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    • 10. 发明公开
    • Process for producing 1,1-Difluorovinyl cycloaliphatic compounds
    • Verfahren zur Herstellung von 1,1-二氟乙烯基 - cycloaliphatischen Verbindungen
    • EP1557404A1
    • 2005-07-27
    • EP05000895.2
    • 2005-01-18
    • AIR PRODUCTS AND CHEMICALS, INC.
    • Lal, Gauri SankarHayes, Kathryn SuePez, Guido Peter
    • C07C17/25C07C22/02C07C22/04C07C22/00
    • C07C17/25C07C22/00
    • This invention relates to a process for the preparation of 1,1-difluoroolefins, e.g., difluorovinyl cycloaliphatic compounds such as difluorovinylcyclohexane and derivatives by the dehydrofluorination of a trifluoromethyl-substituted cycloaliphatic compound and the resulting compositions. This method utilizes a "sterically hindered super-base" system represented by the formula M +- NRR - ; where M is Na or K and R is a secondary, or tertiary alkyl or cycloalkyl group of amines for effecting dehydrofluorination of the trifluoromethyl group leading to the difluorovinyl based cycloaliphatic compounds. The sterically hindered super base can be formed by the, in situ, reaction of a sodium or potassium alkoxide, e.g., K t BuO with a lithium dialkylamide where the lithium is bonded to nitrogen atom of an amine bearing secondary or tertiary aliphatic groups.
    • 本发明涉及一种制备1,1-二氟烯烃的方法,例如二氟乙烯基脂环族化合物如二氟乙烯基环己烷和通过三氟甲基取代的脂环族化合物的脱氟化氢的衍生物和所得组合物。 该方法利用由式M + - NRR - 表示的“空间位阻超基”系统。 其中M是Na或K,R是仲烷基或叔烷基或环烷基的胺,用于实现导致二氟乙烯基的脂环族化合物的三氟甲基的脱氟化氢。 空间位阻的超级碱可以通过钠或钾醇钾例如KtBuO与二烷基氨基锂的原位反应形成,其中锂与带有仲或叔脂族基团的胺的氮原子键合。