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1. 发明专利

HK1209203A1 SYSTEMS AND METHODS FOR GENERATING BIOMARKER SIGNATURES WITH INTEGRATED BIAS CORRECTION AND CLASS PREDICTION 未知
公开(公告)号：HK1209203A1
公开(公告)日：2016-03-24
申请号：HK15109834
申请日：2015-10-08
申请人： PHILIP MORRIS PRODUCTS SA , FLORIAN MARTIN , YANG XIANG
发明人： MARTIN FLORIAN , XIANG YANG
IPC分类号： G06F20060101
摘要： Described herein are systems and methods for correcting a data set and classifying the data set in an integrated manner. A training data set, a training class set, and a test data set are received. A first classifier is generated for the training data set by applying a machine learning technique to the training data set and the training class set, and a first test class set is generated by classifying the elements in the test data set according to the first classifier. For each of multiple iterations, the training data set is transformed, the test data set is transformed, and a second classifier is generated by applying a machine learning technique to the transformed training data set. A second test class set is generated according to the second classifier, and the first test class set is compared to the second test class set.

2. 发明专利

HK1209863A1 SYSTEMS AND METHODS FOR GENERATING BIOMARKER SIGNATURES WITH INTEGRATED DUAL ENSEMBLE AND GENERALIZED SIMULATED ANNEALING TECHNIQUES 未知
公开(公告)号：HK1209863A1
公开(公告)日：2016-04-08
申请号：HK15110399
申请日：2015-10-22
申请人： PHILIP MORRIS PRODUCTS SA , YANG XIANG , JULIA HOENG , FLORIAN MARTIN
发明人： XIANG YANG , HOENG JULIA , MARTIN FLORIAN
IPC分类号： G06F20060101
摘要： Described herein are systems and methods for classifying a data set using an ensemble classification technique. Classifiers are iteratively generated by applying machine learning techniques to a training data set, and training class sets are generated by classifying the elements in the training data set according to the classifiers. Objective values are computed based on the training class sets, and objective values associated with different classifiers are compared until a desired number of iterations is reached, and a final training class set is output.

3. 发明专利

HK1209202A1 SYSTEMS AND METHODS FOR GENERATING BIOMARKER SIGNATURES 未知
公开(公告)号：HK1209202A1
公开(公告)日：2016-03-24
申请号：HK15109833
申请日：2015-10-08
申请人： PHILIP MORRIS PRODUCTS SA , YANG XIANG , JULIA HOENG
发明人： XIANG YANG , JULIA HOENG
IPC分类号： G06F20060101
摘要： The systems and methods described herein include a technique for generating both reproducible and interpretable gene signatures. The technique involves resampling a data set and choosing genes having a high frequency of emergence. In particular, the systems and methods described herein include repeated sampling of data sets, ranking genes based on frequency of occurrence in gene signatures generated through the repeated sampling process, and iteratively selecting the best gene signature.

4. 发明申请

WO2007064941A2 ANGIOGENIC TYROSYL TRNA SYNTHETASE COMPOSITIONS AND METHODS 审中-公开
标题翻译：抗原型酪氨酸TRNA合成酶组合物及方法
公开(公告)号：WO2007064941A2
公开(公告)日：2007-06-07
申请号：PCT/US2006046106
申请日：2006-12-01
申请人： SCRIPPS RESEARCH INST , YANG XIANG-LEI
发明人： YANG XIANG-LEI
IPC分类号： C12N9/22
CPC分类号： C12N9/93
摘要： The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an 14 coil. Preferably, the 5 coil and the 14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50 % compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue substitution relative to the amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the 5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof. The proteins and protein fragments of the invention are angiogenic and are useful for stimulating angiogenesis in mammalian tissues.
摘要翻译：本发明提供了分离的酪氨酰tRNA合成酶（TyrRS）多肽变体，其包含（a）Rossmann折叠区域或其部分，优选包括5个线圈; 和（b）反密码子识别结构域或其部分，优选包含14个线圈。优选地，与天然人类TyrRS中相应的空间分离相比，5线圈和14线圈在变体的三级结构中具有更大的空间分离。与人TyrRS（SEQ ID NO：3）的氨基酸残基序列相比，该变体优选包含至少约50％的氨基酸残基序列同一性，包括相对于氨基酸至少一个非保守氨基酸残基取代人TyrRS的残基序列，并且优选在5线圈中在多肽的三级结构的外部部分上暴露的ELR基序。优选的TyrRS蛋白质变体包含SEQ ID NO：4的氨基酸残基序列或其部分。本发明的蛋白质和蛋白质片段是血管生成的并且可用于刺激哺乳动物组织中的血管发生。

