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1. 发明申请

WO2006128321A1 LASER CONFOCAL MICROARRAY SCANNER 审中-公开
标题翻译：激光共焦微型扫描仪
公开(公告)号：WO2006128321A1
公开(公告)日：2006-12-07
申请号：PCT/CN2005/000771
申请日：2005-06-02
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , WANG, Xianhua , XU, Hui , YE, Jianxin , SUN, Yelei , HUANG, Guoliang , CHENG, Jing
发明人： WANG, Xianhua , XU, Hui , YE, Jianxin , SUN, Yelei , HUANG, Guoliang , CHENG, Jing
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/6452 , G01N2021/6421 , G01N2201/10 , G01N2201/103
摘要： The invention provides a laser microarray scanner for microarray scanning, comprising an optical system, a scanning platform, and a data processing system. During scanning, the optical system remains fixed, and the microarray placed on the scanning platform moves relative to the optical system. The microarray scanner disclosed herein has high scanning speed, high sensitivity, high resolution, and high signal-to-noise ratio, thus is ideal for use in microarray scanning
摘要翻译：本发明提供一种用于微阵列扫描的激光微阵列扫描器，包括光学系统，扫描平台和数据处理系统。在扫描期间，光学系统保持固定，并且放置在扫描平台上的微阵列相对于光学系统移动。本文公开的微阵列扫描器具有高扫描速度，高灵敏度，高分辨率和高信噪比，因此是理想的用于微阵列扫描

2. 发明申请

WO2008128399A1 DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 审中-公开
标题翻译： BIOCHIPS洗涤和杂交装置
公开(公告)号：WO2008128399A1
公开(公告)日：2008-10-30
申请号：PCT/CN2007/002894
申请日：2007-10-09
申请人： CAPITALBIO CORPORATION , TSINGHUA UNIVERSITY , LI, Hang , YE, Jianxin , AI, Xingling , WANG, Xianhua , ZHANG, Liang , CHENG, Jing
发明人： LI, Hang , YE, Jianxin , AI, Xingling , WANG, Xianhua , ZHANG, Liang , CHENG, Jing
IPC分类号： C12M1/00 , C12M1/38 , B08B3/10 , B08B11/00 , C12Q1/68 , G01N33/53 , F16H21/18
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.
摘要翻译：提供了用于生物芯片杂交或洗涤的装置，其包括圆盘传送带（12），平移运动控制器，旋转运动控制器和可选的加热室（13）。旋转运动控制器控制圆盘传送带的旋转运动，并允许其以摆动的方式移动，允许杂交或洗涤盒（11）在传送带上的生物芯片的杂交和/或洗涤期间的液体移动。一旦旋转运动控制器停止，平移运动控制器将转盘回到水平位置，从而确保液体不会溢出。加热室在装置内循环热空气，从而确保在恒温条件下进行杂交和洗涤。

3. 发明公开

EP1811305A1 A MICRO-VOLUME LIQUID EJECTION SYSTEM 审中-公开
标题翻译： MIKROVOLUMEN-FLÜSSIGKEITSAUSSTOSSSYSTEM
公开(公告)号：EP1811305A1
公开(公告)日：2007-07-25
申请号：EP04797362.3
申请日：2004-11-22
申请人： CapitalBio Corporation , Tsinghua University
发明人： WANG, Dong , ZOU, Kun , YE, Jianxin , SUN, Yelei , ZHU, Hui , WANG, Xianhua , CHENG, Jing
IPC分类号： G01N35/10 , B05B9/04
CPC分类号： B01L3/0265 , B01L2400/0487 , B01L2400/0666 , Y10T436/2575
摘要： The present invention relates to a micro-volume liquid ejection system, including an air pressure module, a micro-ejection unit which is connected with the air pressure module by means of pipes, and a control circuit which is connected with the air pressure module and the micro-ejection unit respectively. In the present invention, due to air is used as the pressure medium, on one hand, as the sample does not contact with the pressure regulating module, the efficiency of cleaning process is improved, on the other hand, the volume of the sample needed in the sample ejecting process is only equal to the cavity-dimension of the micro-ejection unit by not need to fill the whole pipe with liquid. During the sample ejecting process, it is not need to regulate the pressure. After the sample ejecting is finished, the sample can be put into its original place, so as to greatly save the sample. The present invention is connected with the manipulator, so as to sample from the sample plate, eject sample and clean the pipes automatically, and it can also dispense a multiplicity of samples to micro-array substrate conveniently. The present invention can be used for transferring or dispensing the micro volume liquid of nL grade and L grade widely, and all kinds of the micro-volume liquid including biological liquid.
摘要翻译：微体积液体喷射系统技术领域本发明涉及一种微体积液体喷射系统，包括空气压力模块，通过管道与空气压力模块连接的微型喷射单元，以及与空气压力模块连接的控制电路，微型喷射单元。在本发明中，由于空气用作压力介质，一方面由于样品不与压力调节模块接触，因此提高了清洗过程的效率，另一方面，样品的体积需要在样品喷射过程中，仅通过不需要用整个管道填充液体就等于微喷射单元的腔体尺寸。在样品喷射过程中，不需要调节压力。样品喷射完成后，样品可以放在原来的位置，大大节省样品。本发明与操纵器连接，以便从样品板上取样，自动排出样品并清洁管道，并且还可以方便地将多个样品分配到微阵列基板。本发明可广泛用于转移或分配nL级和L级微量液体，以及各种微体积液体，包括生物液体。

