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1. 发明申请

WO2018093694A1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开
公开(公告)号：WO2018093694A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/061221
申请日：2017-11-13
申请人： MERCK SHARP & DOHME CORP. , GRESHOCK, Thomas, J. , MULHEARN, James, J. , ROECKER, Anthony, J. , JIAN, Tianying , ZHOU, Gang , GUO, Liangqin , WON, Walter , ZHANG, Ting , ANAND, Rajan , STELMACH, John, E. , WANG, Deping , KIM, Ronald, M. , LAYTON, Mark, E. , BURGEY, Christopher, S. , NANTERMET, Philippe, G.
发明人： GRESHOCK, Thomas, J. , MULHEARN, James, J. , ROECKER, Anthony, J. , JIAN, Tianying , ZHOU, Gang , GUO, Liangqin , WON, Walter , ZHANG, Ting , ANAND, Rajan , STELMACH, John, E. , WANG, Deping , KIM, Ronald, M. , LAYTON, Mark, E. , BURGEY, Christopher, S. , NANTERMET, Philippe, G.
IPC分类号： A61K31/18 , A61K31/38 , A61K31/395 , C07C311/15 , C07C311/16 , C07D285/00
摘要： Disclosed are compounds of Formula A, or a salt thereof: Formula (A), wherein: Het, Q and R 1A to R 4A are defined herein, which compounds have properties for blocking Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating cough, itch, acute pain and neuropathic pain disorders using the same.

2. 发明申请

WO2017106226A1 HYDROXYALKYLAMINE- AND HYDROXYCYCLOALKYLAMINE-SUBSTITUTED DIAMINE-ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开
标题翻译：在电压门控钠通道中具有选择性活性的羟基烷基胺和羟基环烷基胺取代的二胺 - 芳基磺酰胺化合物
公开(公告)号：WO2017106226A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066445
申请日：2016-12-14
申请人： MERCK SHARP & DOHME CORP. , GRESHOCK, Thomas, J. , MULHEARN, James , ZHENG, Junying , KIM, Ronald, M. , ZHANG, Ting , ROECKER, Anthony, J. , WON, Walter , NANTERMET, Philippe , ANAND, Rajan , ZHOU, Gang , WANG, Deping , GUO, Liangqin
发明人： GRESHOCK, Thomas, J. , MULHEARN, James , ZHENG, Junying , KIM, Ronald, M. , ZHANG, Ting , ROECKER, Anthony, J. , WON, Walter , NANTERMET, Philippe , ANAND, Rajan , ZHOU, Gang , WANG, Deping , GUO, Liangqin
IPC分类号： C07D285/08 , C07D417/12 , C07D277/52 , A61K31/4168 , A61K31/4178 , A61K31/4196 , A61K31/551 , A61P29/00 , A61P11/14
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/433 , A61K31/551 , A61K45/06 , C07D277/52 , C07D285/08 , A61K2300/00
摘要： Disclosed are compounds of Formula A, or a salt thereof: Formula (A) wherein R 1 , R 2 , and E are defined herein, which compounds have properties for inhibiting Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain disorders, cough, and itch using the same.
摘要翻译：公开了式A的化合物或其盐：式（A）其中R 1，R 2和E如本文所定义，该化合物具有抑制外周和交感神经元中发现的Na +离子通道的特性。还描述了包含式A化合物或其盐的药物制剂，以及使用它们治疗疼痛病症，咳嗽和瘙痒的方法。

