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1. 发明专利

JP2013048625A Fertilization production of solid-state nonvolatile microorganism metabolic product 审中-公开
标题翻译：固态非挥发性微生物代谢产物的生产
公开(公告)号：JP2013048625A
公开(公告)日：2013-03-14
申请号：JP2012223174
申请日：2012-10-05
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： POMPEJUS MARKUS , FREYER STEPHAN , LOHSCHEIDT MARKUS , ZELDER OSKAR , BOY MATTHIAS , SCHOLTEN EDZARD
IPC分类号： C12P19/14 , C12P39/00
CPC分类号： C12P13/08 , A23K10/12 , A23L7/104 , C12P7/46 , C12P13/02 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/14
摘要： PROBLEM TO BE SOLVED: To provide a method for producing at least one nonvolatile microorganism metabolic product by performing micororganism-fertilization based on sugar.SOLUTION: In the method, a microorganism culture which produces a desired metabolic product is cultivated by using a sugar-containing liquid culture medium containing a monosaccharide content exceeding 20 wt.% on the basis of the total weight of the liquid culture medium, most of volatile components of fertilization liquids are removed, and the pickles are produced by (a1) a step of powdering a starch supply raw material selected from grains, and (a2) a step of liquefying the powdered material in an aqueous liquid under the existence of at least one starch liquefied enzyme, then saccharifying the material by using saccharified enzyme, adding a partial amount of a crushed raw material to the aqueous liquid continuously or in a batch manner, and performing the liquefaction. Related to a solid preparation of the obtained nonvolatile microorganism metabolic product, the method uses the solid preparation as an additive or a supplementary agent to the food of human beings or animals, or fabric, leather, cellose, paper, or for treating the surface the product.
摘要翻译：待解决的问题：提供通过基于糖进行微生物施肥来生产至少一种非挥发性微生物代谢产物的方法。解决方案：在该方法中，通过使用含有超过20重量％的单糖含量的含糖液体培养基，基于液体培养基的总重量培养产生所需代谢产物的微生物培养物去除受精液体的大部分挥发性成分，并且通过（a1）粉碎选自谷物的淀粉供给原料的工序来制造泡菜，（a2）在水溶液中粉化材料的液化步骤存在至少一种淀粉液化酶，然后通过使用糖化酶对材料进行糖化，连续地或间歇地向水性液体中分批加入一部分破碎的原料，并进行液化。与所获得的非挥发性微生物代谢产物的固体制剂相关，该方法使用固体制剂作为人或动物的食物或织物，皮革，纤维素，纸或用于处理表面的添加剂或补充剂产品。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2008212157A Multipromoter for gene expression and use thereof 有权
标题翻译：用于基因表达的多重PCR及其用途
公开(公告)号：JP2008212157A
公开(公告)日：2008-09-18
申请号：JP2008095920
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： HAEFNER STEFAN , SCHROEDER HARTWIG , ZELDER OSKAR , KLOPPROGGE CORINNA , HEROLD ANDREA
IPC分类号： C12N15/09 , C12N1/21 , C12P7/02 , C12P7/40 , C12P13/04 , C12P21/02
CPC分类号： C07K14/34 , C12N15/77
摘要： PROBLEM TO BE SOLVED: To provide a method for preparation of biosynthetic products by developing the production methods for fine chemicals or protein or by increasing or improving the productivity of existing production methods for fine chemicals or proteins. SOLUTION: There is provided multipromoters and expression units, the use thereof for controlling transcription and expression of genes, the expression cassette including these kinds of multipromoters or the expression units, the vector including such expression cassettes, the genetically altered microorganism including such kinds of vectors and/or expression units, and methods for preparing biosynthetic products by culturing the genetically altered microorganism. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过开发精细化学品或蛋白质的生产方法或通过提高或提高现有的精细化学品或蛋白质的生产方法的生产率来提供生物合成产物的制备方法。提供多重启动子和表达单位，其用于控制基因的转录和表达的用途，包括这些种类的多重表达单位或表达单位的表达盒，包含这种表达盒的载体，包括这些表达盒的遗传改变的微生物载体和/或表达单位的种类，以及通过培养遗传改变的微生物来制备生物合成产物的方法。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2008212156A Pef-ts expression unit 有权
标题翻译： PEF-TS表达单位
公开(公告)号：JP2008212156A
公开(公告)日：2008-09-18
申请号：JP2008095810
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： ZELDER OSKAR , KLOPPROGGE CORINNA , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P13/08 , C12R1/15
CPC分类号： C12N15/63 , C07K14/34 , C12N15/77 , C12P13/04
