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1. 发明申请

US20060036284A1 PFO closure devices and related methods of use 有权
公开(公告)号：US20060036284A1
公开(公告)日：2006-02-16
申请号：US11249317
申请日：2005-10-14
申请人： David Blaeser , Peter Keith , Jerome Grudem , Scott Olson , Steven Hackett , Thomas Ressemann , Joel Phillips , Mark Christianson , Dennis Wahr
发明人： David Blaeser , Peter Keith , Jerome Grudem , Scott Olson , Steven Hackett , Thomas Ressemann , Joel Phillips , Mark Christianson , Dennis Wahr
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/00491 , A61B17/0057 , A61B17/0401 , A61B2017/00575 , A61B2017/00592 , A61B2017/00615 , A61B2017/0409 , A61B2017/0458 , A61B2017/0464 , A61B2017/0474 , A61B2017/0496 , A61B2017/22051
摘要： Devices and methods for sealing a passageway formed by a patent foramen ovale (PFO track) in the heart are provided. One method includes providing an abrading device to the PFO track and abrading the tissue within the PFO track. The abraded tissue forming the PFO track is then held together under pressure, either via lowering right atrial pressure or via applying suction to the septum primum to pull it into apposition against the septum secundum. After a sufficient period of time, the pressure is released and the abraded tissue heals to form a robust seal over the PFO track. Additionally, several devices are provided which can be placed into the PFO track to apply adhesive to the walls of the PFO track. The devices may or may not be left within the PFO track. If the devices are not left within the PFO track, the walls of the PFO track, covered with adhesive, are brought into apposition with one another and adhered together. If the device is left within the PFO track, the device is flattened from an expanded configuration to a flattened configuration, and the walls of the PFO track, adhering to the outer surface of the device, are pulled toward each other as the device flattens. The device may also include interior structure to hold the device in a flattened configuration.

2. 发明申请

US20050131447A1 Emboli protection devices and related methods of use 有权
标题翻译： Emboli保护装置及相关使用方法
公开(公告)号：US20050131447A1
公开(公告)日：2005-06-16
申请号：US11034824
申请日：2005-01-14
申请人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
发明人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
IPC分类号： A61B17/00 , A61B17/12 , A61B17/22 , A61B19/00 , A61F2/06 , A61F2/82 , A61F2/84 , A61M25/00
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B90/39 , A61B2017/12127 , A61B2017/22067 , A61F2/95
摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. The evacuation sheath assembly includes an elongated tube defining an evacuation lumen having proximal and distal ends. A proximal sealing surface is provided on a proximal portion of the tube and is configured to form a seal with a lumen of a guided catheter. A distal sealing surface is provided on a distal portion of the tube and is configured to form a seal with a blood vessel. A method of treatment of a blood vessel using the evacuation sheath assembly includes advancing the evacuation sheath assembly into the blood vessel through a guide catheter. Prior to advancing a device across a stenosis to be treated, normal antegrade blood flow in the blood vessel proximate to the stenosis is stopped. While blood flow is stopped, the stenosis is treated. Retrograde blood flow is induced within the blood vessel to carry embolic material dislodged during treating into the evacuation sheath assembly.
摘要翻译：提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。抽真空组件包括限定具有近端和远端的抽空腔的细长管。近侧密封表面设置在管的近端部分上，并被构造成与引导导管的内腔形成密封。远端密封表面设置在管的远端部分上并构造成与血管形成密封。使用排气鞘组件治疗血管的方法包括通过引导导管将排空鞘组件推进到血管中。在将装置推进通过待治疗的狭窄之前，停止在狭窄附近的血管中的正常顺行血流。当血流停止时，狭窄处理。在血管内引起逆行血流，以便在处理进入抽真空鞘组件期间将栓塞物移走。

3. 发明申请

US20060036282A1 Closure devices, related delivery methods and tools, and related methods of use 有权
公开(公告)号：US20060036282A1
公开(公告)日：2006-02-16
申请号：US11198325
申请日：2005-08-08
申请人： Dennis Wahr , David Blaeser , Peter Keith , Thomas Ressemann
发明人： Dennis Wahr , David Blaeser , Peter Keith , Thomas Ressemann
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2018/00214 , A61B2018/00273 , A61B2018/00351
摘要： A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end of fixedly connected to the left atrial anchor and a portion, proximal to the first end, releasably connected to the right atrial anchor. Preferably, the elongate member is flexible.