5. 发明申请

WO2016070175A1 FUNCTIONAL POLYMERS 审中-公开
标题翻译：功能聚合物
公开(公告)号：WO2016070175A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/058596
申请日：2015-11-02
申请人： THE UNIVERSITY OF AKRON , PUGH, Coleen , WRIGHT, Colin , SHERGER, Carolyn , YANG, Xiang , ZHANG, Zheng , WANG, Zewei
发明人： PUGH, Coleen , WRIGHT, Colin , SHERGER, Carolyn , YANG, Xiang , ZHANG, Zheng , WANG, Zewei
IPC分类号： C08G63/682
CPC分类号： C08G63/6822 , C08G63/682 , C08G63/91 , C08G63/912
摘要： Methods of functionalizing α-halogenated hydroxy acid-based polymers and coupling α-halogenated hydroxy acid-based polymers are provided. Suitable α-halogenated hydroxy acid-based polymers include α-halogenated polyesters and α-halogenated acrylate-based inimers. Methods include coupling α-halogenated polyesters and functionalizing α-halogenated polyesters without polymer cleavage. Certain α-halogenated hydroxy acid-based polymers may be functionalized, crosslinked or, intiate polymerization by inducing the α-halogenated hydroxy acid-based polymers to make a dioxolenium ion intermediate. The α-halogenated hydroxy acid-based polymers may also be functionalized using a radical trap.
摘要翻译：提供了官能化α-卤代羟基酸类聚合物和偶联α-卤代羟基酸类聚合物的方法。合适的α-卤代羟基酸类聚合物包括α-卤代聚酯和α-卤代丙烯酸酯基异构体。方法包括偶联α-卤代聚酯和官能化α-卤代聚酯，无聚合物裂解。某些α-卤代羟基酸类聚合物可以通过引入α-卤代羟基酸类聚合物来制备二氧杂环戊离子中间体而被官能化，交联或引发聚合。 α-卤代羟基酸基聚合物也可以使用自由基捕获剂官能化。

6. 发明申请

WO2011097031A2 MONOMERIC FORMS OF HUMAN AMINOACYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 审中-公开
标题翻译：具有非常规生物活性的人体氨酰基-TruNA合成的单体形式
公开(公告)号：WO2011097031A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/000210
申请日：2011-02-04
申请人： THE SCRIPPS RESEARCH INSTITUTE , SCHIMMEL, Paul , YANG, Xiang-lei
发明人： SCHIMMEL, Paul , YANG, Xiang-lei
IPC分类号： A61K38/45
CPC分类号： C12N9/93 , A61K38/45 , C07K16/1045 , C07K16/40 , C12Y601/01 , C12Y601/01001 , C12Y601/01002 , C12Y601/01006 , Y02A50/473
摘要： Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译：提供了分离的单体氨酰-tRNA合成酶多肽和具有非规范生物学活性的多核苷酸，以及与其相关的组合物和方法。

