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1. 发明申请

US20050100977A1 Biochemical sensing device 审中-公开
标题翻译：生化检测装置
公开(公告)号：US20050100977A1
公开(公告)日：2005-05-12
申请号：US10772365
申请日：2004-02-06
申请人： Yuh-Shyong Yang , Chung-Yu Wu , Ude Lu , Yu-Chuan Shih , Ben Hu
发明人： Yuh-Shyong Yang , Chung-Yu Wu , Ude Lu , Yu-Chuan Shih , Ben Hu
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/54 , C12Q1/60 , G01N21/76 , G01N33/487 , G01N33/52 , G01N33/92
CPC分类号： C12Q1/001 , G01N21/76
摘要： The invention is a biochemical sensing device, including a photodiode capable of sensing the light generated by the reaction made by a specific compound, a specific enzyme, and a luminol as well as converting the optical signal into a current signal. Also, there is a current/voltage converting circuit capable of converting the current signal into an analog voltage signal. In turn, the analog voltage signal can be converted into a digital voltage signal through an analog/digital converter. Finally, by using an electronic device, the digital voltage signal can be received and analyzed, and through the analysis, the amount of the specific compound can be measured. The device of the invention can provide a simple real-time medical assay that can be performed in massive amount. For this reason, the drawbacks of a conventional spectrum analysis instrument of being bulky and expensive can be improved.
摘要翻译：本发明是一种生物化学检测装置，其包括能够感测由特定化合物，特定酶和鲁米诺产生的反应产生的光的光电二极管，以及将光信号转换为电流信号。而且，存在能够将电流信号转换为模拟电压信号的电流/电压转换电路。反过来，模拟电压信号可以通过模/数转换器转换成数字电压信号。最后，通过使用电子设备，可以接收和分析数字电压信号，通过分析可以测量具体化合物的量。本发明的装置可以提供可以大量进行的简单的实时医学测定。因此，能够提高笨重且昂贵的常规光谱分析仪器的缺陷。

2. 发明授权

US08563245B2 Method for changing surface properties of a substrate from immobilized biomolecules 有权
标题翻译：从固定化生物分子改变底物表面性质的方法
公开(公告)号：US08563245B2
公开(公告)日：2013-10-22
申请号：US13437340
申请日：2012-04-02
申请人： Ming-Yu Liu , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
发明人： Ming-Yu Liu , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
IPC分类号： C12N11/16 , C12N9/00 , C12Q1/68 , C07H21/02
CPC分类号： C12N11/14
摘要： A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle.
摘要翻译：通过在温和的生物学条件下操纵固定化的生物分子来修饰底物的表面性质的方法。操作包括以下步骤：通过亲和结合标签提供与至少一种与第一蛋白质组合的ssDNA组合的生物分子; 加入与第二种蛋白质缀合的第二种ssDNA，其浓度大于第一种蛋白质的浓度; 并通过化学竞争原理用ssDNA替代第二个蛋白质上的第一个蛋白质。本发明可以包括具有适当设计生物素化DNA探针的步骤，功能化的ssDNA纳米模板可以通过热力学原理回收到其未结合状态。

3. 发明申请

US20120043209A1 MICROFLUIDIC CONTROL APPARATUS AND OPERATING METHOD THEREOF 审中-公开
标题翻译：微流控制装置及其操作方法
公开(公告)号：US20120043209A1
公开(公告)日：2012-02-23
申请号：US13212596
申请日：2011-08-18
申请人： Cheng-Hsien Liu , William Wang , Long Hsu , Yuh-Shyong Yang , Hwan-You Chang , Shih-Mo Yang , Chung-Cheng Chou
发明人： Cheng-Hsien Liu , William Wang , Long Hsu , Yuh-Shyong Yang , Hwan-You Chang , Shih-Mo Yang , Chung-Cheng Chou
IPC分类号： G01N27/447 , B01D21/00 , G01N27/453
CPC分类号： B01L3/50273 , B01D21/0009 , B01L3/502761 , B01L2200/14 , B01L2300/0816 , B01L2300/089 , B01L2400/0418 , B01L2400/082 , G01N35/1095
摘要： A microfluidic control apparatus and operating method thereof. The microfluidic control apparatus includes a photoconductive material layer and a flow passage. When a light with a specific optical pattern is emitted toward the photoconductive material layer, at least three virtual electrodes are formed on the photoconductive material layer according to the specific optical pattern. The at least three virtual electrodes include a first virtual electrode, a second virtual electrode and a third virtual electrode disposed beside the first virtual electrode. There is a specific proportion among a distance between first virtual electrode and third virtual electrode, a width of first virtual electrode, a distance between first virtual electrode and second virtual electrode, and a width of second virtual electrode. When the specific optical pattern changes, the at least three virtual electrodes also change to generate an electro-osmotic force to control the moving state of a microfluid in a flow passage.
摘要翻译：一种微流控制装置及其操作方法。微流控制装置包括光导材料层和流路。当向光导材料层发射具有特定光学图案的光时，根据特定光学图案在光导材料层上形成至少三个虚拟电极。所述至少三个虚拟电极包括设置在第一虚拟电极旁边的第一虚拟电极，第二虚拟电极和第三虚拟电极。在第一虚拟电极和第三虚拟电极之间的距离，第一虚拟电极的宽度，第一虚拟电极和第二虚拟电极之间的距离以及第二虚拟电极的宽度之间存在特定比例。当特定光学图案改变时，至少三个虚拟电极也改变以产生电渗压力以控制流路中微流体的移动状态。

