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1. 发明专利

HK1047449A1 用於基因轉移的病毒包膜載體未知
公开(公告)号：HK1047449A1
公开(公告)日：2003-02-21
申请号：HK02108562
申请日：2002-11-27
申请人： ANGES MG INC , YASUFUMI KANEDA
发明人： YASUFUMI KANEDA
IPC分类号： C12N20060101 , A61K48/00 , C12N7/04 , C12N15/87 , C12N15/88

2. 发明专利

TWI303663B 去活化病毒外套膜 INACTIVATED VIRUS ENVELOPE 有权
公开(公告)号：TWI303663B
公开(公告)日：2008-12-01
申请号：TW090102208
申请日：2001-02-02
申请人：金田安史 YASUFUMI KANEDA , 安增生MG股份有限公司 ANGES MG, INC.
发明人：金田安史 YASUFUMI KANEDA
IPC分类号： C12N , A61K
CPC分类号： C12N7/00 , A61K48/00 , C12N15/87 , C12N15/88 , C12N2710/16663 , C12N2760/18823 , C12N2760/18861 , C12N2760/18863
摘要：本發明係關於一種藉凍結融解處理或與界面活性劑混合而將外來基因導入去活化病毒外套膜,以製備基因導入用載體。本發明尚提供含有該基因導入用載體之基因治療用醫藥組合物,含有該基因導入用載體之套組,以及使用該基因導入用載體之基因導入方法。
简体摘要：本发明系关于一种藉冻结融解处理或与界面活性剂混合而将外来基因导入去活化病毒外套膜,以制备基因导入用载体。本发明尚提供含有该基因导入用载体之基因治疗用医药组合物,含有该基因导入用载体之套组,以及使用该基因导入用载体之基因导入方法。

3. 发明申请

US20130071920A1 Mesenchymal Stem Cell Attractant and Method for Attracting Mesenchymal Stem Cell 有权
标题翻译：间充质干细胞吸引剂和诱导间充质干细胞的方法
公开(公告)号：US20130071920A1
公开(公告)日：2013-03-21
申请号：US13700844
申请日：2011-03-11
申请人： Keiko Kitamura , Yuta Inami , Koichi Nakaoji , Kazuhiko Hamada , Akito Maeda , Tadashi Furumoto , Yasufumi Kaneda , Katsuto Tamai
发明人： Keiko Kitamura , Yuta Inami , Koichi Nakaoji , Kazuhiko Hamada , Akito Maeda , Tadashi Furumoto , Yasufumi Kaneda , Katsuto Tamai
IPC分类号： C12N5/071 , C12N5/07
CPC分类号： A61K36/60 , A61K36/185 , A61K36/47 , A61K36/65 , A61K36/736 , A61K36/74 , C12N5/0662 , C12N5/0663
摘要： The present invention aims to provide a mesenchymal stem cell attractant capable of attracting a mesenchymal stem cell; and others. The present invention provides a mesenchymal stem cell attractant containing at least one selected from the group consisting of an extract of a Bodhi tree, an extract of the root bark of Paeonia suffruticosa Andrews, an extract of Mallotus philippinensis, an extract of Uncaria gambir an extract of Pashanbheda, and an extract of a plant belonging to the genus Prunus.
摘要翻译：本发明旨在提供能够吸引间充质干细胞的间充质干细胞引诱剂; 和别的。本发明提供了含有至少一种选自菩提树提取物，芍药提取物，芍药提取物，马齿苋提取物，乌贼属提取物的提取物的间充质干细胞引诱剂（Pashanbheda），以及属于李属（Prunus）属的植物提取物。

4. 发明授权

US07939504B2 Method of treating skin ulcers with vectors encoding hepatocyte growth factor 有权
标题翻译：用编码肝细胞生长因子的载体治疗皮肤溃疡的方法
公开(公告)号：US07939504B2
公开(公告)日：2011-05-10
申请号：US11763361
申请日：2007-06-14
申请人： Ryuichi Morishita , Kuniaki Nakanishi , Yasufumi Kaneda , Hitoshi Kotani
发明人： Ryuichi Morishita , Kuniaki Nakanishi , Yasufumi Kaneda , Hitoshi Kotani
IPC分类号： A01N43/04 , A01N65/00 , A61K31/70 , A61K48/00
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译：本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。

