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1. 发明申请

WO2011051145A1 ENZYME-FUNCTIONALIZED SUPPORTS 审中-公开
标题翻译：酶功能化支持
公开(公告)号：WO2011051145A1
公开(公告)日：2011-05-05
申请号：PCT/EP2010/065770
申请日：2010-10-20
申请人： GAMBRO LUNDIA AB , FLIEG, Ralf , KLOTZ, Manuela , STORR, Markus , REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , KRAUSE, Bernd , HORNUNG, Markus
发明人： FLIEG, Ralf , KLOTZ, Manuela , STORR, Markus , REMPFER, Martin , FREUDEMANN, Wolfgang , WINZ, Cornelia , KRAUSE, Bernd , HORNUNG, Markus
IPC分类号： C12N11/14 , C12N9/18 , C12N9/80
CPC分类号： C12N9/18 , C09D133/14 , C12N9/80 , C12N11/06 , C12N11/08
摘要： The present disclosure relates to enzymes linked to a solid support by a spacer, a method for producing them and the use of such immobilized enzymes.
摘要翻译：本公开内容涉及通过间隔物与固体支持物连接的酶，其制备方法和这种固定化酶的用途。

2. 发明申请

WO2006106133A1 FILTRATION MEMBRANE 审中-公开
标题翻译：过滤膜
公开(公告)号：WO2006106133A1
公开(公告)日：2006-10-12
申请号：PCT/EP2006/061396
申请日：2006-04-06
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , HORNUNG, Markus , ERTL, Thomas , STORR, Markus
发明人： KRAUSE, Bernd , HORNUNG, Markus , ERTL, Thomas , STORR, Markus
IPC分类号： B01D71/68 , B01D67/00
CPC分类号： B01D71/44 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D69/087 , B01D69/12 , B01D71/52 , B01D71/60 , B01D71/68 , B01D71/82 , B01D2325/02 , B01D2325/026 , B01D2325/12 , B01D2325/16 , B01D2325/42
摘要： The invention is directed to a ultrafiltration membrane that is capable for the retention of endotoxines and cytokine inducing substances (CIS) including bacterial DNA and/or DNA fragments from fluid and/or liquid media. The invention is further directed to a method of manufacturing such ultrafiltration membranes in a high quality and in an effective and time saving procedure, and to the use of such membranes for the retention of substances from fluids or liquids. The ultrafiltration membrane of the invention consists of a polymer blend comprising at least one hydrophobic polymer containing sulfur in its back bone, at least one hydrophilic, uncharged homo-polymer of polyvinylpyrrolidone and at least one polymer containing cationic charges. The method of manufacturing such a ultrafiltration membrane comprises dissolving at least one hydrophobic polymer containing sulfur in its back bone and at least one hydrophilic, uncharged polyvinylpyrrolidone and at least one polymer containing cationic charges in at least one solvent to form a polymer solution, subjecting the formed polymer solution to a diffusion- induced phase separation to prepare a ultrafiltration membrane, washing and subsequently drying of the ultrafiltration membrane.
摘要翻译：本发明涉及能够从流体和/或液体介质中保留包含细菌DNA和/或DNA片段的内毒素和细胞因子诱导物质（CIS）的超滤膜。本发明进一步涉及以高质量和有效且节省时间的方法制造这种超滤膜的方法，以及使用这种膜来保持来自流体或液体的物质。本发明的超滤膜由包含至少一种在其背骨中含有硫的疏水性聚合物，至少一种亲水的，不带电的聚乙烯吡咯烷酮的聚合物和至少一种含有阳离子电荷的聚合物组成的聚合物共混物构成。制造这种超滤膜的方法包括将至少一种含有硫的疏水性聚合物溶解在其背骨中，并且至少一种亲水的，不带电的聚乙烯吡咯烷酮和至少一种含至少一种溶剂中的阳离子电荷的聚合物形成聚合物溶液，形成聚合物溶液进行扩散诱导相分离以制备超滤膜，洗涤并随后干燥超滤膜。

