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1. 发明专利

JP2013231034A Dendritic polymer with enhanced extension and interior functionality 审中-公开
标题翻译：具有增强扩展和内部功能的聚合物聚合物
公开(公告)号：JP2013231034A
公开(公告)日：2013-11-14
申请号：JP2013112814
申请日：2013-05-29
申请人： Dendritic Nanotechnologies Inc , デンドリティックナノテクノロジーズ,インコーポレイテッド
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEL CORDELL R
IPC分类号： C07C309/68 , A61K9/48 , A61K31/405 , A61K45/00 , A61K47/32 , A61K47/34 , A61K47/48 , A61P29/00 , A61P43/00 , C07C217/28 , C07C217/30 , C07C229/12 , C07C237/10 , C07C323/52 , C07F9/38 , C08G59/14 , C08G59/32
CPC分类号： C08G83/003 , C08G59/1477 , C08G59/32 , C08G59/3227 , C08G59/5026
摘要： PROBLEM TO BE SOLVED: To provide dendritic polymers with enhanced extension and interior functionality.SOLUTION: For example, dendritic polymers made in a reaction represented by the following formula are exemplified. Such dendritic polymers are useful as emulsifiers for oil/water emulsions, wet strength imparting agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint.
摘要翻译：要解决的问题：提供具有增强的延伸和内部功能的树枝状聚合物。解决方案：例如，以由下式表示的反应制备的树枝状聚合物被列举。这种树枝状聚合物可用作油/水乳液的乳化剂，纸张制造中的湿强度赋予剂，质子清除剂，聚合物，纳米级单体，用于电子显微镜的校准标准品，制备尺寸选择性膜以及用于在水性配方中改性粘度的试剂如油漆。

2. 发明申请

WO2006105043A3 JANUS DENDRIMERS AND DENDRONS 审中-公开
标题翻译： JANUS DENDRIMERS和DENDRONS
公开(公告)号：WO2006105043A3
公开(公告)日：2007-10-04
申请号：PCT/US2006011160
申请日：2006-03-27
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , PULGAM VEERA REDDY , SWANSON DOUGLAS R , HUANG BAOHUA
发明人： TOMALIA DONALD A , PULGAM VEERA REDDY , SWANSON DOUGLAS R , HUANG BAOHUA
IPC分类号： C08G75/00 , C08G59/68 , C08G61/00 , C08G63/44 , C08G65/04 , C08G73/00
CPC分类号： C08G83/003 , C08G81/00
摘要： This invention provides a cost effective process and new Janus dendrimers where at least two dendrons are attached at the core (with or without a connector group) and where at least two of the dendrons have different functionality. Preferred are those Janus dendrimers where at least one dendron is a PEHAM dendron. Thus these Janus dendrimers are heterobifunctional in character and use unique ligation chemistry with single site functional dendrons, di-dendrons and multi-dendrons. Also included are Janus dendrons which maybe used as intermediates to make the Janus dendrimers or to further react with another reactive moiety. These Janus dendrimers can provide several new dendrimer moieties, namely: combinatorial libraries of bifunctional structures; combined target director and signaling dendrimers; specific targeting entities for diagnostic and therapeutic applications, such as for example targeted MRI agents, targeted radionuclide delivery for diseases such as cancer, and targeted photosensitive or radiowave sensitive agents.
摘要翻译：本发明提供了一种成本有效的方法和新的Janus树枝状大分子，其中至少两个树突状物连接在核心处（具有或不具有连接基团），并且其中至少两个枝状突起具有不同的功能。那些Janus树枝状大分子是首选，其中至少有一个树突是PEHAM树突。因此，这些Janus树枝状大分子在性质上是异双功能的，并且使用独特的连接化学物质，其具有单位点功能性树突，二树枝状突起和多枝状突起。还包括Janus dendron，其可以用作中间体来制备Janus树枝状大分子或进一步与另一反应性部分反应。这些Janus树枝状大分子可以提供几个新的树枝状大分子部分，即：双功能结构的组合文库; 组合目标主任和信号树枝状大分子; 用于诊断和治疗应用的特异性靶向实体，例如靶向MRI剂，用于诸如癌症的疾病的靶向放射性核素递送，以及靶向感光或无线电波敏感剂。

