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1. 发明申请

WO2016126331A1 SYSTEMS AND METHODS OF OPTICAL COHERENCE TOMOGRAPHY WITH A MULTI-FOCAL DELAY LINE 审中-公开
标题翻译：具有多焦点延迟线的光学相干坐标系的系统和方法
公开(公告)号：WO2016126331A1
公开(公告)日：2016-08-11
申请号：PCT/US2015/065612
申请日：2015-12-14
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： PULASKI, Paul , NEAL, Daniel, R. , RAYMOND, Thomas, D. , FARRER, Stephen, W. , HAMRICK, Daniel, R. , COPLAND, Richard, J.
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/1005 , G02B6/12004 , G02B2006/12145 , G02B2006/12159
摘要： An optical coherence tomography (OCT) system includes: a light source; a multi-focal delay line; and a light detector. The multi-focal delay line includes: a positive lens; and an optical switch configured to: receive a light from the light source; selectively direct the sample light to the positive lens via a selected one of a plurality of light interfaces each located a different distance from the focal plane of the positive lens; and direct the sample light to an object to be measured. The light detector is configured to receive return light returned from the object to be measured in response to the sample light, and to receive a reference light produced from the light from the light source, and in response thereto to detect at least one interference signal. An associated OCT method may be performed with the OCT system.
摘要翻译：光学相干断层扫描（OCT）系统包括：光源; 多焦延迟线; 和光检测器。多焦延迟线包括：正透镜; 以及光开关，被配置为：从所述光源接收光; 经由多个光接口中的选定的一个光源选择性地将采样光引导到正透镜，每个光接口与正透镜的焦平面位于不同的距离处; 并将样品光引导到待测量的物体上。光检测器被配置为响应于采样光接收从待测对象返回的返回光，并且接收从光源产生的参考光，并响应于此，检测至少一个干扰信号。 OCT系统可以执行相关的OCT方法。

2. 发明申请

WO2016089395A1 MODEL EYE PRODUCING A SPECKLE PATTERN HAVING A REDUCED BRIGHT-TO-DARK RATIO FOR USE WITH OPTICAL MEASUREMENT SYSTEM FOR CATARACT DIAGNOSTICS 审中-公开
标题翻译：产生具有降低亮度到深度比例的谱图的模型眼睛用于具有用于CATARACT诊断的光学测量系统
公开(公告)号：WO2016089395A1
公开(公告)日：2016-06-09
申请号：PCT/US2014/068412
申请日：2014-12-03
申请人： AMO WAVEFRONT SCIENCES, LLC. , COPLAND, Richard, J. , NEAL, Daniel, R. , RAYMOND, Thomas, D. , XIONG, Wei , PULASKI, Paul, D. , FARRER, Stephen, W. , VIDAL, Carmen, Canovas
发明人： COPLAND, Richard, J. , NEAL, Daniel, R. , RAYMOND, Thomas, D. , XIONG, Wei , PULASKI, Paul, D. , FARRER, Stephen, W. , VIDAL, Carmen, Canovas
IPC分类号： A61B3/00 , A61F9/008 , G09B23/34
CPC分类号： A61B3/00 , A61B3/0025 , A61B3/1015 , A61B2017/00716 , A61B2560/0233 , G09B23/34
摘要： A system includes a model eye and an optical measurement instrument, which includes: a corneal topography subsystem; a wavefront sensor subsystem; and an eye structure imaging subsystem. The subsystems may have a common fixation axis, and be operatively coupled to each other via a controller. The optical measurement instrument may perform measurements of the model eye to verify correct operation of the optical measurement instrument for measuring one or more characteristics of a subject's eye. The model eye may include an optically transmissive structure having a front curved surface and an opposite rear planar surface, and a material structure provided at the rear planar surface of the optically transmissive structure and having a characteristic to cause a speckle pattern of a portion of a coherent light beam that is directed back out the front curved surface of the optically transmissive structure to have a bright-to-dark ratio of less than 2: 1.
摘要翻译：一种系统包括模型眼和光学测量仪器，其包括：角膜地形子系统; 波前传感器子系统; 和眼睛结构成像子系统。子系统可以具有共同的固定轴，并且经由控制器可操作地彼此耦合。光学测量仪器可以执行模型眼睛的测量，以验证用于测量受试者眼睛的一个或多个特征的光学测量仪器的正确操作。模型眼可以包括具有前曲面和相对的后平面的光学透射结构，以及设置在光学透射结构的后平面处的材料结构，并且具有导致一部分的散斑图案的特性相干光束被引导回光学透射结构的前曲面以具有小于2:1的亮暗比。

