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1. 发明申请

WO2015158700A1 MORPHOGENETICALLY ACTIVE HYDROGEL FOR BIOPRINTING OF BIOARTIFICIAL TISSUE 审中-公开
标题翻译：用于生物生物组织的形态活性水凝胶
公开(公告)号：WO2015158700A1
公开(公告)日：2015-10-22
申请号：PCT/EP2015/058042
申请日：2015-04-14
申请人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
发明人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
IPC分类号： C12N5/00 , C12N5/077 , A61L27/36
CPC分类号： C12M33/00 , A61L27/20 , A61L27/26 , A61L27/306 , A61L27/32 , A61L27/38 , A61L27/3847 , A61L27/52 , A61L2430/02 , B29C64/106 , B33Y10/00 , C12N5/0012 , C12N5/0062 , C12N2533/10 , C12N2533/50 , C12N2533/54 , C12N2533/74 , C08L5/04 , C08L89/06
摘要： The invention relates to a combined system for three-dimensional (3D) bioprinting, based on encapsulating of cells into an alginate hydrogel or alginate/gelatin hydrogel, followed by an overlay comprising a morphogenetically active polymer, polyphosphate-calcium complex or biosilica, providing a useful matrix for the cells, including bone-forming cells, to proliferate and be become functionally active, for example, bone cells to mineralize.
摘要翻译：本发明涉及用于三维（3D）生物印刷的组合系统，其基于将细胞包封在藻酸盐水凝胶或藻酸盐/明胶水凝胶中，随后是包含形态发生活性的聚合物，聚磷酸盐 - 钙络合物或生物二烯的覆盖物，包括骨形成细胞在内的细胞的有用基质增殖并变得功能活性，例如骨细胞成矿。

2. 发明申请

WO2005001972A2 VERFAHREN ZUM VORWÄRMEN MINDESTENS EINER BRENNSTOFFZELLE EINES BRENNSTOFFZELLENSYSTEMS, INSBESONDERE EINES HOCHTEMPERATUR-BRENNSTOFFZELLENSYSTEMS EINES FAHRZEUGS, UND ENTSPRECHENDES BRENNSTOFFZELLENSYSTEM 审中-公开
标题翻译：方法预热至少一个燃料电池系统的燃料电池，特别是高温车辆的燃料电池系统和对应的燃料电池系统
公开(公告)号：WO2005001972A2
公开(公告)日：2005-01-06
申请号：PCT/EP2004/006751
申请日：2004-06-23
申请人： AUDI AG , WILHELM, Friedrich , ROMBA, Marcus
发明人： WILHELM, Friedrich , ROMBA, Marcus
IPC分类号： H01M8/04
CPC分类号： H01M8/04302 , H01M8/04014 , H01M8/04223
摘要： Das Verfahren dient zum Vorwärmen mindestens einer Brennstoffzelle (13) eines Brennstoffzellensystems (10), insbesondere eines Hochtemperatur-Brennstoffzellensystems eines Fahrzeugs, auf eine vorgebbare Betriebstemperatur und zum anschliessenden Inbetriebnehmen derselben Brennstoffzelle (13). Hierbei sind folgende Verfahrensschritte vorgesehen: - Erwärmen eines gasförmigen Vorwärmmittelstroms der Brennstoffzelle (13) in einer Gasversorgungseinheit (14) insbesondere mittels mindestens einer Vorwärmmittelverdichtung; - Zuführen des erwärmten Vorwärmmittels in die nicht zur Stromerzeugung in Betrieb stehende Brennstoffzelle (13) bis zur Erzielung einer hinreichenden Betriebstemperatur; - Inbetriebnehmen der vorgewärmten Brennstoffzelle (13) zur Stromerzeugung mittels mindestens eines Betriebsmittelstroms (20,48).
摘要翻译：该过程被用于车辆的高温燃料电池系统的预热的燃料电池系统（10）的至少一个燃料电池（13），特别是预定的工作温度和随后的调试相同的燃料电池（13）。这里，提供了以下方法步骤： - 通过至少一个Vorwärmmittelverdichtung来加热的气态Vorwärmmittelstroms在特别是燃气供给单元（14）的燃料电池（13）; - 喂入加热后的预热侧未用于发电的燃料电池（13），以达到足够的操作温度操作; - 通过至少一个工作介质流（20,48）的装置起动预热的燃料电池（13）以产生电力。

