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1. 发明申请

WO2017009203A1 FOOD COMPOSITIONS FOR MANAGING BODY WEIGHT 审中-公开
标题翻译：用于管理身体重量的食物组合物
公开(公告)号：WO2017009203A1
公开(公告)日：2017-01-19
申请号：PCT/EP2016/066223
申请日：2016-07-08
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN , ACADEMISCH ZIEKENHUIS GRONINGEN , WAGENINGEN UNIVERSITEIT
发明人： ARIE SCHOLS, Hendrik , DE VOS, Paulus , VAN DEN BERG, Marco, Alexander , BRUGGEMAN, Geert , BRUININX, Erik, Martinus, Adrianus, Maria , SAHASRABUDHE, Neha, Mohan , SCHOLTE, Jan , TIAN, Lingmin , SCHEURINK, Anton, Johannes
IPC分类号： A61K31/732 , A61P3/04 , A23L33/00 , A23L33/21 , A23L29/231
CPC分类号： A61K31/732 , A23L29/231 , A23L33/21 , A23V2002/00 , A23V2200/332 , A23V2250/50724
摘要： This invention relates generally to compositions and methods for managing the body mass index, the body fat percentage and/or and/or the distribution of fat storage sites of humans and particularly to the use of food compositions for managing the body mass index, the body fat percentage and/or and/or the distribution of fat storage sites.
摘要翻译：本发明一般涉及用于管理身体质量指数，身体脂肪百分比和/或人体脂肪储存位置的分布和/或分布的组合物和方法，特别涉及用于管理体重指数的食物组合物的使用，身体脂肪百分比和/或/或脂肪储存部位的分布。

2. 发明申请

WO2009113853A3 ADIPATE ESTER OR THIOESTER SYNTHESIS 审中-公开
公开(公告)号：WO2009113853A3
公开(公告)日：2009-09-17
申请号：PCT/NL2009/050115
申请日：2009-03-11
申请人： DSM IP ASSETS B.V. , WU, Liang , TREFZER, Axel, Christoph , DE WILDEMAN, Stefaan, Marie, André , VAN DEN BERG, Marco, Alexander
发明人： WU, Liang , TREFZER, Axel, Christoph , DE WILDEMAN, Stefaan, Marie, André , VAN DEN BERG, Marco, Alexander
IPC分类号： C12P7/44
摘要： The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid(6-ACA), a method for preparing 5-formyl valeric acid (5- FVA), and a method for preparingcaprolactam. Further, the invention relates to a host cell for use in a method according to the invention.

3. 发明申请

WO2021254943A1 UMAMI FLAVOUR COMPOSITION 审中-公开
公开(公告)号：WO2021254943A1
公开(公告)日：2021-12-23
申请号：PCT/EP2021/065922
申请日：2021-06-14
申请人： DSM IP ASSETS B.V.
发明人： JAMALZADEH, Elaheh , VAN DEN BERG, Marco, Alexander
IPC分类号： A23J3/34 , A23J3/16 , A23L27/22 , A23L27/50 , A23J3/346 , A23L27/24
摘要： The present invention relates to a method for producing an umami flavour composition, said method comprises providing a plant based protein isolate and contacting the plant based protein isolate with a protease, with an exopeptidase and with a glutaminase, to produce the umami flavour composition, wherein the plant based protein isolate does not comprise cereal prolamins.

4. 发明申请

WO2019170790A1 YEAST BETA GLUCANS 审中-公开
公开(公告)号：WO2019170790A1
公开(公告)日：2019-09-12
申请号：PCT/EP2019/055631
申请日：2019-03-07
申请人： DSM IP ASSETS B.V. , UNIVERSITY MAASTRICHT
发明人： VAN DEN BERG, Marco, Alexander , CANFORA, Emanuel Enzo , BLAAK, Ellen Elisabeth
IPC分类号： A61K31/716 , A23L29/00 , A23L29/212 , A61P3/04
摘要： The present invention relates to yeast beta glucans for increasing the acetate concentration in the distal colon of a patient. According to another aspect, the present invention relates to yeast beta glucans for use in a method of treating or preventing a condition selected from overweight and obesity in a human or animal patient in need thereof. According to yet another aspect, the present invention relates to an alimentary product, or a food supplement, comprising yeast beta glucan and/or starch. According to another aspect the present invention relates to a method for increasing the acetate concentration in the distal colon of a patient.