3. 发明申请

WO2010078070A3 SYSTEMS AND METHODS FOR MEASURING THE SHAPE AND LOCATION OF AN OBJECT 审中-公开
公开(公告)号：WO2010078070A3
公开(公告)日：2010-07-08
申请号：PCT/US2009/068631
申请日：2009-12-18
申请人： AMO WAVEFRONT SCIENCES,LLC , CAMPBELL, Charles, E. , FARRER, Stephen, W. , NEAL, Daniel, R. , POWERS, William, S. , RAYMOND, Thomas, D. , COPLAND, James
发明人： CAMPBELL, Charles, E. , FARRER, Stephen, W. , NEAL, Daniel, R. , POWERS, William, S. , RAYMOND, Thomas, D. , COPLAND, James
IPC分类号： A61B3/00
摘要： A system for determining the shape of an object and/or a distance of the object from the system includes a first plurality of light source, a second plurality of light sources, and a detector or detector array. The first plurality of light sources are disposed about a central axis and are separated from the central axis by radial distances defining an aperture in the first plurality of light sources. The system also includes an optical system adapted to provide light from the second plurality of light sources through the aperture to the object. The system may further include a computer configured to determine the shape of the object and/or the distance of the object from the system using light from the first and second plurality of light sources that is reflected from the object and received by the detector.

4. 发明申请

WO2017091200A1 METHOD AND SYSTEM FOR EYE MEASUREMENTS AND CATARACT SURGERY PLANNING USING VECTOR FUNCTION DERIVED FROM PRIOR SURGERIES 审中-公开
标题翻译：使用来自先前手术的矢量功能进行眼睛测量和神经科外科手术计划的方法和系统
公开(公告)号：WO2017091200A1
公开(公告)日：2017-06-01
申请号：PCT/US2015/062225
申请日：2015-11-23
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： RAYMOND, Thomas, D. , NEAL, Daniel, R. , COPLAND, Richard, J. , XIONG, Wei , PULASKI, Paul , FARRER, Stephen, W. , CANOVAS, Carmen , HAMRICK, Daniel, R.
IPC分类号： A61F9/008 , A61F2/16 , A61B3/00
CPC分类号： A61B3/0025 , A61F9/00802 , A61F9/00806 , A61F9/00825 , A61F2009/00859 , A61F2009/0087 , A61F2009/00872
摘要： Improved devices, systems, and methods for planning cataract surgery on an eye of a patient incorporate results of prior corrective surgeries into a planned cataract surgery of a particular patient by driving an effective surgery vector function based on data from the prior corrective surgeries. The exemplary effective surgery vector employs an influence matrix which may allow improved refractive corrections to be generated so as to increase the overall efficacy of a cataract surgery by specifying one or more parameters of an intraocular lens (IOL) to be implanted during the cataract surgery.
摘要翻译：通过基于数据驱动有效的手术矢量函数，用于在患者的眼睛上计划白内障手术的改进的装置，系统和方法将先前的矫正手术的结果并入特定患者的计划的白内障手术中从以前的矫正手术。示例性有效手术矢量采用影响矩阵，其可以允许产生改善的屈光矫正，从而通过指定在白内障手术期间植入的人工晶状体（IOL）的一个或多个参数来增加白内障手术的总体功效。

5. 发明申请

WO2012003362A1 COMPACT BINOCULAR ADAPTIVE OPTICS PHOROPTER 审中-公开
标题翻译：紧凑的双极自适应光学器件
公开(公告)号：WO2012003362A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042659
申请日：2011-06-30
申请人： AMO WAVEFRONT SCIENCES LLC , NEAL, Daniel, R.
发明人： NEAL, Daniel, R.
IPC分类号： A61B3/028
CPC分类号： A61B3/08 , A61B3/02 , A61B3/032 , A61B3/036 , A61B3/1015 , A61B3/103 , A61B3/111 , G02B3/0087 , G02B13/22 , G02B27/0025
摘要： A binocular vision apparatus allows a patient to view objects through the apparatus with polychromatic light and monochromatic aberration correction, such that the chromatic aberration of the eye can be combined with the monochromatic aberration correction, so as to provide a more accurate determination of vision quality. The binocular vision apparatus provides left and right viewing optics that can substantially maintain the line of sight of each eye, such that objects can be viewed in a room with 3D depth perception corresponding to the distance of the object from the patient. As both near and far objects can be viewed with binocular aberration correction, the patient can alternate binocular viewing between near and far vision with chromatic aberration so as to evaluate a proposed treatment such as a presbyopia correction.
摘要翻译：双目视觉设备允许患者通过具有多色光和单色像差校正的装置来观看物体，使得眼睛的色差可以与单色像差校正组合，以便提供更精确的视觉质量的确定。双目视觉装置提供可以基本上保持每只眼睛的视线的左右观察光学元件，使得可以在具有与物体距离患者的距离对应的3D深度感知的房间中观看物体。由于可以用双目像差校正来观察近距离物体和远物体，所以患者可以在近视和远视之间交替双目观察与色差，以评估所提出的治疗，例如老花眼矫正。

