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    • 1. 发明申请
    • THE USE OF FLUID INSOLUBLE OXIDIZING AGENTS TO ELIMINATE INTERFERING SUBSTANCES IN OXIDATION-REDUCTION MEASURING SYSTEMS
    • 在氧化还原测量系统中使用流体不溶性氧化剂消除干扰物质
    • WO1990012113A1
    • 1990-10-18
    • PCT/US1990001887
    • 1990-04-12
    • ENZYMATICS, INC.
    • ENZYMATICS, INC.JOHNSTON, James, B.DAUBNEY, Stephan, D.PALMER, John, L.
    • C12Q01/26
    • C12Q1/26
    • Systems and methods are disclosed for removing redox-active substances from aqueous, partially aqueous or non-aqueous fluids. The invention involves contacting the fluid to be treated with a redox-active agent that is insoluble in the fluid, thereby oxidizing interfering redox-active substances. Electron transfer agents can also be employed. The residual redox oxidizing agent is removed from the treated fluid on the basis of its insolubility, so that no residual redox activity remains. The invention is useful for removal of interfering redox-active substances from liquid samples when analytes in the sample are to be measured using reduction-oxidation chemistry and the redox-active interfering substances removed by the disclosed method interfere in the reduction-oxidation analysis. Furthermore, this invention is especially useful to pretreat blood, serum, plasma or other bodily fluids prior to analysis or other use of these fluids, where the presence of reduction-oxidation active substances constitutes an interference in that analysis or use.
    • 公开了用于从水性,部分水性或非水性流体中除去氧化还原活性物质的系统和方法。 本发明涉及使待处理的流体与不溶于流体的氧化还原活性剂接触,从而氧化干扰氧化还原活性物质。 也可以使用电子转移剂。 基于其不溶性,将残留的氧化还原氧化剂从处理过的流体中除去,从而不残留氧化还原活性。 当使用还原氧化化学测量样品中的分析物并且通过所公开的方法除去的氧化还原活性干扰物质干扰还原 - 氧化分析时,本发明可用于从液体样品中去除干扰的氧化还原活性物质。 此外,本发明特别可用于在分析或其它使用这些流体之前预处理血液,血清,血浆或其它体液,其中还原氧化活性物质的存在构成该分析或使用中的干扰。