4. 发明申请

US20110045466A1 Field-effect transistor type biosensor and bio-signal amplification method thereof 审中-公开
标题翻译：场效应晶体管型生物传感器及其生物信号放大方法
公开(公告)号：US20110045466A1
公开(公告)日：2011-02-24
申请号：US12572555
申请日：2009-10-02
申请人： Ming-Yu Lin , Yuh-Shyong Yang , Hsin Chen
发明人： Ming-Yu Lin , Yuh-Shyong Yang , Hsin Chen
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/682 , C12Q1/6804 , C12Q1/6825 , G01N27/4145 , C12Q2565/607 , C12Q2531/125 , C12Q2527/101 , C12Q2521/101
摘要： The present invention discloses a field-effect transistor (FET) type biosensor and a bio-signal amplification method. The biosensor comprises a field-effect transistor chip, a biomolecular immobilization layer and at least one primer. The biomolecular immobilization layer is formed on a gate surface of the FET chip or a surface of an external device connected to a gate. The primer used for performing a nucleic acid amplification is immobilized onto the gate surface or the external device surface by binding with the biomolecular immobilization layer, such that an analyte can have a nucleic acid amplification reaction with the primer at room temperature or a constant temperature environment. With an extension of a nucleic acid sequence, the inducing electricity of the FET gate surface can be increased so as to amplify an inspection signal, thereby enhancing the sensitivity of the FET type biosensor effectively.
摘要翻译：本发明公开了一种场效应晶体管（FET）型生物传感器和生物信号放大方法。生物传感器包括场效应晶体管芯片，生物分子固定化层和至少一个引物。生物分子固定化层形成在FET芯片的栅极表面或连接到栅极的外部器件的表面上。用于进行核酸扩增的引物通过与生物分子固定化酶结合而固定在栅极表面或外部器件表面上，使得分析物可以在室温或恒温环境下与引物进行核酸扩增反应。通过核酸序列的延伸，可以增加FET栅极表面的感应电力，从而放大检查信号，从而有效提高FET型生物传感器的灵敏度。

5. 发明申请

US20090272180A1 CONTINUOUS TESTING DEVICE AND CONTINUOUS TESTING SYSTEM 审中-公开
标题翻译：连续测试设备和连续测试系统
公开(公告)号：US20090272180A1
公开(公告)日：2009-11-05
申请号：US12272872
申请日：2008-11-18
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kun-Hsi Tsai , William Wang , Long Hsu , Cheng-Hsien Liu , Chung-Cheng Chou
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kun-Hsi Tsai , William Wang , Long Hsu , Cheng-Hsien Liu , Chung-Cheng Chou
IPC分类号： G01N33/49
CPC分类号： G01N21/31 , B01L3/502761 , B01L3/502792 , B01L9/527 , B01L2300/0864 , B01L2300/0867 , B01L2400/0424 , B01L2400/0427 , B01L2400/0454 , B03C5/005 , B03C5/026 , G01N21/05 , G01N33/491 , G01N2021/0325 , G01N2021/0346 , G01N2021/058 , G01N2201/062
摘要： A continuous testing device for testing the concentration of a target object in a fluid is provided. The continuous testing device includes a first chip, a signal source and a second chip. The first chip includes a separating unit and a reacting unit. The separating unit separates the target object from a non-target object in the fluid. The reacting unit enables the fluid having separated out the non-target object to react with a reagent. The signal source provides a signal passing through the fluid having reacted with the reagent. The second chip disposed at one side of the first chip includes a signal transducing element and a processing unit. The signal transducing element receives the signal passing through the fluid and outputs an electronic signal corresponding to the input signal. The processing unit acquires the concentration of the target object according to the electronic signal.
摘要翻译：提供了用于测试流体中目标物体的浓度的连续测试装置。连续测试装置包括第一芯片，信号源和第二芯片。第一芯片包括分离单元和反应单元。分离单元将目标物体与流体中的非目标物体分离。反应单元使得分离出非目标物体的流体能够与试剂反应。信号源提供通过与试剂反应的流体的信号。布置在第一芯片的一侧的第二芯片包括信号转换元件和处理单元。信号转换元件接收通过流体的信号并输出与输入信号相对应的电子信号。处理单元根据电子信号获取目标物体的浓度。

