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1. 发明申请

WO2011000773A1 TESTING EFFICACY FOR CELIAC DISEASE 审中-公开
标题翻译： CELIAC疾病的测试效果
公开(公告)号：WO2011000773A1
公开(公告)日：2011-01-06
申请号：PCT/EP2010/058997
申请日：2010-06-24
申请人： DSM IP Assets B.V. , BRUINS, Maaike, Johanna , EDENS, Luppo
发明人： BRUINS, Maaike, Johanna , EDENS, Luppo
IPC分类号： G01N33/564
CPC分类号： G01N33/564 , G01N2800/06 , G06Q99/00
摘要： We describe a method to determine effectiveness of a compound or composition in treatment of celiac disease or gluten intolerance, the method comprising: - administration of the compound or composition to one or more human patients who were on a gluten-free diet for 10 years or less, preferably 6 years or less; - challenge with gluten of the one or more human patients who were administered the compound or composition; and - determining whether there is a change in condition of celiac disease or gluten intolerance of the one or more patients that results from administration of the compound or composition and challenge with gluten; whereby no significant change in condition indicates that the compound or composition would be effective in treating celiac disease or gluten intolerance.
摘要翻译：我们描述了一种确定化合物或组合物治疗乳糜泻或麸质不耐症的有效性的方法，该方法包括：将化合物或组合物施用于一个或多个无麸质饮食的人类患者10年，或少于6岁以下; - 对施用化合物或组合物的一个或多个人类患者的面筋进行挑战; 以及 - 确定由所述化合物或组合物的施用导致的一种或多种患者的腹腔疾病或麸质不耐受状况是否发生变化并用面筋攻击; 因此条件没有显着变化表明化合物或组合物将有效治疗乳糜泻或麸质不耐受。

2. 发明申请

WO2007060247A3 ENZYME PREPARATIONS YIELDING A CLEAN TASTE 审中-公开
公开(公告)号：WO2007060247A3
公开(公告)日：2007-05-31
申请号：PCT/EP2006/068979
申请日：2006-11-28
申请人： DSM IP ASSETS B.V. , SWAAF, DE, Maximiliaan Peter Marie , DIJK, VAN, Albertus, Alard , EDENS, Luppo , DEKKER, Petrus, Jacobus, Theodorus
发明人： SWAAF, DE, Maximiliaan Peter Marie , DIJK, VAN, Albertus, Alard , EDENS, Luppo , DEKKER, Petrus, Jacobus, Theodorus
IPC分类号： C12N9/38 , A23C9/12 , C12N15/56 , C12N1/21
摘要： The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.

3. 发明申请

WO2006114441A1 BLOOD PRESSURE LOWERING PROTEIN HYDROLYSATES 审中-公开
标题翻译：血压降低蛋白水解物
公开(公告)号：WO2006114441A1
公开(公告)日：2006-11-02
申请号：PCT/EP2006/061883
申请日：2006-04-27
申请人： DSM IP ASSETS B.V. , EDENS, Luppo , ROOS, DE, Andre Leonardus , VAN PLATERINK, Christianus, Jacobus
发明人： EDENS, Luppo , ROOS, DE, Andre Leonardus , VAN PLATERINK, Christianus, Jacobus
IPC分类号： A61K38/06 , A61P9/12
CPC分类号： A61K38/06 , C12P21/06
摘要： The present invention describes the tripeptide MAP and/or the tripeptide ITP and/or a salt thereof.
摘要翻译：本发明描述了三肽MAP和/或三肽ITP和/或其盐。

4. 发明申请

WO2006089921A1 BLOOD PRESSURE LOWERING PEPTIDES FROM GLYCOMACROPEPTIDE 审中-公开
标题翻译：血液压力降低胶质纤维蛋白酶
公开(公告)号：WO2006089921A1
公开(公告)日：2006-08-31
申请号：PCT/EP2006/060198
申请日：2006-02-23
申请人： DSM IP Assets B.V. , ROOS, DE, Andre Leonardus , BROECKE, VAN DEN,, Pieter Marinus , EDENS, Luppo
发明人： ROOS, DE, Andre Leonardus , BROECKE, VAN DEN,, Pieter Marinus , EDENS, Luppo
IPC分类号： C12P21/02 , C12P21/06
CPC分类号： C12P21/06 , C12P21/02
摘要： A process to produce IPP from a protein source whereby the protein source comprises a protein having the -I-P-P- sequence and having in the protein amino acid sequence at least 6 times more -I-P-P- present than -V-P-P- (molar basis) which comprises hydrolysing the protein source to liberate at least 40% of the I-P-P- sequence 10 into the peptide IPP and whereby a proteolytic enzyme is used which cleaves at the carboxy-terminus of proline residues present in the protein source, the enzyme is preferably a proline specific endoprotease or proline specific oligopeptidase, more preferably a proline specific endoprotease, and optionally an amino peptidase.
摘要翻译：从蛋白质源产生IPP的方法，其中蛋白源包含具有-IPP序列并且在蛋白质氨基酸序列中的蛋白质比-PP-（摩尔基）存在至少6倍以上的蛋白质，其包括水解蛋白质来源，将至少40％的IPP序列10释放到肽IPP中，由此使用在蛋白质源中存在的脯氨酸残基的羧基末端切割的蛋白水解酶，该酶优选是脯氨酸特异性内切蛋白酶或脯氨酸特异性寡肽酶，更优选脯氨酸特异性内切蛋白酶，和任选的氨基肽酶。

