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1. 发明申请

WO2008015015A2 DENDRITIC POLYGLYCEROL SULFATES AND SULFONATES AND THEIR USE FOR INFLAMMATORY DISEASES 审中-公开
标题翻译：透明聚合物硫酸盐和硫酸盐及其用于炎症疾病
公开(公告)号：WO2008015015A2
公开(公告)日：2008-02-07
申请号：PCT/EP2007/006889
申请日：2007-08-03
申请人： FREIE UNIVERSITÄT BERLIN , CHARITE-UNIVERSITÄTSMEDIZIN BERLIN , HAAG, Rainer , DERNEDDE, Jens , TAUBER, Rudolf , GESCHE, Bernhard , ENDERS, Sven , WEINHART, Heidemarie
发明人： HAAG, Rainer , DERNEDDE, Jens , TAUBER, Rudolf , GESCHE, Bernhard , ENDERS, Sven , WEINHART, Heidemarie
IPC分类号： C08G83/00
CPC分类号： C07C305/10 , C07K14/00 , C08G65/3344 , C08G65/48 , C08G83/003
摘要： The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sulfonates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.
摘要翻译：本发明涉及树突状聚甘油硫酸盐和磺酸盐的新化合物类型以及它们用于治疗疾病，特别是炎性疾病的生产和用途，以及它们作为选择蛋白抑制剂和选择素指示剂的用途。树枝状聚甘油硫酸盐和磺酸盐也适用于成像诊断，特别是在炎性疾病方面。

2. 发明申请

WO2018060341A1 A THERMORESPONSIVE POLYMER AND ITS USE IN A CELL CULTURE SUPPORT 审中-公开
标题翻译：一种热敏性聚合物及其在细胞培养支持中的应用
公开(公告)号：WO2018060341A1
公开(公告)日：2018-04-05
申请号：PCT/EP2017/074648
申请日：2017-09-28
申请人： FREIE UNIVERSITÄT BERLIN
发明人： WEINHART, Heidemarie , STÖBENER, Daniel
IPC分类号： C08G65/26 , C08G65/331 , C08G65/332 , C08G65/22
CPC分类号： C08G65/331 , C08G65/22 , C08G65/2639 , C08G65/2654 , C08G65/3326 , C08G2650/16 , C08L2203/02 , C12N2533/30 , C12N2539/10
摘要： The present invention relates to a thermoresponsive polymer comprising a linear polyether chain of the general formulae (I) Nu-[CH 2 -CR 1 R 2 O] m -[CH 2 -CR 3 R 4 O] n -[CH 2 -CR 5 R 6 O] O -[CH 2 -CR 7 R 8 O] p -H; wherein R 1 , R 3 , R 5 and R 7 are in each case H or a C 1 -C 10 alkyl side chain, wherein R 1 , R 3 , R 5 and R 7 may be the same or different; R 2 and R 4 are in each case a side chain comprising at least one thermoresponsive moiety, wherein R 2 and R 4 may be the same or different; R 6 and R 8 are in each case H, a moiety containing at least one C=C double bond or a photo-crosslinkable moiety selected from a group of aromatic and heteroaromatic compounds, wherein R 6 and R 8 may the same or different, wherein at least one of R 6 and R 8 has to be a photo-crosslinkable moiety, Nu is nucleophilic moiety selected from a group comprising halogen or alkoxy; m, n are in each case or in sum 10-5000, preferably 10-1000, more preferably 100-500; o, p are in each case 1 -20 or in sum 2-20, preferably 3-15, more preferably 5-10. The invention also relates to a cell substrate support comprising the polymer.
摘要翻译：本发明涉及包含通式（I）的线性聚醚链的热响应性聚合物Nu- [CH 2 -CR 1] [R ^{2 O] <子>米 - [CH <子> 2 -CR ^{3 - [R ^{4 0 ] <子>名词 - [CH <子> 2 -CR ^{5 - [R ^{6 O] <子> 0 - [CH <子> 2 -CR ^{7 - [R ^{8 O] <子> p -H; 其中R 1，R 3，R 5和R 7分别为H或C _{可能相同或不同; R 6和R 8分别为H，含有至少一个C = C双键的部分或选自芳族和杂芳族的可光交联部分化合物，其中R 6和R 8可以相同或不同，其中R 6和R 8中的至少一个可以相同或不同，必须是可光交联部分，Nu是选自包括卤素或烷氧基的亲核部分; m，n分别总计为10-5000，优选10-1000，更优选100-500; o，p分别为1-20或总和2-20，优选3-15，更优选5-10。本发明还涉及包含该聚合物的细胞基质载体。}}}}}}}}