6. 发明申请

US20090137947A1 System and method of wireless physiological signal integration 有权
标题翻译：无线生理信号整合的系统与方法
公开(公告)号：US20090137947A1
公开(公告)日：2009-05-28
申请号：US12291876
申请日：2008-11-14
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
IPC分类号： A61M5/00
CPC分类号： A61B5/4839 , A61B5/0002 , A61B5/0006 , A61B5/021 , A61B5/02438 , A61B5/0476 , A61B5/145 , A61B5/14532 , A61B5/1486 , A61B5/14865 , G06F19/00 , G06F19/3468
摘要： A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.
摘要翻译：提供无线生理信号整合的系统。该系统包括无线传输传感器芯片和药物递送系统，其中无线传输传感器芯片包括感测患者的生理信号的传感器，将生理信号转换为转换信号的信号转换模块以及无线传输模块发送转换的信号，并且药物递送系统根据转换的信号确定药物的剂量和提供药物的定时。

7. 发明授权

US08921075B2 Method of manufacturing nanoparticle chain 有权
标题翻译：制造纳米颗粒链的方法
公开(公告)号：US08921075B2
公开(公告)日：2014-12-30
申请号：US13488748
申请日：2012-06-05
申请人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
发明人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12P19/34 , C12Q1/6834 , C12Q2525/151 , C12Q2525/307 , C12Q2563/155
摘要： A method of manufacturing a nanoparticle chain is disclosed. The method comprises the steps of: providing a single-stranded circular primer with a determined length, and amplifying the single-stranded circular primer into single-stranded DNA nanotemplate by an isothermal nucleotide amplification reaction such that an end of the single-stranded DNA nanotemplate is fixed to a surface of a substrate; and adding a single-stranded DNA probe conjugated with nanoparticle at one end of which, and attaching the single-stranded DNA probe to the corresponding sequence on the single-stranded DNA nanotemplate to form a nanoparticles chain. The method of manufacturing a nanoparticle chain further comprises providing a fluid, and the flowing direction of the fluid controls the aligning direction of the nanoparticle chain. Wherein, the inter-nanoparticle distance of the nanoparticle chain can be adjusted by adjusting a reaction temperature or adding the single-stranded DNA probe without conjugating with nanoparticles.
摘要翻译：公开了一种制造纳米颗粒链的方法。该方法包括以下步骤：提供具有确定长度的单链环状引物，并通过等温核苷酸扩增反应将单链环状引物扩增成单链DNA纳米模板，使得单链DNA纳米模板的末端固定在基板的表面上; 并在其一端加入与纳米颗粒缀合的单链DNA探针，并将单链DNA探针连接到单链DNA纳米模板上的相应序列上以形成纳米颗粒链。制造纳米颗粒链的方法还包括提供流体，流体的流动方向控制纳米颗粒链的排列方向。其中，可以通过调节反应温度或加入单链DNA探针而不与纳米颗粒共轭来调节纳米颗粒链的纳米颗粒间距离。

8. 发明授权

US08808229B2 System and method of wireless physiological signal integration 有权
标题翻译：无线生理信号整合的系统与方法
公开(公告)号：US08808229B2
公开(公告)日：2014-08-19
申请号：US12291876
申请日：2008-11-14
申请人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
发明人： Yuh-Shyong Yang , Ming-Yu Lin , Kuei-Shin Tsai , Wen-Ying Chang , Chih-Heng Lin , Jo-Fen Wei
IPC分类号： A61M31/00 , A61B5/00 , G06F19/00 , A61B5/021 , A61B5/145 , A61B5/024 , A61B5/1486 , A61B5/0476
CPC分类号： A61B5/4839 , A61B5/0002 , A61B5/0006 , A61B5/021 , A61B5/02438 , A61B5/0476 , A61B5/145 , A61B5/14532 , A61B5/1486 , A61B5/14865 , G06F19/00 , G06F19/3468
摘要： A system of a wireless physiological signal integration is provided. The system includes a wireless transmission sensor chip and a drug delivering system, wherein the wireless transmission sensor chip includes a sensor sensing a physiological signal of a patient, a signal conversion module converting the physiological signal into a converted signal, and a wireless transmission module wirelessly transmitting the converted signal, and the drug delivering system determines a dose of a drug and a timing for providing the drug according to the converted signal.
摘要翻译：提供无线生理信号整合的系统。该系统包括无线传输传感器芯片和药物递送系统，其中无线传输传感器芯片包括感测患者的生理信号的传感器，将生理信号转换为转换信号的信号转换模块以及无线传输模块发送转换的信号，并且药物递送系统根据转换的信号确定药物的剂量和提供药物的定时。

