专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

EP2391634B1 COMPOSITIONS COMPRISING SUGAR ESTER OF MYCOLIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF. 有权转让
公开(公告)号：EP2391634B1
公开(公告)日：2019-05-22
申请号：EP10702345.9
申请日：2010-01-29
申请人： Bangor University
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , GROOTEN, Johan Adriaan Marc , VANDER BEKEN, Seppe , MAZA-INGLESIAS, Maximilliano
IPC分类号： C07H13/04 , C07H23/00

2. 发明申请

WO2010086667A2 METHOD AND COMPOSITIONS 审中-公开
标题翻译：方法和组成
公开(公告)号：WO2010086667A2
公开(公告)日：2010-08-05
申请号：PCT/GB2010/050146
申请日：2010-01-29
申请人： BANGOR UNIVERSITY , GHENT UNIVERSITY , BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , GROOTEN, Johan Adriaan Marc , VANDER BEKEN, Seppe , MAZA-INGLESIAS, Maximilliano
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , GROOTEN, Johan Adriaan Marc , VANDER BEKEN, Seppe , MAZA-INGLESIAS, Maximilliano
CPC分类号： C07H13/04 , A61K31/7024 , A61K39/04 , C07H23/00 , G01N33/5695
摘要： A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M' is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each β-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.
摘要翻译：一种制备式（III）化合物的方法：其中x为1至6，y为1至12，z为0至10，每个M和每个M'独立地为包含ß- 羟基酸部分，每个S是单糖单元; 所述方法包括使一种或多种霉菌酸与一种或多种糖单元反应，其中每个β-羟基酸部分的羟基在与一个或多个糖单元反应之前被保护。

3. 发明申请

WO2009130508A1 ADJUVANTS FOR USE IN VACCINATION 审中-公开
标题翻译：用于疫苗接种的患者
公开(公告)号：WO2009130508A1
公开(公告)日：2009-10-29
申请号：PCT/GB2009/050410
申请日：2009-04-22
申请人： BANGOR UNIVERSITY , BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc , Ghent University
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc
IPC分类号： A61K39/04 , A61K39/39
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R 1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R 2 , R 3 and R 4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR 5 ; wherein R 5 is alkyl or haloalkyl, and A is S, O or NR 6 , wherein R 6 maybe H or 20 alkyl.
摘要翻译：用作疫苗接种佐剂的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基或亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯，硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是S，O或NR 6，其中R 6可以是H或20烷基。

4. 发明申请

WO2009130506A2 COMPOUNDS FOR USE IN THERAPY 审中-公开
标题翻译：用于治疗的化合物
公开(公告)号：WO2009130506A2
公开(公告)日：2009-10-29
申请号：PCT/GB2009/050408
申请日：2009-04-22
申请人： BANGOR UNIVERSITY , BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc , GHENT UNIVERSITY
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc
IPC分类号： A61K39/04 , A61K39/39
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R 1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R 2 , R 3 and R 4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR 5 ; wherein R 5 is alkyl or haloalkyl, and A is O, S or NR 6 , wherein R 6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R 2，R 3和R 4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚炔基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

5. 发明公开

EP2391634A2 COMPOSITIONS COMPRISING SUGAR ESTER OF MYCOLIC ACID DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF. 有权转让
标题翻译： ZUCKERESTER VONMYCOLSÄUREDERIVATENUMFASSENDE ZUSAMMENSETZUNGEN UND VERFAHREN ZU DEREN HERSTELLUNG
公开(公告)号：EP2391634A2
公开(公告)日：2011-12-07
申请号：EP10702345.9
申请日：2010-01-29
申请人： Bangor University
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , GROOTEN, Johan Adriaan Marc , VANDER BEKEN, Seppe , MAZA-INGLESIAS, Maximilliano
IPC分类号： C07H13/04 , C07H23/00
CPC分类号： C07H13/04 , A61K31/7024 , A61K39/04 , C07H23/00 , G01N33/5695
摘要： A method of preparing a compound of formula (III): wherein x is from 1 to 6, y is from 1 to 12, z is from 0 to 10, each M and each M' is independently a mycolic acid residue including a β-hydroxy acid moiety and each S is a monosaccharide unit; the method comprising reacting one or more mycolic acids with one or more saccharide units wherein the hydroxyl group of each β-hydroxy acid moiety is protected prior to reaction with the one or more saccharide units.
摘要翻译：制备式（III）化合物的方法：其中x为1至6，y为1至12，z为0至10，每个M和每个M'独立地为包含“bgr”的霉菌酸残基。 - 羟基酸部分，每个S是单糖单元; 所述方法包括使一种或多种霉菌酸与一种或多种糖单元反应，其中在与一个或多个糖单元反应之前，保护每个＆bgr-羟酸部分的羟基。

