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1. 发明授权

US08673636B2 Method for enzymatic treatment, device and kit used the same 有权
标题翻译：酶处理方法，使用的装置和试剂盒相同
公开(公告)号：US08673636B2
公开(公告)日：2014-03-18
申请号：US13614766
申请日：2012-09-13
申请人： Ching-Chuan Jiang , Chun-Jen Liao , Wen-Hsiang Chang , Huang-Chi Chen , Wei-Ju Liao , Wen-Hsi Wang
发明人： Ching-Chuan Jiang , Chun-Jen Liao , Wen-Hsiang Chang , Huang-Chi Chen , Wei-Ju Liao , Wen-Hsi Wang
IPC分类号： A01N1/00 , C12M1/00 , A61K38/43
CPC分类号： A61M37/00 , C12M1/40 , C12M21/08 , C12M23/20 , C12M35/08 , C12N5/06
摘要： One embodiment provides a method for enzymatic treatment, including the steps of forming a closed space on a local tissue area with a device and infusing an enzyme solution into the closed space for enzymatic treatment. The method according to the embodiment is capable of treating the local tissue area with enzymes for enhancing cell proliferation in the treated tissue area and preventing damage of the adjacent normal tissues. A device and kit used for the method are also provided.
摘要翻译：一个实施方案提供了一种用于酶处理的方法，包括以下步骤：用装置在局部组织区域上形成封闭空间，并将酶溶液注入封闭空间进行酶处理。根据实施方案的方法能够用酶处理局部组织区域，以增强处理组织区域中的细胞增殖并防止相邻正常组织的损伤。还提供了用于该方法的装置和试剂盒。

2. 发明申请

US20110171715A1 BIOCOMPATIBLE POLYMER AND MAGNETIC NANOPARTICLE WITH BIOCOMPATIBILITY 审中-公开
标题翻译：可生物降解聚合物和具有生物活性的磁性纳米颗粒
公开(公告)号：US20110171715A1
公开(公告)日：2011-07-14
申请号：US12989402
申请日：2008-04-22
申请人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-1 Lin , Shian-Jy Jassy Wang , Kelly Teng
发明人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-1 Lin , Shian-Jy Jassy Wang , Kelly Teng
IPC分类号： C12N9/96 , C07F7/18 , C07K16/00 , C07K2/00 , C07H23/00 , B32B5/16 , B82Y5/00
CPC分类号： C08G65/336 , A61K49/0093 , A61K49/085 , A61K49/12 , A61K49/1848 , A61K49/186 , B82Y5/00 , C07F7/1804 , C08G65/323 , C08G65/326 , C08G65/3328 , C08G65/33306 , Y10T428/2982
摘要： The invention discloses a biocompatible polymer for covalently modifying magnetic nanoparticles. The biocompatible polymer may be coupled to a targeting agent and/or a fluorescent dye. The invention also discloses a magnetic nanoparticle with biocompatibilities comprising the biocompatible polymer.
摘要翻译：本发明公开了用于共价修饰磁性纳米颗粒的生物相容性聚合物。生物相容性聚合物可以与靶向剂和/或荧光染料偶合。本发明还公开了具有包含生物相容性聚合物的生物相容性的磁性纳米颗粒。

3. 发明申请

US20070154397A1 Thermosensitive nanostructure for hyperthermia treatment 有权
标题翻译：热敏纳米结构热疗治疗
公开(公告)号：US20070154397A1
公开(公告)日：2007-07-05
申请号：US11511464
申请日：2006-08-29
申请人： Wen Hsiang Chang , Chao-Hung Kao , Chin-I Lin , Shian-Jy Wang
发明人： Wen Hsiang Chang , Chao-Hung Kao , Chin-I Lin , Shian-Jy Wang
IPC分类号： A61K49/10
CPC分类号： A61K49/1857 , A61K9/1075 , A61K41/0052 , A61K49/1806 , B82Y5/00
摘要： A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.
摘要翻译：用于热疗治疗的热敏纳米结构。磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度（LCST）的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时，热敏聚合物纳米结构崩溃以释放药物，从而提供同时进行的药物治疗。