4. 发明申请

US20070255210A1 Emboli protection devices and related methods of use 有权
标题翻译： Emboli保护装置及相关使用方法
公开(公告)号：US20070255210A1
公开(公告)日：2007-11-01
申请号：US11824451
申请日：2007-06-29
申请人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
发明人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
IPC分类号： A61M29/00
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B90/39 , A61B2017/12127 , A61B2017/22067 , A61F2/95
摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. A method of treating a blood vessel, includes providing an elongate member having proximal and distal ends, a lumen therebetween, the distal end having a braided sheath expandable between a reduced and expanded diameter, and a fluid-tight covering. The elongate member is advanced into a blood vessel that supplies blood to the heart. The braided sheath is expanded to engage the endoluminal surface of the blood vessel and stop antegrade flow.
摘要翻译：提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。一种治疗血管的方法，包括提供具有近端和远端的细长构件，其间的腔，所述远端具有可在缩径和扩张直径之间扩张的编织护套和流体密封的覆盖物。细长构件前进到向心脏供应血液的血管。编织的鞘被扩张以接合血管的内腔表面并停止顺行的流动。

5. 发明申请

US20060116659A1 Emboli protection device and related methods of use 有权
标题翻译： Emboli保护装置及相关使用方法
公开(公告)号：US20060116659A1
公开(公告)日：2006-06-01
申请号：US11337126
申请日：2006-01-19
申请人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
发明人： Dennis Wahr , Thomas Ressemann , Peter Keith , David Blaeser , Michael Berman
IPC分类号： A61M31/00
CPC分类号： A61B17/12136 , A61B17/12045 , A61B17/12109 , A61B90/39 , A61B2017/12127 , A61B2017/22067 , A61F2/95
摘要： An evacuation sheath assembly and method of treating occluded vessels which reduces the risk of distal embolization during vascular interventions is provided. A method of treating a lesion within a blood vessel, e.g., a coronary artery, includes advancing a sheath into the blood vessel, the sheath having a lumen extending to a port at a distal end of the sheath and further having an occlusive member within a distal region of the sheath. The occlusive member is then positioned within the blood vessel proximal to the lesion. Subsequently, the occlusive member is deployed, thereby stopping antegrade flow across the lesion. A contrast agent can then be infused through a port in the sheath. A dilation balloon is then advanced across the lesion. Suction is then applied to the lumen to induce retrograde flow across the lesion after dilating the lesion.
摘要翻译：提供疏散鞘组件和治疗闭塞血管的方法，其减少血管干预期间远端栓塞的风险。治疗血管（例如冠状动脉）内的病变的方法包括使鞘进入血管，护套具有延伸到护套远端端口处的内腔，并且还具有闭塞构件护套的远端区域。然后将闭塞性构件定位在靠近病变的血管内。随后，闭塞成员被部署，从而阻止穿过病变的顺行流动。然后可以通过护套中的端口注入造影剂。然后将扩张气囊推进穿过病变。然后在扩张病变之后，将吸引应用于管腔以诱导穿过病变的逆行流。

6. 发明申请

US20050267526A1 Closure devices, related delivery methods and tools, and related methods of use 审中-公开
标题翻译：关闭装置，相关的运送方式和工具以及相关的使用方法
公开(公告)号：US20050267526A1
公开(公告)日：2005-12-01
申请号：US11185951
申请日：2005-07-21
申请人： Dennis Wahr , David Blaeser , Peter Keith , Thomas Ressemann
发明人： Dennis Wahr , David Blaeser , Peter Keith , Thomas Ressemann
IPC分类号： A61B17/00 , A61B17/12 , A61B18/14 , A61M25/00 , A61B17/08
CPC分类号： A61B17/0057 , A61B18/1492 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2018/00214 , A61B2018/00273 , A61B2018/00351
摘要： A device for sealing a patent foramen ovale (PFO) in the heart is provided. The device includes a left atrial anchor adapted to be placed in a left atrium of the heart, a right atrial anchor adapted to be placed in a right atrium of the heart, and an elongate member adapted to extend through the passageway and connect the left and right atrial anchors. The right atrial anchor preferably includes a plurality of arms and a cover attached to the arms. The left atrial anchor also includes a plurality of arms and preferably does not include a cover. Preferably, the elongate member has a first end of fixedly connected to the left atrial anchor and a portion, proximal to the first end, releasably connected to the right atrial anchor.
摘要翻译：提供了一种用于密封心脏中卵圆孔（PFO）的装置。该装置包括适于放置在心脏的左心房的左心房锚，适于放置在心脏右心房的右心房锚，以及适于延伸通过该通道并连接左心室和/ 右心房锚右心房锚优选地包括多个臂和附接到臂的盖。左心房锚还包括多个臂，优选地不包括盖。优选地，细长构件具有固定地连接到左心房锚的第一端和靠近第一端的可释放地连接到右心房锚的部分。

