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1. 发明申请

WO2008010934A3 TRIAZOLYL PHENYL BENZENESULFONAMIDES 审中-公开
标题翻译：三唑基苯并噻二唑
公开(公告)号：WO2008010934A3
公开(公告)日：2008-03-27
申请号：PCT/US2007015808
申请日：2007-07-10
申请人： CHEMOCENTRYX INC , CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIVAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
发明人： CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIVAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
CPC分类号： C07D401/04 , C07D249/08 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.
摘要翻译：提供了作为CCR2或CCR9受体的有效拮抗剂的化合物（I）。动物实验表明，这些化合物可用于治疗炎症，CCR2和CCR9的标志性疾病。化合物通常为芳基磺酰胺衍生物，并且可用于药物组合物，用于治疗CCR2介导的疾病，CCR9介导的疾病的方法，作为用于鉴定CCR2拮抗剂的测定中的对照和用于鉴定CCR9拮抗剂的测定中的对照。

2. 发明专利

AT498615T 未知
公开(公告)号：AT498615T
公开(公告)日：2011-03-15
申请号：AT07836049
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW , SULLIVAN EDWARD , TAN XUEFEI , THOMAS WILLIAM , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.

3. 发明专利

CO6180465A2 TRIAZOLIL FENIL BENCENOSULFONAMIDAS 未知
公开(公告)号：CO6180465A2
公开(公告)日：2010-07-19
申请号：CO09010534
申请日：2009-02-04
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIVAN EDWARD , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： A61K31/41 , A61P29/00 , C07D249/08 , C07D401/04 , C07D403/04 , C07D405/12 , C07D413/04
摘要： 1.- Un compuesto de la fórmula (I) o una sal del mismo:en dondeAr se selecciona del grupo que consiste de arilo C6-10 sustituido o no sustituido y un heteroarilo de 5 a 10 miembros sustituido o no sustituido; Y4, Y5, Y6 y Y7 se seleccionan cada uno independientemente del grupo que consiste de hidrógeno, halógeno, -CN, -C(O) R15, -CO2R15, -C(O)NR15R16, -OR15, -OC(O)R15, -OC (O) NR15R16, -SR15, -S(O)2R15, -S(O)2R15, -S(O)2NR15R16, -NO2, -NR15C(O)R16, -NR15C(O)OR16, -NR15S(O)2R16, -NR15C(O)NR16R17, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, heterociclilo de 3 a 10 miembros sustituido o no sustituido, arilo C6-10 sustituido o no sustituido, y heteroarilo de 5 a 10 miembros sustituido o no sustituido; R15, R16 y R17 se seleccionan cada uno independientemente del grupo que consiste de hidrógeno, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, arilo C6-10 sustituido o no sustituido, heteroarilo de 5 a 10 miembros sustituido o no sustituido y heterociclilo de 3 a 10 miembros sustituido o no sustituido; y R15 y R16, R16 y R17 o R15 y R17 conjuntamente con los átomos a los cuales se encuentran unidos, pueden formar un anillo de 5, 6 o 7 miembros sustituido o no sustituido; R1 se selecciona del grupo que consiste de hidrógeno, -C(O)R7, -CO2R7, C(O)NR7R8, -S(O)R7, S(O)2R7, -S(O)2NR7R8, alquilo C1-8 sustituido o no sustituido, alquenilo C2-8 sustituido o no sustituido, alquinilo C2-8 sustituido o no sustituido, heterociclilo de 3 a 10 miembros sustituido o no sustituido, arilo C6-10 sustituido o no sustituido, o heteroarilo de 5 a 10 miembros sustituido o no sustituido; R2 se selecciona del grupo que consiste de hidrógeno, halógeno, -CN, -C(O)R7, -CO2R7, -C(O)NR7R8, -OR7, -OC(O)R7, -OC(O)NR7R8, -SR7, -S(O)R7, ...

4. 发明专利

NO341949B1 Triazolylfenylbenzensulfonamider 未知
公开(公告)号：NO341949B1
公开(公告)日：2018-02-26
申请号：NO20090662
申请日：2009-02-11
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIVAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： C07D249/08 , A61K31/41 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Forbindelser er tilveiebragt som virker som potente antagonister av CCR2- eller CCR9-reseptoren. Dyretesting demonstrerer at disse forbindelsene er anvendelige for behandling av inflammasjon, en hovedsykdom for CCR2 og CCR9. Forbindelsene er generelt arylsulfonamidderivater og er anvendelige i farmasøytiske sammensetninger, fremgangsmåter for behandling av CCR2-medierte sykdommer, CCR9-medierte sykdommer, som kontroller i undersøkelser for identifisering av CCR2-antagonister og som kontroller i undersøkelser for identifisering av CCR9-antagonister.