4. 发明公开

EP2137293A1 DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
标题翻译：设备清洗和杂交的生物芯片
公开(公告)号：EP2137293A1
公开(公告)日：2009-12-30
申请号：EP07816508.1
申请日：2007-10-09
申请人： CapitalBio Corporation , Tsinghua University
发明人： LI, Hang , YE, Jianxin , AI, Xingling , WANG, Xianhua , ZHANG, Liang , CHENG, Jing
IPC分类号： C12M1/00 , C12M1/38 , B08B3/10 , B08B11/00 , C12Q1/68 , G01N33/53 , F16H21/18
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809
摘要： A device for biochip hybridization or washing is provided, which comprises a carousel (12), a translational movement controller, a revolving movement controller, and optionally a heating chamber (13). The revolving movement controller controls the revolving movement of the carousel and allows it to move in a wobbling fashion, allowing liquid movement of the hybridization or washing boxes (11) during hybridization and/or washing of biochips on the carousel. The translational movement controller brings the carousel back to horizontal position once the revolving movement controller stops, thereby ensures that the liquid do not spill out. The heating chamber circulates hot air within the device, thereby ensures that the hybridization and washing in a thermostatic condition.

5. 发明授权

EP2137293B1 DEVICE FOR WASHING AND HYBRIDIZATION OF BIOCHIPS 有权
标题翻译：设备清洗和杂交的生物芯片
公开(公告)号：EP2137293B1
公开(公告)日：2012-09-19
申请号：EP07816508.1
申请日：2007-10-09
申请人： CapitalBio Corporation , Tsinghua University
发明人： LI, Hang , YE, Jianxin , AI, Xingling , WANG, Xianhua , ZHANG, Liang , CHENG, Jing
IPC分类号： C12M1/00 , C12M1/38 , B08B3/10 , B01F11/00 , B01L7/00 , B08B3/04 , B08B11/02
CPC分类号： B08B3/044 , B01F11/0028 , B01J2219/00326 , B01J2219/00328 , B01J2219/00527 , B01J2219/00659 , B01L7/00 , B01L2300/0819 , B08B11/02 , Y10S435/809

6. 发明申请

WO2014100073A3 EXPRESSION VECTORS FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2014100073A3
公开(公告)日：2014-06-26
申请号：PCT/US2013/075922
申请日：2013-12-18
申请人： MERCK SHARP & DOHME CORP. , YE, Jianxin
发明人： YE, Jianxin
IPC分类号： C12N15/09 , C12N15/63 , C12N15/79 , C12N15/85 , C12N5/10
摘要： The invention provides expression vectors that support high levels of polypeptide expression in mammalian cells. The vectors contain at least one expression cassette for a target polypeptide; an expression cassette for a eukaryotic selectable marker protein; an expression cassette for a bacterial selectable marker protein, and a bacterial plasmid origin of replication.

7. 发明申请

WO2016022514A2 INHIBITORY RNA FOR ENHANCED PROTEIN PRODUCTION IN RECOMBINANT MAMMALIAN CELLS 审中-公开
标题翻译：用于增强重组蛋白质细胞中增强蛋白质的抑制RNA
公开(公告)号：WO2016022514A2
公开(公告)日：2016-02-11
申请号：PCT/US2015/043523
申请日：2015-08-04
申请人： MERCK SHARP & DOHME CORP. , YE, Jianxin , ALVIN, Krista , ZHANG, Siyan
发明人： YE, Jianxin , ALVIN, Krista , ZHANG, Siyan
IPC分类号： C12P21/02 , C12N15/85
CPC分类号： C12N15/85 , C12N15/111 , C12N2320/12 , C12P21/02
摘要： The invention provides methods and compositions for improving production of exogenous polypeptides in large scale culture of mammalian host cells. The methods and compositions utilize RNA interference to inhibit expression of one or more specific host cell proteins.
摘要翻译：本发明提供用于改善哺乳动物宿主细胞大规模培养中外源多肽生产的方法和组合物。所述方法和组合物利用RNA干扰来抑制一种或多种特异性宿主细胞蛋白的表达。

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