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1. 发明专利

PE20191660A1 DENDRIMEROS TERAPEUTICOS 未知
公开(公告)号：PE20191660A1
公开(公告)日：2019-11-11
申请号：PE2019001564
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： La presente invencion se refiere a dendrimeros de Formulas (I), (II), (III), (IV) y (V) o sal farmaceuticamente aceptable de los mismos, donde: (a) es un nucleo; b es 2; BU son unidades de construccion; BUx son unidades de construccion de generacion x; W es independientemente (PM)c o (H)e; Z es independientemente (L-AA)d o (H)e; PM es PEG 900-1200 o PEG1800-2400; L-AA es un enlazador unido covalentemente a un agente activo. Dichos compuestos se unen covalentemente a un inhibidor de Bcl, el cual es un miembro anti-apoptotico y regula la supervivencia celular de neoplasias malignas, por lo que su inhibicion es util para el tratamiento del cancer. Dichos dendrometros tienen el potencial de mejorar la tolerabilidad in vivo de los inhibidores Bcl, lo que mejora el indice terapeutico y reduce los efectos secundarios. Tambien se refiere a una composicion farmaceutica que contiene dichos dendrimeros.

2. 发明专利

AU2018223149B2 Therapeutic dendrimers 未知
公开(公告)号：AU2018223149B2
公开(公告)日：2021-04-01
申请号：AU2018223149
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

3. 发明专利

SG11201907334QA THERAPEUTIC DENDRIMERS 未知
公开(公告)号：SG11201907334QA
公开(公告)日：2019-09-27
申请号：SG11201907334Q
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE , GRANT IAIN , HENNESSY EDWARD , SECRIST JOHN , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： BU)—(BU2)2 —— (BUx) 2 (. Core A Building Unit in the Outermost Generation Gor e Building Unit Dendron Surface Functional Groups Figure 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT mu °million °nolo HE ioo Ho ino Immo oimIE (10) International Publication Number WO 2018/154004 Al (51) International Patent Classification: A61K 47/60 (2017.01) CO8G 83/00 (2006.01) C08G 6 9 / 1 0 (2006.01) A61P 35/00 (2006.01) C08G 6 9 / 4 0 (2006.01) (21) International Application Number: PCT/EP2018/054420 (22) International Filing Date: 22 February 2018 (22.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/461,983 22 February 2017 (22.02.2017) US 62/488,151 21 April 2017 (21.04.2017) US 62/591,823 29 November 2017 (29.11.2017) US (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 Sodertalje (SE). (72) Inventors: MCCOULL, William; AstraZeneca R&D, Macclesfield Cheshire SK10 4TG (GB). ASHFORD, Mar- ianne, Bernice; AstraZeneca R&D, Macclesfield Cheshire SK10 4TG (GB). GRANT, lain; AstraZeneca R&D, Mac- clesfield Cheshire SK10 4TG (GB). HENNESSY, Ed- ward, John; AstraZeneca R&D Boston 35 Gatehouse Drive, Waltham, Massachusettes 02451 (US). SECRIST, John, Paul; AstraZeneca R&D Boston 35 Gatehouse Dri- ve, Waltham, Massachusettes 02451 (US). OWEN, David; Starpharma Pty Limited 4-6 Southhampton Cresent, Ab- botsford, Victoria 3067 (AU). KELLY, Brian; Starpharma Pty Limited 4-6 Southampton Cresent, Abbotsford, Victoria 3067 (AU). GIANNIS, Michael; Starpharma Pty Limited 4-6 Southampton Cresent, Abbotsford, Victoria 3067 (AU). (74) Agent: STORM, Peter, Jan; AstraZeneca Intellectual Property Milstein Building, Granta Park, Cambridge Cam- bridgeshire CB21 6GH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: THERAPEUTIC DENDRIMERS 1-1 (57) : Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceu- tical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer. C [Continued on next page] WO 2018/154004 Al MIDEDIMOMMIONE10131100HONIIMEMOVH SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3))