3. 发明申请

WO2014202710A1 CAPILLARY DIALYZERS 审中-公开
标题翻译：毛细吸收剂
公开(公告)号：WO2014202710A1
公开(公告)日：2014-12-24
申请号：PCT/EP2014/062922
申请日：2014-06-19
申请人： GAMBRO LUNDIA AB
发明人： HORNUNG, Markus , WOCHNER, Arnd , BUCK, Reinhold , HILDWEIN, Helmut , KANARJOW, Nikolaus
IPC分类号： B01D63/02 , A61M1/16 , B01D69/08
CPC分类号： A61M1/1621 , A61M1/16 , B01D63/02 , B01D69/081 , B01D69/084 , B01D71/42 , B01D71/56 , B01D71/68
摘要： The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibres and from 5-15% non-crimped fibres.
摘要翻译：本公开涉及用于血液净化的毛细管透析器，其包含85-95％卷曲纤维和5-15％非卷曲纤维。

4. 发明申请

WO2014128286A1 VIRUS FILTER 审中-公开
标题翻译：病毒过滤器
公开(公告)号：WO2014128286A1
公开(公告)日：2014-08-28
申请号：PCT/EP2014/053492
申请日：2014-02-24
申请人： GAMBRO LUNDIA AB
发明人： HORNUNG, Markus , KRAUSE, Bernd , GECKELER, Johannes , SCHWEIGER, Ferdinand , DUTCZAK, Szymon , BEITER, Simon
IPC分类号： B01D69/08 , B01D71/42 , B01D71/44
CPC分类号： B01D71/42 , B01D61/14 , B01D65/022 , B01D67/009 , B01D69/02 , B01D69/08 , B01D69/081 , B01D69/085 , B01D69/087 , B01D69/088 , B01D71/44 , B01D2321/34 , B01D2323/345 , B01D2325/026 , B01D2325/04 , C02F2101/00
摘要： The invention relates to a virus filter membrane which can be used for the removal of virus particles including parvovirus. The invention further relates to a method for producing the membrane. The membrane comprises polyacrylonitrile and polyvinylpyrrolidone.
摘要翻译：本发明涉及可用于除去包括细小病毒的病毒颗粒的病毒滤膜。本发明还涉及一种膜的制造方法。膜包括聚丙烯腈和聚乙烯吡咯烷酮。

5. 发明申请

WO2008003610A1 PLASMA SEPARATION MEMBRANE 审中-公开
标题翻译：等离子体分离膜
公开(公告)号：WO2008003610A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056325
申请日：2007-06-25
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , HORNUNG, Markus , GOEHL, Herman
发明人： KRAUSE, Bernd , HORNUNG, Markus , GOEHL, Herman
IPC分类号： B01D71/68 , B01D71/28 , B01D69/08 , B01D67/00
CPC分类号： B01D69/087 , A61M1/3496 , B01D67/0011 , B01D69/02 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2323/12 , Y10T428/1376 , Y10T428/139
摘要： A process for manufacturing of an asymmetric hollow fibre membrane, comprising the steps of extruding a polymer solution through the outer ring slit of a hollow fibre spinning nozzle, simul- taneously extruding a centre fluid through the inner bore of the hollow fibre spinning nozzle, into a precipitation bath, whereby the polymer solution contains 10 to 26 wt-% of polysulfone (PSU), polyethersulfone (PES) or polyarylethersulfone (PAES), 8 to 15 wt-% polyvinylpyrrolidone (PVP), 55 to 75 wt-% N-alkyl-2-pyrrolidone (NAP) and 3 to 9 wt-% water the centre fluid con- tains 70 to 90 wt-% N-alkyl-2-pyrrolidone (NAP) and 10 to 30 wt-% water, and the precipitation bath contains 0 to 20 wt-% N-alkyl-2-pyrrolidone (NAP) and 80 to 100 wt-% water.
摘要翻译：一种不对称中空纤维膜的制造方法，其特征在于，包括以下步骤：通过中空纤维纺丝喷嘴的外圈狭缝挤压聚合物溶液，将中心流体通过中空丝纺丝喷嘴的内孔同时挤出成为沉淀浴，由此聚合物溶液含有10-26重量％的聚砜（PSU），聚醚砜（PES）或聚芳醚砜（PAES），8-15重量％聚乙烯吡咯烷酮（PVP），55-75重量％烷基-2-吡咯烷酮（NAP）和3至9重量％的水，中心流体含有70至90重量％的N-烷基-2-吡咯烷酮（NAP）和10至30重量％的水，并且沉淀浴含有0〜20重量％的N-烷基-2-吡咯烷酮（NAP）和80〜100重量％的水。