5. 发明申请

WO2017009202A1 FOOD AND/OR FEED COMPOSITIONS FOR PREVENTING AND TREATING INFLAMMATORY DISEASES 审中-公开
标题翻译：用于预防和治疗炎症疾病的食品和/或饲料组合物
公开(公告)号：WO2017009202A1
公开(公告)日：2017-01-19
申请号：PCT/EP2016/066222
申请日：2016-07-08
申请人： DSM IP ASSETS B.V. , RIJKSUNIVERSITEIT GRONINGEN , ACADEMISCH ZIEKENHUIS GRONINGEN , WAGENINGEN UNIVERSITEIT
发明人： ARIE SCHOLS, Hendrik , DE VOS, Paulus , VAN DEN BERG, Marco, Alexander , BRUGGEMAN, Geert , BRUININX, Erik, Martinus, Adrianus, Maria , SAHASRABUDHE, Neha, Mohan , SCHOLTE, Jan , TIAN, Lingmin , SCHEURINK, Anton, Johannes
IPC分类号： A61K31/732 , A61P29/00 , A61P37/00 , A61P37/02 , A61P39/00 , A23L35/00
CPC分类号： A61K31/732 , A23K20/163 , A23L29/231 , A23L33/21 , A23V2002/00 , A61P29/00 , A23V2200/324 , A23V2250/50724
摘要： This invention relates generally to compositions and methods for combating inflammatory disease and particularly to the use of food and/or feed compositions for preventing, reducing and/or treating inflammatory disorders, diseases, or discomforts, wherein the compositions comprising at least one specific pectin.
摘要翻译：本发明一般涉及抗炎症疾病的组合物和方法，特别涉及用于预防，减少和/或治疗炎性疾病，疾病或不适的食物和/或饲料组合物的用途，其中所述组合物包含至少一种特定的果胶。

6. 发明申请

WO2004106347A1 CEPHEM COMPOUND 审中-公开
标题翻译： CEPHEM化合物
公开(公告)号：WO2004106347A1
公开(公告)日：2004-12-09
申请号：PCT/NL2004/000367
申请日：2004-05-24
申请人： DSM IP ASSETS B.V. , VAN DEN BERG, Marco, Alexander , BOVENBERG, Roelof, Ary, Lans , RAAMSDONK, Lourina, Madeleine, Leonie , SUTHERLAND, John, David , DE VROOM, Erik , VOLLINGA, Roeland, Christiaan, Roel
发明人： VAN DEN BERG, Marco, Alexander , BOVENBERG, Roelof, Ary, Lans , RAAMSDONK, Lourina, Madeleine, Leonie , SUTHERLAND, John, David , DE VROOM, Erik , VOLLINGA, Roeland, Christiaan, Roel
IPC分类号： C07D501/00
CPC分类号： C07D501/00
摘要： The present invention is concerned with a novel cephem compound, with a process for the production of this compound, which process may contain or consist of fermentative steps, chemical steps, and/or biotransformation steps. A cephem compound according to the present invention characterised by formula (I) or a salt or ester thereof, wherein R is selected from the group consisting of (carboxymethylthio)propionyl (carboxyethylthio)propionyl Y- CH2-CO15 wherein Y is phenyl, phenoxy or tetrazolyl HOOC-X-CO wherein X is defined as (CH 2 ) 4 or wherein X is defined as (CH 2 )P-A-(CH 2 )q, wherein p and q each individually are 0, 1, 2, 3 or 4, and A is CH=CH, C-=C, CHB, C=O, O, S, NH, the nitrogen optionally being substituted or the sulfur optionally being oxidized, and B is hydrogen, halogen, C 1-3 alkoxy, hydroxyl, or optionally substituted methyl, with the proviso that p+q should be 2 or 3, when A is CH=CH or C=-C, or p+q should be 3 or 4, when A is CHB, C=O, 0, S or NH or wherein X is (CH 2 ) m -CH=A-(CH2) n or (CH 2 ) m -C=-C-(CH 2 ) n , wherein m and n each individually are 0, 1, 2 or 3 and m+n = 2 or 3, and A is CH or N, or wherein X is (CH2)p-CH=CH-C H=C-(CH2)q wherein p and q each individually are 0 or 1 and p+q = 0 or 1 and wherein R' is selected from the group consisting of OH O-(alkyl 1-6C) wherein the alkyl can be straight or branched and O-C(alkyl 1-6C)-O-(alkyl 1-6C) wherein the alkyl groups can be straight or branched can inter alia be prepared by fermentative techniques according to the invention and in particular using a suitable microorganism possessing or being transformed with the genes needed for conversion of an appropriate acyl-6-aminopenicillanic acid into the desired compound.
摘要翻译：本发明涉及一种新的头孢烯化合物，其具有生产该化合物的方法，该方法可以含有或由发酵步骤，化学步骤和/或生物转化步骤组成。根据本发明的头孢烯化合物，其特征在于式（I）化合物或其盐或酯，其中R选自（羧甲硫基）丙酰基（羧乙硫基）丙酰基Y-CH 2 -CO 15，其中Y是苯基，苯氧基或四唑基HOOC-X-CO，其中X定义为（CH 2）4或其中X定义为（CH 2）PA-（CH 2）q，其中p和q各自独立地为0,1,2,3或4，并且A 是CH = CH，C = C，CHB，C = O，O，S，NH，任选被取代的氮或任选被氧化的硫，B是氢，卤素，C 1-3烷氧基，羟基或任选地取代的甲基，条件是当A为CH = CH或C = -C时，p + q应为2或3，或p + q应为3或4，当A为CHB时，C = O，O，S 或NH或其中X是（CH 2）m -CH = A-（CH 2）n或（CH 2）m C = -C-（CH 2）n，其中m和n各自独立地是0,1,2或3和m + n = 2或3，A为CH或N，或其中X为（CH 2）p -CH = CH-C H = C-（CH 2）q，其中p和q各自各自为0或1，p + q = 0或1和其中R'选自OH -O-（烷基1-6C），其中烷基可以是直链或支链和OC（烷基1-6C）-O-（烷基1-6C），其中烷基可以是直链或支链可以特别通过根据本发明的发酵技术制备，特别是使用具有或正在转化合适的酰基-6-氨基青霉烷酸所需基因的合适微生物进入所需化合物。