9. 发明申请

US20130273610A1 Method of Manufacturing Nanoparticle Chain 有权
标题翻译：制造纳米粒子链的方法
公开(公告)号：US20130273610A1
公开(公告)日：2013-10-17
申请号：US13488748
申请日：2012-06-05
申请人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
发明人： Yen-Pei Lu , Ming-Yu Lin , Yu-Sheng Lai , Yuh-Shyong Yang , Hsuen-Li Chen , Yu-Cheng Ou
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C12Q1/6834 , C12Q2525/151 , C12Q2525/307 , C12Q2563/155
摘要： A method of manufacturing a nanoparticle chain is disclosed. The method comprises the steps of: providing a single-stranded circular primer with a determined length, and amplifying the single-stranded circular primer into single-stranded DNA nanotemplate by an isothermal nucleotide amplification reaction such that an end of the single-stranded DNA nanotemplate is fixed to a surface of a substrate; and adding a single-stranded DNA probe conjugated with nanoparticle at one end of which, and attaching the single-stranded DNA probe to the corresponding sequence on the single-stranded DNA nanotemplate to form a nanoparticles chain. The method of manufacturing a nanoparticle chain further comprises providing a fluid, and the flowing direction of the fluid controls the aligning direction of the nanoparticle chain. Wherein, the inter-nanoparticle distance of the nanoparticle chain can be adjusted by adjusting a reaction temperature or adding the single-stranded DNA probe without conjugating with nanoparticles.
摘要翻译：公开了一种制造纳米颗粒链的方法。该方法包括以下步骤：提供具有确定长度的单链环状引物，并通过等温核苷酸扩增反应将单链环状引物扩增成单链DNA纳米模板，使得单链DNA纳米模板的末端固定在基板的表面上; 并在其一端加入与纳米颗粒缀合的单链DNA探针，并将单链DNA探针连接到单链DNA纳米模板上的相应序列上以形成纳米颗粒链。制造纳米颗粒链的方法还包括提供流体，流体的流动方向控制纳米颗粒链的排列方向。其中，可以通过调节反应温度或加入单链DNA探针而不与纳米颗粒共轭来调节纳米颗粒链的纳米颗粒间距离。

10. 发明申请

US20130210110A1 Method for Changing Surface Properties of a Substrate from Immobilized Biomolecules 有权
标题翻译：从固定化生物分子改变底物表面性质的方法
公开(公告)号：US20130210110A1
公开(公告)日：2013-08-15
申请号：US13437340
申请日：2012-04-02
申请人： Ming-Yu Lin , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
发明人： Ming-Yu Lin , Yuh-Shyong Yang , Yen-Pei Lu , Chih-Heng Lin
IPC分类号： C12N11/16 , C07K14/195 , C07K14/00
CPC分类号： C12N11/14
摘要： A method that modifies surface properties of a substrate by manipulating the immobilized biomolecules in mild biological condition. The manipulation comprised steps of: providing a biomolecule combined with at least one ssDNA combined with a first protein through an affinity binding tag; adding a second ssDNA conjugated with a second protein with a concentration greater than that of the first protein; and replacing the first protein on the ssDNA with the second protein through chemical competitive principle. The invention may comprise the steps with proper design of biotinylated DNA probes, the functionalized ssDNA nanotemplates can be recovered to its unbound state through a thermodynamic principle.
摘要翻译：通过在温和的生物学条件下操纵固定化的生物分子来修饰底物的表面性质的方法。操作包括以下步骤：通过亲和结合标签提供与至少一种与第一蛋白质组合的ssDNA组合的生物分子; 加入与第二种蛋白质缀合的第二种ssDNA，其浓度大于第一种蛋白质的浓度; 并通过化学竞争原理用ssDNA替代第二个蛋白质上的第一个蛋白质。本发明可以包括具有适当设计生物素化DNA探针的步骤，功能化的ssDNA纳米模板可以通过热力学原理回收到其未结合状态。

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