3. 发明申请

WO2000003963A1 METHOD FOR OXIDISING CYCLOHEXANE IN GAS PHASE BY MEANS OF SOLID MICRO- AND MESOPOROUS CATALYSTS 审中-公开
标题翻译： PROCESS氧化环己烷气相采用固体微孔和介孔催化剂
公开(公告)号：WO2000003963A1
公开(公告)日：2000-01-27
申请号：PCT/EP1999004891
申请日：1999-07-10
申请人： STUDIENGESELLSCHAFT KOHLE MBH , MAIER, Wilhelm, Friedrich , HUNNIUS, Matthias
发明人： STUDIENGESELLSCHAFT KOHLE MBH
IPC分类号： C07C27/12
CPC分类号： C07C29/50 , B01J19/0053 , B01J19/02 , B01J2219/00094 , C07C45/33 , C07C2601/14 , C07C49/403 , C07C35/08
摘要： The invention relates to a one-step catalytic method for selective oxidation of cyclohexane with atmospheric oxygen for producing cyclohexanol and cyclohexanone. The inventive method comprises using amorphous microporous catalysts as well as mesoporous catalysts with different transition metal ions as active centre in a continuously operated reactor, in the gas phase under high pressure.
摘要翻译：本发明涉及一种用于环己烷与氧气环己醇和环己酮的制备中选择性氧化的单级催化方法。所述方法包括使用无定形微孔的，并具有不同的过渡金属离子作为在连续操作的反应器中在升高的压力活性中心在气相中孔催化剂。

4. 发明申请

WO2005068108A1 GIESSMASCHINE 审中-公开
标题翻译：脚轮
公开(公告)号：WO2005068108A1
公开(公告)日：2005-07-28
申请号：PCT/CH2004/000014
申请日：2004-01-14
申请人： LAMEC AG , LAUENER, Wilhelm, Friedrich , LAUENER, Martin
发明人： LAUENER, Wilhelm, Friedrich , LAUENER, Martin
IPC分类号： B22D11/06
CPC分类号： B22D11/0608 , B22D11/0657
摘要： Die vorliegende Giessmaschine sowie das ihr zugrunde liegende Raupengiessverfahren zeichnet sich dadurch aus, dass die die Giessform bildenden Blöcke (4) raupenartig um eine der Giessraupen (2;3) umlaufen und in lateraler Richtung in zusammengehaltene Elemente geteilt sind, wobei sie auf einem Transportmittel sitzend, mindestens auf einem Teil des Raupenumfanges mittels der Anziehungskraft von stationären Magneten auf dem Transportmittel gehalten werden.
摘要翻译：本铸造机以及它的底层Raupengiessverfahren的特征在于，所述腔形成块（4）珠状，浇铸毛虫中的一个（2; 3）循环并在横向方向上被分成约束元件，在运输装置被安置至少在履带周的一部分通过在传输装置中的固定磁铁的吸引力来保持。

5. 发明申请

WO9959716A3 COMBINATIONAL METHOD FOR MICROGRAM-SCALE PRODUCTION AND CHARACTERIZATION OF CRYSTALLINE AND AMORPHOUS LIBRARIES OF MATERIALS 审中-公开
标题翻译：组合方法制备和结晶和无定形材质库表征IN微克尺度
公开(公告)号：WO9959716A3
公开(公告)日：2000-01-13
申请号：PCT/EP9903287
申请日：1999-05-12
申请人： STUDIENGESELLSCHAFT KOHLE MBH , MAIER WILHELM FRIEDRICH , KLEIN JENS , LEHMANN CHRISTIAN , SCHMIDT HANS WERNER
发明人： MAIER WILHELM-FRIEDRICH , KLEIN JENS , LEHMANN CHRISTIAN , SCHMIDT HANS-WERNER
IPC分类号： B01J3/04 , B01J19/00 , B01L3/00 , C07B61/00 , C40B30/08 , C40B40/18 , C40B50/08 , C40B60/14
CPC分类号： C40B80/00 , B01J3/04 , B01J19/0046 , B01J2219/00313 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00659 , B01J2219/00745 , B01J2219/00747 , B01J2219/00754 , B01L3/5085 , B01L2300/0893 , C40B30/08 , C40B40/18 , C40B50/08 , C40B60/14
摘要： The invention relates to a method for wet chemical production of a plurality of libraries of materials consisting of solids, whereby the solids are separated from reaction mixtures in microreaction chambers on a base plate serving at the same time as substrate for the library. Depending on the material chosen for the substrate of the library, solids can be subsequently investigated in a non-destructive manner, e.g. by means of reflecting or penetrating microarea x-ray scattering. Preferably, the reactor consists of a cylindrical pressurized container made of steel having a silicon monocrystal plate as library. A steel plate with tetrafluoroethylene coating is pressed on said Si-monocrystal plate by means of screws, the holes of which form the reaction chambers.
摘要翻译：本发明涉及一种用于湿化学生产由多个固体材料库，其特征在于，将固体从反应混合物在微反应室分离在底板上，其也用作文库衬底的方法。根据材料的库基板的选择，固体随后可以检查非破坏性，例如通过反射或穿透微小区域X射线散射。优选地，所述反应器由具有单晶硅晶片作为一个库基底由钢制成的圆筒形压力容器的。通过拧紧一个Stahplatte压与这些单晶Si光盘，其代表的反应空间的孔特氟隆刀片。

