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1. 发明授权

US08491566B2 Methods and systems for adjusting an insulin delivery profile of an insulin pump 有权
标题翻译：用于调节胰岛素泵的胰岛素递送曲线的方法和系统
公开(公告)号：US08491566B2
公开(公告)日：2013-07-23
申请号：US13311607
申请日：2011-12-06
申请人： Blaine Edward Ramey , Ricky Lee Collins , James L. Pauley, Jr. , Robert David Timmerman
发明人： Blaine Edward Ramey , Ricky Lee Collins , James L. Pauley, Jr. , Robert David Timmerman
IPC分类号： A61M1/00
CPC分类号： G06F19/3468 , A61M5/14244 , A61M2205/35 , A61M2205/3576 , A61M2205/3584 , A61M2205/3592 , G06F19/00
摘要： Systems and methods are disclosed for adjusting the delivery times of an insulin delivery profile of an insulin pump, wherein the insulin pump is operable to automatically deliver insulin to a person having diabetes based on an operating time of the internal clock and a delivery time of an insulin delivery profile. The method may comprise receiving a local time zone time from an external local clock, determining whether the operating time of the internal clock differs from the local time zone time by at least a first predetermined amount of time, requesting the person provide a time adjustment value when the operating time of the internal clock differs from the local time zone time by at least the first predetermined amount of time, receiving the time adjustment value from the person, and adjusting the delivery times of the insulin delivery profile based on the time adjustment value when received.
摘要翻译：公开了用于调节胰岛素泵的胰岛素递送曲线的递送时间的系统和方法，其中所述胰岛素泵可操作以基于所述内部时钟的操作时间自动地向具有糖尿病的人输送胰岛素，并且所述输送时间为胰岛素输送谱。该方法可以包括从外部本地时钟接收本地时区时间，确定内部时钟的操作时间是否与本地时区时间不同至少第一预定时间量，请求该人提供时间调整值当内部时钟的操作时间与本地时区时间不同时，至少第一预定时间量，从人接收时间调整值，并且基于时间调整值调整胰岛素输送简档的传送时间收到时。

2. 发明授权

US08140294B2 Temperature estimations in a blood glucose measuring device 有权
标题翻译：血糖测量装置中的温度估计
公开(公告)号：US08140294B2
公开(公告)日：2012-03-20
申请号：US12479212
申请日：2009-06-05
申请人： Blaine Edward Ramey , Michael L. Brown , James L. Pauley, Jr.
发明人： Blaine Edward Ramey , Michael L. Brown , James L. Pauley, Jr.
IPC分类号： G01K13/00
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/6887 , A61B2560/0252 , A61B2562/0295 , G01K7/42
摘要： Methods of estimating the temperature of a reaction site on a measurement strip in a blood glucose measuring devices are provided. In one embodiment, a method includes determining an activation initiation time, an activation duration time, a thermal magnitude and a temperature elevation for heat generating components within a device. The temperature elevation for each of the heat generating components is determined at least in part by an impulse response matrix [Xi], the activation initiation time, the activation duration time and the thermal magnitude for each of the heat generating components. The method further includes determining a total temperature elevation of the glucose measuring device by summing the temperature elevation of each of the heat generating components, reading a temperature value provided by the temperature measuring element, and determining a reaction site temperature estimation by subtracting the total temperature elevation from the temperature value provided by the temperature measuring element.
摘要翻译：提供了用于估计血糖测量装置中的测量条上的反应部位的温度的方法。在一个实施例中，一种方法包括确定装置内的发热部件的激活开始时间，激活持续时间，热量值和温度升高。每个发热部件的温度升高至少部分地由每个发热部件的脉冲响应矩阵X，激活起始时间，激活持续时间和热量值决定。该方法还包括通过将每个发热部件的温度升高相加来确定葡萄糖测量装置的总温度升高，读取由温度测量元件提供的温度值，并通过减去总温度来确定反应部位温度估计由温度测量元件提供的温度值提升。

3. 发明授权

US06814844B2 Biosensor with code pattern 有权
标题翻译：具有代码模式的生物传感器
公开(公告)号：US06814844B2
公开(公告)日：2004-11-09
申请号：US09942515
申请日：2001-08-29
申请人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, Jr.
发明人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy I. Ranney , James L. Pauley, Jr.
IPC分类号： G01N27327
CPC分类号： G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要： The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译：本发明涉及生物传感器。生物传感器包括支撑基底，位于支撑基底上的导电涂层，所述涂层被形成以限定电极和编码图案，其中导电涂层和基底之间存在足够的对比度，使得代码图案是可辨别的，以及与所述支撑基板配合以限定通道的盖。至少一部分电极定位在通道中。

4. 发明授权

US07476827B1 Method of making a biosensor 有权
标题翻译：制作生物传感器的方法
公开(公告)号：US07476827B1
公开(公告)日：2009-01-13
申请号：US10976740
申请日：2004-10-29
申请人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
发明人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
IPC分类号： B23K26/38
CPC分类号： G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要： The present invention relates to a method of forming a biosensor. The method includes providing a substrate coated with a electrically conductive material, ablating the electrically conductive material to form electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and applying a reagent to at least one of the electrodes.
摘要翻译：本发明涉及形成生物传感器的方法。该方法包括提供涂覆有导电材料的基材，烧蚀导电材料以形成电极和编码图案，其中在导电涂层和基板之间存在足够的对比度，使得代码图案是可辨别的，并且施加试剂至少一个电极。

5. 发明授权

US07780827B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US07780827B1
公开(公告)日：2010-08-24
申请号：US11158772
申请日：2005-06-22
申请人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
发明人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要： The present invention relates to a biosensor. The biosensor includes a support substrate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译：本发明涉及生物传感器。所述生物传感器包括支撑衬底，位于所述支撑衬底上的导电涂层，所述涂层被形成以限定电极和编码图案，其中所述导电涂层和所述衬底之间存在足够的对比度，使得所述代码图案是可辨别的，以及与所述支撑基板配合以限定通道的盖。至少一部分电极定位在通道中。

6. 发明授权

US08888973B2 Encoded biosensors and methods of manufacture and use thereof 有权
标题翻译：编码生物传感器及其制造和使用方法
公开(公告)号：US08888973B2
公开(公告)日：2014-11-18
申请号：US13194031
申请日：2011-07-29
申请人： John T. Austera , Terry A. Beaty , Abner D. Joseph , Nathan E. Manlove , Steven K. Moore , James L. Pauley, Jr. , Randall K. Riggles
发明人： John T. Austera , Terry A. Beaty , Abner D. Joseph , Nathan E. Manlove , Steven K. Moore , James L. Pauley, Jr. , Randall K. Riggles
IPC分类号： G01N33/50 , G01N27/327 , G01N33/487
CPC分类号： G01N27/3272 , G01N33/48771
摘要： An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
摘要翻译：公开了一种分析物测试传感器带，其具有编码信息的方法以及其形成方法，并使用分析物测试传感器条进行分析物测试。可以基于条带的电气方面的电阻值（例如主要电阻元件和次级电阻元件）来编码与条带或批/条带的属性有关的信息，次电阻元件具有多个的状态由闭合抽头的位置限定，以形成用于辅助电阻元件的唯一电阻性通路，该电阻元件包括主电阻元件的一部分，取决于封闭抽头的位置。这些状态可以通过二次加工步骤形成在条带的制造中，其中多个抽头被切断，在关闭状态下仅留下一个龙头。

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