4. 发明申请

US20060228551A1 Core-shell structure with magnetic, thermal, and optical characteristics and manufacturing method thereof 有权
标题翻译：具有磁，热和光学特性的核 - 壳结构及其制造方法
公开(公告)号：US20060228551A1
公开(公告)日：2006-10-12
申请号：US11237681
申请日：2005-09-29
申请人： Ming-Yao Chen , Wen-Hsiang Chang , Chin-I Lin , Shian-Jy Wang , Yuh-Jiuan Lin
发明人： Ming-Yao Chen , Wen-Hsiang Chang , Chin-I Lin , Shian-Jy Wang , Yuh-Jiuan Lin
IPC分类号： B05D7/00 , B32B5/16 , B32B15/02
CPC分类号： B22F1/025 , B22F1/0018 , B22F2998/10 , B82Y25/00 , B82Y30/00 , H01F1/0054 , Y10S428/90 , Y10S977/779 , Y10T428/12181 , Y10T428/2982 , Y10T428/2991 , Y10T428/32 , Y10T428/325 , B22F1/0022 , B22F1/0088
摘要： A core-shell structure with magnetic, thermal, and optical characteristics. The optical absorption band is tailorable by choice of the mixing ratio of the core/shell component to give the desired shell thickness. The core-shell structure is particularly suitable for biomedical applications such as MRI (magnetic resonance imaging) developer, specific tissue identification developer, and magnetic thermal therapy.
摘要翻译：具有磁，热和光学特性的核 - 壳结构。通过选择芯/壳组分的混合比来获得所需的壳厚度，可以限制光吸收带。核 - 壳结构特别适用于生物医学应用，如MRI（磁共振成像）显影剂，特定组织鉴定显影剂和磁热疗法。

5. 发明申请

US20060200813A1 FIRMWARE UPDATING SYSTEM 审中-公开
标题翻译：固件更新系统
公开(公告)号：US20060200813A1
公开(公告)日：2006-09-07
申请号：US10906657
申请日：2005-03-01
申请人： Sea-Weng Young , Peter Liu , Wen-Hsiang Chang
发明人： Sea-Weng Young , Peter Liu , Wen-Hsiang Chang
IPC分类号： G06F9/44
CPC分类号： G06F8/65
摘要： A method of updating firmware of a circuit module includes providing a switch for selectively connecting the circuit module to a computing system and an update module. The circuit module enters a reset mode and an input/output pin of the circuit module switches to an input mode in response to power being supplied to the circuit module. The input/output pin is pulled to a first digital logic value, which controls the switch to connect the circuit module to the update module. While the circuit module is in the reset mode, the circuit module receives updated firmware from the update module. Then the circuit module enters a normal operation mode and switches the input/output pin to an output mode for outputting a second digital logic value. When the input/output pin outputs the second digital logic value, the input/output pin controls the switch to connect the circuit module to the computing system.
摘要翻译：更新电路模块的固件的方法包括提供用于选择性地将电路模块连接到计算系统和更新模块的开关。电路模块进入复位模式，电路模块的输入/输出引脚响应供电给电路模块的电源而切换到输入模式。输入/输出引脚被拉到第一个数字逻辑值，它控制开关将电路模块连接到更新模块。当电路模块处于复位模式时，电路模块从更新模块接收更新的固件。然后电路模块进入正常操作模式，并将输入/输出引脚切换到输出模式以输出第二数字逻辑值。当输入/输出引脚输出第二个数字逻辑值时，输入/输出引脚控制开关将电路模块连接到计算系统。

6. 发明授权

US08741615B2 Magnetic nanoparticle with biocompatibility 有权
标题翻译：具有生物相容性的磁性纳米颗粒
公开(公告)号：US08741615B2
公开(公告)日：2014-06-03
申请号：US13600209
申请日：2012-08-30
申请人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-I Lin , Shian-Jy Jassy Wang , Kelly Teng
发明人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-I Lin , Shian-Jy Jassy Wang , Kelly Teng
IPC分类号： C07F7/18 , C07K16/00 , C07K2/00 , C07H23/00 , C12N9/96
CPC分类号： C08G65/336 , A61K49/0093 , A61K49/085 , A61K49/12 , A61K49/1848 , A61K49/186 , B82Y5/00 , C07F7/1804 , C08G65/323 , C08G65/326 , C08G65/3328 , C08G65/33306 , Y10T428/2982
摘要： A magnetic nanoparticle is provided in the disclosure. The magnetic nanoparticle includes a magnetic nanoparticle; a biocompatible polymer of the following formula (II) covalently coupled to the magnetic nanoparticle, wherein R1 is alkyl, aryl, carboxyl, or amino; n is an integer from 5 to 1000; and m is an integer from 1 to 10.
摘要翻译：在本公开中提供磁性纳米颗粒。磁性纳米颗粒包括磁性纳米颗粒; 共价连接到磁性纳米颗粒的下式（II）的生物相容性聚合物，其中R1是烷基，芳基，羧基或氨基; n为5〜1000的整数， m为1〜10的整数。

7. 发明授权

US08586095B2 Thermosensitive nanostructure for hyperthermia treatment 有权
标题翻译：热敏纳米结构热疗治疗
公开(公告)号：US08586095B2
公开(公告)日：2013-11-19
申请号：US11511464
申请日：2006-08-29
申请人： Wen Hsiang Chang , Chao-Hung Kao , Chin-I Lin , Shian-Jy Wang
发明人： Wen Hsiang Chang , Chao-Hung Kao , Chin-I Lin , Shian-Jy Wang
IPC分类号： A61K9/16
CPC分类号： A61K49/1857 , A61K9/1075 , A61K41/0052 , A61K49/1806 , B82Y5/00
摘要： A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.
摘要翻译：用于热疗治疗的热敏纳米结构。磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度（LCST）的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时，热敏聚合物纳米结构崩溃以释放药物，从而提供同时进行的药物治疗。

