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1. 发明授权

US06230572B1 Instrument for measuring and classifying nanometer aerosols 有权
标题翻译：用于测量和分类纳米气溶胶的仪器
公开(公告)号：US06230572B1
公开(公告)日：2001-05-15
申请号：US09249723
申请日：1999-02-12
申请人： David Y. H. Pui , Da-Ren Chen , Frederick R. Quant , Gilmore J. Sem , Heinz Fissan , Detlef Hummes , Frank Dorman
发明人： David Y. H. Pui , Da-Ren Chen , Frederick R. Quant , Gilmore J. Sem , Heinz Fissan , Detlef Hummes , Frank Dorman
IPC分类号： G01N100
CPC分类号： B82Y15/00 , G01N15/0266 , Y10S977/88 , Y10S977/881 , Y10S977/958
摘要： An apparatus for classifying polydisperse aerosols includes aerosol and sheath gas conduits for conducting a sample aerosol and a sheath gas toward a merger area. At the merger area the sheath gas and about ten percent of the sample aerosol merge, then travel through a differential mobility analyzer (DMA) and along a tubular electrode of the DMA. Selected particles, i.e. particles having electrical mobilities within a narrow range, pass through a collection aperture of the electrode. The DMA output, an aerosol consisting of the selected particles, is provided to a condensation particle counter or other device for determining the aerosol concentration. The remainder of the sample aerosol is conducted away from the merger area along a bypass flow conduit. The bypass flow and an improved aerodynamic design provide for a slit at the merger area that is sufficiently narrow to minimize unwanted electric field penetration at the slit and DMA entrance. An annular flow restriction feature in the bypass conduit promotes and maintains laminar, uniform-velocity flow near the slit. The collection aperture is located medially along the tubular electrode, to prevent electrical field fringing near the aperture.
摘要翻译：用于分类多分散气溶胶的装置包括用于将样品气溶胶和护套气体导向合并区域的气溶胶和鞘气导管。在合并区域，护套气体和约10％的样品气溶胶合并，然后通过差示迁移率分析仪（DMA）和DMA的管状电极行进。所选择的粒子，即具有窄范围内的电迁移率的粒子通过电极的收集孔。将DMA输出（由所选颗粒组成的气溶胶）提供给冷凝颗粒计数器或用于确定气溶胶浓度的其它装置。样品气溶胶的其余部分沿旁路流动导管远离合并区域。旁路流动和改进的空气动力学设计为合并区域的狭缝提供足够窄的狭缝，以最小化狭缝和DMA入口处的不需要的电场穿透。旁通管道中的环形流动限制特征促进并维持狭缝附近的层流均匀的流速。收集孔沿着管状电极向内定位，以防止孔附近的电场边缘。

2. 发明授权

US07972661B2 Electrospraying method with conductivity control 有权
标题翻译：电喷雾法电导率控制
公开(公告)号：US07972661B2
公开(公告)日：2011-07-05
申请号：US11906998
申请日：2007-10-04
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： B05D1/06
CPC分类号： B01J2/006 , A61K39/00 , A61K48/00 , B01J2/04 , B01J2219/00371 , B01J2219/00436 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/081 , B05B5/082 , B05B5/084 , B05B5/087 , B05B13/04 , C12M35/02 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.
摘要翻译：使用电喷雾装置和/或方法来涂覆颗粒。例如，可以通过喷雾分配器端部的至少一个开口提供包括至少一个液体悬浮液的流。流动至少包括颗粒和涂层材料。通过在喷雾分配器端部与与其分离的电极之间产生不均匀的电场，在喷雾分配器端的前方建立悬浮至少颗粒的微滴喷雾。当微滴蒸发时，颗粒被涂覆有至少一部分涂层材料。例如，悬浮液可以包括生物材料颗粒。

