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1. 发明申请

US20210121585A1 PSMA targeted radiotherapy medicine and preparation method thereof 有权
公开(公告)号：US20210121585A1
公开(公告)日：2021-04-29
申请号：US16663387
申请日：2019-10-25
申请人： MING-HSIN LI , Sheng-Nan Lo , Shih-Wei Lo , Shih-Ying Lee , Su-Jung Chen , Shih-Min Wang , Ming-Wei Chen , Wei-Lin Lo
发明人： MING-HSIN LI , Sheng-Nan Lo , Shih-Wei Lo , Shih-Ying Lee , Su-Jung Chen , Shih-Min Wang , Ming-Wei Chen , Wei-Lin Lo
IPC分类号： A61K51/08
摘要： The invention features a novel precursor provided for radioisotope labeling with ligands for specific binding of prostate-specific membrane antigen (PSMA) for prostate cancer diagnosis and treatment, and the pharmacophore of a PSMA inhibitor composed of three molecules of glutamic acid, urea and lysine is provided with three variable linkers based on pharmacological activity of the PSMA inhibitor for labeling with radioactive nucleus Ga-67, Ga-68, In-111, Lu-177, Cu-64, or Y-90 through a chelating agent for imaging analysis of human tumor models of prostate cancer and serving as a PSMA-targeted radioligand therapy for prostate cancer diseases.

2. 发明申请

US20200078478A1 Structural molecule of peptide derivative for PSMA-targeting radiotherapy diagnosis and treatment 审中-公开
公开(公告)号：US20200078478A1
公开(公告)日：2020-03-12
申请号：US16125787
申请日：2018-09-10
申请人： Ming-Hsin Li , Ming-Wei Chen , Shin-Min Wang , Shih-Wei Lo , Chun-Fang Feng , Cheng-Hui Chuang , Sheng-Nan Lo
发明人： Ming-Hsin Li , Ming-Wei Chen , Shin-Min Wang , Shih-Wei Lo , Chun-Fang Feng , Cheng-Hui Chuang , Sheng-Nan Lo
IPC分类号： A61K51/04
摘要： A PSMA targeting peptide derivative for radiotherapy, which is a structural molecule developed for diagnosis or treatment of prostate cancer, as prostate-specific membrane antigen (PSMA) is a protein present on the surface of healthy prostate cells, which is often at a high level of expression on the surface of prostate cancer cells, and the molecular composition of PSMA inhibitor is mainly composed of glutamic acid, urea and lysine, in addition to the linker of the present invention, PSMA inhibitor can be combined with a chelating agent and truncated Evans Blue, which can be labeled with radionuclides Ga-67, Ga-68, In-111, Lu-177, Cu-64 or Y-90, used for image analysis and analysis of human prostate cancer tumor pattern as a new PSMA targeting peptide receptor radionuclide therapy (PRRT), and which has a longer half-life in vivo and is featured by specific binding of PSMA for radiotherapy diagnosis or treatment.

3. 发明申请

US20130043688A1 Air-Guiding Carrier Type Wind Power Collection Device 有权
标题翻译：空气导向式风力发电装置
公开(公告)号：US20130043688A1
公开(公告)日：2013-02-21
申请号：US13280402
申请日：2011-10-25
申请人： Chang-Hsien Tai , Shi-Wei Lo , Uzu-Kuei Hsu
发明人： Chang-Hsien Tai , Shi-Wei Lo , Uzu-Kuei Hsu
IPC分类号： F03D9/00
CPC分类号： F03D9/32 , F03D1/02 , F03D1/04 , F03D9/007 , F03D9/25 , F03D13/20 , F05B2240/131 , F05B2240/922 , H02S10/12 , Y02E10/728
摘要： An air-guiding carrier type wind power collection device includes a floating body and two air guiding tubes. The floating body includes a compartment filled with an uprising gas having a density lower than that of air. The floating body includes a floating assembly controlling a pressure and a temperature of the uprising gas received in the compartment. The air guiding tubes extend through the compartment of the floating body. Each air guiding tube has an air inlet and an air outlet. The air outlet includes a peripheral wall having a windward section and a guiding section. The peripheral wall has a cutout portion formed between the windward section and the guiding section. An air channel is formed between and in communication with the air inlet and the air outlet of each air guiding tube. A wind power generating assembly is mounted in each of the air channels.
摘要翻译：一种空气引导式风力收集装置，包括浮体和两个导气管。浮体包括填充有密度低于空气密度的上升气体的隔室。浮体包括浮动组件，其控制在隔室中容纳的上升气体的压力和温度。空气引导管延伸穿过浮体的隔室。每个导气管都有一个空气入口和一个空气出口。空气出口包括具有迎风部分和引导部分的周壁。周壁具有形成在上风部和引导部之间的切口部。空气通道形成在每个空气引导管的进气口和空气出口之间并与之连通。风力发电组件安装在每个空气通道中。