6. 发明申请

WO2016004131A1 SYSTEM AND METHOD FOR CORNEAL TOPOGRAPHY WITH FLAT PANEL DISPLAY 审中-公开
标题翻译：具有平板显示器的角度地形的系统和方法
公开(公告)号：WO2016004131A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038702
申请日：2015-06-30
申请人： AMO WAVEFRONT SCIENCES, LLC
发明人： FARRER, Stephen, W. , POWERS, W., Shea , NEAL, Daniel, R. , VOSS, Larry, B.
IPC分类号： A61B3/107
CPC分类号： A61B3/107
摘要： A corneal topographer includes: a flat panel display configured to display a light pattern and to project the light pattern onto a cornea of an eye disposed on a first side of the flat panel display; an optical system disposed on a second side of the flat panel display, the optical system being configured to receive and process reflected light from the cornea that passes through the flat panel display from the cornea to the optical system; a camera configured to receive the processed reflected light from the optical system and to capture therefrom a reflected light pattern from the cornea produced in response to the projected light pattern; and one or more processors configured to execute an algorithm to compare the projected light pattern to the reflected light pattern from the cornea, and to produce a topographic map of the cornea based on a result of the comparison.
摘要翻译：角膜地形图包括：平板显示器，被配置为显示光图案并将光图案投影到设置在平板显示器的第一侧上的眼睛的角膜上; 光学系统，设置在所述平板显示器的第二侧上，所述光学系统被配置为接收来自角膜的反射光，所述角膜通过所述平板显示器从所述角膜到所述光学系统; 相机，被配置为从所述光学系统接收经处理的反射光并且从其中捕获响应于所述投影光图案而产生的角膜的反射光图案; 以及一个或多个处理器，被配置为执行算法以比较来自角膜的反射光图案的投影光图案，并且基于比较的结果来产生角膜的地形图。

7. 发明申请

WO2009124306A1 REGISTERING MULTIPLE OPHTHALMIC DATASETS 审中-公开
标题翻译：注册多个OPHTHALMIC DATASETS
公开(公告)号：WO2009124306A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039607
申请日：2009-04-06
申请人： AMO WAVEFRONT SCIENCES, LLC , NEAL, Daniel, R. , ZICKLER, Leander
发明人： NEAL, Daniel, R. , ZICKLER, Leander
IPC分类号： A61B3/15 , A61B3/103 , A61B3/107 , A61F9/01
CPC分类号： G06T5/50 , A61F9/00804 , A61F9/00827 , A61F2009/00848 , A61F2009/00851 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , G06T7/33 , G06T2207/20221 , G06T2207/30041
摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).
摘要翻译：便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的尝试在完全相同的时间获取图像或其他数据。有利的是，可以识别患者在测量之间的移动（和/或在测量序列期间），以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化等）。

8. 发明申请

WO2009058747A1 SYSTEM AND METHODS OF PHASE DIVERSITY WAVEFRONT SENSING 审中-公开
标题翻译：相位差波浪感测的系统与方法
公开(公告)号：WO2009058747A1
公开(公告)日：2009-05-07
申请号：PCT/US2008/081402
申请日：2008-10-28
申请人： AMO WAVEFRONT SCIENCES, LLC. , RAYMOND, Thomas, D. , PULASKI, Paul , FARRER, Stephen, W. , NEAL, Daniel, R. , GREENAWAY, Alan, H. , FAICHNIE, David, M. , CAMPBELL DALGARNO, Heather, I. , CRAIK, Graham, N.
发明人： RAYMOND, Thomas, D. , PULASKI, Paul , FARRER, Stephen, W. , NEAL, Daniel, R. , GREENAWAY, Alan, H. , FAICHNIE, David, M. , CAMPBELL DALGARNO, Heather, I. , CRAIK, Graham, N.
IPC分类号： G01J1/02 , G01J1/04
CPC分类号： G01J9/00 , G01J2009/002 , G01J2009/0203
摘要： A phase diversity wavefront sensor includes an optical system including at least one optical element for receiving a light beam; a diffractive optical element having a diffractive pattern defining a filter function, the diffractive optical element being arranged to produce, in conjunction with the optical system, images from the light beam associated with at least two diffraction orders; and a detector for detecting the images and outputting image data corresponding to the detected images. In one embodiment, the optical system, diffractive optical element, and detector are arranged to provide telecentric, pupil plane images of the light beam. A processor receives the image data from the detector, and executes a Gerchberg- Saxton phase retrieval algorithm to measure the wavefront of the light beam.
摘要翻译：相位分集波前传感器包括光学系统，该光学系统包括用于接收光束的至少一个光学元件; 具有限定滤光器功能的衍射图案的衍射光学元件，所述衍射光学元件布置成与所述光学系统结合产生与至少两个衍射级相关联的光束的图像; 以及用于检测图像并输出与检测到的图像相对应的图像数据的检测器。在一个实施例中，光学系统，衍射光学元件和检测器被布置成提供光束的远心光瞳平面图像。处理器从检测器接收图像数据，并且执行Gerchberg-Saxton相位检索算法来测量光束的波前。