7. 发明申请

WO2011097031A3 MONOMERIC FORMS OF HUMAN AMINOACYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES 审中-公开
标题翻译：具有非经济生物活性的人类氨基甲酰基合成酶的单体形式
公开(公告)号：WO2011097031A3
公开(公告)日：2011-10-06
申请号：PCT/US2011000210
申请日：2011-02-04
申请人： SCRIPPS RESEARCH INST , SCHIMMEL PAUL , YANG XIANG-LEI , SLIKE BONNIE , XU XIAOLING , GUO MIN
发明人： SCHIMMEL PAUL , YANG XIANG-LEI , SLIKE BONNIE , XU XIAOLING , GUO MIN
IPC分类号： C12N9/14
CPC分类号： C12N9/93 , A61K38/45 , C07K16/1045 , C07K16/40 , C12Y601/01 , C12Y601/01001 , C12Y601/01002 , C12Y601/01006
摘要： Isolated monomelic aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto.
摘要翻译：提供了分离的单体氨酰-tRNA合成酶多肽和具有非规范生物活性的多核苷酸，以及与其相关的组合物和方法。

8. 发明申请

WO2011071541A3 CADHERIN MODULATORY AGENTS 审中-公开
标题翻译： CADHERIN调节剂
公开(公告)号：WO2011071541A3
公开(公告)日：2011-12-29
申请号：PCT/US2010003155
申请日：2010-12-13
申请人： SCRIPPS RESEARCH INST , YANG XIANG-LEI
发明人： YANG XIANG-LEI
IPC分类号： A61K31/40
CPC分类号： A61K31/711
摘要： Compositions are provided comprising agents such as small molecules that modulate the biological activity of cadherins, the angiostatic activity of tryptophanyl-tRNA synthetases (WRS), or both. Also provided are methods of using such compositions for modulating cadherin-mediated activities, such as angiogenesis, and for treating conditions associated with these activities.
摘要翻译：提供的组合物包含诸如调节钙粘蛋白的生物活性的小分子，色氨酰-tRNA合成酶（WRS）的血管抑制活性或二者的试剂。还提供了使用这样的组合物来调节钙粘蛋白介导的活性例如血管生成以及用于治疗与这些活动相关的病症的方法。

9. 发明申请

WO2011071541A2 CADHERIN MODULATORY AGENTS 审中-公开
标题翻译： CADHERIN调节剂
公开(公告)号：WO2011071541A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/003155
申请日：2010-12-13
申请人： THE SCRIPPS RESEARCH INSTITUTE , YANG, Xiang-Lei
发明人： YANG, Xiang-Lei
IPC分类号： A61K31/711
CPC分类号： A61K31/711
摘要： Compositions are provided comprising agents such as small molecules that modulate the biological activity of cadherins, the angiostatic activity of tryptophanyl-tRNA synthetases (WRS), or both. Also provided are methods of using such compositions for modulating cadherin-mediated activities, such as angiogenesis, and for treating conditions associated with these activities.
摘要翻译：提供组合物，其包含调节钙粘着蛋白的生物活性，色氨酰-tRNA合成酶（WRS）的血管生成抑制活性或两者的试剂例如小分子。还提供了使用这些组合物调节钙粘蛋白介导的活性（例如血管生成）和治疗与这些活性相关的病症的方法。

10. 发明申请

WO2007064941A3 ANGIOGENIC TYROSYL TRNA SYNTHETASE COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2007064941A3
公开(公告)日：2007-06-07
申请号：PCT/US2006/046106
申请日：2006-12-01
申请人： THE SCRIPPS RESEARCH INSTITUTE , YANG, Xiang-Lei
发明人： YANG, Xiang-Lei
IPC分类号： C12Q1/68
摘要： The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably including an 14 coil. Preferably, the 5 coil and the 14 coil have a greater spatial separation in the tertiary structure of the variant compared to the corresponding spatial separation in native human TyrRS. The variant preferably comprises an amino acid residue sequence identity of at least about 50 % compared to the amino acid residue sequence of human TyrRS (SEQ ID NO: 3), includes at least one non-conservative amino acid residue substitution relative to the amino acid residue sequence of human TyrRS, and preferably presents an exposed ELR motif in the 5 coil on an external portion of the tertiary structure of the polypeptide. A preferred TyrRS protein variant comprises the amino acid residue sequence of SEQ ID NO: 4 or a portion thereof. The proteins and protein fragments of the invention are angiogenic and are useful for stimulating angiogenesis in mammalian tissues.

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