5. 发明申请

WO2006067163A3 BLOOD PRESSURE LOWERING OLIGOPEPTIDES IN A SINGLE ENZYMATIC STEP 审中-公开
公开(公告)号：WO2006067163A3
公开(公告)日：2006-06-29
申请号：PCT/EP2005/057000
申请日：2005-12-21
申请人： DSM IP Assets B.V. , EDENS, Luppo , ROOS, DE, Andre Leonardus , SCHOUTEN, Olaf Leonardus , DEEN, Philippus Antonius
发明人： EDENS, Luppo , ROOS, DE, Andre Leonardus , SCHOUTEN, Olaf Leonardus , DEEN, Philippus Antonius
IPC分类号： A61K38/06 , C12P21/06
摘要： A process to produce IPP and VPP from a protein source that comprises the -I- P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P- sequence present in the protein source is converted into the peptide VPP, which comprises the use of a proline specific endoprotease and an amino- peptidase preferably in a single enzymatic step.

6. 发明申请

WO2005117595A1 METHOD TO IMPROVE FLAVOUR OF BAKED CEREAL PRODUCTS 审中-公开
标题翻译：改善谷物产品风味的方法
公开(公告)号：WO2005117595A1
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052533
申请日：2005-06-02
申请人： DSM IP Assets B.V. , EDENS, Luppo , HILLE, Jan Dirk Rene
发明人： EDENS, Luppo , HILLE, Jan Dirk Rene
IPC分类号： A21D8/04
CPC分类号： A21D8/042 , A21D13/00
摘要： The present invention describes the use of a proline-specific endoprotease to improve the flavour of baked cereal products. The invention also relates to novel compositions comprising a proline-specific endoprotease and an exopeptidase and dough comprising such composition suitable for improving flavour in baked cereal products, a method for improving flavour in baked products, and to baked products having an improved flavour.
摘要翻译：本发明描述了脯氨酸特异性内切蛋白酶用于改善烘焙谷物产品风味的用途。本发明还涉及包含脯氨酸特异性内切蛋白酶和外肽酶和面团的新型组合物，其包含适合于改善烘焙谷物产品中风味的组合物，改善焙烤产品中风味的方法，以及具有改善风味的烘焙产品。

7. 发明申请

WO2005082160A1 NOVEL FOOD PRODUCTION PROCESS 审中-公开
标题翻译：新食品生产过程
公开(公告)号：WO2005082160A1
公开(公告)日：2005-09-09
申请号：PCT/EP2005/002159
申请日：2005-02-28
申请人： DSM IP ASSETS B.V. , STREEKSTRA, Hugo , EDENS, Luppo
发明人： STREEKSTRA, Hugo , EDENS, Luppo
IPC分类号： A23L1/015
CPC分类号： A23K10/14 , A21D8/042 , A21D13/22 , A23L5/25 , A23L5/28 , A23L19/18 , C12Y305/01 , C12Y305/01001 , C12Y305/01002
摘要： Process for the production of a food or feed product, comprising adding an enzyme to the surface of an intermediate form of the food or feed product, and subsequently applying at least one heating step, whereby the enzyme is capable of modifying amino acids present in the intermediate form of the food or feed product. The invention also relates to food or feed products obtained by the process of the invention.
摘要翻译：用于生产食品或饲料产品的方法，包括向中间形式的食品或饲料产品的表面添加酶，随后施加至少一个加热步骤，由此该酶能够修饰存在于中间形式的食品或饲料产品。本发明还涉及通过本发明的方法获得的食品或饲料产品。

