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1. 发明专利

SG11202106617VA ENGINEERED TRANSAMINASE POLYPEPTIDES 未知
公开(公告)号：SG11202106617VA
公开(公告)日：2021-07-29
申请号：SG11202106617V
申请日：2020-01-13
申请人： CODEXIS INC
发明人： NAZOR JOVANA , MICKLITSCH CHRISTOPHER , DUAN DA , SOWELL-KANTZ AURIC , MILLER STEVEN , KOSJEK BIRGIT , FARASAT IMAN , MARSHALL NICHOLAS
IPC分类号： C12N9/10 , C12N15/09 , C12N15/54 , C12N15/63 , C12P13/04 , C12Q1/52
摘要： The present invention provides engineered transaminase polypeptides and compositions thereof, as well as polynucleotides encoding the engineered transaminase polypeptides. Methods for producing transaminase enzymes are also provided. In some embodiments, the engineered transaminase polypeptides are optimized to provide improved enzyme properties under minimal aqueous conditions in wet organic solvents.

2. 发明专利

SG11202012109UA ENGINEERED PHOSPHOPENTOMUTASE VARIANT ENZYMES 未知
公开(公告)号：SG11202012109UA
公开(公告)日：2021-01-28
申请号：SG11202012109U
申请日：2019-07-02
申请人： CODEXIS INC
发明人： NOVICK SCOTT , YI XIANG , DELLAS NIKKI , ALVIZO OSCAR , NAZOR JOVANA , DUAN DA , MITCHELL VESNA , VROOM JONATHAN , SIVARAMAKRISHNAN SANTHOSH , SUBRAMANIAN NANDHITHA , MOORE JEFFREY , HUFFMAN MARK , RODRIGUEZ-GRANILLO AGUSTINA , VERMA DEEPTAK , MURPHY GRANT , MARSHALL NICHOLAS , RUSSELL JAY , CANADA KEITH
IPC分类号： C12P19/02 , C12P19/38
摘要： The present invention provides engineered phosphopentomutase (PPM) enzymes, polypeptides having PPM activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PPM enzymes are also provided. The present invention further provides compositions comprising the PPM enzymes and methods of using the engineered PPM enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

3. 发明专利

SG11202012111UA ENGINEERED PURINE NUCLEOSIDE PHOSPHORYLASE VARIANT ENZYMES 未知
公开(公告)号：SG11202012111UA
公开(公告)日：2021-01-28
申请号：SG11202012111U
申请日：2019-07-02
申请人： CODEXIS INC
发明人： NOVICK SCOTT , DELLAS NIKKI , MITCHELL VESNA , DUAN DA , NAZOR JOVANA , ALVIZO OSCAR , SOWELL-KANTZ AURIC , MOORE JEFFREY , HUFFMAN MARK , RODRIGUEZ-GRANILLO AGUSTINA , VERMA DEEPTAK , MARSHALL NICHOLAS , RUSSELL JAY , CANADA KEITH
IPC分类号： A61K38/45 , C12N9/00 , C12N9/10 , C12N15/52 , C12N15/54
摘要： The present invention provides engineered purine nucleoside phosphorylase (PNP) enzymes, polypeptides having PNP activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing PNP enzymes are also provided. The present invention further provides compositions comprising the PNP enzymes and methods of using the engineered PNP enzymes. The present invention finds particular use in the production of pharmaceutical compounds.