7. 发明申请

US20070010787A1 Embolic protection device and methods of use 有权
标题翻译：栓塞保护装置及使用方法
公开(公告)号：US20070010787A1
公开(公告)日：2007-01-11
申请号：US11177473
申请日：2005-07-07
申请人： Steven Hackett , Eric Stainbrook , Thomas Janecek , Chad Trembath , Andrew Dusbabek , John Drontle , Joel Phillips , Thomas Ressemann , Kyle Thunstrom , Peter Keith
发明人： Steven Hackett , Eric Stainbrook , Thomas Janecek , Chad Trembath , Andrew Dusbabek , John Drontle , Joel Phillips , Thomas Ressemann , Kyle Thunstrom , Peter Keith
IPC分类号： A61M29/00
CPC分类号： A61B17/22032 , A61M25/005 , A61M25/10181 , A61M2025/0034 , A61M2025/0037 , A61M2205/8225
摘要： An evacuation sheath assembly and method of reducing or removing a blockage within a vessel without permitting embolization of particulate matter is provided. The evacuation sheath assembly includes a first elongate tubular member, having proximal and distal ends and a main lumen configured to be placed in fluid communication with a blood vessel. An expandable member is provided on a distal portion of the tubular member and is configured to form a seal with the blood vessel. The evacuation assembly further includes a second elongate tubular member having proximal and distal ends and an inflation lumen configured to be placed in fluid communication with the expandable member and a gas inflator. The gas inflator includes a high pressure gas source and a mechanism for regulating the pressure of the gas delivered by the gas inflator. The gas inflator is configured to be placed in fluid communication with the proximal end of the inflation lumen in order to provide a regulated pressure gas source for inflating the expandable member. A method of treatment of a blood vessel using the evacuation sheath assembly includes advancing the evacuation sheath assembly into the blood vessel through a guide catheter. The expandable member is inflated to provide form a seal between the blood vessel and the guide catheter and a vacuum is applied to the main lumen of the first elongate tubular member to cause retrograde blood flow and carry fluid into the main lumen of the evacuation sheath assembly.
摘要翻译：提供疏散护套组件以及在不允许颗粒物质栓塞的情况下减少或去除容器内的堵塞的方法。抽真空组件包括第一细长管状构件，其具有近端和远端以及构造成与血管流体连通的主腔。可膨胀构件设置在管状构件的远侧部分上并构造成与血管形成密封。排气组件还包括具有近端和远端的第二细长管状构件和构造成与膨胀构件和气体充气器流体连通的膨胀腔。气体充气机包括高压气体源和用于调节由气体充气机输送的气体的压力的机构。气体充气器被配置成与膨胀腔的近端流体连通，以便提供用于使可膨胀构件膨胀的调节压力气体源。使用排气鞘组件治疗血管的方法包括通过引导导管将排空鞘组件推进到血管中。可膨胀构件被膨胀以在血管和引导导管之间形成密封，并且将真空施加到第一细长管状构件的主腔，以引起逆行血流并将流体携带到排泄鞘组件的主腔内。

8. 发明授权

US5645533A Apparatus and method for performing an intravascular procedure and exchanging an intravascular device 失效
标题翻译：用于进行血管内手术和交换血管内装置的装置和方法
公开(公告)号：US5645533A
公开(公告)日：1997-07-08
申请号：US379091
申请日：1995-01-26
申请人： David Blaeser , Janita Burmeister , Peter Keith , Thomas Ressemann
发明人： David Blaeser , Janita Burmeister , Peter Keith , Thomas Ressemann
IPC分类号： A61M25/00 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0004 , A61M2025/0047 , A61M2025/0079 , A61M2025/0098 , A61M2025/0175 , A61M2025/0183 , A61M2025/1063 , A61M2025/1079 , A61M2025/1093 , A61M25/0067 , A61M25/0069 , A61M25/0075
摘要： A method and apparatus are provided for performing a balloon angioplasty procedure and for exchanging a guide wire and an intravascular catheter during the procedure. An intravascular balloon catheter includes an elongated shaft having a proximal portion adapted to extend outside the body of a patient during use, a distal portion adapted for connection to a dilation balloon and adapted for positioning intravascularly during use, and an inflation lumen extending therethrough in fluid flow communication with the balloon. In one aspect of the invention, an elongated guide lumen is connected to the catheter such that the guide lumen and catheter are movable relative to each other during use. A proximal portion of the guide lumen is adapted to extend outside the body of a patient during use, and a distal portion of the guide lumen is adapted to extend distally of the balloon during use. In another aspect of the invention, one or both of a guide wire and an intravascular device can be withdrawn from the guide lumen while the guide lumen remains substantially stationary. In yet another aspect of the invention, proximal and distal seal members are adapted to provide a substantially sealing fit around an intravascular device to inhibit the egress of fluid from the balloon.
摘要翻译：提供了一种用于执行球囊血管成形术程序并在手术期间更换导丝和血管内导管的方法和装置。血管内气囊导管包括细长轴，其具有适于在使用期间延伸到患者身体外部的近端部分，适于连接到扩张气囊的远端部分，并且适于在使用期间血管内定位，以及在流体中延伸穿过的充气腔与气球的流动通信。在本发明的一个方面，细长的引导腔连接到导管，使得引导腔和导管在使用期间可相对于彼此移动。引导腔的近端部分适于在使用期间延伸到患者身体的外部，并且引导腔的远侧部分适于在使用期间向远端延伸。在本发明的另一方面，引导管和血管内装置中的一个或两个可以在引导腔保持基本上静止的同时从引导腔中取出。在本发明的另一方面，近端和远端密封构件适于提供围绕血管内装置的基本密封配合，以抑制流体从气囊的流出。

