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1. 发明申请

WO2006069133A3 IONIC DRUG-DETERGENT COMPLEXES 审中-公开
标题翻译：离子洗脱剂复合物
公开(公告)号：WO2006069133A3
公开(公告)日：2008-03-27
申请号：PCT/US2005046309
申请日：2005-12-19
申请人： ALZA CORP , WONG PATRICK S L , YAN DONG
发明人： WONG PATRICK S L , YAN DONG
IPC分类号： A61K47/48
CPC分类号： A61K9/19 , A61K9/146 , A61K9/1647 , A61K47/541
摘要： Disclosed herein are substances that include a complex that includes a drug moiety ionically bound to a counter-ion; wherein a solubility of the complex is greater than a solubility of the drug moiety. Also disclosed are compositions and dosage forms made from such substances and complexes; methods of making compositions, substances, and complexes; and methods of administering the same to patients.
摘要翻译：本文公开了包括复合物的物质，其包括与抗衡离子离子结合的药物部分; 其中所述络合物的溶解度大于所述药物部分的溶解度。还公开了由这些物质和配合物制成的组合物和剂型; 制备组合物，物质和配合物的方法; 以及将其用于患者的方法。

2. 发明申请

WO2005041926A1 COMPOSITIONS AND DOSAGE FORMS FOR ENHANCED ABSORPTION OF 3-AMINO-N-BUTYL-PHOSPHINIC ACID 审中-公开
标题翻译：用于增强吸收3-氨基-N-丁基 - 磷酸的组合物和剂型
公开(公告)号：WO2005041926A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/036041
申请日：2004-10-29
申请人： ALZA CORPORATION , WONG, Patrick, S., L. , YAN, Dong , LAM, Andrew , HWANG, Stephen , GUITTARD, George, V.
发明人： WONG, Patrick, S., L. , YAN, Dong , LAM, Andrew , HWANG, Stephen , GUITTARD, George, V.
IPC分类号： A61K9/00
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： Disclosed are substances, compositions, dosage forms and methods relating to drugs including 3-aminopropyl-n-butyl-phosphinic acid; structural homologs thereof; 3-aminopropyl-n-butyl-phosphinic acid complexes; complexes that comprise structural homologs of 3-aminopropyl-n-butyl-phosphinic acid; pharmaceutically acceptable salts of 3-aminopropyl-n-butyl-phosphinic acid or structural homologs thereof; and mixtures of the above.
摘要翻译：公开的是涉及包括3-氨基丙基 - 正丁基 - 次膦酸的药物的物质，组合物，剂型和方法; 其结构同系物; 3-氨基丙基 - 正丁基 - 次膦酸络合物; 包含3-氨基丙基 - 正丁基 - 次膦酸的结构同系物的复合物; 3-氨基丙基 - 正丁基次膦酸的药学上可接受的盐或其结构同系物; 和上述的混合物。

3. 发明申请

WO2005041925A2 COMPOSITIONS AND DOSAGE FORMS FOR ENHANCED ABSORPTION 审中-公开
标题翻译：增强吸收的组合物和剂型
公开(公告)号：WO2005041925A2
公开(公告)日：2005-05-12
申请号：PCT/US2004/036040
申请日：2004-10-29
申请人： ALZA CORPORATION , GUITTARD, George, V. , WONG, Patrick, S., L. , YAN, Dong
发明人： WONG, Patrick, S., L. , YAN, Dong
IPC分类号： A61K9/00
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： Disclosed is controlled delivery of pharmaceutical agents and methods, dosage forms and devices therefore. In particular, formulation, dosage forms, methods and devices for enhanced absorption and controlled delivery drug compounds are disclosed.
摘要翻译：公开了药剂的控制递送和因此的方法，剂型和装置。具体而言，公开了用于增强吸收和控释递送药物化合物的制剂，剂型，方法和装置。

4. 发明申请

WO2005041923A1 COMPOSITIONS AND DOSAGE FORMS FOR ENHANCED ABSORPTION OF METFORMIN 审中-公开
标题翻译：用于增强金属吸收的组合物和剂型
公开(公告)号：WO2005041923A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/036038
申请日：2004-10-29
申请人： ALZA CORPORATION , WONG, Patrick, S., L. , YAN, Dong , GUITTARD, George, V.
发明人： WONG, Patrick, S., L. , YAN, Dong , GUITTARD, George, V.
IPC分类号： A61K9/00
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： A complex comprised of metformin and a transport moiety, such as a fatty acid, is described. The complex has an enhanced absorption in the gastrointestinal tract, particularly the lower gastrointestinal tract. The complex, and compositions and dosage forms prepared using the complex, provide for absorption by the body of the drug through a period of ten to twenty-four hours, thus enabling a once-daily dosage form for metformin.
摘要翻译：描述了由二甲双胍和运输部分组成的复合物，例如脂肪酸。该复合物在胃肠道，特别是下胃肠道中具有增强的吸收。使用复合物制备的复合物，组合物和剂型可以使药物的体内吸收十到二十四小时，从而能够每日一次的二甲双胍剂型。