5. 发明申请

US20090269850A1 Mutant Paramyxovirus and Method for Production Thereof 有权
标题翻译：突变型副粘病毒及其生产方法
公开(公告)号：US20090269850A1
公开(公告)日：2009-10-29
申请号：US12085355
申请日：2006-11-24
申请人： Yasufumi Kaneda , Katsuto Tamai , Kotaro Saga , Masako Kawachi
发明人： Yasufumi Kaneda , Katsuto Tamai , Kotaro Saga , Masako Kawachi
IPC分类号： C12N15/86 , C12N7/01 , C12N5/10 , C07K14/00 , C07K16/00 , C07H21/02 , C07H21/04
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/30 , C07K2319/33 , C12N15/1131 , C12N15/86 , C12N2310/14 , C12N2760/18821 , C12N2760/18822 , C12N2760/18843 , C12N2760/18845 , C12N2810/859
摘要： The present invention provides a modified paramyxovirus containing a reduced amount of receptor-binding protein compared with the wild type; a method of preparing a modified paramyxovirus, comprising the following steps: (1) a step for introducing a nucleic acid that suppresses the expression of a receptor-binding protein of a paramyxovirus into an animal cell, (2) a step for infecting the paramyxovirus to the cell, and (3) a step for isolating paramyxovirus particles replicated in the cell; and a modified paramyxovirus prepared by the method of preparation mentioned above.The present invention also provides a chimera protein wherein a fusion protein of a virus has been joined or bound to a peptide that binds specifically to a cell surface marker; a nucleic acid that encodes the chimera protein; an animal cell capable of expressing the chimera protein on the cell surface thereof; a modified paramyxovirus expressing the chimera protein on the virus particle surface thereof; and a method of preparing a tissue targeting paramyxovirus, comprising: (1) a step for supplying a nucleic acid that encodes a chimera protein wherein a fusion protein of a virus has been joined or bound to a peptide that binds specifically to a cell surface marker of the target cells, (2) a step for introducing the nucleic acid supplied in (1) into an animal cell in an expressible state, and expressing the same, (3) a step for infecting a paramyxovirus to the cell, and (4) a step for isolating paramyxovirus particles replicated in the cell.
摘要翻译：本发明提供了与野生型相比含有减少量的受体结合蛋白的修饰的副粘病毒; 一种制备修饰的副粘病毒的方法，包括以下步骤：（1）将抑制副粘病毒的受体结合蛋白的表达的核酸引入动物细胞的步骤，（2）感染副粘病毒的步骤（3）用于分离复制在细胞中的副粘病毒颗粒的步骤; 和通过上述制备方法制备的修饰的副粘病毒。本发明还提供一种嵌合体蛋白，其中病毒的融合蛋白已经与特异性结合于细胞表面标记的肽结合或结合; 编码嵌合蛋白的核酸; 能够在其细胞表面上表达嵌合体蛋白质的动物细胞; 在病毒颗粒表面上表达嵌合体蛋白质的修饰的副粘病毒; 以及制备组织靶向副粘病毒的方法，包括：（1）提供编码嵌合体蛋白的核酸的步骤，其中病毒的融合蛋白已经结合或与特异性结合于细胞表面标记的肽结合的靶细胞，（2）将（1）中提供的核酸以可表达状态引入动物细胞中并表达其的步骤，（3）感染细胞的副粘病毒的步骤，（4 ）分离在细胞中复制的副粘病毒颗粒的步骤。

6. 发明申请

US20090224854A1 ACOUSTIC WAVE FILTER 失效
标题翻译：声波滤波器
公开(公告)号：US20090224854A1
公开(公告)日：2009-09-10
申请号：US12397719
申请日：2009-03-04
申请人： Kouta OHKUBO , Yasufumi Kaneda
发明人： Kouta OHKUBO , Yasufumi Kaneda
IPC分类号： H03H9/00
CPC分类号： H03H9/02637 , H03H9/0057 , H03H9/6473 , H03H9/6476
摘要： An acoustic wave filter includes a piezoelectric substrate, an IDT (interdigital transducer) formed on the piezoelectric substrate, and reflectors located at both sides of the IDT and composed of electrode fingers, at least one of the electrode fingers of at least one of the reflectors including at least one gap within a propagation path of an acoustic wave.
摘要翻译：声波滤波器包括压电基片，形成在压电基片上的IDT（叉指式换能器）和位于IDT两侧并由电极指构成的反射器，至少一个反射器的电极指中的至少一个包括在声波的传播路径内的至少一个间隙。

7. 发明申请

US20070287677A1 Rad51 Expression Inhibitors, Pharmaceutical Agents Containing The Inhibitors As Active Ingredients, And Uses Thereof 审中-公开
标题翻译： Rad51表达抑制剂，含有作为活性成分的抑制剂的药剂及其用途
公开(公告)号：US20070287677A1
公开(公告)日：2007-12-13
申请号：US10594659
申请日：2005-03-30
申请人： Yasufumi Kaneda
发明人： Yasufumi Kaneda
IPC分类号： A61K31/70 , A61K31/28 , A61P43/00 , C07D239/42 , C07H21/04 , C12N15/00 , C12N5/08
CPC分类号： A61K31/282 , A61K31/7088 , A61K33/24 , A61K45/06 , C12N15/113 , C12N2310/14 , A61K2300/00
摘要： A double stranded RNA having a specific nucleotide sequence is useful for treating cellular proliferative disorders. The double stranded RNA acts as siRNA against the Rad51 gene. The double stranded RNA of the present invention inhibits cellular proliferation itself. In addition, co-administration of the double stranded RNA with a chemotherapeutic agent further enhances its pharmacological effect. The combined use of the double stranded RNA with an agent having a nucleic acid synthesis-inhibitory activity or a nucleic acid-impairing activity is particularly effective.
摘要翻译：具有特异性核苷酸序列的双链RNA可用于治疗细胞增殖性疾病。双链RNA作为针对Rad51基因的siRNA。本发明的双链RNA本身抑制细胞增殖。此外，双链RNA与化学治疗剂的共同给药进一步增强其药理作用。双链RNA与具有核酸合成抑制活性或核酸损害活性的试剂的组合使用是特别有效的。