3. 发明申请

WO2022268979A1 METHOD FOR ACTIVATING DENDRITIC CELLS 审中-公开
公开(公告)号：WO2022268979A1
公开(公告)日：2022-12-29
申请号：PCT/EP2022/067225
申请日：2022-06-23
申请人： FREIE UNIVERSITÄT BERLIN
发明人： WEINHART, Heidemarie , STÖBENER, Daniel , PEISER, Matthias
IPC分类号： C12N5/0784 , C12N5/0786 , A61K31/74 , A61K31/75 , C08L71/00 , C08G65/331 , C09D171/02 , C08G65/3318 , C12N2533/30 , C12N5/0639
摘要： The present invention relates to a method for activating dendritic cells in vitro, comprising the following steps: a) providing a substrate, wherein a surface of the substrate comprises at least one poly(glycidyl ether) derivative according to general formula (I); b) contacting the substrate with a dendritic cell in an isosmotic aqueous solution or buffer.

4. 发明申请

WO2007141248A1 VERFAHREN ZUR HERSTELLUNG VON LINEAREN, METHYLIERTEN POLYGLYCEROLDERIVATEN UND IHRE VERWENDUNG ZUR FUNKTIONALISIERUNG VON OBERFLÄCHEN 审中-公开
标题翻译：用于生产LINEAR，聚甲基衍生物及其使用功能化曲面
公开(公告)号：WO2007141248A1
公开(公告)日：2007-12-13
申请号：PCT/EP2007/055489
申请日：2007-06-04
申请人： FREIE UNIVERSITÄT BERLIN , WYSZOGRODZKA, Monika , HAAG, Rainer , WEINHART, Heidemarie
发明人： WYSZOGRODZKA, Monika , HAAG, Rainer , WEINHART, Heidemarie
IPC分类号： C08G65/08
CPC分类号： C08G65/26 , A61L27/34 , C08G65/329
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung von definiert aufgebauten linearen , methylierten Polyglycerolderivaten auf Glycidyimethyletherbasis mit einem Poiymerisationsgrad von 1 bis 1000 mit engen Molmasseverteiiungen ermitteit durch GPC (Gel Permeation Chromatography) und Polydispersitäten kleiner 2, vorzugsweise kleiner 1.1 (PS-Standard), durch ringöffnende anionische Polymerisation des Glycidylmethylethers in Gegenwart einer wasserstoffaktiven Starterverbindung unter basischer Katalyse. Insbesondere betrifft die Erfindung Polymere der allgemeinen Formel I. Gegenstand der Erfindung ist auch die Verwendung dieser linearen, methylierten Polyg Iceroiderivate zur Funktionaiisierung beliebiger Oberflächen. So weisen Oberflächen, die eine Beschichtung mit den neuen Polyg lycerol-Derivaten besitzen, hervorragende proteinresistente Eigenschaften auf.
摘要翻译：本发明涉及一种用于制备定义的结构化线性甲基化聚甘油的衍生物的至Glycidyimethyletherbasis与从1 Poiymerisationsgrad至1000具有窄Molmasseverteiiungen ermitteit通过GPC（凝胶渗透色谱）和多分散性小于2，优选小于1.1（PS-标准），通过开环的方法在氢活性起始化合物的存在下Glycidylmethylethers的阴离子聚合，用碱性催化。特别地，本发明涉及通式I本发明也提供使用这些线性的，甲基化的多聚G Iceroiderivate Funktionaiisierung任何表面的聚合物。因此，有具有与新的多聚G lycerol衍生物优秀抗蛋白质性能的涂层的表面。