5. 发明申请

WO2022047692A1 CONTAINER COMPRISING LAMINATE OF POLYETHYLENE 审中-公开
公开(公告)号：WO2022047692A1
公开(公告)日：2022-03-10
申请号：PCT/CN2020/113202
申请日：2020-09-03
申请人： THE PROCTER & GAMBLE COMPANY , CHENG, Zhan , ZHOU, Lei , RONG, Jiashao , YAN, Dong
发明人： CHENG, Zhan , ZHOU, Lei , RONG, Jiashao , YAN, Dong
IPC分类号： B32B27/32 , C08J5/18 , B29C55/12 , B29C55/04 , B29C55/18 , B65D30/02 , B32B27/30 , B65D30/08
摘要： A container comprising a laminate is provided, wherein the laminate comprises a first layer of machine direction oriented polyethylene (MDO-PE), a second layer of biaxial oriented polyethylene (BO-PE), and a third layer of polyethylene (PE).

6. 发明申请

WO2010078429A1 PHARMACEUTICAL DOSAGE FORMS AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：药物剂型及其制备方法
公开(公告)号：WO2010078429A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069824
申请日：2009-12-30
申请人： IMPAX LABORATORIES, INC. , YAN, Dong , SIEW, Lee, Foong , TING, Richard , CHEN, Tzu-Yuan , PAWAR, Mahendra, Sudhakar
发明人： YAN, Dong , SIEW, Lee, Foong , TING, Richard , CHEN, Tzu-Yuan , PAWAR, Mahendra, Sudhakar
IPC分类号： A61K31/216
CPC分类号： A61K31/216 , A61K9/14 , A61K9/1652 , A61K9/1676 , A61K9/2077 , A61K9/2081 , A61K9/5078
摘要： The invention provides solid dispersions of at least one insoluble active pharmaceutical ingredient, pharmaceutical dosage forms comprising the solid dispersions, and methods of manufacturing same. In an embodiment, a solid dispersion of the present invention includes a plurality of coated particles comprising inert particles with a coating, wherein the coating comprises an insoluble active pharmaceutical ingredient dispersed in a hydrophilic polymer, and wherein the inert particles comprise nonpareils; and a plurality of granules comprising an insoluble active pharmaceutical ingredient with at least one pharmaceutically acceptable excipient. In an embodiment, the insoluble active pharmaceutical ingredient in the coating and the insoluble active pharmaceutical ingredient of the granules are the same type. A solid dispersion of the present invention may optionally be encapsulated in capsules or compressed into a tablet. Also disclosed are methods of making solid dispersions and methods of reducing plasma triglyceride and increasing high-density lipoprotein employing the solid dispersion.
摘要翻译：本发明提供至少一种不溶性活性药物成分的固体分散体，包含固体分散体的药物剂型及其制造方法。在一个实施方案中，本发明的固体分散体包括多个包含具有涂层的惰性颗粒的涂覆颗粒，其中所述涂层包含分散在亲水性聚合物中的不溶性活性药物成分，并且其中所述惰性颗粒包括非疏液剂; 以及包含不溶性活性药物成分与至少一种药学上可接受的赋形剂的多种颗粒。在一个实施方案中，包衣中的不溶性活性药物成分和颗粒的不溶性活性药物成分是相同类型的。本发明的固体分散体可任选地包封在胶囊中或压制成片剂。还公开了制备固体分散体的方法和使用固体分散体降低血浆甘油三酯和增加高密度脂蛋白的方法。

