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1. 发明申请

WO2020120642A1 CHROMAN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开
公开(公告)号：WO2020120642A1
公开(公告)日：2020-06-18
申请号：PCT/EP2019/084772
申请日：2019-12-12
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： CHEN, Dongdong , FENG, Song , LIU, Yongfu , TAN, Xuefei , ZHENG, Jiamin
IPC分类号： A61P31/12 , C07D311/32 , A61K31/352
摘要： The present invention provides compounds having the general formula (I) wherein R 1 to R 10 , Gi, G 2 , X and m are as described herein, compositions including the compounds and methods of using the compounds for treating hepatitis B.

2. 发明申请

WO2020148354A1 SUBSTITUTED CHROMEN-4-ONE FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION 审中-公开
公开(公告)号：WO2020148354A1
公开(公告)日：2020-07-23
申请号：PCT/EP2020/050953
申请日：2020-01-16
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： CHEN, Dongdong , FENG, Song , LIANG, Chungen , MIAO, Kun , TAN, Xuefei , SHEN, Hong
IPC分类号： A61P31/12 , C07D311/30 , A61K31/352
摘要： The present invention provides novel compounds having the general formula: (I) wherein R 1 to R 10 , G i , G 2 and m are as described herein, compositions including the impounds and methods of using the compounds for the treatment of hepatitis B.

3. 发明申请

WO2020083855A1 NOVEL TRICYCLIC COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE 审中-公开
公开(公告)号：WO2020083855A1
公开(公告)日：2020-04-30
申请号：PCT/EP2019/078620
申请日：2019-10-22
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FENG, Song , JIANG, Min , TAN, Xuefei , WU, Jun
IPC分类号： A61P31/12 , C07D491/052 , A61K31/436 , A61K31/4725 , A61K31/444 , A61K31/407
摘要： The present application provides compounds having the general formula: formula (I), wherein R1, R 2 , A, X and m are as described herein, compositions including the compounds and methods of using the compounds. The compounds are useful as inhibitors of cccDNA for treating Hepatitis B Virus (HBV) infections.

4. 发明申请

WO2014184163A1 AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION 审中-公开
标题翻译：用于治疗和预防呼吸道感染病毒感染的AZA-OXO-INDOLES
公开(公告)号：WO2014184163A1
公开(公告)日：2014-11-20
申请号：PCT/EP2014/059699
申请日：2014-05-13
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FENG, Song , GAO, Lu , GUO, Lei , HUANG, Mengwei , LIANG, Chungen , WANG, Baoxia , WANG, Lisha , WU, Guolong , YUN, Hongying , ZHANG, Weixing , ZHENG, Xiufang , ZHU, Wei
IPC分类号： C07D471/04 , C07D519/00 , A61K31/437 , A61P31/16
CPC分类号： C07D471/10 , C07D471/04 , C07D519/00
摘要： The invention provides compounds having the general formula: wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , W 1 , W 2 , W 3 , A and X are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译：本发明提供具有以下通式的化合物：其中R1，R2，R3，R4，R5，R6，W1，W2，W3，A和X如本文所述，包括化合物的组合物和使用该化合物的方法。

5. 发明申请

WO2013020993A1 COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE 审中-公开
标题翻译：用于治疗和预防呼吸道感染病毒性疾病的化合物
公开(公告)号：WO2013020993A1
公开(公告)日：2013-02-14
申请号：PCT/EP2012/065499
申请日：2012-08-08
申请人： F. HOFFMANN-LA ROCHE AG , CHEN, Li , FENG, Lichun , FENG, Song , GAO, Lu , GUO, Tao , HUANG, Mengwei , LIANG, Chungen , LIU, Yongfu , WANG, Lisha , WONG, Jason Christopher , WU, Jim Zhen , WU, Xihan , YUN, Hongying , ZHENG, Xiufang
发明人： CHEN, Li , FENG, Lichun , FENG, Song , GAO, Lu , GUO, Tao , HUANG, Mengwei , LIANG, Chungen , LIU, Yongfu , WANG, Lisha , WONG, Jason Christopher , WU, Jim Zhen , WU, Xihan , YUN, Hongying , ZHENG, Xiufang
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , A61K31/553 , A61K31/554 , A61P11/00 , A61P31/12
CPC分类号： C07D493/10 , C07D401/04 , C07D401/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D491/107
摘要： A compound of formula (I), as well as pharmaceutically acceptable salt thereof, wherein R 1 to R 10 , A, Q, X and Y are as defined in description and in claims, can be used as a medicament for the treatment of respiratory syncytial virus.
摘要翻译：式（I）化合物及其药学上可接受的盐，其中R 1至R 10，A，Q，X和Y如描述和权利要求中所定义，可用作治疗呼吸道合胞病毒的药物。