5. 发明公开

EP4108764A1 METHOD FOR ACTIVATING DENDRITIC CELLS 无效
公开(公告)号：EP4108764A1
公开(公告)日：2022-12-28
申请号：EP21181551.9
申请日：2021-06-24
申请人： Freie Universität Berlin
发明人： WEINHART, Heidemarie , STÖBENER, Daniel , PEISER, Matthias
IPC分类号： C12N5/0784 , C12N5/0786 , A61K31/74 , A61K31/75 , C08L71/00
摘要： The present invention relates to a method for activating dendritic cells in vitro, comprising the following steps: a) providing a substrate, wherein a surface of the substrate comprises at least one poly(glycidyl ether) derivative according to general formula (I); b) contacting the substrate with a dendritic cell in an isosmotic aqueous solution or buffer.

6. 发明公开

EP2046868A2 DENDRITIC POLYGLYCEROL SULFATES AND SULFONATES AND THEIR USE FOR INFLAMMATORY DISEASES 审中-公开
标题翻译：树突状POLYGLYCERINSULFATE和磺酸盐及其用途炎症性疾病
公开(公告)号：EP2046868A2
公开(公告)日：2009-04-15
申请号：EP07786550.9
申请日：2007-08-03
申请人： Freie Universität Berlin , Charité - Universitätsmedizin Berlin
发明人： HAAG, Rainer , DERNEDDE, Jens , TAUBER, Rudolf , BERNHARD, gesche , ENDERS, Sven , WEINHART, Heidemarie , TÜRK, Holger , VON BONIN, Anne , ZÜGEL, Ulrich
IPC分类号： C08G83/00
CPC分类号： C07C305/10 , C07K14/00 , C08G65/3344 , C08G65/48 , C08G83/003
摘要： The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sulfonates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.

7. 发明公开

EP4359512A1 METHOD FOR ACTIVATING DENDRITIC CELLS 审中-实审
公开(公告)号：EP4359512A1
公开(公告)日：2024-05-01
申请号：EP22737834.6
申请日：2022-06-23
申请人： Freie Universität Berlin
发明人： WEINHART, Heidemarie , STÖBENER, Daniel , PEISER, Matthias
IPC分类号： C12N5/0784 , C12N5/0786 , A61K31/74 , A61K31/75 , C08L71/00 , C08G65/331 , C09D171/02
CPC分类号： C12N5/0639 , C09D171/02 , C08G65/3318 , C12N2533/3020130101

8. 发明公开

EP2044141A1 VERFAHREN ZUR HERSTELLUNG VON LINEAREN, METHYLIERTEN POLYGLYCEROLDERIVATEN UND IHRE VERWENDUNG ZUR FUNKTIONALISIERUNG VON OBERFLÄCHEN 审中-公开
标题翻译：用于生产LINEAR，聚甲基衍生物及其使用功能化曲面
公开(公告)号：EP2044141A1
公开(公告)日：2009-04-08
申请号：EP07729876.8
申请日：2007-06-04
申请人： Freie Universität Berlin
发明人： WYSZOGRODZKA, Monika , HAAG, Rainer , WEINHART, Heidemarie
IPC分类号： C08G65/08
CPC分类号： C08G65/26 , A61L27/34 , C08G65/329
摘要： The invention relates to a process for preparing linear , methylated polyglycerol derivatives which are based on glycidyl methyl ether and have a defined structure and have a degree of polymerization of from 1 to 1000 and narrow molar mass distributions determined by GPC (gel permeation chromatography) and polydispersities of less than 2, preferably less than 1.1 (PS standard), by ring-opening anionic polymerization of the glycidyl methyl ether in the presence of a hydrogen-active starter compound and a basic catalyst. In particular, the invention relates to polymers of the general formula I. The invention also provides for the use of these linear, methylated polyglycerol derivatives for functionalizing any surfaces. Thus, surfaces which have a coating comprising the novel polyglycerol derivatives have excellent protein-resistant properties.

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