4. 发明申请

US20120302151A1 Intake and Exhaust Method and A Structure Utilizing the Same 审中-公开
标题翻译：进气和排气方法及其利用结构
公开(公告)号：US20120302151A1
公开(公告)日：2012-11-29
申请号：US13204855
申请日：2011-08-08
申请人： Chang-Hsien Tai , Shi-Wei Lo , Liang-Ji Chang
发明人： Chang-Hsien Tai , Shi-Wei Lo , Liang-Ji Chang
IPC分类号： F24F7/04
CPC分类号： F24F7/08 , E04F17/04 , F24F2007/001 , F24F2007/004 , F24F2221/52
摘要： An intake and exhaust structure includes an outer duct, an inner duct and an air-guiding cover. The outer duct has a first end and a second end. The inner duct has a first end, a second end and an intake air channel. The inner duct is disposed in the outer duct, and a circular air channel is defined between the inner and outer ducts. The air-guiding cover has an inner wall and an air inlet at two ends thereof, wherein the inner wall is coupled with the second end of the inner duct.
摘要翻译：进气和排气结构包括外部管道，内部管道和空气引导盖。外管具有第一端和第二端。内管具有第一端，第二端和进气通道。内部管道设置在外部管道中，并且在内部和外部管道之间限定圆形空气通道。空气引导盖在其两端具有内壁和空气入口，其中内壁与内管的第二端连接。

5. 发明授权

US08228307B2 Portable computer and touch input device 有权
标题翻译：便携式电脑和触摸输入设备
公开(公告)号：US08228307B2
公开(公告)日：2012-07-24
申请号：US12562441
申请日：2009-09-18
申请人： Yu-Wei Lo
发明人： Yu-Wei Lo
IPC分类号： G06F3/041
CPC分类号： G06F1/169 , G06F1/1616 , G06F1/1662 , G06F3/0238 , G06F3/04886
摘要： The invention discloses a portable computer comprising a host, a touch input device disposed in the host, and a displayer pivoted on the host. The touch input device comprises a touch module, a switch and a controller. The controller is coupled to the touch module and the switch. The touch module is for performing a first touch function or a second touch function and for displaying a first touch pattern or a second touch pattern correspondingly. The switch drives the controller to control the touch module to perform the first touch function or the second touch function and control the touch module to display the first touch pattern or the second touch pattern correspondingly.
摘要翻译：本发明公开了一种便携式计算机，其包括主机，设置在主机中的触摸输入设备和在主机上枢转的显示器。触摸输入装置包括触摸模块，开关和控制器。控制器耦合到触摸模块和开关。触摸模块用于执行第一触摸功能或第二触摸功能，并且用于相应地显示第一触摸模式或第二触摸模式。开关驱动控制器来控制触摸模块执行第一触摸功能或第二触摸功能，并且控制触摸模块相应地显示第一触摸模式或第二触摸模式。