7. 发明申请

WO2021105341A1 PROCESS FLAVOUR 审中-公开
公开(公告)号：WO2021105341A1
公开(公告)日：2021-06-03
申请号：PCT/EP2020/083609
申请日：2020-11-27
申请人： DSM IP ASSETS B.V.
发明人： DE KOK, Petrus, Maria,Theresia, Peter , AMMERLAAN, Brenda, Catharina, Henriëtte , VAN DEN BERG, Marco, Alexander
IPC分类号： A23L5/10 , A23L19/00 , A23L23/10 , A23P30/20 , A23L27/10 , A23L33/125 , A23L33/16
摘要： The present invention relates to a method for producing a process flavour comprising: a) preparing a composition comprising a vegetable and an alkaline earth metal chloride; b) intimately mixing the composition in an extruder under conditions of temperature and reaction time sufficient for the process flavour to develop; wherein the composition does not comprise yeast, yeast extract or yeast autolysate; wherein the amount of vegetable is within the range of 35 to 98% (w/w) of the composition.

8. 发明申请

WO2018224698A1 YOGHURT COMPRISING REBAUDIOSIDE M 审中-公开
公开(公告)号：WO2018224698A1
公开(公告)日：2018-12-13
申请号：PCT/EP2018/072664
申请日：2018-08-22
申请人： DSM IP ASSETS B.V.
发明人： VAN DEN BERG, Marco, Alexander , MALJAARS, Cornelia, Elizabeth, Paulina , NIJMEIJER, Marieke
IPC分类号： A23C9/13 , A23C11/10 , A23L27/30
CPC分类号： A23C9/1307 , A23C11/106 , A23L27/36 , A23V2002/00 , A23V2250/262
摘要： A yogurt comprises rebaudioside M in an amount of from about 15 ppm to about 600 ppm, preferably from about 25 ppm to about 600 ppm, and an added sugar in an amount of from about 0% to about 10% (wt).

9. 发明申请

WO2010015625A1 ADIPOYL-7-ADCA PRODUCING STRAINS 审中-公开
标题翻译： ADIPOYL-7-ADCA生产菌株
公开(公告)号：WO2010015625A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/060088
申请日：2009-08-04
申请人： DSM IP ASSETS B.V. , VAN DEN BERG, Marco, Alexander , BOVENBERG, Roelof, Ary, Lans
发明人： VAN DEN BERG, Marco, Alexander , BOVENBERG, Roelof, Ary, Lans
IPC分类号： C12N1/14 , C12N15/01
CPC分类号： C12P37/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N9/93
摘要： The present invention relates to a mutant microbial strain capable of producing an N-adipoylated β-lactam compound when cultured in a culture medium comprising adipic acid characterized in that the strain has an improved incorporation yield of the adipic acid from the culture medium into the N-adipoylated β-lactam compound compared to the non-mutant parent strain.
摘要翻译：本发明涉及在含有己二酸的培养基中培养时能够产生N-己二酰化的β-内酰胺化合物的突变微生物菌株，其特征在于该菌株具有改进的己二酸与非突变亲本菌株相比，从培养基中转化成N-己二酰化β-内酰胺化合物。

10. 发明申请

WO2005040186A3 METHOD FOR PREPARING A MODIFIED HOST CELL 审中-公开
公开(公告)号：WO2005040186A3
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011615
申请日：2004-10-14
申请人： DSM IP Assets B.V. , VAN DEN BERG, Marco, Alexander
发明人： VAN DEN BERG, Marco, Alexander
IPC分类号： C07H21/00
摘要： The present invention relates to a method for preparation of a modified host cell which comprises the steps of (a) transfecting a host cell with at least one compound of interest to which a label is covalently coupled and (b) isolating the transfected host cell, wherein the label provides to the host cell a non-inheritable trait. Modified host cells according to the invention can be directly separated from the non-modified host cell. To this end use is made of labels, which can be monitored at the modified cells (such as fluorescent labels) and which enable separation of the modified and non-modified host cells by suitable means. In case of fluorescent labels use can be made of a Fluorescent Activated Cell Sorter. Suitable compounds of interest according to this invention are compounds, which enable to change permanently or transiently a metabolic property of the host cell. Examples of compounds are polynucleotides, proteins or metabolites. The host cells modified according to the present invention can be used for the production of proteins, metabolites and cell biomass.

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