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1. 发明专利

DE69835854D1 未知
公开(公告)号：DE69835854D1
公开(公告)日：2006-10-26
申请号：DE69835854
申请日：1998-06-23
申请人： BAYER CORP
发明人： ZELMANOVIC DAVID , MOSKALSKI WILLIAM , DECLERCQ RONNY , LOUWET FRANK , KUCKERT EBERHARD DR , PODSZUN WOLFGANG DR
IPC分类号： G01N15/10 , G01N33/49 , G01N15/00 , G01N15/14
摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

2. 发明专利

ES2273384T3 USO DE PARTICULAS POLIMERICAS SINTETICAS COMO PRATONES Y CALIBRADORES EN CITOMETRIA DE FLUJO. 未知
公开(公告)号：ES2273384T3
公开(公告)日：2007-05-01
申请号：ES98111504
申请日：1998-06-23
申请人： BAYER CORP
发明人： ZELMANOVIC DAVID , MOSKALSKI WILLIAM , DECLERCQ RONNY , LOUWET FRANK , KUCKERT EBERHARD DR , PODSZUN WOLFGANG DR
IPC分类号： G01N15/10 , G01N33/49 , G01N15/00 , G01N15/14
摘要： LA INVENCION DESCRIBE NUEVOS PROCEDIMIENTOS PARA CALIBRAR O NORMALIZAR INSTRUMENTOS DE CITOMETRIA DEL FLUJO, USANDO PARTICULAS O PERLAS DE POLIMERO SINTETICO QUE TIENEN PROPIEDADES FISICAS QUE PROPORCIONAN VENTAJAS PARA SU USO EN TALES INSTRUMENTOS. LAS PARTICULAS O PERLAS DE POLIMERO EMPLEADAS EN LOS PROCEDIMIENTOS DE CALIBRACION SON ESFERICAS, TIENEN UN DIAMETRO MEDIO DE PARTICULAS DE 1 A 8 MICRAS APROXIMADAMENTE, UNA DISTRIBUCION RELATIVAMENTE ESTRECHA DE PARTICULAS Y UN BAJO INDICE DE REFRACCION, ES DECIR, DE 1,35 A 1,45 APROXIMADAMENTE. LAS PARTICULAS SON SEGURAS, ESTABLES DURANTE PERIODOS PROLONGADOS DE TIEMPO Y SON PARTICULARMENTE ADECUADAS PARA SU EMPLEO COMO SUSTANCIAS DE CALIBRACION DE ANALIZADORES EN HEMATOLOGIA. LA INVENCION PROPORCIONA UN PERFECCIONAMIENTO VENTAJOSO RESPECTO A LOS TIPOS DE PATRONES USADOS ACTUALMENTE PARA CALIBRAR UNA SERIE DE INSTRUMENTOS QUE SE APOYAN EN LA DIFUSION LUMINOSA, COMBINADA CON OTROS PARAMETROS QUE IDENTIFICAN Y MIDEN PARTICULAS BIOLOGICAS O CELULAS, ASI COMO PARTICULAS NO BIOLOGICAS. EN PARTICULAR, USANDOSE EL PROCEDIMIENTO DE CALIBRACION/NORMALIZACION Y LAS PARTICULAS POLIMERICAS SEGUN LA PRESENTE INVENCION, SE PERMITE LA CALIBRACION Y NORMALIZACION DE LOS INSTRUMENTOS DE HEMATOLOGIA PARA LA SUBSIGUIENTE DETERMINACION, EXACTA Y FIABLE, DEL NUMERO DE GLOBULOS ROJOS, RETICULOCITOS, GLOBULOS BLANCOS Y PLAQUETAS EN MUESTRAS DE SANGRE COMPLETA.

3. 发明专利

DE69835854T2 未知
公开(公告)号：DE69835854T2
公开(公告)日：2007-03-08
申请号：DE69835854
申请日：1998-06-23
申请人： BAYER CORP
发明人： ZELMANOVIC DAVID , MOSKALSKI WILLIAM , DECLERCQ RONNY , LOUWET FRANK , KUCKERT EBERHARD DR , PODSZUN WOLFGANG DR
IPC分类号： G01N15/10 , G01N33/49 , G01N15/00 , G01N15/14
摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

4. 发明专利

AT339681T 未知
公开(公告)号：AT339681T
公开(公告)日：2006-10-15
申请号：AT98111504
申请日：1998-06-23
申请人： BAYER CORP
发明人： ZELMANOVIC DAVID , MOSKALSKI WILLIAM , DECLERCQ RONNY , LOUWET FRANK , KUCKERT EBERHARD DR , PODSZUN WOLFGANG DR
IPC分类号： G01N33/49 , G01N15/00 , G01N15/10 , G01N15/14
摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

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