8. 发明申请

WO2015086737A1 MEDICAMENT AND METHOD FOR TREATING INNATE IMMUNE RESPONSE DISEASES 审中-公开
标题翻译：治疗免疫应答疾病的药物和方法
公开(公告)号：WO2015086737A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077355
申请日：2014-12-11
申请人： DSM IP ASSETS B.V.
发明人： BRUINS, Maaike Johanna , EDENS, Luppo , NAN, Lenneke
IPC分类号： A23L1/03 , A21D8/04 , A61K38/48 , C12N9/62 , C11D3/386
CPC分类号： A61K38/488 , A21D8/042 , A23L5/25 , A23L29/06 , A23V2002/00 , A61K9/0053 , A61K38/482 , C12C5/004 , C12N9/62 , C12Y304/21026 , C12Y304/23018 , C12Y304/23019 , A61K2300/00
摘要： This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and / or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.
摘要翻译：本发明涉及一种药物或膳食补充剂，其包含能够水解植物食物过敏原的黑曲霉曲霉菌肽酶，更具体地，涉及α-淀粉酶/胰蛋白酶抑制剂，从而治疗由于人的先天免疫应答引起的疾病，和/ 或允许延迟所述疾病的发作。本发明涉及黑曲霉曲霉菌肽酶能够水解存在于小麦和相关谷物中的α-淀粉酶/胰蛋白酶抑制剂的发现，所述抑制剂是先天免疫应答的强诱导剂。此外，本发明涉及水解α-淀粉酶/胰蛋白酶抑制剂的方法，包括将包含α-淀粉酶/胰蛋白酶抑制剂的食物组合物与黑曲霉曲霉菌肽酶一起孵育，其中所述抑制剂被水解。它还涉及包含黑曲霉曲霉菌肽酶和另外的酶的酶组合物以及包含黑曲霉曲霉菌肽酶的食品。

9. 发明申请

WO2015086735A1 USE OF THE ASPERGILLUS NIGER ASPERGILLOGLUTAMIC PEPTIDASE TO IMPROVE ANIMAL PERFORMANCE 审中-公开
标题翻译：使用青US ER ER ER IC IC IC IC ASE TO ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE ANCE
公开(公告)号：WO2015086735A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077353
申请日：2014-12-11
申请人： DSM IP ASSETS B.V.
发明人： BRUINS, Maaike Johanna , EDENS, Luppo , LENEKE, Nan
IPC分类号： A23K1/165 , A23K1/18 , C12N9/62
CPC分类号： A23K20/189 , A23K10/14 , A23K20/174 , A23K20/30 , A23K50/30 , A23K50/75 , A61K38/488 , C12Y304/23019
摘要： This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha- amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers. Furthermore, the present invention relates to a method of improving animal performance comprising improving feed conversion ratio, and/or improving daily weight gain, and/or reducing intestinal inflammation, and/or reducing nitrogen excretion in an animal fed a feed stuff containing alpha- amylase and/or trypsin inhibitors, comprising orally administering a sufficient amount of the Aspergillus niger aspergilloglutamic peptidase. It also relates to the pretreatment of feedstuff with the Aspergillus niger aspergilloglutamic peptidase.
摘要翻译：本发明涉及黑曲霉曲霉菌肽酶在含有谷物，豆类，油籽和/或块茎的饲料组合物中的用途，以改善动物性能，减少氮排泄和/或减少肠道炎症。此外，本发明涉及包含黑曲霉曲霉菌肽酶的饲料组合物或饲料添加剂。本发明涉及黑曲霉曲霉菌肽酶能够有效水解存在于小麦，大麦和相关谷类物种中的α-淀粉酶/胰蛋白酶抑制剂以及水解存在于脉冲，油籽中的胰蛋白酶抑制剂的发现，和块茎。此外，本发明涉及一种改善动物性能的方法，包括改善饲料转化率，和/或改善每日体重增加，和/或减少肠道炎症，和/或减少饲喂含α-淀粉样蛋白饲料的动物的氮排泄，淀粉酶和/或胰蛋白酶抑制剂，包括口服施用足量的黑曲霉曲霉菌肽酶。它还涉及用黑曲霉曲霉菌肽酶预处理饲料。

10. 发明申请

WO2014191571A1 IMMOBILIZED PROLINE-SPECIFIC ENDOPROTEASE 审中-公开
标题翻译：固定化的特异性内切酶
公开(公告)号：WO2014191571A1
公开(公告)日：2014-12-04
申请号：PCT/EP2014/061305
申请日：2014-06-02
申请人： DSM IP ASSETS B.V.
发明人： HISENI, Aida , GALAEV, Igor , EDENS, Luppo
IPC分类号： C12N11/08 , C12N9/62 , C12C5/00 , C12H1/00
CPC分类号： C12N11/08 , C12C5/004 , C12C11/11 , C12N9/62 , C12N11/06 , C12Y304/21026
摘要： The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier hasa particle size range of 100 to 400 µm. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
摘要翻译：本发明涉及固定化的脯氨酸特异性内切蛋白酶，其中将脯氨酸特异性内切蛋白酶固定在已经用氨基二亚甲基官能化的甲基丙烯酸酯的载体上，其中载体的粒度范围为100-400μm。本发明还涉及一种生产啤酒的方法，包括制备糊状物，发酵啤酒和稳定啤酒的步骤，其中啤酒与固定化的脯氨酸特异性内切蛋白酶一起温育。

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