8. 发明申请

US20070281888A1 Gene Promoting Vascular Endothelial Cell Growth 有权
标题翻译：基因促进血管内皮细胞生长
公开(公告)号：US20070281888A1
公开(公告)日：2007-12-06
申请号：US10593518
申请日：2005-03-17
申请人： Tomoyuki Nishikawa , Hironori Nakagami , Yasufumi Kaneda
发明人： Tomoyuki Nishikawa , Hironori Nakagami , Yasufumi Kaneda
IPC分类号： A61K38/18 , A61K31/7052 , A61P43/00 , A61P5/00 , C07H21/00 , C07K14/00 , C12N15/00 , C12N15/63 , C12N15/87 , C12N5/08
CPC分类号： C12N15/86 , A61K31/7088 , A61K38/00 , A61K48/00 , C07K14/515 , C07K14/52 , C12N2760/18643 , C12N2760/18671
摘要： It is intended to provide a novel polypeptide having an activity of growing vascular endothelial cells, an activity of promoting transcription form c-fos promoter, an activity of promoting transciption from VEGF promoter and/or an angiogenic activity; a polynucleotide encoding this polypeptide; the above polypeptide and/or a pharmaceutical composition containing the polypeptide for treating a disease selected from the group consisting of obstructive arteriosclerosis, Buerger's disease, peripheral vascular disorder, angina, myocardial infraction, brain infarction, ischemic heart disease and ischemic brain disease; a method of treating these diseases; and an antibacterial composition. The above problems can be solved by isolating a novel peptide having the above-described activities and a nucleotide encoding this peptide.
摘要翻译：旨在提供具有生长血管内皮细胞活性的新型多肽，促进c-fos启动子转录的活性，促进VEGF启动子的转录活性和/或血管生成活性的活性; 编码该多肽的多核苷酸; 上述多肽和/或含有治疗选自以下的疾病多肽的药物组合物：阻塞性动脉硬化，Buerger氏病，外周血管病症，心绞痛，心肌梗死，脑梗塞，缺血性心脏病和缺血性脑病; 一种治疗这些疾病的方法; 和抗菌组合物。通过分离具有上述活性的新肽和编码该肽的核苷酸可以解决上述问题。

9. 发明申请

US20070264321A1 METHOD OF TREATING SKIN WOUNDS WITH VECTORS ENCODING HEPATOCYTE GROWTH FACTOR 有权
标题翻译：用编码肝细胞生长因子的向量处理皮肤伤口的方法
公开(公告)号：US20070264321A1
公开(公告)日：2007-11-15
申请号：US11763361
申请日：2007-06-14
申请人： Ryuichi Morishita , Kuniaki Nakanishi , Yasufumi Kaneda , Hitoshi Kotani
发明人： Ryuichi Morishita , Kuniaki Nakanishi , Yasufumi Kaneda , Hitoshi Kotani
IPC分类号： A61K31/711 , A61K9/127 , A61P17/02 , C12N15/63
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译：本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。

10. 发明授权

US07291904B2 Downsized package for electric wave device 有权
标题翻译：电波装置小型封装
公开(公告)号：US07291904B2
公开(公告)日：2007-11-06
申请号：US11115253
申请日：2005-04-27
申请人： Takashi Matsuda , Suguru Warashina , Masanori Ueda , Osamu Kawachi , Yasufumi Kaneda
发明人： Takashi Matsuda , Suguru Warashina , Masanori Ueda , Osamu Kawachi , Yasufumi Kaneda
IPC分类号： H01L23/02 , H01L23/06 , H01L23/48 , H01L23/52 , H03H9/10
CPC分类号： H03H9/1071 , H01L2224/05568 , H01L2224/05573 , H01L2224/16225 , H01L2924/00014 , H01L2924/15174 , H01L2924/15184 , H03H9/0071 , H03H9/059 , H03H9/1078 , H01L2224/05599
摘要： A package substrate includes signal pads provided on a main surface of the package substrate, footpads provided on a backside of the package substrate, and a sealing electrode provided on the main surface to surround the signal pads, the signal pads being electrically coupled to the footpads, the sealing electrode being insulated from the footpads.
摘要翻译：封装衬底包括设置在封装衬底的主表面上的信号焊盘，设置在封装衬底的背面上的脚垫和设置在主表面上以围绕信号焊盘的密封电极，信号焊盘电耦合到脚垫密封电极与脚垫绝缘。

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