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    • 4. 发明授权
    • Use of oligomers and polymers for drug solubilization, stabilization, and delivery
    • 低聚物和聚合物用于药物溶解,稳定和递送的应用
    • US07897563B2
    • 2011-03-01
    • US12337991
    • 2008-12-18
    • David S. SoaneDaniel J. Suich
    • David S. SoaneDaniel J. Suich
    • A61K38/02A61K47/30A61K47/36A61K47/42
    • B82Y5/00A61K9/1075A61K47/6907
    • The invention relates to the use of oligomers and polymers capable of rendering insoluble drugs soluble, protecting unstable drugs, and facilitating the delivery of drugs to their site of action. This invention further relates to processes for the preparation of such oligomers and polymers, and to compositions containing them. In some instances, oligomers, polymers, and/or mixtures thereof can be used to protect a protein drug. Such structures can include at least one recognition element covalently attached to a hydrophilic element, wherein said recognition element or elements interact noncovalently with the protein drug to form a complex in which said protein drug is protected from degradation, recognition by the immune system, and/or renal excretion.
    • 本发明涉及能够使不溶性药物溶解的低聚物和聚合物的使用,保护不稳定的药物以及促进将药物运送到其作用部位。 本发明还涉及制备这种低聚物和聚合物的方法以及含有它们的组合物。 在一些情况下,可以使用低聚物,聚合物和/或其混合物来保护蛋白质药物。 这种结构可以包括共价连接到亲水元件的至少一个识别元件,其中所述识别元件或元件与蛋白质药物非共价相互作用以形成复合物,其中所述蛋白质药物被保护免于降解,免疫系统的识别和/ 或肾脏排泄。
    • 7. 发明授权
    • Method for moving charged particles
    • 移动带电粒子的方法
    • US06964735B2
    • 2005-11-15
    • US10016483
    • 2001-12-10
    • David S. SoaneZoya M. Soane
    • David S. SoaneZoya M. Soane
    • B01D57/02B01F13/00B01J19/00C07K1/26G01N27/447G03F7/00
    • B01D57/02B01F13/0059B01F13/0076B01J19/0093B01J2219/00853B01J2219/00912B82Y10/00B82Y40/00C07K1/26G01N27/44752G01N27/44773G03F7/0002
    • Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium. The devices although preferably small in size, preferably generate large numbers (100 or more) of electrical fields to a movement area which preferably contains a liquid buffered or gel medium. Mixtures of charged molecules are pulled through the gel by the force of the electrical fields. The fields are preferably activated simultaneously or sequentially one after another at various speeds to create complex force field distributions or moving field waves along the separation medium. Charged molecules capable of moving quickly through the gel will be moved along by the faster moving field waves and be separated from slower moving molecules. The fields can be activated by computer software and can be used to move molecules away from and toward each other to obtain rapid and complex chemical synthesis, sequencing or reaction protocols.
    • 公开的装置和方法用于通过施加足够强度的多个电场来移动带电分子通过介质,并施加足够的时间,以使带电分子移动通过介质。 尽管尺寸优选小的装置优选地对于优选含有液体缓冲或凝胶介质的运动区域产生大量(100个或更多个)电场。 带电分子的混合物被电场的力拉入凝胶。 这些场优选地以各种速度一个接一个地同时或顺序地被激活,以产生沿着分离介质的复数的力场分布或移动的场波。 能够快速移动通过凝胶的带电分子将沿着更快的移动场波移动并与较慢的移动分子分离。 这些领域可以通过计算机软件激活,并且可以用于将分子移开和相互移动,以获得快速和复杂的化学合成,测序或反应方案。
    • 10. 发明授权
    • Nanoscopic hair care products
    • 纳米护发产品
    • US06821509B2
    • 2004-11-23
    • US10269272
    • 2002-10-11
    • David S. SoaneMatthew R. Linford
    • David S. SoaneMatthew R. Linford
    • A61K706
    • A61Q5/10A61K8/0241A61K8/44A61K8/84A61K8/88A61K2800/413A61K2800/5424A61K2800/5426A61K2800/57A61K2800/594B82Y5/00
    • The present invention is directed to a hair treatment preparation comprising a payload in an intimate relationship to a polymeric nanostructure, the polymeric nanostructure being reactive to hair or capable of being immobilized onto or in hair. The nanoscopic nature of the entities being engineered ensures three distinct characteristics. First, the imparted attribute can be either nearly permanent or semi-permanent, depending on the attachment chemistry. In the semi-permanent version, the intended effect can be controllably erased by removal of the nanostructure by simple chemical or physical means. Second, the nanoscopic entities are invisibly small. Their presence does not deteriorate the hand or feel of the hair. Third, the nano-technology approach is infinitely flexible and adaptable. It can be coupled with many existing dyes, colorants, UV absorbers, fragrances, softening agents and the like for hair treatment. Methods for treating hair with the hair treatment preparations of the invention are also encompassed.
    • 本发明涉及包含与聚合物纳米结构紧密关系的有效载荷的毛发处理制剂,所述聚合物纳米结构对毛发具有反应性或能够固定在头发上或毛发上。 被设计的实体的纳米尺度性质确保了三个不同的特征。 首先,赋予的属性可以是几乎永久的或半永久的,这取决于附着化学性质。 在半永久性版本中,可以通过简单的化学或物理手段去除纳米结构来可控地消除预期的效果。 其次,纳米镜实体看起来很小。 他们的存在不会使头发的手或感觉恶化。 第三,纳米技术方法无限灵活,适应性强。 它可以与用于毛发处理的许多现有的染料,着色剂,UV吸收剂,香料,软化剂等相结合。 还包括用本发明的头发处理制剂治疗头发的方法。