8. 发明申请

US20120329129A1 MAGNETIC NANOPARTICLE WITH BIOCOMPATIBILITY 有权
标题翻译：具有生物活性的磁性纳米颗粒
公开(公告)号：US20120329129A1
公开(公告)日：2012-12-27
申请号：US13600209
申请日：2012-08-30
申请人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-I Lin , Shian-Jy Jassy Wang , Kelly Teng
发明人： Wen-Hsiang Chang , Wen-Uan Hsieh , Shiu-Hua Huang , Chin-I Lin , Shian-Jy Jassy Wang , Kelly Teng
IPC分类号： C07F7/18 , C07K16/00 , C07K2/00 , C07H23/00 , C12N9/96 , C07F19/00 , C07K14/00 , B82Y5/00
CPC分类号： C08G65/336 , A61K49/0093 , A61K49/085 , A61K49/12 , A61K49/1848 , A61K49/186 , B82Y5/00 , C07F7/1804 , C08G65/323 , C08G65/326 , C08G65/3328 , C08G65/33306 , Y10T428/2982
摘要： A magnetic nanoparticle is provided in the disclosure. The magnetic nanoparticle includes a magnetic nanoparticle; a biocompatible polymer of the following formula (II) covalently coupled to the magnetic nanoparticle, wherein R1 is alkyl, aryl, carboxyl, or amino; n is an integer from 5 to 1000; and m is an integer from 1 to 10.
摘要翻译：在本公开中提供磁性纳米颗粒。磁性纳米颗粒包括磁性纳米颗粒; 共价连接到磁性纳米颗粒的下式（II）的生物相容性聚合物，其中R1是烷基，芳基，羧基或氨基; n为5〜1000的整数， m为1〜10的整数。

9. 发明授权

US6100803A Infrared illuminative warning detector 失效
标题翻译：红外照明警告检测器
公开(公告)号：US6100803A
公开(公告)日：2000-08-08
申请号：US247624
申请日：1999-02-10
申请人： Wen-Hsiang Chang
发明人： Wen-Hsiang Chang
IPC分类号： F21V21/30 , F21V33/00 , G08B13/19 , G08B13/18
CPC分类号： G08B13/19 , F21V21/30 , F21V33/0076
摘要： An infrared illuminative warning detector including a base seat formed with at least four perforations for two light shades and two detector heads to insert in. A bulb is installed in each light shade. An infrared detector is disposed in each detector head for detecting alien article within a detection range and lighting up the bulb. Each light shade and detector head is disposed with at least one shifting mechanism for freely changing operation position. The light shades and the detector heads on the base seat are able to detect in different directions at the same time to provide a warning and illumination function in the case of intrusion of alien article.
摘要翻译：一种红外照明警报检测器，包括形成有用于两个光阴影的至少四个穿孔的基座，以及插入的两个检测器头。每个光阴中安装有灯泡。在每个检测器头部设置红外检测器，用于检测检测范围内的外来物品并点燃灯泡。每个遮光罩和探测头设置有至少一个移动机构，用于自由地改变操作位置。基座上的灯光和探测器头能够同时检测不同方向，以便在外来物品入侵的情况下提供警告和照明功能。

10. 发明授权

US5862984A Ornamental artificial fountain apparatus 失效
标题翻译：装饰人造喷泉装置
公开(公告)号：US5862984A
公开(公告)日：1999-01-26
申请号：US709157
申请日：1996-09-06
申请人： Wen-Hsiang Chang
发明人： Wen-Hsiang Chang
IPC分类号： B05B17/08
CPC分类号： B05B17/08
摘要： An ornamental artificial fountain apparatus according to the invention includes a water basin, in which a peripherally extending annular water pipe with a plurality of nozzles is provided at a decent level. The inclination angles of nozzles are adjustable. Inside the water basin there is installed a guide pole in which a control mechanism is provided to regulate the water stream flowing through the guide pole and its spreading area. A multiple-port joint connects the pump with the annular water pipe and the guide pole by its two side branch pipes. By means of a cock on the multiple-port joint, the water flow entering the annular water pipe and the guide pole can be tuned at will. Moreover, along with the ascent and descent of a canopy of the guide pole as well as nozzles of assorted inclination angles, the apparatus can generate varying water streams and water curtains.
摘要翻译：根据本发明的装饰人造喷泉装置包括一个水盆，其中具有多个喷嘴的周向延伸的环形水管以相当的水平设置。喷嘴的倾斜角度可调。在水盆内设有引导杆，在该引导杆上设有一个控制机构，以调节流经导柱及其扩散区域的水流。多口接头通过其两个侧支管将泵与环形水管和导柱连接。通过多口接头上的旋塞，可以随意调节进入环形水管和导柱的水流。此外，随着导杆顶盖的上升和下降以及各种倾斜角的喷嘴，该装置可以产生变化的水流和水幕。

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