3. 发明授权

US08028646B2 Coating medical devices 有权
标题翻译：涂层医疗器械
公开(公告)号：US08028646B2
公开(公告)日：2011-10-04
申请号：US11390606
申请日：2006-03-28
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： B05C7/02
CPC分类号： B05B5/0255 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/622 , A61L2420/02 , B05B1/14 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/08 , B05B5/082 , B05B7/066 , B05B7/0884 , B05B13/0228 , B05D1/002 , B05D1/04 , B05D1/045
摘要： Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g., using an electric field and/or a thermophoretic effect).
摘要翻译：用于涂覆医疗装置（例如，支架结构）的至少一部分的方法和系统包括在限定体积内提供多个涂层颗粒（例如，单分散涂层颗粒）。例如，可以使用一个或多个喷嘴结构来提供颗粒，其中每个喷嘴结构包括终止于分配端的至少一个开口。通过使用分配端和医疗装置之间的不均匀的电场，可以通过从一个或多个喷嘴结构的分配端分配具有与其相关联的电荷的多个微滴，来将多个涂层颗粒设置在限定的体积中。当微滴蒸发时，电荷集中在颗粒上。利用设置在限定体积中的多个涂覆颗粒，这样的颗粒可以朝向医疗装置的至少一个表面移动以在其上形成涂层（例如，使用电场和/或热溶胶效应）。

4. 发明授权

US07951428B2 Electrospray coating of objects 有权
标题翻译：物体的电喷雾涂层
公开(公告)号：US07951428B2
公开(公告)日：2011-05-31
申请号：US11701200
申请日：2007-01-31
申请人： Robert A. Hoerr , John V. Carlson , Da-Ren Chen , David Y. H. Pui
发明人： Robert A. Hoerr , John V. Carlson , Da-Ren Chen , David Y. H. Pui
IPC分类号： B05D1/04
CPC分类号： A61F2/06 , B05B1/06 , B05B1/14 , B05B5/025 , B05B5/08 , B05B7/061 , B05D1/04 , B05D1/06 , C25D5/003 , C25D5/006 , C25D17/007 , C25D21/12
摘要： Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with an open matrix coating. The open matrix coating is formed by electrospray using one or more nozzle structures each having at least an inner and outer opening. A first flow of a liquid spray composition is provided to the inner opening and a second flow of a liquid diluent composition is provided to the outer opening (e.g., the liquid diluent composition including at least one solvent, such as a composition having a dielectric constant equal to or greater than 10).
摘要翻译：电喷雾方法和用于用开放基质涂层涂覆物体（例如医疗装置，例如支架结构）的系统。开放基质涂层通过使用一个或多个喷嘴结构的电喷雾形成，每个喷嘴结构至少具有内部和外部开口。液体喷雾组合物的第一流动被提供到内部开口，并且液体稀释剂组合物的第二流动被提供到外部开口（例如，液体稀释剂组合物包括至少一种溶剂，例如具有介电常数的组合物等于或大于10）。

5. 发明授权

US07279322B2 Electrospraying apparatus and method for coating particles 有权
标题翻译：电喷雾装置和涂布颗粒的方法
公开(公告)号：US07279322B2
公开(公告)日：2007-10-09
申请号：US10809660
申请日：2004-03-25
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： C12N15/88
CPC分类号： B01J2/006 , A61K39/00 , A61K48/00 , B01J2/04 , B01J2219/00371 , B01J2219/00436 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/081 , B05B5/082 , B05B5/084 , B05B5/087 , B05B13/04 , C12M35/02 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.
摘要翻译：使用电喷雾装置和/或方法来涂覆颗粒。例如，可以通过喷雾分配器端部的至少一个开口提供包括至少一个液体悬浮液的流。流动至少包括颗粒和涂层材料。通过在喷雾分配器端部与与其分离的电极之间产生不均匀的电场，在喷雾分配器端的前方建立悬浮至少颗粒的微滴喷雾。当微滴蒸发时，颗粒被涂覆有至少一部分涂层材料。例如，悬浮液可以包括生物材料颗粒。