6. 发明申请

US20120083304A1 ELECTRONIC APPARATUS AND ASSOCIATED FREQUENCY ADJUSTING METHOD 有权
标题翻译：电子设备及相关频率调整方法
公开(公告)号：US20120083304A1
公开(公告)日：2012-04-05
申请号：US12895877
申请日：2010-10-01
申请人： Ming-Jie Yang , Chu-Wei Lo
发明人： Ming-Jie Yang , Chu-Wei Lo
IPC分类号： H04B7/00
CPC分类号： H03J1/005 , H03L7/16 , H04W56/0035
摘要： An electronic apparatus includes a processing unit. The processing unit, when detecting a frequency offset between an radio frequency (RF) module and a corresponding base station (BS), controls an oscillator to change a frequency of a first reference clock signal outputted therefrom by a first frequency variation, and controls a compensation unit to change a frequency of a second reference clock signal outputted therefrom by a second frequency variation. Wherein the compensation unit receives and adjusts the first reference clock signal from the oscillator to output the second reference clock signal, and the frequency offset substantially equals the first frequency variation plus the second frequency variation.
摘要翻译：电子设备包括处理单元。处理单元在检测射频（RF）模块与相应基站（BS）之间的频率偏移时，控制振荡器改变第一基准时钟信号从其输出的第一频率变化的频率，并控制一个补偿单元，以通过第二频率变化来改变从其输出的第二基准时钟信号的频率。其中，所述补偿单元从所述振荡器接收并调整所述第一参考时钟信号以输出所述第二参考时钟信号，并且所述频率偏移基本上等于所述第一频率变化加上所述第二频率变化。

7. 发明申请

US20100181377A1 CARD READER WITH NEAR FIELD COMMUNICATION FUNCTION AND NEAR FIELD COMMUNICATION DEVICE THEREOF 审中-公开
标题翻译：具有近场通信功能的卡读取器及其近场通信设备
公开(公告)号：US20100181377A1
公开(公告)日：2010-07-22
申请号：US12397631
申请日：2009-03-04
申请人： Chang-Chih Chen , Jen-Wei Lo
发明人： Chang-Chih Chen , Jen-Wei Lo
IPC分类号： G06K7/01
CPC分类号： G06K7/0004 , G06K7/10237 , G06K19/07732 , G06K19/07769
摘要： A card reader with a near field communication (NFC) function is provided. The card reader includes a connector for connecting a host, a radio frequency (RF) antenna, and a circuit board having a secure digital (SD) reader chip and a micro SD interface slot. The micro SD interface slot has two RF pads coupled to the RF antenna, and a micro SD memory card having a flash memory chip, a control circuit, and a smart card circuit is inserted into the micro SD interface slot in a detachable manner. Thereby, the host can access data in the flash memory chip through the SD reader chip and the micro SD interface slot, and the smart card circuit can perform a NFC through the RF antenna and the micro SD interface slot.
摘要翻译：提供具有近场通信（NFC）功能的读卡器。读卡器包括用于连接主机，射频（RF）天线和具有安全数字（SD）读取器芯片和微型SD接口时隙的电路板的连接器。微型SD接口槽具有耦合到RF天线的两个RF焊盘，并且具有闪存芯片，控制电路和智能卡电路的微型SD存储卡以可拆卸的方式插入到微型SD接口插槽中。因此，主机可以通过SD读取器芯片和微SD接口插槽访问闪存芯片中的数据，智能卡电路可以通过RF天线和微型SD接口插槽执行NFC。

8. 发明申请

US20100149801A1 LED OPTICAL LENS AND ILLUMINATION DEVICE THEREOF 审中-公开
标题翻译： LED光学透镜及其照明装置
公开(公告)号：US20100149801A1
公开(公告)日：2010-06-17
申请号：US12509282
申请日：2009-07-24
申请人： Chih-Wei LO , I-Lin Chu
发明人： Chih-Wei LO , I-Lin Chu
IPC分类号： F21V5/00
CPC分类号： F21V5/04 , F21W2131/103 , F21Y2115/10 , G02B19/0014 , G02B19/0061 , G02B27/0955
摘要： A LED optical lens and an illumination device thereof are revealed. The optical lens includes a light-source side surface and an image side surface of the LED optical lens that both are designed respectively according to mathematical expressions of freeform surfaces such as Anamorphic formula and Toric formula Thus the optical lens has different curvatures along different axes. After light from LED emitting into the optical lens at a fixed incident angle, emergent light with different divergence angles along different axes is generated. For example, the divergence angle along the long axis is larger than that along the short axis. Therefore a uniform and near rectangular distribution pattern is formed on the target area Moreover, a plurality of optical lenses aligned along the same axes is arranged at a holder to form a lens array. The lens array is used together with a LED array so as to form a LED illumination device.
摘要翻译：揭示了一种LED光学透镜及其照明装置。光学透镜包括LED光学透镜的光源侧表面和图像侧表面，它们分别根据诸如变形公式和Toric公式的自由曲面的数学表达式设计。因此，光学透镜沿着不同的轴具有不同的曲率。来自LED的光以固定的入射角发射到光学透镜中时，产生沿不同轴线具有不同发散角的出射光。例如，沿着长轴的发散角大于沿着短轴的发散角。因此，在目标区域上形成均匀且接近矩形的分布图案。此外，沿着相同的轴排列的多个光学透镜被布置在保持器上以形成透镜阵列。透镜阵列与LED阵列一起使用以形成LED照明装置。

