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1. 发明申请

WO2012142325A1 COMBINATION OF MOTESANIB, A TAXANE AND A PLATINUM-CONTAINING ANTI-CANCER DRUG FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER IN A POPULATION SUBSET 审中-公开
标题翻译：用于治疗人群中非小细胞肺癌的莫桑比克，一种泰素和含铂的抗癌药物的组合
公开(公告)号：WO2012142325A1
公开(公告)日：2012-10-18
申请号：PCT/US2012/033376
申请日：2012-04-12
申请人： AMGEN INC. , HEI, Yong-Jiang , YAO, Bin
发明人： HEI, Yong-Jiang , YAO, Bin
IPC分类号： A61K31/337 , A61K31/395 , A61K31/555 , A61P35/00
CPC分类号： A61K33/24 , A61K31/337 , A61K31/444 , A61K31/555 , A61K2300/00
摘要： The present invention provides a method of improving survival associated with cancer in a subset of the general population. The invention provides a method of improving survival associated with cancer in patients of Asian ethnic background. In addition, the present application relates to the treatment of angiogenesis related disease in an Asian patient with kinase inhibitors. In addition the present application relates to the treatment of non-small cell lung cancer in an Asian patient with motesanib.
摘要翻译：本发明提供了在一般群体的子集中改善与癌症相关的存活的方法。本发明提供了一种在亚洲种族背景下改善与癌症相关的存活的方法。此外，本申请涉及在具有激酶抑制剂的亚洲患者中治疗血管生成相关疾病。此外，本申请涉及在具有motesanib的亚洲患者中治疗非小细胞肺癌。

2. 发明申请

WO2011143635A3 APPARATUS, SYSTEMS AND METHODS FOR PRODUCING CUSHIONING MATERIAL 审中-公开
公开(公告)号：WO2011143635A3
公开(公告)日：2011-11-17
申请号：PCT/US2011/036548
申请日：2011-05-13
申请人： CHAN, Simon C., S. , YONG, Jiang, Wen , NUEVOPAK INTERNATIONAL LIMITED
发明人： CHAN, Simon C., S. , YONG, Jiang, Wen
IPC分类号： B31D5/00
摘要： A dunnage machine and system, and a method of producing dunnage. The dunnage machine can have rotatable forming members with recesses formed thereon. Stationary protruding members can extend into the recesses. A cutting system is provided for cutting dunnage produced by the dunnage machine or system, and a lock mechanism is also provided for locking the cutting system when a cover is removed from the dunnage machine.

3. 发明申请

WO2011143635A2 APPARATUS, SYSTEMS AND METHODS FOR PRODUCING CUSHIONING MATERIAL 审中-公开
标题翻译：装饰材料的制造，系统和方法
公开(公告)号：WO2011143635A2
公开(公告)日：2011-11-17
申请号：PCT/US2011036548
申请日：2011-05-13
申请人： CHAN SIMON C S , YONG JIANG WEN , NUEVOPAK INTERNAT LTD
发明人： CHAN SIMON C S , YONG JIANG WEN
IPC分类号： B31B1/00
CPC分类号： B31D5/0043 , B31D5/0047 , B31D2205/0047 , B31D2205/0058 , B31D2205/007 , B31D2205/0076 , B31D2205/0094
摘要： A dunnage machine and system, and a method of producing dunnage. The dunnage machine can have rotatable forming members with recesses formed thereon. Stationary protruding members can extend into the recesses. A cutting system is provided for cutting dunnage produced by the dunnage machine or system, and a lock mechanism is also provided for locking the cutting system when a cover is removed from the dunnage machine.
摘要翻译：垫料机和系统，以及生产垫料的方法。垫料机可以具有形成在其上的凹部的可旋转成形构件。固定突出构件可延伸到凹槽中。提供了一种用于切割垫料机或系统产生的垫料的切割系统，并且还提供了一种锁定机构，用于当盖子从垫料机器移除时用于锁定切割系统。

