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1. 发明申请

WO2011153009A1 METHODS OF TREATING BLADDER CANCER 审中-公开
标题翻译：治疗乳腺癌的方法
公开(公告)号：WO2011153009A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/037449
申请日：2011-05-20
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K47/42 , A61K9/14 , A61P35/04
CPC分类号： A61K38/38 , A61K9/0019 , A61K9/146 , A61K31/282 , A61K31/337 , A61K31/555 , A61K31/7068 , A61K47/42 , A61K2300/00
摘要： The present invention provides methods and compositions for treating bladder cancer, including metastatic bladder cancer and non-muscle-invasive bladder cancer, by administering a composition comprising nanoparticles that comprise a taxane and an albumin.
摘要翻译：本发明提供了通过施用包含紫杉烷和白蛋白的纳米颗粒的组合物来治疗膀胱癌的方法和组合物，包括转移性膀胱癌和非肌肉侵袭性膀胱癌。

2. 发明申请

WO2011156119A1 COMBINATION THERAPY METHODS FOR TREATING PROLIFERATIVE DISEASES 审中-公开
标题翻译：用于治疗增殖性疾病的组合治疗方法
公开(公告)号：WO2011156119A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/037450
申请日：2011-05-20
申请人： ABRAXIS BIOSCIENCE, LLC , DESAL, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAL, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K9/14 , A61K31/337 , A61K47/42 , A61K31/16 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/146 , A61K9/5169 , A61K31/16 , A61K31/167 , A61K31/282 , A61K31/706 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that modifies the epigenetics in a cell.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括第一疗法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及可包括施用有效量的第二疗法的至少一种修饰细胞中表观遗传学的其它试剂。

3. 发明申请

WO2008076373A1 BREAST CANCER THERAPY BASED ON HORMONE RECEPTOR STATUS WITH NANOPARTICLES COMPRISING TAXANE 审中-公开
标题翻译：基于激素受体状态的乳腺癌治疗与包含TAXANE的纳米颗粒
公开(公告)号：WO2008076373A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/025645
申请日：2007-12-14
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K9/51 , A61K31/337 , A61K47/42 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/5169 , A61K31/282 , A61K31/475 , A61K31/505 , A61K31/513 , A61K31/5377 , A61K31/661 , A61K31/664 , A61K31/7034 , A61K31/704 , A61K31/7068 , A61K39/39558 , A61K47/42 , A61K47/64 , A61K47/643
摘要： The present invention relates to methods and kits for the treatment of breast cancer based on hormone receptor status of progesterone receptor and estrogen receptor comprising the administration of a taxane alone, in combination with at least one other and other therapeutic agents, as well as other treatment modalities useful in the treatment of breast cancer. In particular, the invention relates to the use of nanoparticles comprising paclitaxel and albumin (such as Abraxane®) either alone or in combination with other chemotherapeutic agents or radiation, which may be used for the treatment of breast cancer which does not express estrogen receptor and/or progesterone receptor.
摘要翻译：本发明涉及用于基于孕激素受体和雌激素受体的激素受体状态治疗乳腺癌的方法和试剂盒，其包括单独施用紫杉烷与至少一种其它治疗剂以及其它治疗剂用于治疗乳腺癌的方式。特别地，本发明涉及包含紫杉醇和白蛋白（例如Abraxane）的纳米颗粒单独使用或与其它化学治疗剂或辐射组合的用途，其可用于治疗不表达雌激素受体的乳腺癌， /或孕激素受体。

4. 发明申请

WO2011123393A1 METHODS OF ENHANCING DRUG DELIVERY AND EFFECTIVENESS OF THERAPEUTIC AGENTS 审中-公开
标题翻译：增加治疗药物的药物递送和有效性的方法
公开(公告)号：WO2011123393A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030206
申请日：2011-03-28
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K9/14 , A61P35/00
CPC分类号： A61K47/42 , A61K31/337 , A61K31/573 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as "the drug uptake capability"). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.
摘要翻译：本发明在一个方面提供了增强靶组织中治疗剂摄取的方法，以及通过共同施用组合物来治疗疾病（例如癌症）或通过治疗剂治疗的有效性的方法包括包含白蛋白和难溶性水溶性药物如紫杉烷与治疗剂的纳米颗粒。本发明的另一方面提供了一种治疗方法或选择用于治疗疾病（例如癌症）的患者的方法，其中治疗剂和包含纳米颗粒的组合物包含白蛋白和水难溶性药物，例如基于目标组织的一个或多个特征的紫杉烷，其与靶组织中紫杉烷纳米颗粒组合物共同给药的结果相关或指示获得增强的治疗剂摄取的能力（称为“药物摄取能力” ）。还提供了可用于本文所述方法的药物组合物，制品和试剂盒。

5. 发明申请

WO2011025838A1 COMBINATION THERAPY WITH NANOPARTICLE COMPOSITIONS OF TAXANE AND HEDGEHOG INHIBITORS 审中-公开
标题翻译：与TAXANE和HEDGEHOG抑制剂纳米复合物的组合治疗
公开(公告)号：WO2011025838A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046684
申请日：2010-08-25
申请人： ABRAXIS BIOSCIENCE, LLC , TAO, Chunlin , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： TAO, Chunlin , DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K9/20
CPC分类号： A61K47/42 , A61K9/5169 , A61K31/337 , A61K31/4355 , A61K31/7056
摘要： The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a hedgehog inhibitor that inhibits a hedgehog signaling pathway.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及抑制刺猬蛋白信号传导途径的刺猬蛋白抑制剂。