3. 发明申请

WO2016126570A1 AMINOQUINAZOLINE COMPOUNDS AS A2A ANTAGONIST 审中-公开
标题翻译：氨基喹啉化合物作为A2A拮抗剂
公开(公告)号：WO2016126570A1
公开(公告)日：2016-08-11
申请号：PCT/US2016/015881
申请日：2016-02-01
申请人： MERCK SHARP & DOHME CORP. , ALI, Amjad , ZHOU, Gang , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , TING, Pauline, C. , BIJU, Purakkattle , RUIZ, Manuel de Lera , DEGRADO, Sylvia, J. , TUNG, Alexander, L. , HENDERSON, Timothy, J. , HONG, Liwu , KIM, Jae-Hun , KIM, David Won-Shik , LEE, Joe, F. , WU, Jie , WU, Heping , XIAO, Yushi , YU, Tao , ZHU, Xiaohong , MCCORMICK, Kevin, D. , TAGAT, Jayaram, R. , XIAO, Dong , KHAN, Tanweer , CAO, Jianhua , BERLIN, Michael , ZHANG, Yonglian
发明人： ALI, Amjad , ZHOU, Gang , KUANG, Rongze , LIM, Yeon-Hee , LO, Michael Man-Chu , TING, Pauline, C. , BIJU, Purakkattle , RUIZ, Manuel de Lera , DEGRADO, Sylvia, J. , TUNG, Alexander, L. , HENDERSON, Timothy, J. , HONG, Liwu , KIM, Jae-Hun , KIM, David Won-Shik , LEE, Joe, F. , WU, Jie , WU, Heping , XIAO, Yushi , YU, Tao , ZHU, Xiaohong , MCCORMICK, Kevin, D. , TAGAT, Jayaram, R. , XIAO, Dong , KHAN, Tanweer , CAO, Jianhua , BERLIN, Michael , ZHANG, Yonglian
IPC分类号： A61K31/517 , C07D239/84 , C07D403/12
CPC分类号： C07D239/84 , A61K31/517 , A61P25/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
摘要翻译：本发明涉及被认为可用作A2A受体拮抗剂的通式I化合物或其药学上可接受的盐。

4. 发明申请

WO2014101113A1 PIPERAZINE-SUBSTITUTED 7-METHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 审中-公开
标题翻译：哌嗪取代的具有A2A拮抗剂性质的7-甲氧基 - [1,2,4]三唑[1,5-C]喹唑啉-5-胺化合物
公开(公告)号：WO2014101113A1
公开(公告)日：2014-07-03
申请号：PCT/CN2012/087851
申请日：2012-12-28
申请人： MERCK SHARP & DOHME CORP. , ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda V. , WON, Walter , WU, Heping , ANAND, Rajan
发明人： ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda V. , WON, Walter , WU, Heping , ANAND, Rajan
IPC分类号： C07D487/04 , A61K31/4196 , A61K31/517 , A61K31/519 , A61P25/28
CPC分类号： C07D487/04 , C07D487/08 , C07D487/18 , C07D513/04
摘要： Disclosed are compounds of Formula (A), as defined herein, which have binding activity for an A 2A -receptor and are believed to be useful for treatment or management of CNS diseases or conditions which can be treated or managed using compounds which have A 2A receptor antagonist activity.
摘要翻译：公开了本文定义的式（A）化合物，其具有对A2A受体的结合活性，并被认为可用于治疗或治疗CNS疾病或病症，其可以使用具有A2A受体拮抗剂的化合物治疗或治疗活动。

5. 发明申请

WO2012047772A3 IMIDAZOLE DERIVATIVES 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：WO2012047772A3
公开(公告)日：2012-06-07
申请号：PCT/US2011054524
申请日：2011-10-03
申请人： SCHERING CORP , TING PAULINE C , ASLANIAN ROBERT G , KUANG RONGZE , WU HEPING , ZHOU GANG
发明人： TING PAULINE C , ASLANIAN ROBERT G , KUANG RONGZE , WU HEPING , ZHOU GANG
IPC分类号： A01N43/50
CPC分类号： C07D401/04 , C07D401/14
摘要： Described herein are compounds of formula (I). The compounds of formula (I) act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译：本文描述的是式（I）的化合物。式（I）化合物作为DGAT1抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。