摘要： PROBLEM TO BE SOLVED: To provide the use of nucleic acid sequence for controlling the transcription and expression of genes, a new promoter and expression unit, a method for altering or arising the transcription speed and/or an expression speed of genes, the expression cassette including the expression unit, genetically altered microorganism having the altered or arisen transcription speed and/or expression speed, and a method for producing biosynthetic products by culturing the genetically altered microorganism. SOLUTION: There is provided a nucleic acid that has a specific sequence and a promoter activity, an expression unit including the nucleic acid, an expression cassette, an expression vector, a genetically altered microorganism, and a method for production of threonine by culturing the microorganism. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供用于控制基因的转录和表达的核酸序列的使用，新的启动子和表达单位，改变或产生转录速度和/或基因的表达速度的方法，具有表达单位的表达盒，具有改变或出现的转录速度和/或表达速度的遗传改变的微生物，以及通过培养遗传改变的微生物来生产生物合成产物的方法。解决方案：提供了具有特定序列和启动子活性的核酸，包括核酸，表达盒，表达载体，遗传改变的微生物的表达单位和通过以下方法生产苏氨酸的方法：培养微生物。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2008212154A Psod expression unit 有权
标题翻译： Psod表达单位
公开(公告)号：JP2008212154A
公开(公告)日：2008-09-18
申请号：JP2008095699
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/77 , C12P13/08 , C12R1/15
CPC分类号： C12N15/77
摘要： PROBLEM TO BE SOLVED: To provide the use of a nucleic acid sequence for controlling the transcription and expression of a gene, to provide a new promoter and expression unit itself, to provide a method for modifying or inducing the transcription rate and/or the expression rate of the gene, to provide an expression cassette comprising the expression unit, to provide a genetically modified microorganism having the modified or induced transcription rate and/or expression rate and to provide a method for producing a biosynthetic product by culturing the genetically modified microorganism. SOLUTION: There is provided the use of (A) a specific nucleic acid sequence, (B) a sequence induced from the specific nucleic acid sequence by substitution, insertion or deletion of a nucleotide and having at least 90% homogeneity to the sequence at the nucleic acid level, (C) a nucleic acid sequence hybridizing to the nucleic acid sequence under stringent conditions or (D) a nucleic acid comprising a fragment functionally equivalent to the sequence (A), (B) or (C) and having a promoter activity. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供用于控制基因的转录和表达的核酸序列的用途，以提供新的启动子和表达单元本身，以提供修饰或诱导转录速率和/ 或基因的表达速率，以提供包含表达单元的表达盒，以提供具有修饰或诱导的转录速率和/或表达率的遗传修饰微生物，并提供通过遗传培养生产生物合成产物的方法修饰微生物。提供（A）特定核酸序列的用途，（B）通过取代，插入或缺失核苷酸并且具有至少90％同一性的特异性核酸序列诱导的序列（C）在严格条件下与核酸序列杂交的核酸序列或（D）包含与（A），（B）或（C）和（B）的序列功能等同的片段的核酸和具有启动子活性。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2008212155A Pef-tu expression unit 有权
标题翻译： PEF-TU表达单位
公开(公告)号：JP2008212155A
公开(公告)日：2008-09-18
申请号：JP2008095756
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC分类号： C12N15/09 , C07K14/34 , C12N20060101 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/67 , C12N15/77 , C12P1/00 , C12P13/08 , C12P13/12 , C12R1/15
CPC分类号： C07K14/34 , C12N15/77 , C12P13/08 , C12P13/12
摘要： PROBLEM TO BE SOLVED: To provide a nucleic acid sequence regulating the gene transcription and expression, to provide a new promoter and expression unit, to provide a method for altering or inducing the gene transcription rate and/or expression rate, to provide an expression cassette comprising the expression unit, to provide a genetically modified microorganism having the altered or the induced transcription rate and/or expression rate, and to provide a method for producing a biosynthetic product by culturing the genetically modified microorganism. SOLUTION: There are provided a nucleic acid sequence composed of a specific sequence and having a promoter activity, the expression unit comprising the nucleic acid, an expression vector comprising the expression unit and the method for preparing the biosynthetic product, particularly lysine by culturing the microorganism genetically modified with the nucleic acid having the promotor activity. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供调节基因转录和表达的核酸序列，以提供新的启动子和表达单元，以提供改变或诱导基因转录速率和/或表达率的方法，以提供包含表达单元的表达盒，提供具有改变的或诱导的转录速率和/或表达率的遗传修饰的微生物，并提供通过培养经遗传修饰的微生物来生产生物合成产物的方法。提供了由特异性序列构成的具有启动子活性的核酸序列，包含核酸的表达单位，包含表达单位的表达载体和通过以下步骤制备生物合成产物的方法，特别是赖氨酸：培养用具有启动子活性的核酸进行遗传修饰的微生物。版权所有（C）2008，JPO＆INPIT