6. 发明授权

US07498063B2 High mass throughput particle generation using multiple nozzle spraying 有权
公开(公告)号：US07498063B2
公开(公告)日：2009-03-03
申请号：US10889341
申请日：2004-07-12
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： B05D1/04
CPC分类号： B05B5/032 , A61F2/86 , B05B1/14 , B05B5/025 , B05B5/0255 , B05B5/08 , B05B5/087 , B05B7/0408 , B05B7/066 , B05B13/06
摘要： Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

7. 发明授权

US5973904A Particle charging apparatus and method of charging particles 失效
标题翻译：粒子充电装置和粒子充电方法
公开(公告)号：US5973904A
公开(公告)日：1999-10-26
申请号：US949154
申请日：1997-10-10
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： B05B5/053 , G01N15/02 , H01J49/04 , H05H1/24
CPC分类号： H05H1/24 , B05B5/0533 , G01N15/0266 , H01J49/04
摘要： A method for charging of aerosol particles includes providing a charger housing having a longitudinal axis extending between an inlet and an outlet of the charger housing with a stream of aerosol particles flowing parallel to the longitudinal axis from the inlet to the outlet. A confined electric field is created within the housing parallel to the longitudinal axis for directing a stream of unipolar ions to flow parallel to the longitudinal axis of the charger housing towards the outlet for use in charging the stream of aerosol particles. To further reduce charged particle loss within the charger housing, a clean sheath may be created between the stream of aerosol particles and the charger housing, an outlet electric field may be created proximate the outlet of the charger housing such that charged particles are forced towards the longitudinal axis, and/or the stream of aerosol is contracted proximate the outlet of the charger housing forcing the charged particles toward the longitudinal axis. Apparatus for carrying out the method is also described.
摘要翻译：一种用于装载气溶胶颗粒的方法包括提供充电器壳体，该充电器壳体具有在充电器壳体的入口和出口之间延伸的纵向轴线，其具有平行于纵向轴线从入口到出口流动的气溶胶粒子流。在壳体内平行于纵向轴线产生限制的电场，用于引导单极离子流平行于充电器壳体的纵向轴线朝向出口流动以用于对气溶胶颗粒物流充电。为了进一步减少充电器壳体内的带电粒子损失，可以在气溶胶粒子流和充电器壳体之间产生干净的鞘，可以在充电器壳体的出口附近产生出口电场，使得带电粒子被迫朝向纵向轴线和/或气溶胶流在靠近充电器壳体的出口处收缩，迫使带电粒子朝向纵向轴线。还描述了用于执行该方法的装置。

8. 发明授权

US07247338B2 Coating medical devices 有权
标题翻译：涂层医疗器械
公开(公告)号：US07247338B2
公开(公告)日：2007-07-24
申请号：US10301473
申请日：2002-11-21
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： A61L27/04 , B05D1/04
CPC分类号： B05B5/0255 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/622 , A61L2420/02 , B05B1/14 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/08 , B05B5/082 , B05B7/066 , B05B7/0884 , B05B13/0228 , B05D1/002 , B05D1/04 , B05D1/045
摘要： Methods and systems for coating at least a portion of a medical device (e.g., a stent structure) include providing a plurality of coating particles (e.g., monodisperse coating particles) in a defined volume. For example, the particles may be provided using one or more nozzle structures, wherein each nozzle structure includes at least one opening terminating at a dispensing end. The plurality of coating particles may be provided in the defined volume by dispensing a plurality of microdroplets having an electrical charge associated therewith from the dispensing ends of the one or more nozzle structures through use of a nonuniform electrical field between the dispensing ends and the medical device. Electrical charge is concentrated on the particle as the microdroplet evaporates. With a plurality of coating particles provided in the defined volume, such particles can be moved towards at least one surface of the medical device to form a coating thereon (e.g., using an electric field and/or a thermophoretic effect).
摘要翻译：用于涂覆医疗装置（例如，支架结构）的至少一部分的方法和系统包括在限定体积内提供多个涂层颗粒（例如，单分散涂层颗粒）。例如，可以使用一个或多个喷嘴结构来提供颗粒，其中每个喷嘴结构包括终止于分配端的至少一个开口。通过使用分配端和医疗装置之间的不均匀的电场，可以通过从一个或多个喷嘴结构的分配端分配具有与其相关联的电荷的多个微滴，来将多个涂层颗粒设置在限定的体积中。当微滴蒸发时，电荷集中在颗粒上。利用设置在限定体积中的多个涂覆颗粒，这样的颗粒可以朝向医疗装置的至少一个表面移动以在其上形成涂层（例如，使用电场和/或热溶胶效应）。