6. 发明申请

WO2010059606A3 INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE 审中-公开
标题翻译：二乙酰胆碱酯酶抑制剂
公开(公告)号：WO2010059606A3
公开(公告)日：2010-09-16
申请号：PCT/US2009064747
申请日：2009-11-17
申请人： SCHERING CORP , TING PAULINE C , ASLANIAN ROBERT G , CAPLEN MARY ANN , CAO JIANHUA , KIM DAVID WON-SHIK , KIM HYUNJIN , KUANG RONGZE , LEE JOE F , SCHWERDT JOHN H , WU HEPING , ZHOU GANG , ZORN NICOLAS
发明人： TING PAULINE C , ASLANIAN ROBERT G , CAPLEN MARY ANN , CAO JIANHUA , KIM DAVID WON-SHIK , KIM HYUNJIN , KUANG RONGZE , LEE JOE F , SCHWERDT JOHN H , WU HEPING , ZHOU GANG , ZORN NICOLAS
IPC分类号： C07D401/12 , A61K31/422 , A61K31/427 , A61K31/506 , A61P3/00 , A61P9/00 , C07D401/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown below.
摘要翻译：本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物以及该化合物用于治疗或预防心血管疾病，代谢障碍，肥胖或肥胖相关障碍的用途，糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。本发明的说明性化合物如下所示。

7. 发明申请

WO2017106409A1 DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS 审中-公开
标题翻译：电压门控钠通道中具有选择性活性的二氨基 - 烷基氨基酰基芳基磺酰胺化合物
公开(公告)号：WO2017106409A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066765
申请日：2016-12-15
申请人： MERCK SHARP & DOHME CORP. , GRESHOCK, Thomas, J. , MULHEARN, James , GUO, Liangqin , ZHANG, Ting , WANG, Deping , KIM, Ronald, M. , LAYTON, Mark, E. , KELLY, Michael, J., III , ANAND, Rajan , JIAN, Tianying , NANTERMET, Philippe , ROECKER, Anthony, J. , WON, Walter , ZHOU, Gang
发明人： GRESHOCK, Thomas, J. , MULHEARN, James , GUO, Liangqin , ZHANG, Ting , WANG, Deping , KIM, Ronald, M. , LAYTON, Mark, E. , KELLY, Michael, J., III , ANAND, Rajan , JIAN, Tianying , NANTERMET, Philippe , ROECKER, Anthony, J. , WON, Walter , ZHOU, Gang
IPC分类号： A61K31/425 , A61P43/00 , C07C311/15
CPC分类号： A61K45/06 , C07D277/52 , C07D285/135 , C07D417/12
摘要： Disclosed are compounds of Formula A, or a salt thereof, where Q, X, R1 and R2 are as defined herein, which compounds have properties for inhibiting Na v 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating pain (acute, post-operative, neuropathic), or cough or itch disorders using the same.
摘要翻译：公开了式A化合物或其盐，其中Q，X，R 1和R 2如本文所定义，所述化合物具有抑制Na v 1.7离子的性质通道发现周边和交感神经元。还描述了包含式A化合物或其盐的药物制剂，以及使用它们治疗疼痛（急性，手术后，神经性）或咳嗽或搔痒疾病的方法。

8. 发明申请

WO2014105664A1 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES 审中-公开
标题翻译：哌嗪取代[1,2,4]三唑[1,5-C]喹唑啉-5-胺化合物与A2A拮抗剂性质
公开(公告)号：WO2014105664A1
公开(公告)日：2014-07-03
申请号：PCT/US2013/076775
申请日：2013-12-20
申请人： MERCK SHARP & DOHME CORP. , ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram, R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda, V. , WON, Walter , WU, Heping , ANAND, Rajan
发明人： ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram, R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda, V. , WON, Walter , WU, Heping , ANAND, Rajan
IPC分类号： A61K31/4985 , A61K31/519
CPC分类号： C07D487/04 , C07D487/08 , C07D487/18 , C07D513/04
摘要： Disclosed are compounds of Formula A: (structurally represented) where "RG1", "RG2a", "RG4", "RG5", "MG1", "n" and "m" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
摘要翻译：公开了式A化合物（结构上表示），其中“RG1”，“RG2a”，“RG4”，“RG5”，“MG1”，“n”和“m”在本文中定义为哪些化合物是A2A受体的拮抗剂。本文还公开了本文所述的化合物作为A2a受体的拮抗剂的潜在治疗或预防涉及A2A受体的神经障碍和疾病的用途。本文还公开了包含这些化合物的药物组合物和这些药物组合物的用途。