3. 发明申请

WO2006088958A8 ENCAPSULATED(CHELATE OR LIGAND) DENDRITIC POLYMERS 审中-公开
标题翻译：包封（CHELATE或LIGAND）DENDRITIC POLYMERS
公开(公告)号：WO2006088958A8
公开(公告)日：2007-07-26
申请号：PCT/US2006005334
申请日：2006-02-15
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , HUANG BAOHUA
发明人： TOMALIA DONALD A , HUANG BAOHUA
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： C08G83/003
摘要： An encapsulated chelate dendritic polymer and an encapsulated ligand dendritic polymer are disclosed which have unique properties. These encapsulated chelate dendritic polymers may have associated with its dendritic polymer surface target directors, proteins, DNA, RNA (including single strands) or any other moieties that will assist in diagnosis, therapy or delivery of this encapsulated chelate dendritic polymer. These encapsulated dendritic polymers are suitable as contrast agents for use in imaging in an animal, for other imaging techniques, for EPR, and as scavenger agents for chelant therapy. Formulations for these uses are also included within the scope of this invention.
摘要翻译：公开了包封的螯合树枝状聚合物和包封的配体树枝状聚合物，其具有独特的性质。这些包封的螯合树枝状聚合物可能与其树突状聚合物表面靶向导体，蛋白质，DNA，RNA（包括单链）或将有助于诊断，治疗或递送这种包封的螯合树枝状聚合物的任何其它部分相关联。这些包封的树突状聚合物适合作为用于动物成像的对比剂，其它成像技术用于EPR，以及用作螯合剂治疗的清除剂。这些用途的制剂也包括在本发明的范围内。

4. 发明申请

WO2006115547A3 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A3
公开(公告)日：2009-06-04
申请号：PCT/US2005047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
IPC分类号： C08J3/00 , C08J9/32 , C08K9/00 , C12N15/87
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers of the macromolecular structure of Figure 1 are disclosed. The dendritic polymers have enhanced amplification and interior functionality. The dendritic polymers are made by use of fact, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled manner to rapidly and precisely build dendritic structures with cleaner chemistry and often with single products. Additional benefits include lower excesses of regents, lower levels of dilution, higher capacity, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The compositions prepared have novel internal functionality, including increased thermal stability and no reverse Michael's reaction, and reach encapsulation surface densities at lower generations.
摘要翻译：公开了图1的大分子结构的树枝状聚合物。树枝状聚合物具有增强的扩增和内部功能。树枝状聚合物通过使用事实，反应性开环化学（或其它快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建具有更清洁化学物质的树突状结构并且经常与单一产物一起制备。额外的好处包括摄入量过低，稀释水平降低，容量更大，容易扩展到商业尺寸，新的材料范围以及更低的成本。制备的组合物具有新颖的内部功能，包括增加的热稳定性和没有相反的迈克尔反应，并在较低的代下达到包封表面密度。

5. 发明申请

WO2006115547A8 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006115547A8
公开(公告)日：2007-02-15
申请号：PCT/US2005047635
申请日：2005-12-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY , HEINZELMANN JOSEPH R , SVENSON SONKE , REYNA LORI A , ZHURAVEL MICHAEL A , CHAUHAN ABHAY SINGH , DEMATTEI CORDELL R
IPC分类号： A61K48/00 , A61K31/785 , C12N15/87
CPC分类号： C12N15/87 , A61K47/59 , A61K47/593 , A61K47/595 , A61K48/00 , A61K49/0002 , B82Y5/00 , B82Y10/00 , C08G83/003 , C08L101/005 , C09B67/0013
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易扩展到商业尺寸，新的材料范围和更低的成本。制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和更少或没有反向迈克尔反应），并在较低代次达到包封表面密度。出乎意料的是，多功能分支细胞试剂与多官能核心的这些反应不产生交联材料。这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂作为油漆。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如药物递送，转染和诊断，这些树枝状聚合物具有用于承载材料的附加性能。

