专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2020264137A1 RECOMBINANT TRANSFER VECTORS FOR PROTEIN EXPRESSION IN INSECT AND MAMMALIAN CELLS 审中-公开
公开(公告)号：WO2020264137A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039584
申请日：2020-06-25
申请人： X-CHEM, INC.
发明人： LITOVCHICK, Alexander , CHANDRAN, Ragunath , VON RECHENBERG, Moritz , CUOZZO, John
IPC分类号： C12N15/63 , C12N15/86
摘要： Described herein are recombinant vectors and methods for their use in expressing recombinant proteins in both insect and mammalian cells. The invention is based on recombinant transfer vectors that enable expression of one or more transgenes to be directed by an insect cell-competent promoter and a mammalian cell-competent promoter, both present within a single expression cassette in the vector, and active conditional on the host cell.

2. 发明申请

WO2014012010A1 DNA-ENCODED LIBRARIES HAVING ENCODING OLIGONUCLEOTIDE LINKAGES NOT READABLE BY POLYMERASES 审中-公开
标题翻译：编码未经POLYMERASES读取的寡核苷酸连接的DNA编码的文库
公开(公告)号：WO2014012010A1
公开(公告)日：2014-01-16
申请号：PCT/US2013/050303
申请日：2013-07-12
申请人： X-CHEM, INC.
发明人： KEEFE, Anthony, D. , LITOVCHICK, Alexander , CLARK, Matthew, A.
IPC分类号： C40B40/06
CPC分类号： C12N15/1065 , C12N15/1044 , C12N15/1068 , C12Q1/6869 , C12Q2563/179 , C12Q2565/514
摘要： The present invention relates to complexes of oligonucleotide-encoded libraries and methods of tagging and using such libraries. In particular, the oligonucleotides and methods can include complexes having at least one linkage for which a polymerase has reduced ability to read or translocate through.
摘要翻译：本发明涉及寡核苷酸编码的文库的复合物以及标记和使用这些文库的方法。特别地，寡核苷酸和方法可以包括具有至少一个连接的复合物，聚合酶具有降低的读取或移位的能力。

3. 发明申请

WO2010094036A1 METHODS OF CREATING AND SCREENING DNA-ENCODED LIBRARIES 审中-公开
标题翻译：创建和筛选DNA编码图书馆的方法
公开(公告)号：WO2010094036A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/024314
申请日：2010-02-16
申请人： X-CHEM, INC. , WAGNER, Richard, W.
发明人： WAGNER, Richard, W.
IPC分类号： C40B40/08 , C40B70/00
CPC分类号： C12N15/1065 , C07H21/00 , C12N15/1068 , C40B40/04 , C40B40/06 , C40B40/08 , C40B50/06 , C40B70/00
摘要： The present invention features a number of methods for identifying one or more compounds that bind to a biological target. The methods include synthesizing a library of compounds, wherein the compounds contain a functional moiety having one or more diversity positions. The functional moiety of the compounds is operatively linked to an initiator oligonucleotide that identifies the structure of the functional moiety.
摘要翻译：本发明的特征在于用于鉴定结合生物靶标的一种或多种化合物的许多方法。所述方法包括合成化合物文库，其中化合物含有具有一个或多个多样性位置的官能部分。化合物的功能部分可操作地连接到识别功能部分结构的引发剂寡核苷酸。

4. 发明申请

WO2018195134A1 METHODS FOR IDENTIFYING COMPOUNDS 审中-公开
公开(公告)号：WO2018195134A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028050
申请日：2018-04-18
申请人： X-CHEM, INC.
发明人： SIGEL, Eric, Alan , XUE, Ling , MULHERN, Christopher, James , MOCCIA, Dennis, Joseph
IPC分类号： C07H21/00 , C40B40/10 , G06F19/16 , G06F19/18 , G06F19/28
摘要： The present disclosure provides virtual screening methods utilizing data sets from nucleotide-encoded libraries (e.g., DNA-encoded libraries). These methods allow for high confidence predictions of binding interactions between candidate compounds and proteins of interest useful for the development of therapeutics.

5. 发明申请

WO2021050555A1 COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2021050555A1
公开(公告)日：2021-03-18
申请号：PCT/US2020/049956
申请日：2020-09-09
申请人： X-CHEM, INC.
发明人： ZHANG, Ying , LEE, Esther, C.y. , MCRINER, Andrew, J. , HUPP, Christopher, D.
IPC分类号： C07D261/18 , C07D267/14 , C07D403/12
摘要： The present invention relates to compositions and methods for the treatment of disorders that lead to accumulation of oxalate, such as primary hyperoxaluria 1.

