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1. 发明申请

US20090192218A1 USE OF PHTHALIDE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES MELLITUS 有权
标题翻译：用于治疗和预防糖尿病的PHTHALIDE衍生物的使用
公开(公告)号：US20090192218A1
公开(公告)日：2009-07-30
申请号：US12412577
申请日：2009-03-27
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365 , A61P3/10 , C07D307/77
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

2. 发明授权

US08242168B2 Use of phthalide derivatives for the treatment of type 2 diabetes mellitus 有权
标题翻译：使用苯酞衍生物治疗2型糖尿病
公开(公告)号：US08242168B2
公开(公告)日：2012-08-14
申请号：US12412577
申请日：2009-03-27
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Renata Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/34
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

3. 发明申请

US20070082947A1 Use of phthalide derivatives for the treatment and prevention of diabetes mellitus 审中-公开
标题翻译：使用苯酞衍生物治疗和预防糖尿病
公开(公告)号：US20070082947A1
公开(公告)日：2007-04-12
申请号：US10556199
申请日：2004-05-05
申请人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
发明人： Daniel D'Orazio , Antoine De Saizieu , Goede Schueler , Daniel Raederstorff , Sandra Teixeira , Ying Wang Schmidt , Peter Weber , Swen Wolfram
IPC分类号： A61K31/365
CPC分类号： A61K31/343
摘要： The present invention relates to the use of a compound as effective agent for the prevention or treatment of diabetes mellitus in a mammal. Said compounds being selected from the group of phthalide derivatives and exhibit excellent blood glucose lowering effects and thus are effective agents in the prevention or treatment of diabetes mellitus in mammals.
摘要翻译：本发明涉及化合物作为哺乳动物预防或治疗糖尿病的有效药物的用途。所述化合物选自苯酞衍生物，表现出优异的降血糖作用，因此是预防或治疗哺乳动物糖尿病的有效药剂。

4. 发明申请

US20090221693A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20090221693A1
公开(公告)日：2009-09-03
申请号：US12299644
申请日：2007-05-02
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Swen Wolfram
IPC分类号： A61K31/352 , C07D311/82 , A61P21/00
CPC分类号： A61K31/352
摘要： The present invention refers to compounds of the general formulae I as defined above, preferably α-mangostin, for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function and endurance. Other fields of use are eating disorders such as bulimia and anorexia nervosa, use for accelerating wound healing, and/or use for the treatment/prevention of bone disorders such as osteoporosis and osteopenia. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of preventing and/or treating the above mentioned disorders/diseases, as well as to methods of maintaining the healthy state and/or improving the baseline conditions in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the prevention and/or treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及用于预防和改善肌肉疾病的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中用作/组合物的上述通式I的化合物，优选α-谷歌蛋白并改善肌肉功能和耐力。其他使用领域是进食障碍，例如贪食症和神经性厌食症，用于加速伤口愈合，和/或用于治疗/预防骨病，如骨质疏松症和骨质减少症。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，预防和/或治疗上述疾病/疾病的方法，以及维持健康状态和/或改善哺乳动物包括人类和式I本身化合物的基线条件的方法。本发明的另一个目的是这些化合物在制备用于预防和/或治疗上述疾病/疾病的组合物中的用途。

5. 发明申请

US20100041746A1 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：US20100041746A1
公开(公告)日：2010-02-18
申请号：US12301505
申请日：2007-05-24
申请人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
发明人： Daniel D'Orazio , Daniel Raederstorff , Goede Schueler , Ying Wang-Schmidt , Karin Wertz , Swen Wolfram
IPC分类号： A61K31/352 , A61K31/12 , A61K31/36 , C07C49/255 , C07D317/46 , C07D311/02 , A61P21/00
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle:fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如炎性肠综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

6. 发明授权

US08227508B2 Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses 有权
标题翻译：含有鼠尾草酚和/或罗斯曼醇的饮食和药物组合物及其用途
公开(公告)号：US08227508B2
公开(公告)日：2012-07-24
申请号：US12514881
申请日：2007-11-22
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
IPC分类号： A61K31/352 , C07D311/78
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

7. 发明申请

US20100048688A1 DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING CARNOSOL AND/OR ROSMANOL AND THEIR USES 有权
标题翻译：含有卡罗糖醇和/或罗莫诺的膳食和药物组合物及其用途
公开(公告)号：US20100048688A1
公开(公告)日：2010-02-25
申请号：US12514881
申请日：2007-11-22
申请人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
发明人： Ann Fowler , Regina Goralczyk , Claus Kilpert , Hasan Mohajeri , Daniel Raederstorff , Antoine De Saizieu , Goede Schueler , Ying Wang-Schmidt , Christof Wehrli
IPC分类号： A61K31/352 , C07D311/78 , A61P25/00
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