6. 发明申请

WO2015118046A1 HEMODIALYZER FOR BLOOD PURIFICATION 审中-公开
标题翻译：血液透析器用于血液净化
公开(公告)号：WO2015118046A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052365
申请日：2015-02-05
申请人： GAMBRO LUNDIA AB
发明人： HORNUNG, Markus , KRAUSE, Bernd , STORR, Markus , HERBST, Philipp , WOCHNER, Arnd , BOSCHETTI-DE-FIERRO, Adriana , VOIGT, Manuel , ZWEIGART, Carina , LOERCHER, Joachim , BUCK, Reinhold , BEHR, Heinrich , BECK, Werner
IPC分类号： B01D61/24 , B01D63/02 , B01D69/08 , B01D71/44 , B01D71/68
CPC分类号： B01D71/68 , A61M1/3479 , B01D61/243 , B01D63/021 , B01D69/084 , B01D69/087 , B01D71/38 , B01D71/44 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/20
摘要： The present disclosure relates to a dialyzer comprising a bundle of semipermeable hollow fiber membranes which is suitable for blood purification, wherein the dialyzer has an increased ability to remove larger molecules while at the same time it is able to effectively remove small uremic toxins and efficiently retain albumin and larger proteins. The invention also relates to using said dialyzer in hemodialysis.
摘要翻译：本公开涉及一种透析器，其包括适于血液净化的半透明中空纤维膜束，其中所述透析器具有增加去除较大分子的能力，同时能够有效去除小的尿毒症毒素并有效保留白蛋白和较大的蛋白质。本发明还涉及在血液透析中使用所述透析器。

7. 发明申请

WO2015118045A1 MEMBRANE FOR BLOOD PURIFICATION 审中-公开
标题翻译：血液净化膜
公开(公告)号：WO2015118045A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052364
申请日：2015-02-05
申请人： GAMBRO LUNDIA AB
发明人： BOSCHETTI-DE-FIERRO, Adriana , VOIGT, Manuel , KRAUSE, Bernd , HORNUNG, Markus , STORR, Markus , BEHR, Heinrich , BECK, Werner , ZWEIGART, Carina , BUCK, Reinhold , HERBST, Philipp , LOERCHER, Joachim , WOCHNER, Arnd
IPC分类号： B01D63/02 , B01D69/08 , B01D71/44 , B01D71/68 , A61M1/16
CPC分类号： B01D71/68 , A61M1/16 , A61M1/1621 , A61M1/3413 , B01D61/243 , B01D63/021 , B01D69/081 , B01D69/084 , B01D69/087 , B01D71/38 , B01D71/44 , B01D2323/06 , B01D2323/12 , B01D2325/022 , B01D2325/025 , B01D2325/026 , B01D2325/04 , B01D2325/20
摘要： The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications.
摘要翻译：本公开涉及适于血液净化的半透膜，例如，通过血液透析，其具有增加去除较大分子的能力，同时有效地保留白蛋白。膜的特征在于分子保留开始（MWRO）为9.0kD至14.5kD，分子量截留值（MWCO）为55kD至130kD，由葡聚糖筛分曲线确定，并可通过工业上可行的方法制备不包括在干燥前用盐处理。因此，本发明还涉及用于生产膜的方法及其在医学应用中的应用。