4. 发明申请

WO2005042496A1 (BENZIMIDAZOL-2-YL)-PHENYL-BENZYL-AMINE DERIVATIVES AND METHODS FOR INHIBITING HEPARANASE ACTIVITY 审中-公开
标题翻译：（苯并咪唑-2-基） - 苯基 - 苯胺衍生物及其抑制HEPARANASE活性的方法
公开(公告)号：WO2005042496A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034672
申请日：2004-10-21
申请人： IMCLONE SYSTEMS INCORPORATED , LIU, Hu , PAN, Weitao , XU, Yong-Jiang
发明人： LIU, Hu , PAN, Weitao , XU, Yong-Jiang
IPC分类号： C07D235/18
CPC分类号： C07D401/14 , C07D235/14 , C07D235/16 , C07D235/30 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention encompasses heparanase inhibitors, particularly to certain (benzimidazol-2-yl)-phenyl-benzyl-amine derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and methods of treating heparanase-dependent diseases and conditions in mammals by administering a therapeutically effective amount of the compounds to the mammals.
摘要翻译：本发明包括乙酰肝素酶抑制剂，特别是抑制乙酰肝素酶的某些（苯并咪唑-2-基） - 苯基 - 苄基 - 胺衍生物，含有这些化合物的药物组合物，制备该化合物的方法，以及治疗乙酰肝素酶依赖性疾病的方法和哺乳动物通过向哺乳动物施用治疗有效量的化合物的条件。

5. 发明申请

WO2003052194A1 MIST IRON 审中-公开
标题翻译： MIST铁
公开(公告)号：WO2003052194A1
公开(公告)日：2003-06-26
申请号：PCT/IB2002/005122
申请日：2002-12-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , WONG, Nyik, S. , YONG, Jiang , GUO, Tao , ASOK S/O KASEVAN, Kumar
发明人： WONG, Nyik, S. , YONG, Jiang , GUO, Tao , ASOK S/O KASEVAN, Kumar
IPC分类号： D06F75/22
CPC分类号： D06F75/22 , D06F75/10
摘要： An iron comprising a housing (1), a heatable soleplate (4) and means for generating very fine liquid droplets to be expelled from at least one discharge opening (9) of the iron, said means comprising at least one air passage (8) for pressurized air supply and at least one liquid passage (13) for pressurized liquid supply, said air passage (8) and said liquid passage (13) communicating with each other for mixing air and liquid, said mixture of air and liquid being supplied to the discharge opening (9). To improve the generation of fine liquid droplets (mist) an outlet of the liquid passage (8) ends into the air passage (13) upstream of the discharge opening (9) to introduce liquid into the air passage and an outlet of the air passage is provided with a nozzle (10) having said discharge opening (9). Preferably the pressurized air and liquid supply is obtained by means of electric pumps (6,7). The liquid may be water or a (diluted) additive liquid.
摘要翻译：一种熨斗，包括壳体（1），可加热底板（4）和用于产生要从铁的至少一个排放开口（9）排出的非常细的液滴的装置，所述装置包括至少一个空气通道（8）用于加压空气供应和用于加压液体供应的至少一个液体通道（13），所述空气通道（8）和所述液体通道（13）彼此连通以混合空气和液体，所述空气和液体混合物供应到排出口（9）。为了改善细液滴（雾）的产生，液体通道（8）的出口在排出口（9）的上游端部进入空气通道（13），以将液体引入空气通道和空气通道的出口设置有具有所述排出口（9）的喷嘴（10）。优选地，加压空气和液体供应通过电动泵（6,7）获得。液体可以是水或（稀释的）添加剂液体。

6. 发明申请

WO2011070088A1 ANTI-C4.4A ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗C4.4A抗体及其用途
公开(公告)号：WO2011070088A1
公开(公告)日：2011-06-16
申请号：PCT/EP2010/069216
申请日：2010-12-08
申请人： BAYER SCHERING PHARMA AKTIENGESELLSCHAFT , LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
发明人： LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译：本发明提供重组抗原结合区和抗体以及含有对多个肿瘤中过表达的膜锚定的29kDa C4,4a多肽具有特异性的此类抗原结合区的功能片段。肺，结肠直肠，胰腺，前列腺，肾和乳腺癌。因此，这些抗体可用于治疗这些和其他病症和病症。本发明的抗体也可用于诊断领域，以及用于进一步研究C4.4a在与癌症相关的疾病进展中的作用。本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。

7. 发明申请

WO2005042495A1 (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY 审中-公开
标题翻译：（苯并咪唑-2-基） - 苯基 - 苯基脲化合物及其抑制HEPARANASE活性的方法
公开(公告)号：WO2005042495A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034671
申请日：2004-10-21
申请人： IMCLONE SYSTEMS INCORPORATED , LIU, Hu , PAN, Weitao , XU, Yong-Jiang
发明人： LIU, Hu , PAN, Weitao , XU, Yong-Jiang
IPC分类号： C07D235/18
CPC分类号： C07D235/18
摘要： The present invention encompasses heparanase inhibitors, particularly to certain (benzimidazol-2-yl)-phenyl-phenyl-urea derivatives that inhibit heparanase, pharmaceutical compositions that contain the compounds, methods for making the compounds, and methods of treating heparanase-dependent diseases and conditions in mammals by administering a therapeutically effective amount of the compounds to the mammals.
摘要翻译：本发明包括乙酰肝素酶抑制剂，特别是抑制乙酰肝素酶的某些（苯并咪唑-2-基） - 苯基 - 苯基 - 脲衍生物，含有该化合物的药物组合物，制备该化合物的方法，以及治疗乙酰肝素酶依赖性疾病的方法和哺乳动物通过向哺乳动物施用治疗有效量的化合物的条件。