4. 发明专利

CA3053069A1 THERAPEUTIC DENDRIMERS 未知
公开(公告)号：CA3053069A1
公开(公告)日：2018-08-30
申请号：CA3053069
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

5. 发明专利

UA125655C2 ТЕРАПЕВТИЧНІ ДЕНДРИМЕРИ 未知
公开(公告)号：UA125655C2
公开(公告)日：2022-05-11
申请号：UAA201909735
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
摘要： Розкритідендримериформули (I): (I) іїхніфармацевтичноприйнятнісолі. Такожрозкритіфармацевтичнікомпозиції, щомістятьдендримерформули (I), таспособиїхзастосуваннядлялікуванняраку.

6. 发明专利

CL2019002240A1 Dendrímeros terapéuticos. 未知
公开(公告)号：CL2019002240A1
公开(公告)日：2019-11-29
申请号：CL2019002240
申请日：2019-08-08
申请人： ASTRAZENECA AB
发明人： ASHFORD MARIANNE BERNICE , SECRIST JOHN PAUL , MCCOULL WILLIAM , GRANT IAIN , HENNESSY EDWARD JOHN , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： SE DIVULGAN DENDRÍMEROS DE FÓRMULA (I), Y SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS. TAMBIÉN SE DIVULGAN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN EL DENDRÍMERO DE FÓRMULA (I) Y MÉTODOS PARA USAR LOS MISMOS PARA EL TRATAMIENTO DEL CÁNCER.

7. 发明专利

ECSP19056271A DENDRÍMEROS TERAPÉUTICOS 未知
公开(公告)号：ECSP19056271A
公开(公告)日：2019-08-30
申请号：ECDI201956271
申请日：2019-08-06
申请人： ASTRAZENECA AB
发明人： GRANT IAIN , SECRIST JOHN , KELLY BRIAN , OWEN DAVID , MCCOULL WILLIAM , GIANNIS MICHAEL , HENNESSY EDWARD , ASHFORD MARIANNE
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： Se divulgan dendrímeros de fórmula (I): y sales farmacéuticamente aceptables de los mismos. También se divulgan composiciones farmacéuticas que comprenden el dendrímero de fórmula (I) y métodos para usar los mismos para el tratamiento del cáncer.

8. 发明专利

PH12019501896A1 THERAPEUTIC DENDRIMERS 未知
公开(公告)号：PH12019501896A1
公开(公告)日：2019-10-21
申请号：PH12019501896
申请日：2019-08-15
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

9. 发明专利

AU2018223149A1 Therapeutic dendrimers 未知
公开(公告)号：AU2018223149A1
公开(公告)日：2019-10-03
申请号：AU2018223149
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , GRANT IAIN , HENNESSY EDWARD JOHN , SECRIST JOHN PAUL , OWEN DAVID , KELLY BRIAN , GIANNIS MICHAEL
IPC分类号： A61K47/60 , A61P35/00 , C08G69/10 , C08G69/40 , C08G83/00
摘要： Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

10. 发明专利

CR20190361A DENDRÍMEROS TERAPÉUTICOS 未知
公开(公告)号：CR20190361A
公开(公告)日：2019-09-24
申请号：CR20190361
申请日：2018-02-22
申请人： ASTRAZENECA AB
发明人： GRANT IAIN , HENNESSY EDWARD JOHN , GIANNIS MICHAEL , MCCOULL WILLIAM , ASHFORD MARIANNE BERNICE , OWEN DAVID , SECRIST JOHN PAUL , KELLY BRIAN
IPC分类号： C08G69/40 , A61K31/451 , A61K47/00 , A61P35/00 , C08G69/10 , C08G83/00
摘要： Se divulgan dendrímeros de fórmula (I) y sales farmacéuticamente aceptables de los mismos. También se divulgan composiciones farmacéuticas que comprenden el dendrímero de fórmula (I) y métodos para usar los mismos para el tratamiento del cáncer.Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

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