6. 发明申请

WO2010121000A1 PRION-FREE NANOPARTICLE COMPOSITIONS AND METHODS 审中-公开
标题翻译：无免疫纳米颗粒组合物和方法
公开(公告)号：WO2010121000A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031197
申请日：2010-04-15
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , PEYKOV, Viktor , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , PEYKOV, Viktor , SOON-SHIONG, Patrick
IPC分类号： G01N33/53
CPC分类号： A61K9/5169 , A61K9/1658 , A61K31/337 , A61K47/42 , B82Y5/00 , G01N33/6896 , G01N2800/2828 , Y10S210/905
摘要： Prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs are disclosed. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
摘要翻译：公开了包含白蛋白和基本上不溶于水的药物的纳米颗粒的无朊病毒组合物。还提供了制备无朊病毒组合物和从纳米颗粒组合物中除去朊病毒蛋白的方法。还提供了使用组合物的方法以及用于实施方法的试剂盒。

7. 发明申请

WO2011123395A1 METHODS OF TREATING CANCER 审中-公开
标题翻译：癌症治疗方法
公开(公告)号：WO2011123395A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030209
申请日：2011-03-28
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K9/14 , A61K31/337 , A61K31/555 , A61P35/00
CPC分类号： A61K47/48284 , A61K9/0019 , A61K9/14 , A61K9/146 , A61K9/5052 , A61K31/337 , A61K31/555 , A61K33/24 , A61K45/06 , A61N5/10 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , A61K2300/00
摘要： The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present application also provides methods of treating prostate cancer by administering to the individual a) an effective amount of a composition comprising nanoparticles comprising docetaxel and an albumin; and b) an effective amount of a steroid.
摘要翻译：本发明提供了通过给予a）包含包含紫杉醇和白蛋白的纳米颗粒和b）铂基药剂（例如卡铂）的组合物来治疗非小细胞肺癌（NSCLC）的方法和组合物。本申请还提供了通过向个体施用a）有效量的包含多烯紫杉醇和白蛋白的纳米颗粒的组合物来治疗前列腺癌的方法; 和b）有效量的类固醇。

8. 发明申请

WO2008150532A1 METHODS AND COMPOSITIONS FOR TREATING RECURRENT CANCER 审中-公开
标题翻译：治疗癌症的方法和组合
公开(公告)号：WO2008150532A1
公开(公告)日：2008-12-11
申请号：PCT/US2008/007024
申请日：2008-06-02
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K31/555 , A61P35/00
CPC分类号： A61K47/42 , A61K9/5169 , A61K31/282 , A61K31/337 , A61K31/555 , A61K38/38 , A61K47/643 , A61K47/6929 , Y10S977/773 , Y10S977/906 , A61K2300/00
摘要： The present invention provides methods of treating recurrent cancer (such as recurrent ovarian, peritoneal, or fallopian tube cancer) in an individual, comprising administering to the individual an effective amount of a composition (such as Nab -paclitaxel or Abraxane ® ) comprising nanoparticles comprising a taxane and a carrier protein.
摘要翻译：本发明提供了治疗个体中复发性癌症（例如复发性卵巢，腹膜或输卵管癌）的方法，包括向个体施用有效量的包含纳米颗粒的组合物（例如Nab-紫杉醇或Abraxane），其包含紫杉烷和载体蛋白。

9. 发明申请

WO2008137148A3 METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION 审中-公开
公开(公告)号：WO2008137148A3
公开(公告)日：2008-11-13
申请号：PCT/US2008/005792
申请日：2008-05-05
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K31/436 , A61P9/12
摘要： The present invention features methods for treating, stabilizing, preventing, and/or delaying pulmonary hypertension by administering nanoparticles that comprise rapamycin or a derivative thereof and/or nanoparticles that comprise a taxane (e.g., paclitaxel) or a derivative thereof. The invention also provides compositions (e.g., unit dosage forms) comprising nanoparticles that comprise a carrier protein and rapamycin or a derivative thereof and/or nanoparticles that comprise a carrier protein and a taxane (e.g. paclitaxel) or a derivative thereof.

10. 发明申请

WO2008109163A1 NANOPARTICLE COMPRISING RAPAMYCIN AND ALBUMIN AS ANTICANCER AGENT 审中-公开
标题翻译：包含RAPAMYCIN和ALBUMIN作为抗原剂的纳米颗粒
公开(公告)号：WO2008109163A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/003096
申请日：2008-03-07
申请人： ABRAXIS BIOSCIENCE, LLC. , DESAI, Neil, P. , SOON-SHIONG, Patrick , TRIEU, Vuong
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick , TRIEU, Vuong
IPC分类号： A61K9/51 , A61K31/436 , A61K47/42 , A61P35/00
CPC分类号： A61K9/5169 , A61K9/0019 , A61K9/19 , A61K31/436 , A61K31/517 , A61K31/675 , A61K31/685 , A61K31/704 , A61K45/06 , A61K47/42 , A61N5/10 , A61N7/00 , A61K2300/00
摘要： The present invention features methods for treating, stabilizing, preventing, and/or delaying cancer by administering nanoparticles that comprise rapamycin or a derivative thereof. The invention also provides compositions ( e.g ., unit dosage forms) comprising nanoparticles that comprise a carrier protein and rapamycin or a derivative thereof. The invention further provides combination therapy methods of treating cancer comprising administering to an individual an effective amount of nanoparticles that comprise rapamycin or a derivative thereof and a second therapy.
摘要翻译：本发明的特征在于通过施用包含雷帕霉素或其衍生物的纳米颗粒来治疗，稳定，预防和/或延缓癌症的方法。本发明还提供包含载体蛋白质和雷帕霉素或其衍生物的纳米颗粒的组合物（例如，单位剂量形式）。本发明进一步提供了治疗癌症的联合治疗方法，包括向个体施用有效量的包含雷帕霉素或其衍生物的纳米颗粒和第二疗法。

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