6. 发明申请

WO1988004585A1 PROCESS AND DEVICE FOR COOLING ROLLERS 审中-公开
标题翻译：冷却辊的工艺和装置
公开(公告)号：WO1988004585A1
公开(公告)日：1988-06-30
申请号：PCT/CH1987000171
申请日：1987-12-14
申请人： LAUENER ENGINEERING AG , LAUENER, Wilhelm, Friedrich
发明人： LAUENER ENGINEERING AG
IPC分类号： B22D11/06
CPC分类号： F28F5/02 , B22D11/0682
摘要： In rollers, especially those used for continuous casting of strips (40) of aluminium and other metals, the coolant flows between the roller shell (7) and the roller core (8) through axial cooling channels (26). The counterflow principle is here applied, so that the coolant alternatively flows in the cooling channels (26) from one front side (41, 41 a) to the other and is discharged there. A bore divided into an axial channel (15) and into a tubular channel (16) for supplying and discharging the coolant extends from one front side of the roller (1) to the other front side. Alternating supply and discharge ducts for the cooling channels (26) that extend over the whole length of the roller core (8) are arranged in such a manner near both roller front sides that the coolant flows according to the counterflow principle. The cooling channels (26) are formed of longitudinal grooves in the core (8) and shell (7) of the roller.

7. 发明申请

WO2015132304A1 SYNERGISTIC COMPOSITION COMPRISING QUERCETIN AND POLYPHOSPHATE FOR TREATMENT OF BONE DISORDERS 审中-公开
标题翻译：包含奎类和多磷酸盐用于治疗骨质疏松症的协同组合物
公开(公告)号：WO2015132304A1
公开(公告)日：2015-09-11
申请号：PCT/EP2015/054523
申请日：2015-03-04
申请人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
发明人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
IPC分类号： A61K33/06 , A61K33/42 , A61P19/10
CPC分类号： A61K31/352 , A61K31/455 , A61K33/06 , A61K33/42 , A61K38/43 , A61K2300/00
摘要： The invention concerns a composition containing quercetin and polyphosphate that acts synergistically on bone formation compared with the bone mineralization stimulating effects of the two components alone, and the application of this composition for treatment of bone disorders like osteoporosis. The effects of the composition containing quercetin and polyphosphate can further be increased by addition of monomeric or polymeric silicate or bicarbonate/calcium carbonate.
摘要翻译：本发明涉及含有槲皮素和多磷酸盐的组合物，与单独使用两种组分的骨矿化刺激作用相比起来，其与骨形成协同作用，以及该组合物用于治疗骨质疏松症等骨骼疾病的应用。含有槲皮素和多磷酸盐的组合物的作用可以通过加入单体或聚合硅酸盐或碳酸氢盐/碳酸钙来进一步提高。

8. 发明申请

WO1997031059A1 FORMALDEHYDE-FREE BINDER FOR MOULDINGS 审中-公开
标题翻译：甲醛无粘接成型
公开(公告)号：WO1997031059A1
公开(公告)日：1997-08-28
申请号：PCT/EP1997000768
申请日：1997-02-19
申请人： BASF AKTIENGESELLSCHAFT , RECK, Bernd , WISTUBA, Eckehardt , BECKERLE, Wilhelm, Friedrich , KISTENMACHER, Axel , RUPANER, Robert , HUMMERICH, Rainer
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08L57/00
CPC分类号： C08K5/17 , B27N3/00 , C08L35/00 , C08L97/00 , Y10T428/249925 , C08L2666/26
摘要： Disclosed is the use of a formaldehyde-free aqueous binder as a binder for sustainable raw materials in the form of fibres, chips or particles for making mouldings, said binder containing: A) a polymer obtained by radical polymerisation consisting to the extent of 5 to 100 wt% of an ethylenically unsaturated acid anhydride or bicarboxylic acid, the carboxylic acid groups of which can form an anhydride group, and B) an alkanol amine with at least two hydroxyl groups.
摘要翻译：使用不含甲醛的水性粘合剂，其包括A）通过自由基聚合的聚合物含有重量的烯属不饱和酸酐或者烯属不饱和二羧酸，其羧基可以形成酸酐的％得到的聚合物，是5〜100，和B）具有链烷醇胺的至少两个羟基基团，作为用于在纤维，碎片或用于制造模制品刨花形式的可再生原料的粘结剂。