4. 发明专利

SG11201909712TA KETOREDUCTASE POLYPEPTIDES AND POLYNUCLEOTIDES 未知
公开(公告)号：SG11201909712TA
公开(公告)日：2019-11-28
申请号：SG11201909712T
申请日：2018-04-13
申请人： CODEXIS INC
发明人： MOORE JEFFREY , LIANG JACK , PENFIELD JONATHAN , NAZOR JOVANA , DELLAS NIKKI , MITCHELL VESNA , DUAN DA , FARASAT IMAN , RODRIGUEZ-GRANILLO AGUSTINA , MURPHY GRANT , MARSHALL NICHOLAS
IPC分类号： C12P7/04 , C12N9/00
摘要： selective oxidation 2. selective reduction NAD S-selective NADH KRED-NADH-102 R-selective KRED-101 NADP NADPH NADH Oxidase H2O - 02 (1a) .0 , 110H (1) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT o iimion ono o oloim imio (10) International Publication Number WO 2018/200214 A2 (51) International Patent Classification: C12P 7/04 (2006.01) C12N 9/00 (2006.01) (21) International Application Number: PCT/US2018/027450 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/491,161 27 April 2017 (27.04.2017) US (71) Applicant: CODEXIS, INC. [US/US]; 200 Penobscot Dri- ve, Redwood City, CA 94063 (US). (72) Inventors: MOORE, Jeffrey, C.; 126 East Lincoln Av- enue, Rahway, NJ 07065 (US). LIANG, Jack; 200 Penob- scot Drive, Redwood City, CA 94063 (US). PENFIELD, Jonathan; 11269 Skyline Ct., Truckee, CA 96161 (US). NAZOR, Jovana; 200 Penobscot Drive, Redwood City, CA 94063 (US). DELLAS, Nikki; 200 Penobscot Drive, Redwood City, CA 94063 (US). MITCHELL, Vesna; 200 Penobscot Drive, Redwood City, CA 94063 (US). DUAN, Da; 200 Penobscot Drive, Redwood City, CA 94063 (US). FARASAT, Iman; 126 East Lincoln Avenue, Rahway, NJ 07065 (US). RODRIGUEZ-GRANILLO, Agustina; 126 East Lincoln Avenue, Rahway, NJ 07065 (US). MURPHY, Grant; 126 East Lincoln Avenue, Rahway, NJ 07065 (US). MARSHAL, Nicholas; 126 East Lincoln Avenue, Rahway, NJ 07065 (US). (74) Agent: MACKNIGHT, Kamrin, T.; Codexis, Inc., 200 Penobscot Drive, Redwood City, CA 94063 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = (54) Title: KETOREDUCTASE POLYPEPTIDES AND POLYNUCLEOTIDES OH Na2PO4 Na2P03 phosphite dehydrogenase PDH-101 FIG. 1 W O 20 18/ 200214 A2 (57) : The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved prop- erties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketore- ductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase en- zymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system. [Continued on next page] WO 2018/200214 A2 IMIOHOIMIREIHHIMINIRIlinThin KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g)) with sequence listing part of description (Rule 5.2(a))

5. 发明专利

SG11202012138XA ENGINEERED GALACTOSE OXIDASE VARIANT ENZYMES 未知
公开(公告)号：SG11202012138XA
公开(公告)日：2021-01-28
申请号：SG11202012138X
申请日：2019-07-02
申请人： CODEXIS INC
发明人： MICKLITSCH CHRISTOPHER , ALVIZO OSCAR , NAZOR JOVANA , MANIAR HARVINDER , KRAWCZYK MIKAYLA , BORRA-GARSKE MARGIE , SUBRAMANIAN NANDHITHA , FRYSZKOWSKA ANNA , MARSHALL NICHOLAS , RODRIGUEZ-GRANILLO AGUSTINA , VERMA DEEPTAK , ANDREWS DEWAN
IPC分类号： C12N9/04 , C12P21/04
摘要： The present invention provides engineered galactose oxidase (GOase) enzymes, polypeptides having GOase activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. Methods for producing GOase enzymes are also provided. The present invention further provides compositions comprising the GOase enzymes and methods of using the engineered GOase enzymes. The present invention finds particular use in the production of pharmaceutical and other compounds.

6. 发明专利

CA3061133A1 KETOREDUCTASE POLYPEPTIDES AND POLYNUCLEOTIDES 未知
公开(公告)号：CA3061133A1
公开(公告)日：2018-11-01
申请号：CA3061133
申请日：2018-04-13
申请人： CODEXIS INC
发明人： MOORE JEFFREY C , LIANG JACK , PENFIELD JONATHAN , NAZOR JOVANA , DELLAS NIKKI , MITCHELL VESNA , DUAN DA , FARASAT IMAN , RODRIGUEZ-GRANILLO AGUSTINA , MURPHY GRANT , MARSHALL NICHOLAS
IPC分类号： C12P7/04 , C12N9/00
摘要： The present invention provides engineered ketoreductase and phosphite dehydrogenase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase and phosphite dehydrogenase enzymes, as well as polynucleotides encoding the engineered ketoreductase and phosphite dehydrogenase enzymes, host cells capable of expressing the engineered ketoreductase and phosphite dehydrogenase enzymes, and methods of using the engineered ketoreductase and phosphite dehydrogenase enzymes to synthesize a chiral catalyst used in the synthesis of antiviral compounds, such as nucleoside inhibitors. The present invention further provides methods of using the engineered enzymes to deracemize a chiral alcohol in a one-pot, multi-enzyme system.

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