5. 发明专利

EA015710B1 ТРИАЗОЛИЛ ФЕНИЛБЕНЗОЛСУЛЬФОНАМИДЫ 未知
公开(公告)号：EA015710B1
公开(公告)日：2011-10-31
申请号：EA200900168
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIWAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Раскрытысоединения, которыедействуюткакмощныеантагонисты CCR2 или CCR9 рецепторов. Испытаниенаживотныхдемонстрирует, чтоэтисоединениямогутбытьиспользованыдлялечениявоспаления, критериальногозаболеваниядля CCR2 и CCR9. Этисоединенияв основномпроизводныеарилсульфонамидаи могутбытьиспользованыв фармацевтическихкомпозициях, способахлечения CCR2-опосредованныхзаболеваний, CCR9-опосредованныхзаболеваний, каксредстваконтроляв анализахдляидентификации CCR2 антагонистови каксредстваконтроляв анализахдляидентификации CCR9 антагонистов.

6. 发明专利

ZA200900281B TRIAZOLYL PHENYL BENZENESULFONAMIDES 未知
公开(公告)号：ZA200900281B
公开(公告)日：2010-02-24
申请号：ZA200900281
申请日：2009-01-13
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNEL ANDREW M K , SULLIVAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.

7. 发明专利

CA2657776A1 TRIAZOLYL PHENYL BENZENESULFONAMIDES 未知
公开(公告)号：CA2657776A1
公开(公告)日：2008-01-24
申请号：CA2657776
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： TAN XUEFEI , SULLIVAN EDWARD J , PENNELL ANDREW M K , THOMAS WILLIAM D , PUNNA SREENIVAS , UNGASHE SOLOMON , ZENG YIBIN , HU CHENG , MELIKIAN ANITA , NOVACK AARON , CHARVAT TREVOR T
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful f or treating inflammation, a hallmark disease for CCR2 and CCR9. The compound s are generally aryl sulfonamide derivatives and are useful in pharmaceutica l compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 - mediated diseases, as controls in assays for the identification of CCR2 anta gonists and as controls in assays for the identification of CCR9 antagonists .

8. 发明专利

AU2007275873A1 Triazolyl phenyl benzenesulfonamides 未知
公开(公告)号：AU2007275873A1
公开(公告)日：2008-01-24
申请号：AU2007275873
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： ZENG YIBIN , MELIKIAN ANITA , TAN XUEFEI , HU CHENG , NOVACK AARON , PENNELL ANDREW M K , UNGASHE SOLOMON , CHARVAT TREVOR T , THOMAS WILLIAM D , PUNNA SREENIVAS , SULLIVAN EDWARD J
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.

9. 发明专利

BRPI0714407A2 未知
公开(公告)号：BRPI0714407A2
公开(公告)日：2013-03-05
申请号：BRPI0714407
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： CHARVAT TREVOR T , HU CHENG , MELIKIAN ANITA , NOVACK AARON , PENNELL ANDREW M K , SULLIVAN EDWARD J , TAN XUEFEI , THOMAS WILLIAM D , UNGASHE SOLOMON , ZENG YIBIN , PUNNA SREENIVAS
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.

10. 发明专利

AU2007275873B2 Triazolyl phenyl benzenesulfonamides 未知
公开(公告)号：AU2007275873B2
公开(公告)日：2012-06-14
申请号：AU2007275873
申请日：2007-07-10
申请人： CHEMOCENTRYX INC
发明人： ZENG YIBIN , MELIKIAN ANITA , TAN XUEFEI , HU CHENG , NOVACK AARON , PENNELL ANDREW M K , UNGASHE SOLOMON , CHARVAT TREVOR T , THOMAS WILLIAM D , PUNNA SREENIVAS , SULLIVAN EDWARD J
IPC分类号： C07D249/08 , A61K31/41 , A61P29/00 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D413/04
摘要： Compounds (I) are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR2 -mediated diseases, CCR9 -mediated diseases, as controls in assays for the identification of CCR2 antagonists and as controls in assays for the identification of CCR9 antagonists.

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