9. 发明申请

WO1996030128A1 METHOD AND ARRANGEMENT FOR PRESERVING CAVITIES IN WORKPIECES 审中-公开
标题翻译：方法和系统进行保存孔洞工件
公开(公告)号：WO1996030128A1
公开(公告)日：1996-10-03
申请号：PCT/EP1996001221
申请日：1996-03-21
申请人： EISENMANN MASCHINENBAU KG , SIMON, Martin , WILHELM, Friedrich , MANNHERZ, Jörg , SAUM, Willi , WANKELMUTH, Hans, R.
发明人： EISENMANN MASCHINENBAU KG
IPC分类号： B05C09/14
CPC分类号： B05D7/227 , B05B13/0609 , B05B13/0627 , B05B14/00 , B05B14/40 , B05B16/20 , B05C7/04 , B05C9/14
摘要： The invention concerns a method and arrangement for preserving the cavities in workpieces using a molten material, for example wax, and is particularly suitable for preserving cavities in vehicle bodywork. The object of the invention is to develop the method and arrangement such that simpler servicing conditions, lower maintenance costs, reduced susceptibility to failure and adaptability to different workpiece sizes and shapes are possible. The novel features of the method and arrangement according to the invention are that a working chamber/immersion area (4) has a predeterminable operating temperature; the workpiece (W) is delivered to the working chamber in a correspondingly pre-tempered state; and at least some of the components guiding the preserving means are heated by the heating system for the working chamber (4). In a further development of the invention, an immersion frame (10), which holds the workpieces to be immersed, consists at least partially of standardized profiled structural sections and can thus be adapted over rapidly and in a variable manner.
摘要翻译：本发明涉及一种方法，以及用于与熔融好，例如保护工件的腔体系统蜡，和特别适用于汽车车身的空腔保护。本发明的目的是该方法和系统的形式，例如，一个简单的维修条件，降低维护成本和停机时间更少，以及变异性不同的工件的尺寸和形状中给出。新颖一个工作空间/洪水地区（4）具有对应于预加热的工作空间，以本发明的方法和系统现在供给和从加热系统承载部件至少部分地对工作空间中的防腐剂可预先确定的工作温度，所述工件（W）（4）加热。在进一步的改进中，还提供的是一个保持为驱驱框架（10）至少部分地由标准化建筑型材工件，因此是可变的并且迅速转化。

10. 发明申请

WO2016012583A1 PRINTABLE MORPHOGENETIC PHASE-SPECIFIC CHITOSAN-CALCIUM-POLYPHOSPHATE SCAFFOLD FOR BONE REPAIR 审中-公开
标题翻译：用于骨修复的可切割的形态特异性CHITOSAN-钙 - 多磷酸盐
公开(公告)号：WO2016012583A1
公开(公告)日：2016-01-28
申请号：PCT/EP2015/066979
申请日：2015-07-24
申请人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
发明人： MÜLLER, Werner Ernst Ludwig Georg , SCHRÖDER, Heinrich-Christoph Wilhelm Friedrich , WANG, Xiaohong
IPC分类号： A61L27/20 , A61L27/46 , A61L27/52 , A61L27/56 , A61L27/58 , C08L5/08
CPC分类号： A61L27/46 , A61L27/20 , A61L27/52 , A61L27/56 , A61L27/58 , A61L2430/02 , C08B37/003 , C08B37/0084 , C08L5/04 , C08L5/08 , C12N5/0654
摘要： This invention concerns a formula for the synthesis of a printable hybrid material, formed of carboxymethyl chitosan (CMC) and polyphosphate (polyP). Both polymers are linked together by calcium ions. The inventive CMC-polyP material, in combination with alginate, is biocompatible, biodegradable and useful for three-dimensional (3D) printing and 3D cell printing (bioprinting). The CMC-polyP scaffold, hardened by exposure to calcium ions, is morphogenetically active and can be used in bone tissue engineering, as a bio mimetic 3 -phase scaffold that mimics and induces essential phases in bone repair, including blood clot formation and platelet degranulation (release of growth factors and cytokines) (Phase 1: initiation phase), calcium carbonate bioseed formation (Phase 2: nucleation) and expression / activation of bone alkaline phosphatase (Phase 3: hydroxyapatite - biomineral formation).
摘要翻译：本发明涉及由羧甲基壳聚糖（CMC）和多磷酸盐（polyP）形成的可印刷杂化材料的合成配方。两种聚合物通过钙离子连接在一起。本发明的CMC-polyP材料与藻酸盐组合是生物相容的，可生物降解的并且可用于三维（3D）印刷和3D细胞印刷（生物印刷）。通过暴露于钙离子而硬化的CMC-polyP支架具有形态发生活性，可用于骨组织工程，作为模拟和诱导骨修复中必需阶段的生物模拟3-相支架，包括血块形成和血小板脱颗粒（生长因子和细胞因子的释放）（阶段1：起始阶段），碳酸钙生物体形成（阶段2：成核）和骨碱性磷酸酶的表达/活化（阶段3：羟基磷灰石 - 生物矿物形成）。

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