6. 发明申请

WO2006065266A9 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的树枝状聚合物
公开(公告)号：WO2006065266A9
公开(公告)日：2006-12-21
申请号：PCT/US2005013864
申请日：2005-04-20
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
IPC分类号： C08J3/00 , C08J9/32 , C08J9/40 , C08K9/00
CPC分类号： C08G83/003 , C08G59/1477 , C08G59/32 , C08G59/3227 , C08G59/5026
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymer are made by use of fast, reactive ring opening chemistry (or other fast reactions) combined with the use of branch cell reagants in a controlled way to rapidly and precisely build dendrimer structures, generation by generation, with precise structures with cleaner chemistry, typically single products, lower excesses of reagants, lower levels of dilution, higher capacity method, more easily scale to commercial dimensions, new ranges of materials, and lower cost. The dendrimer composition prepared have novel internal functionality, greater stability, e.g., thermal stability and less or no reverse Michaels reaction, and which reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of poly-functional branch cell reagents with polyfunctional surfaces do not create gelled materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic have additional properties due to the unique characteristics of the dendritic polymer.
摘要翻译：公开了具有增强的放大和内部功能的树枝状聚合物。这些树状聚合物是通过使用快速，反应性开环化学（或其他快速反应），并结合使用分子细胞反应物，以可控的方式快速精确地构建树枝状聚合物结构，逐代生成，具有精确的结构和更清洁的化学，通常是单一产品，更低的稀料过量，更低的稀释水平，更高的产能方法，更容易扩展到商业规模，新的材料范围和更低的成本。所制备的树枝状聚合物组合物具有新的内部官能团，更高的稳定性，例如热稳定性和更少的或不反向的迈克尔斯反应，并且在较低代时达到包封表面密度。出乎意料的是，多功能分支细胞试剂与多功能表面的这些反应不会产生胶凝材料。这种树枝状聚合物可用作油/水乳剂的破乳剂，制造纸中的湿强度剂，质子清除剂，电子显微镜的校准标准品，制备尺寸选择膜和用于改变水性制剂如油漆中粘度的试剂。当这些树枝状聚合物具有与其表面和/或内部相关的携带材料时，由于树枝状聚合物的独特特性，这些树枝状聚合物具有附加性能。

7. 发明申请

WO2005029539A3 STABILIZED AND CHEMICALLY FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：稳定和化学官能化纳米粒子
公开(公告)号：WO2005029539A3
公开(公告)日：2005-05-06
申请号：PCT/US2004023483
申请日：2004-07-21
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , HUANG BOAHUA
发明人： TOMALIA DONALD A , HUANG BOAHUA
IPC分类号： B05D7/00 , B05D7/24 , C09K11/02 , C09K11/56 , C09K11/88 , H01L20060101
CPC分类号： C09K11/025 , B22F1/0018 , B22F1/0074 , B22F2998/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C01B19/007 , C09K11/565 , C09K11/883 , B22F1/0022
摘要： Dendronization of nano-scale surfaces with focal point reactive dendrons to produce stabilized chemically functionalized nano-particles having quantum dot dimensions.
摘要翻译：具有焦点反应性枝晶的纳米级表面的树突化以产生具有量子点尺寸的稳定的化学官能化纳米颗粒。

