting the presence of the mRNA. Still other methods are provided for detecting the presence or absence of a polynucleotide of interest on a nucleic acid array, the method having the steps of providing a nucleic acid sample comprising a polynucleotide; providing an enzyme to amplify the polynucleotide using an azido nucleotide derivative; amplifying said polynucleotide to provide azido labeled amplified nucleic acids; reacting the azido groups on said nucleic acids with a detectable label to provide labeled nucleic acids; hybridizing said amplified nucleic acids to a nucleic acid array; and detecting the presence or absence of said polynucleotide. Still other methods are presented for detecting polynucleotides on a nucleic acid array using ligases and terminal transferases to end label polynucleotides.
摘要翻译：提供了通过化学修饰多核苷酸以含有可检测标记物来检测多核苷酸与核酸阵列的杂交的方法。根据本发明的一个方面，提供了一种用于检测核酸样品中mRNA的存在的方法，该方法具有以下步骤：提供mRNA样品和叠氮基修饰的核苷酸，将引物与mRNA杂交，逆转录 mRNA以提供叠氮基修饰的DNA，然后使叠氮基与可检测标记反应，将标记的RNA与核酸阵列杂交并检测mRNA的存在。还提供了用于在核酸阵列上检测感兴趣的多核苷酸的存在或不存在的其它方法，所述方法具有提供包含多核苷酸的核酸样品的步骤; 提供使用叠氮基核苷酸衍生物扩增多核苷酸的酶; 扩增所述多核苷酸以提供叠氮基标记的扩增核酸; 使所述核酸上的叠氮基与可检测标记物反应以提供标记的核酸; 将所述扩增的核酸与核酸阵列杂交; 并检测所述多核苷酸的存在或不存在。还提出了使用连接酶和末端转移酶终止标记多核苷酸检测核酸阵列上的多核苷酸的其它方法。

7. 发明申请

US20060134672A1 Macromolecular arrays on polymeric brushes & methods for preparing the same 审中-公开
标题翻译：聚合物刷上的大分子阵列及其制备方法
公开(公告)号：US20060134672A1
公开(公告)日：2006-06-22
申请号：US11289897
申请日：2005-11-30
申请人： Ying Chang , Curtis Frank , Glenn McGall
发明人： Ying Chang , Curtis Frank , Glenn McGall
IPC分类号： C12Q1/68 , C08G63/91 , C12M1/34
CPC分类号： C07H21/00 , C07B2200/11 , C08F4/02 , C08F289/00 , C08F290/06 , C08L51/08 , C08L51/10 , C40B40/00 , G01N33/544
摘要： Polymeric brush substrates and methods for their preparation are provided. Methods are also provided for preparing macromolecular arrays on such polymeric brush substrates. Using polymeric brush substrates allows control over functional site density as well as wettability and porosity of the substrate. These polymeric brushes are useful in solid-phase synthesis of arrays of peptides, polynucleotides or small organic molecules.
摘要翻译：提供聚合物刷底物及其制备方法。还提供了用于在这种聚合物刷基底上制备高分子阵列的方法。使用聚合物刷基质可以控制基质的功能位点密度以及润湿性和孔隙率。这些聚合物刷可用于肽，多核苷酸或小有机分子阵列的固相合成。

8. 发明申请

US20060110727A9 Modified nucleic acid probes 失效
标题翻译：修饰的核酸探针
公开(公告)号：US20060110727A9
公开(公告)日：2006-05-25
申请号：US10418414
申请日：2003-04-18
申请人： Glenn McGall , Charles Miyada , Maureen Cronin , Jennifer Tan , Mark Chee
发明人： Glenn McGall , Charles Miyada , Maureen Cronin , Jennifer Tan , Mark Chee
IPC分类号： C12Q1/68 , C07H21/04 , C07D473/02 , C07D45/02
CPC分类号： C40B80/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6832 , C40B40/06 , C40B60/14
摘要： Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译：提供了连接到固体底物的寡核苷酸类似物阵列和与使用相关的方法。寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。

9. 发明申请

US20050181421A1 Methods of array synthesis 审中-公开
标题翻译：阵列合成方法
公开(公告)号：US20050181421A1
公开(公告)日：2005-08-18
申请号：US11084308
申请日：2005-03-18
申请人： Mark Trulson , Glenn McGall , Jacqueline Fidanza
发明人： Mark Trulson , Glenn McGall , Jacqueline Fidanza
IPC分类号： B01J19/00 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , C12Q1/68 , C07H21/04 , G01N33/53
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00427 , B01J2219/00432 , B01J2219/00529 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , C07H21/00 , C40B40/06 , C40B50/14 , C40B60/14 , Y02P20/55
摘要： Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers
摘要翻译：使用辐射活化催化剂（RAC），自催化反应和保护基团来实现高灵敏度，高分辨率，多种聚合物图案阵列的辐射导向组合合成。当照射时，RAC产生可与增强子反应的催化剂，例如那些涉及自催化反应自催化反应产生至少一种从合成中间体中除去保护基的产物本发明具有广泛的应用，并且特别适用于聚合物的固相组合合成

10. 发明申请

US20050123775A1 Functionalized silicon compounds and methods for their synthesis and use 有权
标题翻译：官能化硅化合物及其合成和使用方法
公开(公告)号：US20050123775A1
公开(公告)日：2005-06-09
申请号：US10857329
申请日：2004-05-28
申请人： Glenn McGall , Jonathan Forman
发明人： Glenn McGall , Jonathan Forman
IPC分类号： A01N57/00 , A61K31/665 , B05D3/00 , B32B9/04 , C03B19/14 , C07F7/10 , C07F7/18 , C07H19/00 , C07H21/00 , C08G73/02 , C08G77/00 , C08G77/04 , C08L83/00 , C12M1/34 , C12Q1/68 , G01N15/06 , G01N33/00
CPC分类号： C08G73/0206 , C03C17/30 , C03C2218/113 , C07F7/1804 , C09D179/02 , C09D183/08 , C09D183/14 , Y10T428/31663
摘要： Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.
摘要翻译：提供了官能化硅化合物及其合成和使用的方法。官能化的硅化合物包括至少一个活化的硅基团和至少一个可衍生的官能团。示例性的可衍生的官能团包括羟基，氨基，羧基和硫醇，以及其修饰形式，例如活化或受保护的形式。官能化的硅化合物可以共价连接到表面以形成可用于广泛的不同应用的官能化表面。在一个实施方案中，将硅化合物连接到包含二氧化硅（例如玻璃底物）的底物的表面上，以在基底上提供功能化的表面，分子（包括多肽和核酸）可以附着于该功能化表面。在一个实施方案中，在官能化硅化合物共价连接到固体二氧化硅底物的表面上以在基底上形成官能化涂层之后，核酸阵列可以共价连接到基底上。因此，该方法允许形成固定在底物上的高密度核酸阵列，其可用于例如进行高体积核酸杂交测定。

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