6. 发明专利

JP2013146269A Method of producing cadaverine 有权
标题翻译：生产CADAVERINE的方法
公开(公告)号：JP2013146269A
公开(公告)日：2013-08-01
申请号：JP2013010693
申请日：2013-01-24
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： ZELDER OSKAR , JEONG WEOL KYU , KLOPPROGGE CORINNA , HEROLD ANDREA , SCHROEDER HARTWIG
IPC分类号： C12P13/00 , C08G69/28 , C12N1/21 , C12N15/09 , C12P13/02 , C12R1/15
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： PROBLEM TO BE SOLVED: To provide a method of producing cadaverine.SOLUTION: A method of producing cadaverine comprises: constructing a recombinant microorganism having a deregulated lysine decarboxylase gene and at least one deregulated gene selected from a group (i) of aspartokinase and other specific enzymes provided that at least one second gene (i) other than the aspartokinase is deregulated when the aspartokinase is deregulated as the gene (i); and culturing the microorganism.
摘要翻译：要解决的问题：提供一种生产尸胺的方法。解决方案：一种生产尸胺的方法，包括：构建具有失调的赖氨酸脱羧酶基因和至少一种去调节基因的重组微生物，所述基因选自（i）天冬氨酸激酶和其他特异性酶提供了当天冬氨酸激酶作为基因（i）失调时，除了天冬氨酸激酶之外的至少一种第二基因（i）被解除调节; 并培养微生物。

7. 发明专利

JP2008259505A Method of producing fine chemical material by fermentation 有权
标题翻译：通过发酵生产精细化学材料的方法
公开(公告)号：JP2008259505A
公开(公告)日：2008-10-30
申请号：JP2008095922
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
IPC分类号： C12N1/21 , C12N9/16 , C12N15/09 , C12P13/08
CPC分类号： C12P13/08 , C12N9/16
摘要： PROBLEM TO BE SOLVED: To provide a method for accumulating and producing fine chemical materials (e.g., lysine) in a medium of an microorganism or the microorganism by increasing metabolic inflow through pentose phosphate route in the microorganism. SOLUTION: A method for increasing generation of fine chemical materials such as lysine from a microorganism, e.g., a corynebacterium by deregulating a ferment-encoding gene, i.e., fructose-1,6-bisphosphatase, is provided. Further, a new method for producing lysine by regulating carbon inflow directing to oxaloacetic acid (OAA), is also provided. In one a preferable embodiment, a method for producing lysine by using fructose or sucrose as the carbon source is provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供一种通过在微生物中通过戊糖磷酸途径增加代谢流入而在微生物或微生物的培养基中积累和生产精细化学物质（例如赖氨酸）的方法。解决方案：提供了通过使发酵编码基因（即果糖-1,6-二磷酸酶）失调来增加来自微生物例如棒状杆菌的精细化学物质如赖氨酸的产生的方法。此外，还提供了通过调节引入草酰乙酸（OAA）的碳流入来生产赖氨酸的新方法。在一个优选实施方案中，提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。版权所有（C）2009，JPO＆INPIT