9. 发明申请

WO2012000733A1 WELDED PRODUCT, WELDING METHOD, AND CIRCUIT BREAKER 审中-公开
标题翻译：焊接产品，焊接方法和断路器
公开(公告)号：WO2012000733A1
公开(公告)日：2012-01-05
申请号：PCT/EP2011/058929
申请日：2011-05-31
申请人： SIEMENS AKTIENGESELLSCHAFT , BAO, Zhang Yao , CAO, Ren Jun , SHEN, Hua , SU, Fu Jian , ZHOU, Gang
发明人： BAO, Zhang Yao , CAO, Ren Jun , SHEN, Hua , SU, Fu Jian , ZHOU, Gang
IPC分类号： B23K11/20 , B23K35/00
CPC分类号： B23K11/20 , B23K35/004 , B23K35/007 , B23K2201/38 , B23K2203/22
摘要： The present invention provides a welded product which comprises a first element and a second element, and further comprises a third element, wherein the melting point of said third element is between that of the material of said first element and the material of said second element, one end of said first element is fixed into an accommodation space formed by said third element and said third element is welded onto said second element. It is made easy to weld together two parts to be welded by way of the medium effects of the third element, so that the welded product can meet the application requirements regarding mechanical strength and electric strength.
摘要翻译：本发明提供了一种焊接产品，其包括第一元件和第二元件，并且还包括第三元件，其中所述第三元件的熔点位于所述第一元件的材料和所述第二元件的材料之间，所述第一元件的一端被固定到由所述第三元件形成的容纳空间中，并且所述第三元件被焊接到所述第二元件上。通过第三元件的介质效应使两个待焊接部分焊接在一起变得容易，使得焊接产品可以满足关于机械强度和电气强度的应用要求。

10. 发明申请

WO2002078070A1 A DEVICE FOR EPITAXIALLY GROWING OBJECTS BY CVD 审中-公开
标题翻译：通过CVD外延生长物体的装置
公开(公告)号：WO2002078070A1
公开(公告)日：2002-10-03
申请号：PCT/SE2002/000560
申请日：2002-03-22
申请人： ABB RESEARCH LIMITED , LIU, Yuijing , LÖFGREN, Peter , HALLIN, Christer , ZHOU, Gang
发明人： LIU, Yuijing , LÖFGREN, Peter , HALLIN, Christer , ZHOU, Gang
IPC分类号： H01L21/205
CPC分类号： C23C16/45508 , C23C16/4557 , C23C16/4584 , C30B25/105 , C30B25/12 , H01L21/67115
摘要： A device for epitaxially growing objects by Chemical Vapour Deposition on substrates (13) comprises a casing (2) defining a room (5) for receiving a holder (11) carrying a plurality of substrates and adapted to be rotated about a substantially vertical axis as well as means for rotating said holder during the growth. The device has also means (10) for feeding a gas mixture for the growth into said room through an inlet (9) being directed substantially along said vertical axis and means (15) for heating said gas mixture inside said room for decomposition thereof and depositing of articles so formed on the substrate for growing layers thereon in a substantially vertical direction for said growth. The room (5) is delimited by a susceptor having fixed walls (7, 8) of a substantial thickness. The heating means (15) is adapted to heat the susceptor walls for heating said gas mixture substantially through radiation from the hot susceptor walls.
摘要翻译：用于通过化学气相沉积在衬底（13）上外延生长物体的装置包括限定用于容纳承载多个衬底的保持器（11）的房间（5）的壳体（2），并且适于围绕基本垂直的轴线旋转，以及用于在生长期间旋转所述保持器的装置。装置还具有用于通过基本上沿着垂直轴线引导的入口（9）将用于生长的气体混合物供给到所述房间的装置（10）和用于加热所述室内的气体混合物以进行分解的装置（15）在衬底上形成的制品在其上沿着用于生长的大致垂直方向上生长层。房间（5）由具有相当厚度的固定壁（7,8）的基座限定。加热装置（15）适于基本上通过来自热感受器壁的辐射加热基座壁以加热所述气体混合物。

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