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1. 发明授权

US06991777B2 Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe 失效
标题翻译：用于体内评估生理条件和/或器官或系统功能的方法，包括使用极化129 Xe评估心肺疾病如慢性心力衰竭的方法
公开(公告)号：US06991777B2
公开(公告)日：2006-01-31
申请号：US10236156
申请日：2002-09-06
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli
IPC分类号： A61K49/00
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/485 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized 129Xe at a selected site(s) in selected environments in vivo. The gas exchange signal data can be used to evaluate: (a) the thickness of a barrier, such as a membrane, lining, wall or width of a lumen; (b) the operational condition or function of a membrane, body system or portion thereof; (c) cerebral perfusion; and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a disorder or disease, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat a disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得核磁共振光谱信号数据，该信号数据对应于在选定环境中的选定位点处的极化极性Xe的行为。气体交换信号数据可用于评估：（a）屏障的厚度，例如膜，衬里，壁或管腔宽度; （b）膜，体系或其部分的操作条件或功能; （c）脑灌注; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断疾病或疾病的方法，和/或用于监测施用于治疗疾病或疾病的治疗剂的功效的方法。

2. 发明申请

US20060002856A1 Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129Xe 审中-公开
标题翻译：体内评估生理条件和/或器官或系统功能的方法，包括评估心肺功能障碍的方法，例如使用极化的129Xe的慢性心力衰竭
公开(公告)号：US20060002856A1
公开(公告)日：2006-01-05
申请号：US11224204
申请日：2005-09-12
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli
IPC分类号： A61K49/00 , A61B5/05
CPC分类号： G01R33/5601 , A61B5/055 , G01R33/485 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain NMR spectroscopy signal data that corresponds to the behavior of the polarized 129Xe at a selected site(s) in selected environments in vivo. The gas exchange signal data can be used to evaluate: (a) the thickness of a barrier, such as a membrane, lining, wall or width of a lumen; (b) the operational condition or function of a membrane, body system or portion thereof; (c) cerebral perfusion; and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a disorder or disease, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat a disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得核磁共振光谱信号数据，该信号数据对应于在选定环境中的选定位点处的极化极性Xe的行为。气体交换信号数据可用于评估：（a）屏障的厚度，例如膜，衬里，壁或管腔宽度; （b）膜，体系或其部分的操作条件或功能; （c）脑灌注; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断疾病或疾病的方法，和/或用于监测施用于治疗疾病或疾病的治疗剂的功效的方法。

3. 发明申请

US20110104067A1 METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE 审中-公开
标题翻译：使用极化129XE的NMR信号进行血管生成和/或功能的血管生成评估方法
公开(公告)号：US20110104067A1
公开(公告)日：2011-05-05
申请号：US12987313
申请日：2011-01-10
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

4. 发明授权

US07867477B2 Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe 有权
标题翻译：使用极化129Xe的NMR信号进行肺生理学和/或功能的体内评估的方法
公开(公告)号：US07867477B2
公开(公告)日：2011-01-11
申请号：US11623352
申请日：2007-01-16
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

5. 发明申请

US20070110669A1 Methods for In Vivo Evaluation of Pulmonary Physiology And/Or Function Using NMR Signals of Polarized 129Xe 有权
标题翻译：使用极化129Xe的NMR信号进行肺生理学和/或功能的体内评估方法
公开(公告)号：US20070110669A1
公开(公告)日：2007-05-17
申请号：US11623352
申请日：2007-01-16
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
IPC分类号： A61K49/00
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得在所选择的结构，环境或系统中的极化129 Xe的NMR光谱信号的动态数据集。信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

6. 发明授权

US07179450B2 Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe 失效
标题翻译：使用偏振Xe的NMR信号进行肺生理学和/或功能的体内评价的方法
公开(公告)号：US07179450B2
公开(公告)日：2007-02-20
申请号：US10356240
申请日：2003-01-31
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译：在某些实施方案中，本发明的方法获得在所选择的结构，环境或系统中的极化129 Xe的NMR光谱信号的动态数据集。信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。

7. 发明授权

US08911709B2 Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129XE MRI 有权
标题翻译：使用超极化129XE MRI评估肺气转移的系统和方法
公开(公告)号：US08911709B2
公开(公告)日：2014-12-16
申请号：US11866552
申请日：2007-10-03
申请人： Bastiaan Driehuys , Gary Price Cofer
发明人： Bastiaan Driehuys , Gary Price Cofer
IPC分类号： A61B5/055 , A61B5/08 , G01N24/08 , A61B5/00
CPC分类号： G01R33/483 , A61B5/055 , A61B5/08 , A61B5/1075 , A61B5/416 , A61B5/4887 , A61B5/7239 , G01N24/08 , G01R33/34076 , G01R33/465 , G01R33/4816 , G01R33/5601 , G01R33/56341
摘要： Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129Xe MRI RBC image.
摘要翻译：用于评估肺气体交换和/或肺泡毛细血管屏障状态的方法和系统包括获得溶解在患者的肺的气体交换区域中的红细胞（RBC）中的至少一个MRI图像和/或129Xe的图像数据。图像足够敏感，允许临床医生或图像识别程序基于129Xe MRI RBC图像评估肺气体交换，屏障厚度或屏障功能中的至少一个。