8. 发明专利

JP2008200046A Process for preparation of amino acids without trehalose 审中-公开
标题翻译：制备没有TREHALOSE的氨基酸的方法
公开(公告)号：JP2008200046A
公开(公告)日：2008-09-04
申请号：JP2008095754
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： KLOPPROGGE CORINNA , ZELDER OSKAR , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN , LIEBL WOLFGANG
IPC分类号： C12P13/04 , C12R1/13 , C12R1/15
CPC分类号： C12P13/04
摘要： PROBLEM TO BE SOLVED: To provide methods for producing an amino acid, preferably of the group consisting of lysine, threonine, methionine, glutamate.
SOLUTION: The invention relates to the method for producing the amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein the microorganism is partially or completely deficient in at least one of the gene loci of the group which is formed by otsAB, treZ and treS, and subsequent isolation of the amino acid from the culture medium.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供优选由赖氨酸，苏氨酸，甲硫氨酸，谷氨酸组成的组的氨基酸的制备方法。解决方案：本发明涉及生产氨基酸的方法，包括培养棒杆菌属或短杆菌属的微生物，其中微生物部分或完全缺乏由otsAB形成的基团的至少一个基因座，treZ和treS，然后从培养基中分离氨基酸。版权所有（C）2008，JPO＆INPIT

9. 发明专利

JP2008237218A Pgro EXPRESSION UNIT 有权
标题翻译： Pgro表达单位
公开(公告)号：JP2008237218A
公开(公告)日：2008-10-09
申请号：JP2008095696
申请日：2008-04-02
申请人： Basf Se , ビーエーエスエフソシエタス・ヨーロピアBasf Se
发明人： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC分类号： C12N15/09 , C07K14/34 , C12N1/15 , C12N1/19 , C12N1/21 , C12N9/00 , C12N15/77 , C12P13/08
CPC分类号： C12P13/08 , C07K14/34 , C12N15/77
摘要： PROBLEM TO BE SOLVED: To provide the use of nucleic acid sequences for regulating gene transcription and expression, a novel promoter and an expression unit itself, a method for modifying or inducing the gene transcription rate and/or expression rate, an expression cassette containing the expression unit, genetically modified microorganism having a modified or induced transcription rate and/or expression rate, and a method for producing biosynthetic products by culturing the genetically modified microorganism. SOLUTION: The use of a nucleic acid having promotor activity containing (A) a specific nucleic acid sequence for transcribing the gene, (B) a sequence having at least 90% homology and derived by substitution, insertion or deletion of nucleotides from the (A) sequence, (C) a nucleic acid sequence hybridizing under stringent conditions with the (A) sequence or (D) a functionally equivalent fragment of the sequence (A), (B) or (C) is provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供用于调节基因转录和表达的核酸序列的使用，新型启动子和表达单元本身，修饰或诱导基因转录速率和/或表达率的方法，表达含有表达单位的盒，具有修饰或诱导的转录速率和/或表达率的遗传修饰微生物，以及通过培养经遗传修饰的微生物生产生物合成产物的方法。解决方案：使用具有启动子活性的核酸，其含有（A）用于转录该基因的特异性核酸序列，（B）具有至少90％同源性并通过其核苷酸取代，插入或缺失衍生的序列（A）序列，（C）在严格条件下与（A）序列杂交的核酸序列或（D）序列（A），（B）或（C）的功能等同片段的核酸序列。版权所有（C）2009，JPO＆INPIT

10. 发明公开

EP2888351A4 GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS 审中-公开
标题翻译： GENE UND PROZESSE ZUR HERSTELLUNG VON CLAVIN-ALKALOIDEN
公开(公告)号：EP2888351A4
公开(公告)日：2016-04-27
申请号：EP13831449
申请日：2013-08-13
申请人： BASF SE , EVOLVA SA
发明人： NAESBY MICHAEL , FOLLY CHRISTOPHE , NIELSEN CURT AIMÉ FRIIS , HATSCH ANAELLE , SCHWAB MARKUS , ZELDER OSKAR , HAEFNER STEFAN , SCHRÖDER HARTWIG , HOFF BIRGIT , MOLT ANDREA , DITRICH KLAUS , BREUER MICHAEL , HARTMANN HOLGER , KÖRBER KARSTEN
IPC分类号： C12N15/52 , C12N9/00 , C12N9/10 , C12N9/88 , C12N9/90 , C12P17/18
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.
摘要翻译：用于重组生产角鲨毒碱生物碱如环圈子，festuclavine，agroclavine，chanoclavine和chanoclavine醛的微生物和方法，以及多肽，多核苷酸和包含这样的多核苷酸的载体，其可以用于制造棒状的方法提供生物碱。

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