9. 发明申请

US20070185415A1 Steerable guide wire with torsionally stable tip 审中-公开
标题翻译：导向扭矩稳定的导丝
公开(公告)号：US20070185415A1
公开(公告)日：2007-08-09
申请号：US11652234
申请日：2007-01-10
申请人： Thomas Ressemann , Pete Keith , Steven Willard , Peter Ness , Steven Hackett
发明人： Thomas Ressemann , Pete Keith , Steven Willard , Peter Ness , Steven Hackett
IPC分类号： A61M25/00
CPC分类号： A61M25/09 , A61M25/0133 , A61M25/09025 , A61M2025/09083 , A61M2025/09175 , A61M2025/09191
摘要： A steerable guide wire includes a core wire having a proximal end and a distal end. A braided filament is affixed to the distal end of the core wire. An outer coil surrounds at least a portion of the core wire and the braided filament. A proximal end of the braided filament is secured to a distal end of the coil. By locating the braided filament in the distal tip portion of the guide wire, a guide wire is provided that is highly flexible, has a high degree of tensile integrity, and is highly steerable, even in tortuous vasculature. Filter and balloon catheters having braided filaments at the distal end are also described.
摘要翻译：可导向的导丝线包括具有近端和远端的芯线。编织丝固定在芯线的远端。外部线圈围绕芯线和编织细丝的至少一部分。编织丝的近端固定到线圈的远端。通过将编织丝定位在导丝的远侧末端部分，提供了一种导丝，其具有高柔性，具有高度的拉伸完整性，并且即使在曲折的脉管系统中也是高度可操纵的。还描述了在远端具有编织细丝的过滤器和球囊导管。

10. 发明申请

US20080015497A1 DEVICE AND METHOD FOR TREATING CONSTRICTED SINUS PASSAGEWAY 有权
标题翻译：用于处理有争议的SINUS PASSAGEWAY的装置和方法
公开(公告)号：US20080015497A1
公开(公告)日：2008-01-17
申请号：US11782612
申请日：2007-07-24
申请人： Peter Keith , Thomas Ressemann , Theordore Truitt
发明人： Peter Keith , Thomas Ressemann , Theordore Truitt
IPC分类号： A61M25/10
CPC分类号： A61M29/02 , A61B17/12022 , A61B17/12104 , A61B17/12136 , A61B17/24 , A61B17/3421 , A61B17/3468 , A61B90/30 , A61B90/50 , A61B2017/1205 , A61B2090/3945 , A61F2/82 , A61M2029/025 , A61M2210/0618 , A61M2210/0681
摘要： A balloon catheter for treating a constricted sinus passageway of a patient includes an elongate flexible shaft defining a lumen therein, the elongate flexible shaft having a proximal end and distal region. The elongate flexible shaft may include a kink-resistant coil in the distal region. A hub is affixed to the proximal end of the elongate flexible shaft, the hub including a port in communication with the lumen. An expandable member is disposed on the distal region of the elongate flexible shaft, wherein an interior portion of the expandable member is in communication with the lumen.
摘要翻译：用于治疗患者的收缩性窦通道的气囊导管包括在其中限定内腔的细长柔性轴，所述细长柔性轴具有近端和远端区域。细长柔性轴可以在远侧区域中包括耐扭结线圈。毂固定到细长柔性轴的近端，毂包括与内腔连通的端口。可扩张构件设置在细长柔性轴的远侧区域上，其中可扩张构件的内部与内腔连通。

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