6. 发明申请

WO2011039130A1 NEW BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS FXR AGONISTS 审中-公开
标题翻译：新的苯并咪唑衍生物及其作为FXR AGONISTS的用途
公开(公告)号：WO2011039130A1
公开(公告)日：2011-04-07
申请号：PCT/EP2010/064217
申请日：2010-09-27
申请人： F. HOFFMANN-LA ROCHE AG , BENSON, Gregory Martin , BLEICHER, Konrad , FENG, Song , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer E. , PLANCHER, Jean-Marc , RICHTER, Hans , RUDOLPH, Markus , TAYLOR, Sven
发明人： BENSON, Gregory Martin , BLEICHER, Konrad , FENG, Song , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer E. , PLANCHER, Jean-Marc , RICHTER, Hans , RUDOLPH, Markus , TAYLOR, Sven
IPC分类号： C07D235/18 , C07D401/04 , C07D403/10 , C07D403/12 , C07D405/14 , C07D417/14 , A61K31/4184 , A61K31/4439
CPC分类号： C07D401/04 , C07D235/18 , C07D403/10 , C07D403/12 , C07D405/14 , C07D417/14
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, B, R 1 , R 2 , R 3 , R 4 , R 5 , n, m and p have the significance given in claim 1.
摘要翻译：式（I）化合物及其药学上可接受的盐可以以药物组合物的形式使用，其中A，B，R 1，R 2，R 3，R 4，R 5，n，m和p具有权利要求1中给出的含义。

7. 发明申请

WO2020079106A1 CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE 审中-公开
公开(公告)号：WO2020079106A1
公开(公告)日：2020-04-23
申请号：PCT/EP2019/078131
申请日：2019-10-17
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FENG, Song , LIANG, Chungen , LIU, Yongfu , TAN, Xuefei , WU, Jun , WANG, Jianping
IPC分类号： A61P31/12 , C07D311/22 , C07D311/24 , C07D405/04 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/12 , C07D471/08 , C07D487/10 , A61K31/352
摘要： The present invention provides novel compounds having the general formula (I) wherein R 1 to R 6 , and m are as described herein, compositions including the compounds and methods of using the compounds.

8. 发明申请

WO2020052774A1 FLAVONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE 审中-公开
公开(公告)号：WO2020052774A1
公开(公告)日：2020-03-19
申请号：PCT/EP2018/074851
申请日：2018-09-14
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： CHEN, Dongdong , FENG, Song , LI, Chao , LIANG, Chungen , LIU, Yongfu , SHEN, Hong , TAN, Xuefei , WANG, Li , WU, Jun
IPC分类号： C07D311/30 , C07D335/06 , C07D405/04 , A61P31/20 , A61K31/352 , A61K31/382
摘要： The application provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DNA) inhibitors.

9. 发明申请

WO2014009302A1 NOVEL INDAZOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION 审中-公开
标题翻译：治疗和预防性呼吸道感染病毒感染的新进展
公开(公告)号：WO2014009302A1
公开(公告)日：2014-01-16
申请号：PCT/EP2013/064349
申请日：2013-07-08
申请人： F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC.
发明人： FENG, Song , GAO, Lu , HONG, Di , WANG, Lisha , YUN, Hongying , ZHAO, Shu-Hai
IPC分类号： C07D403/06 , C07D471/04 , A61K31/46 , A61P31/12
CPC分类号： C07D491/107 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D471/04
摘要： The invention provides novel compounds having the general formula: formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 7 , A 1 , A 2 and A 3 are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译：本发明提供具有通式的式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 7，A 1，A 2和A 3如本文所述，包括该化合物的组合物和使用该化合物的方法。