7. 发明申请

WO2006113568A8 CONTROLLED DELIVERY DOSAGE FORM OF TRAMADOL AND GABAPENTIN 审中-公开
标题翻译： TRAMADOL和GABAPENTIN的控释递送剂型
公开(公告)号：WO2006113568A8
公开(公告)日：2007-12-13
申请号：PCT/US2006014314
申请日：2006-04-13
申请人： ALZA CORP , HWANG STEPHEN S , CHAPLAN SANDRA , YAN DONG , WONG PATRICK S L , ABRAHAM DAVID
发明人： HWANG STEPHEN S , CHAPLAN SANDRA , YAN DONG , WONG PATRICK S L , ABRAHAM DAVID
IPC分类号： A61K9/00 , A61K9/20 , A61K9/48 , A61K31/135 , A61K31/197
CPC分类号： A61K31/135 , A61K9/0004 , A61K31/14 , A61K31/197 , A61K31/35 , A61K2300/00
摘要： Disclosed are substances, compositions, dosage forms and methods that comprise tramadol and substances that comprise gabapentin.
摘要翻译：公开了包含曲马多和包含加巴喷丁的物质的物质，组合物，剂型和方法。

8. 发明申请

WO2006113568A2 COMBINATION OF TRAMADOL AND SUBSTANCES THAT COMPRISE GABAPENTIN 审中-公开
标题翻译：含有卡巴醌的TRAMADOL和物质的组合
公开(公告)号：WO2006113568A2
公开(公告)日：2006-10-26
申请号：PCT/US2006/014314
申请日：2006-04-13
申请人： ALZA CORPORATION , WONG, Patrick, S., L. , HWANG, Stephen S. , CHAPLAN, Sandra , YAN, Dong , ABRAHAM, David
发明人： HWANG, Stephen S. , CHAPLAN, Sandra , YAN, Dong , ABRAHAM, David
IPC分类号： A61K9/00 , A61K9/20 , A61K9/48 , A61K31/135 , A61K31/197
CPC分类号： A61K31/135 , A61K9/0004 , A61K31/14 , A61K31/197 , A61K31/35 , A61K2300/00
摘要： Disclosed are substances, compositions, dosage forms and methods that comprise tramadol and substances that comprise gabapentin.
摘要翻译：公开了包含曲马多和包含加巴喷丁的物质的物质，组合物，剂型和方法。

9. 发明申请

WO2005041924A3 ADMINISTRATION OF LEVODOPA AND CARBIDOPA 审中-公开
标题翻译：莱维多和卡比洛的管理
公开(公告)号：WO2005041924A3
公开(公告)日：2005-11-10
申请号：PCT/US2004036039
申请日：2004-10-29
申请人： ALZA CORP , WONG PATRICK S L , YAN DONG , HWANG STEPHEN , GUITTARD GEORGE V
发明人： WONG PATRICK S L , YAN DONG , HWANG STEPHEN , GUITTARD GEORGE V
IPC分类号： A61K9/00 , A61K9/127 , A61K9/20 , A61K9/22 , A61K9/24 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/205 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/48 , B65D88/76 , C07C53/126 , C07C229/08 , C07C229/28 , C07C229/34 , C07C279/00 , A61P3/10
CPC分类号： A61K31/662 , A61K9/0004 , A61K31/155 , A61K31/185 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/20 , A61K31/295 , A61K31/66 , A61K33/26 , A61K47/541 , A61K47/585 , A61K2300/00
摘要： Disclosed are substances, compositions, dosage forms and methods that comprise levodopa and/or carbidopa.
摘要翻译：公开了包含左旋多巴和/或卡比多巴的物质，组合物，剂型和方法。

10. 发明申请

WO2002092832A2 HUMAN AND NON-HUMAN PRIMATE HOMOLOGUES OF NKD PROTEIN, NUCLEIC ACID SEQUENCES ENCODING, AND USES THEREOF 审中-公开
标题翻译： NKD蛋白质的人类和非人类初始HOMOLOGY，核酸序列编码及其用途
公开(公告)号：WO2002092832A2
公开(公告)日：2002-11-21
申请号：PCT/US2001/044092
申请日：2001-11-27
申请人： CHIRON CORPORATION , ROHAN, Michael , CHAN, Vivien , YAN, Dong
发明人： ROHAN, Michael , CHAN, Vivien , YAN, Dong
IPC分类号： C12Q
CPC分类号： C07K14/4702 , A61K38/00
摘要： A novel protein and corresponding DNA involved in Wnt signaling is taught. Antibodies, antisense and ribozymes that target expression of this protein are also provided. Therapies and detection methods ivolve detecting and regulating expression of this protein are further provided.
摘要翻译：教导了一种涉及Wnt信号传导的新型蛋白质和相应的DNA。还提供了靶向该蛋白表达的抗体，反义和核酶。进一步提供了检测和调节该蛋白表达的疗法和检测方法。

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