9. 发明授权

US06746869B2 Electrospraying apparatus and method for coating particles 有权
公开(公告)号：US06746869B2
公开(公告)日：2004-06-08
申请号：US10162031
申请日：2002-06-03
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： C12N1588
CPC分类号： B01J2/006 , A61K39/00 , A61K48/00 , B01J2/04 , B01J2219/00371 , B01J2219/00436 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/081 , B05B5/082 , B05B5/084 , B05B5/087 , B05B13/04 , C12M35/02 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.

10. 发明授权

US06399362B1 Electrospraying apparatus and method for introducing material into cells 有权
标题翻译：用于将材料引入电池的电喷雾装置和方法
公开(公告)号：US06399362B1
公开(公告)日：2002-06-04
申请号：US09577747
申请日：2000-05-23
申请人： David Y. H. Pui , Da-Ren Chen
发明人： David Y. H. Pui , Da-Ren Chen
IPC分类号： C12M142
CPC分类号： B01J2/006 , A61K39/00 , A61K48/00 , B01J2/04 , B01J2219/00371 , B01J2219/00436 , B05B5/025 , B05B5/03 , B05B5/0533 , B05B5/081 , B05B5/082 , B05B5/084 , B05B5/087 , B05B13/04 , C12M35/02 , C12N15/8207 , C12N15/87 , C12N15/895
摘要： A method of introducing biological material into cells includes providing one or more target cells and establishing a spray of substantially dispersed particles including biological material. The substantially dispersed particles have an electrical charge applied thereto such that one or,more of the substantially dispersed particles of the spray is introduced into one or more of the target cells. The spray of substantially dispersed particles may be established by dispensing a spray of microdroplets suspending particles. The electrical charge is concentrated on the suspended particles as the microdroplet evaporates. The suspended particles may include carrier particles with biological material or the suspended particles may be particles of biological material alone. The space charge effect of the concentrated electrical charge on the substantially dispersed particles of the spray enable one or more of the particles to be introduced into one or more of the target cells. An apparatus for introducing biological material into one or more target cells includes a biological material source including at least biological material and a dispensing device operably connected to the biological material source to receive biological material therefrom. The dispensing device provides a spray of substantially dispersed particles of at least the biological material with the spray of substantially dispersed particles having an electrical charge applied thereto.
摘要翻译：将生物材料引入细胞的方法包括提供一个或多个靶细胞并建立包括生物材料的基本上分散的颗粒的喷雾。基本上分散的颗粒具有施加到其上的电荷，使得喷雾的一个或多个基本上分散的颗粒被引入到一个或多个靶细胞中。基本上分散的颗粒的喷雾可以通过分配微滴悬浮颗粒的喷雾来建立。当微滴蒸发时，电荷集中在悬浮颗粒上。悬浮颗粒可以包括具有生物材料的载体颗粒，或悬浮颗粒可以是单独的生物材料颗粒。浓缩电荷对基本分散的喷雾颗粒的空间电荷效应使得一个或多个颗粒被引入到一个或多个靶细胞中。用于将生物材料引入一个或多个靶细胞的装置包括至少包括生物材料的生物材料源和可操作地连接到生物材料源以从其接收生物材料的分配装置。分配装置提供至少具有生物材料的基本分散的颗粒的喷雾，其中施加有电荷的基本分散的颗粒的喷雾。

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