9. 发明申请

WO2009003172A3 SYSTEM AND METHOD FOR MEASURING CORNEAL TOPOGRAPHY 审中-公开
标题翻译：用于测量角膜地形的系统和方法
公开(公告)号：WO2009003172A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/068588
申请日：2008-06-27
申请人： AMO WAVEFRONT SCIENCES, LLC , CAMPBELL, Charles, E. , FARRER, Stephen, W. , NEAL, Daniel, R. , POWERS, William, S. , RAYMOND, Thomas, D.
发明人： CAMPBELL, Charles, E. , FARRER, Stephen, W. , NEAL, Daniel, R. , POWERS, William, S. , RAYMOND, Thomas, D.
IPC分类号： A61B3/107 , G01B11/24
摘要： A system measures a corneal topography of an eye. The system includes a group of first light sources arranged around a central axis, the group being separated from the axis by a radial distance defining an aperture in the group; a plurality of second light sources; a detector array; and an optical system adapted to provide light from the second light sources through the aperture to a cornea of an eye, and to provide images of the first light sources and images of the second light sources from the cornea, through the aperture, to the detector array. The optical system includes an optical element having a focal length,/ The second light sources are disposed to be in an optical path approximately one focal length,/ away from the optical element.
摘要翻译：
系统测量眼睛的角膜地形。所述系统包括围绕中心轴线布置的一组第一光源，所述组与所述轴线分开限定所述组中的孔径的径向距离; 多个第二光源; 一个探测器阵列; 以及光学系统，其适于将来自第二光源的光通过孔提供给眼角膜，并且将第一光源的图像和来自角膜的第二光源的图像通过孔提供给检测器阵列。该光学系统包括具有焦距的光学元件。第二光源被布置为处于距离光学元件大约一个焦距的光路中。

10. 发明申请

WO2012092584A1 IMPROVED TREATMENT PLANNING METHOD AND SYSTEM FOR CONTROLLING LASER REFRACTIVE SURGERY 审中-公开
标题翻译：改进的治疗计划方法和控制激光折射手术的系统
公开(公告)号：WO2012092584A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/068169
申请日：2011-12-30
申请人： AMO WAVEFRONT SCIENCES LLC. , RAYMOND, Thomas, D. , NEAL, Daniel, R.
发明人： RAYMOND, Thomas, D. , NEAL, Daniel, R.
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F2009/00857 , A61F2009/00859 , A61F2009/00872 , A61F2009/0088
摘要： Improved devices, systems, and methods for diagnosing, planning treatments of, and/or treating the refractive structures of an eye of a patient incorporate results of prior refractive corrections into a planned refractive treatment of a particular patient by driving an effective treatment vector function based on data from the prior eye treatments. The exemplary effective treatment vector employs an influence matrix which may allow improved refractive corrections to be generated so as to increase the overall accuracy of laser eye surgery (including LASIK, PRK, and the like), customized intraocular lenses (IOLs), refractive femtosecond treatments, and the like.
摘要翻译：用于诊断，规划治疗和/或治疗患者的眼睛的折射结构的改进的装置，系统和方法将先前的屈光矫正的结果并入特定患者的计划折射治疗中，通过驱动基于有效治疗矢量的功能来自先前的眼睛治疗的数据。示例性的有效治疗载体使用影响矩阵，其可以允许产生改善的屈光矫正以增加激光眼睛手术（包括LASIK，PRK等），定制的眼内透镜（IOL），折射飞秒处理，等等。

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