8. 发明授权

US08044094B2 Agents for preventing and treating disorders connected to impaired neurotransmission 失效
标题翻译：用于预防和治疗与神经传递受损有关的障碍的药剂
公开(公告)号：US08044094B2
公开(公告)日：2011-10-25
申请号：US11665072
申请日：2005-10-21
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Goede Schueler , Bernd Mussler
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Goede Schueler , Bernd Mussler
IPC分类号： A61K31/37
CPC分类号： A61K31/37 , A23L2/39 , A23L7/126 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2200/322
摘要： The present invention refers to coumarin ethers of the formula (I), wherein R1 is H, OH or (E)-3-methyl-but-2-enyl, R2 is selected from the group consisting of methyl, 3-(4,5-dihydro-5,5-dimethyl-4-furanon-2-yl)-2-(E/Z)-butenyl, (E/Z)-3,7-dimethylocta-2,6-dienyl, 7-hydroxy-3,7-dimethyl-2-octen-6-on-yl and (E/Z,E/Z)-11-acetyl-oxy-3,7,11,11-tetramethyl-undeca-2,7-dien-10-on-yl, R3 is H, R1 and R2O together for the group —O—C(C(═CH2)CH3)H—CH2—O— or the group —C(H)═C(H)—C(CH3)2—O— or R2O and R3 together form the group —O—C(H)(C(CH3)2(H)—O—C(O)CH3)—CH2—, preferably to obliquin, for use as medicaments, especially for the treatment and/or prevention of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and plant extracts containing such coumarin ethers and their uses.
摘要翻译：本发明涉及式（I）的香豆素醚，其中R1是H，OH或（E）-3-甲基 - 丁-2-烯基，R2选自甲基，3-（4， 2-（E / Z） - 丁烯基，（E / Z）-3,7-二甲基辛-2,6-二烯基，7-羟基 -3,7-二甲基-2-辛烯-6-酮和（E / Z，E / Z）-11-乙酰氧基-3,7,11,11-四甲基 - 十一碳-2,7-二烯（C（= CH 2）CH 3）H-CH 2 -O-或基团-C（H）= C（H） - 基，R 3为H，R 1和R 2 O为-O C（CH 3）2 -O-或R 2 O和R 3一起形成-O-C（H）（C（CH 3）2（H）-O-C（O）CH 3）-CH 2基团，优选为阴性，用作药物，特别是用于治疗和/或预防与神经传递受损有关的障碍，以及含有这种香豆素醚的饮食和药物组合物和植物提取物及其用途。

9. 发明申请

US20120183635A1 ROSEMARY EXTRACTS, DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES 审中-公开
标题翻译：挥发性提取物，含有它们的食物和药物组合物及其用途
公开(公告)号：US20120183635A1
公开(公告)日：2012-07-19
申请号：US13433318
申请日：2012-03-29
申请人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
发明人： Antoine De Saizieu , Ann Fowler , Regina Goralczyk , Claus Kilpert , Goede Schueler
IPC分类号： A61K36/53 , A61P25/00
CPC分类号： A61K36/53
摘要： Rosemary extracts are used in the treatment of disorders connected to reduced neurotransmission, as well as dietary and pharmaceutical compositions containing these rosemary extracts.
摘要翻译：迷迭香提取物用于治疗与减少的神经传递相关的疾病，以及含有这些迷迭香提取物的饮食和药物组合物。

10. 发明申请

US20100184852A1 ORGANIC COMPOUNDS FOR TREATMENT OF DISORDERS CONNECTED TO IMPAIRED NEUROTRANSMISSION 审中-公开
标题翻译：用于治疗与受损神经递质连接的疾病的有机化合物
公开(公告)号：US20100184852A1
公开(公告)日：2010-07-22
申请号：US12376621
申请日：2007-08-10
申请人： Antoine De Saizieu , Regina Goralczyk , Goede Schueler
发明人： Antoine De Saizieu , Regina Goralczyk , Goede Schueler
IPC分类号： A61K31/365 , C07D307/88 , A61P25/22 , A61P25/00 , A61P25/24 , A61P25/20
CPC分类号： A61K31/343
摘要： The present invention refers to compounds of the general formula (I) wherein R1 is hydrogen or hydroxy; R2 is butyl or butyryl if R1 is hydroxy, but R2 is butyl if R1 is hydrogen; or R3 and R2 taken together are 1-propylidene or 1-butylidene optionally substituted by hydroxy, methyl, or 3-(α, β-dimethylacryloyloxy); the dotted line is an optional bond; X is an optionally substituted aliphatic C4-residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is X1, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 and R4 are, independently from each other, hydrogen or hydroxy; and R5 is hydroxy or butyryl, for use in the treatment of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions containing such compounds, and their uses.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是氢或羟基; 如果R 1是羟基，则R 2是丁基或丁酰基，但如果R 1是氢，则R 2是丁基; 或者R 3和R 2一起是1-羟基，甲基或3-（α，β-二甲基丙烯酰氧基）任意取代的1-亚丙基或1-亚丁基。虚线是可选的键; X是选自X 1，X 2，X 3，X 4和X 5的任选取代的脂族C 4残基; 其中如果式（I）中的虚线不存在，X是X 2，X 3或X 5; 如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3和R 4彼此独立地为氢或羟基; 和R5是羟基或丁酰基，用于治疗与受损的神经传递相关的疾病，以及含有这些化合物的饮食和药物组合物及其用途。

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