8. 发明授权

US10144005B2 Catalysts 有权
公开(公告)号：US10144005B2
公开(公告)日：2018-12-04
申请号：US14343174
申请日：2011-09-08
申请人： Richard William Kemp , Ronald Hage , Wei Zhao , Jianrong Zhang , Yong Jiang , Hong Xie
发明人： Richard William Kemp , Ronald Hage , Wei Zhao , Jianrong Zhang , Yong Jiang , Hong Xie
IPC分类号： B01J31/26 , C07F13/00 , B01J31/22
摘要： The present invention concerns the synthesis of dry powdered manganese complexes using spray-drying or freeze-drying methods.

9. 发明申请

US20170076422A1 METHODS AND APPARATUS TO SUPPORT DYNAMIC ADJUSTMENT OF GRAPHICS PROCESSING UNIT FREQUENCY 审中-公开
标题翻译：支持图形处理单元频率的动态调整的方法和装置
公开(公告)号：US20170076422A1
公开(公告)日：2017-03-16
申请号：US15122108
申请日：2014-03-27
申请人： Lei Shen , Guei-Yuan Lueh , Yong Jiang , lntel Corporation
发明人： Lei Shen , Guei-Yuan Lueh , Yong Jiang
IPC分类号： G06T1/60 , G06F9/50 , G06T1/20 , G06F1/32
CPC分类号： G06T1/60 , G06F1/324 , G06F1/3243 , G06F1/3296 , G06F8/451 , G06F9/505 , G06T1/20 , Y02D10/126 , Y02D10/152
摘要： Disclosed methods support dynamic adjustment of graphics processing unit (GPU) frequency. According to one embodiment, a program comprises workload to execute, at least in part, on a GPU of a data processing system. A predetermined memory/compute ratio for the program is automatically retrieved, in response to the program being called for execution. The memory/compute ratio represents a ratio of memory accesses within the program, relative to compute operations within the program. In addition, a frequency of the GPU is automatically adjusted, based on the predetermined memory/compute ratio for the program. For instance, the GPU may be set to a relatively low frequency if the predetermined memory/compute ratio is relatively high, or to a relatively high frequency if the predetermined ratio is relatively low. After the frequency of the GPU is automatically adjusted, the program may execute, at least in part, on the GPU. Other embodiments are described and claimed.
摘要翻译：公开的方法支持图形处理单元（GPU）频率的动态调整。根据一个实施例，程序包括至少部分地在数据处理系统的GPU上执行的工作负载。响应于要执行的程序，自动检索程序的预定存储器/计算比。存储器/计算比率表示程序内存储器访问的比率，相对于程序内的计算操作。此外，基于程序的预定存储器/计算比率，自动调整GPU的频率。例如，如果预定的存储器/计算比率相对较高，则GPU可以被设置为相对低的频率，或者如果预定比率相对较低，则可以将其设置为相对较低的频率。在GPU的频率被自动调整之后，该程序可以至少部分地在GPU上执行。描述和要求保护其他实施例。

10. 发明申请

US20150095896A1 RUNTIME DISPATCHING AMONG A HETEROGENEOUS GROUP OF PROCESSORS 有权
标题翻译：在异质性处理器组中的运行时间分配
公开(公告)号：US20150095896A1
公开(公告)日：2015-04-02
申请号：US13977315
申请日：2012-05-30
申请人： Yong Jiang , Ruijia Li , Lei Shen
发明人： Yong Jiang , Ruijia Li , Lei Shen
IPC分类号： G06F9/45 , G06F9/48
CPC分类号： G06F9/5094 , G06F8/52 , G06F9/4552 , G06F9/4881 , G06F9/505 , Y02D10/22
摘要： Systems, apparatus, articles, and methods are described including operations for runtime dispatching among a heterogeneous group of processors.
摘要翻译：描述了系统，装置，物品和方法，其包括在异构处理器组之间的运行时调度的操作。

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