8. 发明申请

WO2005019290A3 ULTRA HIGH MOLECULAR WEIGHT HYBRID DENDRIGRAFT ARCHITECTURES 审中-公开
标题翻译：超高分子量混合动力架构
公开(公告)号：WO2005019290A3
公开(公告)日：2006-07-20
申请号：PCT/US2004025045
申请日：2004-08-03
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R
IPC分类号： C08G81/00 , C08F271/02 , C08G20060101 , C08G83/00
CPC分类号： C08G83/002 , C08G83/005
摘要： Mono-reactive dendrigrafts prepared by convergent self-branching polymerization and their subsequent grafting to linear, dendritic, and dendrigraft, branched, and hyper-branched substrates to prepare ultra-high molecular weight dendrigraft architectures using alkyl halides and aryl halides as initiators.
摘要翻译：通过收敛的自支化聚合制备的单反应性树枝状物，并将它们随后接枝到线型，树枝状和树枝状结构，支化和超支化底物上，以制备超高分子量树枝状结构，使用烷基卤和芳基卤化物引发剂。

9. 发明申请

WO2006065266A2 DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY 审中-公开
标题翻译：具有增强放大和内部功能的聚合物聚合物
公开(公告)号：WO2006065266A2
公开(公告)日：2006-06-22
申请号：PCT/US2005013864
申请日：2005-04-20
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
发明人： TOMALIA DONALD A , SWANSON DOUGLAS R , HUANG BAOHUA , PULGAM VEERA REDDY
IPC分类号： C08F20/02
CPC分类号： C08G83/003 , C08G59/1477 , C08G59/32 , C08G59/3227 , C08G59/5026
摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymer are made by use of fast, reactive ring opening chemistry (or other fast reactions) combined with the use of branch cell reagants in a controlled way to rapidly and precisely build dendrimer structures, generation by generation, with precise structures with cleaner chemistry, typically single products, lower excesses of reagants, lower levels of dilution, higher capacity method, more easily scale to commercial dimensions, new ranges of materials, and lower cost. The dendrimer composition prepared have novel internal functionality, greater stability, e.g., thermal stability and less or no reverse Michaels reaction, and which reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of poly-functional branch cell reagents with polyfunctional surfaces do not create gelled materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic have additional properties due to the unique characteristics of the dendritic polymer.
摘要翻译：公开了具有增强的扩增和内部功能的树枝状聚合物。这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞反应物以受控的方式制备，以快速和精确地构建树枝状聚合物结构，一代代，具有更清洁化学物质的精确结构，通常是单一产品，较低的反应物过剩，较低的稀释水平，更高的容量方法，更容易扩展到商业尺寸，新的材料范围和较低的成本。所制备的树枝状聚合物组合物具有新的内部官能团，更高的稳定性，例如热稳定性和更少或没有反向迈克尔斯反应，并且在较低代次下达到包封表面密度。出乎意料的是，具有多官能表面的多功能分支细胞试剂的这些反应不产生胶凝材料。这种树枝状聚合物可用作油/水乳液的破乳剂，制造纸中的湿强剂，质子清除剂，电子显微镜校准标准品，制备尺寸选择性膜，以及用于改进水性配方如油漆中的粘度的试剂。当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，这些树枝状结构具有额外的性质。

10. 发明申请

WO2005040074A2 CRICK-WATSON BASE PAIRED DENDRIMER STRUCTURES 审中-公开
标题翻译： CRICK-WATSON基础配对的DENDRIMER结构
公开(公告)号：WO2005040074A2
公开(公告)日：2005-05-06
申请号：PCT/US2004027500
申请日：2004-08-24
申请人： DENDRITIC NANOTECHNOLOGIES INC , TOMALIA DONALD A , DEMATTEI CORDELL
发明人： TOMALIA DONALD A , DEMATTEI CORDELL
IPC分类号： C07C20060101 , C07H21/02 , C07C
CPC分类号： C07H21/02
摘要： A Crick-Watson base paired dendrimer structure comprising a unit having the following formula: D-bp-D, where D is a dendrimer and bp comprises a Crick-Watson base paired deoxyribonucleic acid.
摘要翻译： Crick-Watson碱基配对树状聚合物结构，其包含具有下式的单元：D-bp-D，其中D是树枝状大分子，bp包含Crick-Watson碱基配对的脱氧核糖核酸。

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