8. 发明申请

US20110077506A1 METHODS AND COMPOSITIONS FOR MOLECULAR IMAGING 审中-公开
标题翻译：用于分子成像的方法和组合物
公开(公告)号：US20110077506A1
公开(公告)日：2011-03-31
申请号：US12988463
申请日：2009-04-17
申请人： Bastiaan Driehuys , Rosa Tamara Branca
发明人： Bastiaan Driehuys , Rosa Tamara Branca
IPC分类号： A61B5/055 , A61B6/00
CPC分类号： A61K49/00 , G01R33/0213 , G01R33/022
摘要： Methods for imaging a target cell, tissue, or organ in a subject. In some embodiments, the methods include the steps of (a) administering to the subject a contrast agent that includes a paramagnetic or superparagmanetic material and a targeting moiety that targets the contrast agent to the cell, tissue, or organ; (b) introducing into the target cell, tissue, or organ, or into the vicinity thereof, a hyperpolarized gas; and (c) imaging the target cell, tissue, or organ by detecting the presence of the contrast agent in, on, or near the target cell, tissue, or organ. Also provided are methods for screening for metastasis of a tumor and/or a cancer to the lung of a subject, methods for imaging a cavity in a subject, methods for imaging a target cell, tissue, or organ in a cavity, compositions for performing the disclosed methods, and systems and kits that include the disclosed compositions and/or reagents for performing the disclosed methods.
摘要翻译：成像对象中靶细胞，组织或器官的方法。在一些实施方案中，所述方法包括以下步骤：（a）向受试者施用包含顺磁性或超临床材料的造影剂和靶向造影剂的细胞，组织或器官的靶向部分; （b）向目标细胞，组织或器官或其附近引入超极化气体; 和（c）通过检测靶细胞，组织或器官中，上或附近的造影剂的存在来对靶细胞，组织或器官进行成像。还提供了用于筛选肿瘤和/或癌症对受试者肺的转移的方法，用于对受试者中的空腔成像的方法，用于在腔中成像靶细胞，组织或器官的方法，用于执行公开的方法以及包括用于执行所公开的方法的所公开的组合物和/或试剂的系统和试剂盒。

9. 发明授权

US07560096B2 Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products 失效
公开(公告)号：US07560096B2
公开(公告)日：2009-07-14
申请号：US10617326
申请日：2003-07-10
申请人： Bastiaan Driehuys , Klaus D. Hagspiel
发明人： Bastiaan Driehuys , Klaus D. Hagspiel
IPC分类号： A61B5/055
CPC分类号： A61K49/1815 , A61B5/055 , A61B5/416 , A61M5/1483 , G01R33/5601
摘要： A method of screening for pulmonary embolism uses gaseous phase polarized 129Xe which is injected directly into the vasculature of a subject. The gaseous 129Xe can be delivered in a controlled manner such that the gas substantially dissolves into the vasculature proximate to the injection site. Alternatively, the gas can be injected such that it remains as a gas in the bloodstream for a period of time (such as about 8-29 seconds). The injectable formulation of polarized 129Xe gas is presented in small quantities of (preferably isotopically enriched) hyperpolarized 129Xe and can provide high-quality vasculature MRI images or NMR spectroscopic signals with clinically useful signal resolution or intensity. One method injects the polarized 129Xe as a gas into a vein and also directs another quantity of polarized gas into the subject via inhalation. In this embodiment, the perfusion uptake allows arterial signal information and the injection (venous side) allows venous signal information. The dual delivery is used to generate a combined introduction path with a more complete image signal of both the arterial and venous side of the pulmonary vasculature. In this NMR imaging method, the pulmonary embolism screening method can use the same NMR chest coil for the excitation and detection of the 129Xe signals. The direct injection of small quantities of gas at particular sites along the vasculature targets specific target regions to provide increased signal intensity NMR images. The disclosure also includes related methods directed to other diagnostic vasculature regions physiological and conditions. Associated delivery and dispensing systems and methods, containers, and quantitative formulations of the polarized gas are also described.

10. 发明申请

US20080089846A1 SYSTEMS AND METHODS FOR ASSESSING PULMONARY GAS TRANSFER USING HYPERPOLARIZED 129XE MRI 有权
标题翻译：使用超高分辨率129XE MRI评估肺气转移的系统和方法
公开(公告)号：US20080089846A1
公开(公告)日：2008-04-17
申请号：US11866552
申请日：2007-10-03
申请人： Bastiaan Driehuys , Gary Cofer
发明人： Bastiaan Driehuys , Gary Cofer
IPC分类号： A61B5/055 , G06G7/48
CPC分类号： G01R33/483 , A61B5/055 , A61B5/08 , A61B5/1075 , A61B5/416 , A61B5/4887 , A61B5/7239 , G01N24/08 , G01R33/34076 , G01R33/465 , G01R33/4816 , G01R33/5601 , G01R33/56341
摘要： Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood cells (RBC) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129Xe MRI RBC image.
摘要翻译：用于评估肺气体交换和/或肺泡毛细血管屏障状态的方法和系统包括获得溶解在气体中的红细胞（RBC）中的至少一个MRI图像和/或图像数据，交换患者肺部的区域。该图像是足够敏感的，以允许临床医师或图像识别程序基于 Xe MRI RBC图像来评估肺气体交换，屏障厚度或屏障功能中的至少一个。

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