6. 发明申请

WO2016109423A8 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 审中-公开
公开(公告)号：WO2016109423A8
公开(公告)日：2016-07-07
申请号：PCT/US2015/067667
申请日：2015-12-28
申请人： X-CHEM, INC.
发明人： KEEFE, Anthony, D. , LITOVCHICK, Alexander , CLARK, Matthew , WAGNER, Richard W.
IPC分类号： C07H21/02
摘要： The present invention relates to methods for producing encoded chemical entities. In particular, the oligonucleotides and methods can include encoded chemical entities having wild-type linkages formed through chemical ligation techniques. The present invention relates to an oligonucleotide tagging strategy that utilizes wild-type linkages (e.g., phosphodiester linkages) derived from oligonucleotide pairs bearing 5'-monophospho and 3'-hydroxy termini and also from 5'-hydroxy and 3'-monophospho termini using cvanoimidazole and Zn 2+ which provides relatively high yields. This chemical ligation method is template-dependent and permits the use of orthogonal 3'- and 5'-phosohates resulting in a high degree of control over the sequential ligation of encoding oligonucleotides with a low rate of misincorporation or miscoding, including in a double-stranded context.

7. 发明申请

WO2016109423A1 METHODS FOR TAGGING DNA-ENCODED LIBRARIES 审中-公开
标题翻译：标记DNA编码的图书馆的方法
公开(公告)号：WO2016109423A1
公开(公告)日：2016-07-07
申请号：PCT/US2015/067667
申请日：2015-12-28
申请人： X-CHEM, INC.
发明人： KEEFE, Anthony, D. , LITOVCHICK, Alexander , CLARK, Matthew , WAGNER, Richard, W.
IPC分类号： C07H21/02
CPC分类号： C12N15/1065 , C07H1/00 , C07H21/02 , C12N15/1068
摘要： The present invention relates to methods for producing encoded chemical entities. In particular, the oligonucleotides and methods can include encoded chemical entities having wild-type linkages formed through chemical ligation techniques. One strategy that can be utilized that simultaneously takes advantage of chemical ligation as a means to encode chemical history, while also retaining the ability of polymerases to directly recover tag sequence and association information, is to perform chemical ligation in a manner that generates wildtype phosphodiester linkages. Such methods generally utilize condensing agents such as cyanogen bromide or similar along with 5'-phosphate and 3'-hydroxyl oligonucleotides in a double-stranded or templated context. Similarly cyanogen bromide has also been shown to chemically ligate pairs of substrate oligonucleotides that are 5'-hydroxyl and 3'-phosphate. However, these methods suffer from poor efficiency making them ill-suited for use in an iterative process such as tagging DNA-encoded libraries.
摘要翻译：本发明涉及生产编码化学实体的方法。特别地，寡核苷酸和方法可以包括具有通过化学连接技术形成的野生型连接的编码化学实体。可以同时利用化学连接作为编码化学历史的手段的一种策略，同时保留聚合酶直接回收标签序列和缔合信息的能力是以产生野生型磷酸二酯键的方式进行化学连接。这样的方法通常在双链或模板化环境中使用缩合剂如溴化氰或类似物以及5'-磷酸和3'-羟基寡核苷酸。类似地，溴化氰也被证明化学连接了5'-羟基和3'-磷酸的底物寡核苷酸对。然而，这些方法的效率差，使得它们不适合用于迭代过程，例如标记DNA编码的文库。

8. 发明申请

WO2021050688A1 COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：WO2021050688A1
公开(公告)日：2021-03-18
申请号：PCT/US2020/050142
申请日：2020-09-10
申请人： X-CHEM, INC.
发明人： LEE, Esther, C. Y. , MCRINER, Andrew J. , HUPP, Christopher D. , KOHLMANN, Anna , EYERMANN, Charles Joseph
IPC分类号： C12N15/113 , C12N15/90 , C12N9/22
摘要： The present invention relates to compositions and methods for the treatment of HA01 -associated disorders, such as primary hyperoxaluria 1.

9. 发明申请

WO2021016525A1 METHODS FOR TAGGING AND ENCODING OF PRE-EXISTING COMPOUND LIBRARIES 审中-公开
公开(公告)号：WO2021016525A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/043419
申请日：2020-07-24
申请人： X-CHEM, INC.
发明人： KEEFE, Anthony, D. , CHEN, Zhen
IPC分类号： C12N15/10 , C04B50/04 , C04B70/00
摘要： The present disclosure relates to methods of encoding pre-existing compounds with oligonucleotide tags. In particular, libraries of pre-existing compounds are tagged with oligonucleotides in order to encode identifying information, thereby improving methods of screening and identifying compounds having a desired property.

10. 发明申请

WO2017190048A1 COVALENT BTK INHIBITORS AND USES THEREOF 审中-公开
标题翻译：共价BTK抑制剂及其用途
公开(公告)号：WO2017190048A1
公开(公告)日：2017-11-02
申请号：PCT/US2017/030185
申请日：2017-04-28
申请人： X-CHEM, INC.
发明人： CLARK, Matthew , KEEFE, Anthony, D. , GUILINGER, John , ZHANG, Ying , TIAN, Xia
IPC分类号： A61K47/10 , A61K31/505
摘要： The present invention features compounds having BTK inhibitory activity. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing various medical conditions, such as cardiovascular diseases, respiratory diseases, inflammation, and diabetes.
摘要翻译：本发明的特征在于具有BTK抑制活性的化合物。本发明化合物单独或与其它药物活性剂组合可用于治疗或预防各种医学病症，例如心血管疾病，呼吸系统疾病，炎症和糖尿病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式