10. 发明申请

WO2010034657A1 3-AMINO-INDAZOLE OR 3-AMINO-4,5,6,7-TETRAHYDRO-INDAZOLE DERIVATIVES 审中-公开
标题翻译： 3-氨基吲哚或3-氨基-4,5,6,7-四氢吲哚衍生物
公开(公告)号：WO2010034657A1
公开(公告)日：2010-04-01
申请号：PCT/EP2009/061966
申请日：2009-09-15
申请人： F. HOFFMANN-LA ROCHE AG , BENSON, Gregory, Martin , BLEICHER, Konrad , FENG, Song , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer, E. , PLANCHER, Jean-Marc , RICHTER, Hans , MARKUS, Rudolph , TAYLOR, Sven
发明人： BENSON, Gregory, Martin , BLEICHER, Konrad , FENG, Song , GRETHER, Uwe , KUHN, Bernd , MARTIN, Rainer, E. , PLANCHER, Jean-Marc , RICHTER, Hans , MARKUS, Rudolph , TAYLOR, Sven
IPC分类号： C07D231/56 , A61K31/416 , A61P3/06 , A61P3/10 , C07D401/12 , C07D407/12
CPC分类号： C07D231/56 , C07D401/12 , C07D407/12
摘要： This invention relates to novel indazole derivatives of formula (I), wherein R 1 to R 7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be use as medicaments. The compounds are selective modulators of the farnesoid-X-receptor, preferably agonists u j[ιe farnesoid-X-receptor (FXR) is a member of the nuclear hormone receptor superfamily of transcription factors. Diseases which are affected by FXR modulators include increased lipid and cholesterol levels, particularly high LDL-cholesterol, high triglycerides, low HDL-cholesterol, dyslipidemia, diseases of cholesterol absorption, atherosclerotic disease, peripheral occlusive disease, ischemic, stroke, diabetes, particularly non-insulin dependent diabetes mellitus, metabolic syndrome, diabetic nephropathy, obesity, cholesterol gallstone disease, cholestasis/fibrosis of the liver, non alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), psoriasis, cancer, particularly gastrointestinal cancer, osteoporosis, Parkinson's disease and Alzheimer's disease. Preferred diseases (and conditions) which are affected by FXR modulators are prevention or treatment of high LDL cholesterol levels high triglycerides, dyslipidemia, cholesterol gallstone disease, cancer, non-insulin dependent diabetes mellitus and metabolic syndrome. Particularly preferred diseases which arc affected by FXR modulators arc high LDL cholesterol, high triglyceride levels and dyslipidemia.
摘要翻译：本发明涉及式（I）的新的吲唑衍生物，其中R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐。这些化合物是FXR调节剂，可用作药物。这些化合物是法呢基-X-受体的选择性调节剂，优选激动剂uj [法新颖-X-受体（FXR）是转录因子的核激素受体超家族的成员。受FXR调节剂影响的疾病包括增加脂质和胆固醇水平，特别是高LDL-胆固醇，高甘油三酸酯，低HDL-胆固醇，血脂异常，胆固醇吸收疾病，动脉粥样硬化疾病，外周性闭塞性疾病，缺血性，中风，糖尿病，特别是非 - 胰岛素依赖性糖尿病，代谢综合征，糖尿病肾病，肥胖症，胆固醇胆结石疾病，肝脏胆汁郁积/纤维化，非酒精性脂肪性肝炎（NASH），非酒精性脂肪性肝病（NAFLD），牛皮癣，癌症，特别是胃肠癌，骨质疏松症，帕金森病和阿尔茨海默病。受FXR调节剂影响的首选疾病（和病症）是预防或治疗高LDL胆固醇水平高甘油三酯，血脂异常，胆固醇胆结石疾病，癌症，非胰岛素依赖性糖尿病和代谢综合征。受FXR调节剂影响的特别优选的疾病具有高LDL胆固醇，高甘油三酯水平和血脂异常。

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