6. 发明公开

EP2278996A1 ADJUVANTS FOR USE IN VACCINATION 审中-公开
标题翻译： ADJUVANSFÜRIMPFUNG
公开(公告)号：EP2278996A1
公开(公告)日：2011-02-02
申请号：EP09736007.7
申请日：2009-04-22
申请人： Bangor University , Universiteit Gent
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc
IPC分类号： A61K39/04 , A61K39/39
CPC分类号： A61K39/39 , A61K2039/55555
摘要： A compound of formula (I) for use as an adjuvant in vaccination; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R
1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
2 , R
3 and R
4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene or cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester, thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
5 ; wherein R
5 is alkyl or haloalkyl, and A is S, O or NR
6 , wherein R
6 maybe H or 20 alkyl.
摘要翻译：描述了用于疫苗接种中佐剂的式IId化合物; 其中R 6为氢或C 1至C 4烷基，R 7为氢或C 1至C 4烷基，p为16至30，q为8至24，r为12至28，s为12至28 。

7. 发明公开

EP2278995A2 COMPOUNDS FOR USE IN THERAPY 审中-公开
标题翻译： VERBINDUNGENFÜRTHERAPEUTISCHE ZWECKE
公开(公告)号：EP2278995A2
公开(公告)日：2011-02-02
申请号：EP09735284.3
申请日：2009-04-22
申请人： Bangor University , Universiteit Gent
发明人： BAIRD, Mark Stephen , AL-DULAYYMI, Juma' a Raheem Najeem , THEUNISSEN, Cornelias , KOZA, Gani , VANDER BEKEN, Seppe , GROOTEN, Johan Adriaan Marc
IPC分类号： A61K39/04 , A61K39/39
CPC分类号： A61K31/00 , A61K9/0073 , A61K9/127 , C07B2200/07 , C07C59/11 , C07C59/13 , C07C59/185 , C07C59/215 , C07C2601/02
摘要： A compound of formula (I) for use in the treatment of a disease of the immune system; wherein R is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 50 carbon atoms; R
1 is an optionally-substituted alkyl, alkenyl, alkynyl, aryl, arylalkyl or alkylaryl moiety having from 1 to 40 carbon atoms; each of R
2 , R
3 and R
4 is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, arylalkylene or alkylarylene moiety having from 1 to 40 carbon atoms; each of X, Y and Z is independently selected from an optionally-substituted alkylene, alkenylene, alkynylene, arylene, alkylarylene, cycloalkylene, ketone, ester, amide, imide, imine, thioether, ether, thioester and thioketone; and P is selected from hydrogen, an alkyl group, a sugar residue, or a metal, phosphonium or ammonium species; wherein at least one of X, Y and Z includes a moiety selected from cyclopropyl, C=A, C-AH and C-OR
5 ; wherein R
5 is alkyl or haloalkyl, and A is O, S or NR
6 , wherein R
6 may be H or 20 alkyl.
摘要翻译：用于治疗免疫系统疾病的式（I）化合物; 其中R是具有1至50个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R1是具有1至40个碳原子的任选取代的烷基，烯基，炔基，芳基，芳基烷基或烷芳基部分; R2，R3和R4各自独立地选自具有1至40个碳原子的任选取代的亚烷基，亚烯基，亚炔基，亚芳基，芳基亚烷基或烷基亚芳基; X，Y和Z各自独立地选自任选取代的亚烷基，亚烯基，亚烯基，亚芳基，亚烷基亚芳基，亚环烷基，酮，酯，酰胺，酰亚胺，亚胺，硫醚，醚，硫酯和硫酮; 并且P选自氢，烷基，糖残基或金属，鏻或铵物质; 其中X，Y和Z中的至少一个包括选自环丙基，C = A，C-AH和C-OR 5的部分; 其中R 5是烷基或卤代烷基，A是O，S或NR 6，其中R 6可以是H或20烷基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式