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1. 发明申请

WO03007845A9 DRY HEMOSTATIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION 审中-公开
标题翻译：干燥剂组合物及其制备方法
公开(公告)号：WO03007845A9
公开(公告)日：2004-04-01
申请号：PCT/US0220022
申请日：2002-06-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： QIAN ZHEN , OSAWA EDWARD A , REICH CARY J
IPC分类号： A61L15/16 , A61F2/02 , A61K38/39 , A61K38/48 , A61L24/00 , A61L24/10 , C09H9/00
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译：制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。

2. 发明申请

WO2008016983A3 RAPIDLY ACTING DRY SEALANT AND METHODS FOR USE AND MANUFACTURE 审中-公开
标题翻译：快速干燥密封剂及其使用和制造方法
公开(公告)号：WO2008016983A3
公开(公告)日：2009-03-26
申请号：PCT/US2007074984
申请日：2007-08-01
申请人： BAXTER INT , BAXTER HEALTHCARE SA , RHEE WOONZA M , REICH CARY J , OSAWA A EDWARD , VEGA FELIX
发明人： RHEE WOONZA M , REICH CARY J , OSAWA A EDWARD , VEGA FELIX
IPC分类号： A61L24/00 , A61L24/06 , A61L31/04 , A61L31/14
CPC分类号： A61K47/42 , A61K9/70 , A61K38/363 , A61K38/4833 , A61K47/34 , A61L24/001 , A61L24/0031 , A61L24/06 , A61L31/044 , A61L31/145 , A61L31/146 , Y10T428/249983 , C08L71/02
摘要： Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.
摘要翻译：提供组合物，方法和试剂盒用于密封应用。通过将第一可交联组分与第二可交联组分组合以形成具有间隙的多孔基质并将多孔基质与形成水凝胶的组分混合以填充至少一些间隙来制备组合物。组合物表现出最小的溶胀特性。

3. 发明公开

EP1414370A4 DRY HEMOSTATIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION 有权
标题翻译：干燥的止血成分和方法FOR THEIR
公开(公告)号：EP1414370A4
公开(公告)日：2005-11-09
申请号：EP02744588
申请日：2002-06-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： QIAN ZHEN , OSAWA EDWARD A , REICH CARY J
IPC分类号： A61L15/16 , A61F2/02 , A61K38/39 , A61K38/48 , A61L24/00 , A61L24/10 , C09H9/00
CPC分类号： A61K38/4833 , A61L24/0031 , A61L24/104 , A61L2400/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.

4. 发明专利

PT2049165E SELANTE SECO DE ACÇÃO RÁPIDA E MÉTODOS PARA USO E FABRICO 未知
公开(公告)号：PT2049165E
公开(公告)日：2012-05-25
申请号：PT07813656
申请日：2007-08-01
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： VEGA FELIX , RHEE WOONZA M , REICH CARY J , OSAWA A EDWARD
IPC分类号： A61L24/06 , A61L24/00 , A61L31/04 , A61L31/14

5. 发明专利

NZ575077A RAPIDLY ACTING DRY SEALANT AND METHODS FOR USE AND MANUFACTURE 未知
公开(公告)号：NZ575077A
公开(公告)日：2011-12-22
申请号：NZ57507707
申请日：2007-08-01
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： RHEE WOONZA M , REICH CARY J , OSAWA A
IPC分类号： A61L24/00 , A61L24/06 , A61L31/04 , A61L31/14
摘要： Disclosed herein is a dry solid sealant matrix composition comprising: · a first cross-linkable component; · a second cross-linkable component that cross-links with the first cross-linkable component under reaction enabling conditions; and · a hydrogel-forming component; wherein the concentration of combined first and second cross-linkable components is from 5 to 75% of the total mass of the composition and the concentration of the hydrogel forming component is from 25 to 95% of the total mass of the composition; and wherein under reaction-enabling conditions the first and second cross-linkable component cross-link to form a porous matrix having interstices, and wherein the hydrogel-forming component is capable of being hydrated to form a hydrogel to fill at least some of the interstices.