8. 发明申请

WO2013014218A1 PROCESS FOR PRODUCING A SPINNING SOLUTION 审中-公开
标题翻译：生产纺丝溶液的方法
公开(公告)号：WO2013014218A1
公开(公告)日：2013-01-31
申请号：PCT/EP2012/064644
申请日：2012-07-26
申请人： GAMBRO LUNDIA AB , WAGNER, Steffen , KRAUSE, Bernd , HORNUNG, Markus
发明人： WAGNER, Steffen , KRAUSE, Bernd , HORNUNG, Markus
IPC分类号： B29B7/48 , C08J3/00 , C08J3/02 , C08L39/06 , C08L81/06 , C08J3/11
CPC分类号： C08J3/11 , B01D61/145 , B01D61/243 , B01D67/0011 , B01D69/087 , B01D2323/10 , B01D2323/22 , B29B7/481 , B29B7/84 , B29C47/369 , B29C47/40 , B29C47/6087 , C08J3/005 , D01D1/02 , D01F6/56 , D01F6/94
摘要： The present disclosure relates to a continuous process for preparing a spinning solution for dialysis membranes which involves a multiple screw extruder.
摘要翻译：本公开涉及一种制备涉及多螺杆挤出机的透析膜纺丝溶液的连续方法。

9. 发明申请

WO2008046779A1 HOLLOW FIBER MEMBRANE AND METHOD FOR MANUFACTURING THEREOF 审中-公开
标题翻译：中空纤维膜及其制造方法
公开(公告)号：WO2008046779A1
公开(公告)日：2008-04-24
申请号：PCT/EP2007/060838
申请日：2007-10-11
申请人： GAMBRO LUNDIA AB , KRAUSE, Bernd , GÖHL, Hermann , HORNUNG, Markus , KRAFT, Carina
发明人： KRAUSE, Bernd , GÖHL, Hermann , HORNUNG, Markus , KRAFT, Carina
IPC分类号： B01D69/02 , B01D69/08 , B01D71/68
CPC分类号： B01D71/68 , A61B5/14525 , A61M1/16 , B01D63/02 , B01D69/02 , B01D69/08 , B01D69/087 , B01D71/44 , B01D71/62 , B01D2323/06 , B01D2323/08 , B01D2323/12 , B01D2323/22 , B01D2325/022
摘要： The present invention concerns a semipermeable hollow fiber membrane having an outer wall surface, an inner wall surface and an interior lumen extending along the length thereof and having the selective layer on the outer wall surface with a surface roughness below 10nm. According to the invention the membrane has the smallest pore size on the outer wall surface, and has an outer wall surface which is smooth, continuous and homogeneous in a nanoscopic scale and four to five distinct layers of different pore size and density. Further the present invention concerns a process for manufacturing thereof and the use thereof.
摘要翻译：本发明涉及一种具有外壁表面，内壁表面和沿其长度延伸的内腔的半透性中空纤维膜，并且在外壁表面上具有表面粗糙度低于10nm的选择层。根据本发明，膜在外壁表面具有最小的孔径，并且具有在纳米尺度上光滑，连续和均匀的外壁表面，以及不同孔径和密度的四至五个不同层。此外，本发明涉及其制造方法及其用途。

10. 发明申请

WO2021130145A1 SPINNERET 审中-公开
公开(公告)号：WO2021130145A1
公开(公告)日：2021-07-01
申请号：PCT/EP2020/087375
申请日：2020-12-21
申请人： GAMBRO LUNDIA AB
发明人： BUCK, Reinhold , GROSSMANN, Evelyn , HORNUNG, Markus , LOEFFLER, Markus , BEHR, Heinrich , WOCHNER, Arnd , SCHEUERMANN, Carl-Philipp
IPC分类号： B01D69/08 , D01D4/02 , D01D5/24 , D01D5/06 , B01D2323/42 , B01D69/085 , B01D69/087
摘要： The present disclosure relates to a spinneret for producing hollow fiber membranes in a phase inversion process.

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