6. 发明专利

CO6150197A2 SELLADOR SECO DE ACCION RAPIDA Y METODOS DE USO Y FABRICACION 未知
公开(公告)号：CO6150197A2
公开(公告)日：2010-04-20
申请号：CO09020987
申请日：2009-03-02
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： RHEE WOONZA , REICH CARY J , OSAWA EDWARD A , VEGA FELIX
IPC分类号： A61L24/00
摘要： 1.- Una composición que comprende: un primer componente reticulable; un segundo componente reticulable que se reticula con el primer componente reticulable bajo condiciones que permiten la reacción; y un componente que forma un hidrogel; en donde el primer y segundo componentes reticulables se reticulan para formar una matriz porosa que tiene intersticios, y en donde el componente que forma un hidrogel tiene la capacidad de ser hidratado para formar un hidrogel para llenar al menos algunos de los intersticios. 2.- La composición tal como se describe en la revindicación 1, caracterizada porque el primer componente reticulable comprende múltiples grupos nucleofílicos y el segundo componente reticulable comprende múltiples grupos electrofílicos. 3.- La composición tal como se describe en la reivindicación 1, caracterizada porque el primer componente reticulable comprende un óxido de polialquileno multi-nucleofílico que tiene m grupos nucleofílicos, y el segundo componente reticulable comprende un óxido de polialquileno multi-electrofílico que tiene n grupos electrofílicos, caracterizada porque m y n son cada uno mayores o iguales a dos, y en donde m+n es mayor o igual a cinco. 4.- La composición tal como se describe en la reivindicación 3, caracterizada porque n es dos, y en donde m es mayor o igual a tres. 5.- La composición tal como se describe en la reivindicación 4, caracterizada porque el óxido de alquileno multi-nucleofílico es tetrafuncionalmente activado. 6.- La composición tal como se describe en la indicación 3, caracterizada porque m es dos, y en donde n es mayor o igual a tres. 7.- La composición tal como se describe en la reivindicación 6, caracterizada porque el óxido de polialquileno multi-electrofílico es tetrafuncionalmente activado. 8.- La composición tal como se describe en la reivindicación 3, caracterizada porque el óxido de polialquileno multi-nucleofílico y el óxido de polialquileno multi-electrofílico son tetrafuncionalmente activados.

7. 发明专利

ZA200900977B RAPIDLY ACTING DRY SEALANT AND METHODS FOR USE AND MANUFACTURE 未知
公开(公告)号：ZA200900977B
公开(公告)日：2009-12-30
申请号：ZA200900977
申请日：2009-02-11
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： VEGA FELIX , OSAWA A EDWARD , REICH CARY J , RHEE WOONZA M
摘要： Compositions, methods, and kits are provided for sealing applications. Compositions are prepared by combining a first cross-linkable component with a second cross-linkable component to form a porous matrix having interstices, and combining the porous matrix with a hydrogel-forming component to fill at least some of the interstices. The compositions exhibit minimal swelling properties.

8. 发明专利

DE60230079D1 未知
公开(公告)号：DE60230079D1
公开(公告)日：2009-01-08
申请号：DE60230079
申请日：2002-06-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： OSAWA EDWARD A , REICH CARY J , QIAN ZHEN
IPC分类号： A61F2/02 , A61L15/16 , A61K38/39 , A61K38/48 , A61L24/00 , A61L24/10 , C09H9/00
摘要： A method for preparing a substantially dry cross-linked gelatin powder is described. The method comprises providing a solution of a non-cross-linked gelatin and then cross-linking the non-cross-linked gelatin while in solution in the presence of a rehydration aid. The cross-linked gelatin is then washed to remove at least 50% w/w of the rehydration aid, dried and the dry solid ground to produce a cross-linked gelatin powder typically having a moisture content below 20% w/w. A composition comprising a cross-linked gelatin powder that was cross-linked in the presence of a re-hydration aid is also described. The powder has an aqueous re-hydration rate of at least 3.0 g/g.

9. 发明专利

CA2453592A1 DRY HEMOSTATIC COMPOSITIONS AND METHODS FOR THEIR PREPARATION 未知
公开(公告)号：CA2453592A1
公开(公告)日：2003-01-30
申请号：CA2453592
申请日：2002-06-21
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： REICH CARY J , OSAWA EDWARD A , QIAN ZHEN
IPC分类号： A61L15/16 , A61F2/02 , A61K38/39 , A61K38/48 , A61L24/00 , A61L24/10 , C09H9/00 , A61L17/00 , A61P7/04
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate t o produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross- linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross- linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous r e- hydration medium, typically thrombin-containing saline.

10. 发明专利

ES2711416T3 Material sellante seco de acción rápida y métodos para su uso y fabricación 未知
公开(公告)号：ES2711416T3
公开(公告)日：2019-05-03
申请号：ES12150108
申请日：2007-08-01
申请人： BAXTER INT , BAXTER HEALTHCARE SA
发明人： RHEE WOONZA M , REICH CARY J , OSAWA EDWARD A , VEGA FELIX
IPC分类号： A61L24/00 , A61L24/06 , A61L24/10 , A61L27/40 , A61L27/56 , A61L31/04 , A61L31/14
摘要： Composición seca para conseguir la hemostasis o la contención de otro fluido en un contexto in vivo de matriz para aplicar a un vertebrado con el fin de facilitar la contención de fluido, que comprende: un componente formador de hidrogel que actúa como absorbente; un primer componente reticulable que comprende múltiples grupos nucleófilos y; un segundo componente reticulable que comprende múltiples grupos electrófilos, donde el primer componente y el segundo componente se reticulan para formar una matriz poroso que presenta intersticios, y el componente formador de hidrogel es capaz de hidratarse para formar un hidrogel que rellena al menos algunos de los intersticios.

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