9. 发明申请

US20100104650A1 CHARGED MESOPOROUS SILICA NANOPARTICLE-BASED DRUG DELIVERY SYSTEM FOR CONTROLLED RELEASE AND ENHANCED BIOAVAILABILITY 有权
标题翻译：用于控制释放和增强生物利用度的基于MESOPOROUS二氧化硅纳米脂的药物递送系统
公开(公告)号：US20100104650A1
公开(公告)日：2010-04-29
申请号：US12581965
申请日：2009-10-20
申请人： Chia-Hung Lee , Leu-Wei Lo , Chung-Shi Yang , Chung-Yuan Mou
发明人： Chia-Hung Lee , Leu-Wei Lo , Chung-Shi Yang , Chung-Yuan Mou
IPC分类号： A61K47/34 , A61K9/14
CPC分类号： A61K9/5115
摘要： A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug.
摘要翻译：公开了一种带电介孔二氧化硅纳米颗粒（MSN）的药物递送系统，用于控制释放和增强的生物利用度。该系统包括带正电荷的MSN，其具有二氧化硅基质和基质中的孔和/或纳米通道阵列。基质，全部表面和孔和/或纳米通道的整个物质包含多个硅烷醇（Si-OH）和季铵官能团。带负电荷的生物活性化合物的生物利用度可以通过将其加载到孔和/或纳米通道中来增加。在孔和/或纳米通道壁上的表面上的硅烷醇（Si-OH）官能团可以在pH高于带正电荷的MSN的pI的流体中游离去质子化并导致带负电荷的药物的持续释放从孔和/或纳米通道，从而提高药物的生物利用度。

10. 发明申请

US20100073314A1 PORTABLE COMPUTER AND TOUCH INPUT DEVICE 有权
标题翻译：便携式计算机和触摸输入设备
公开(公告)号：US20100073314A1
公开(公告)日：2010-03-25
申请号：US12562441
申请日：2009-09-18
申请人： Yu-Wei Lo
发明人： Yu-Wei Lo
IPC分类号： G06F3/041
CPC分类号： G06F1/169 , G06F1/1616 , G06F1/1662 , G06F3/0238 , G06F3/04886
摘要： The invention discloses a portable computer comprising a host, a touch input device disposed in the host, and a displayer pivoted on the host. The touch input device comprises a touch module, a switch and a controller. The controller is coupled to the touch module and the switch. The touch module is for performing a first touch function or a second touch function and for displaying a first touch pattern or a second touch pattern correspondingly. The switch drives the controller to control the touch module to perform the first touch function or the second touch function and control the touch module to display the first touch pattern or the second touch pattern correspondingly.
摘要翻译：本发明公开了一种便携式计算机，其包括主机，设置在主机中的触摸输入设备和在主机上枢转的显示器。触摸输入装置包括触摸模块，开关和控制器。控制器耦合到触摸模块和开关。触摸模块用于执行第一触摸功能或第二触摸功能，并且用于相应地显示第一触摸模式或第二触摸模式。开关驱动控制器来控制触摸模块执行第一触摸功能或第二触摸功能，并且控制触摸模块相应地显示第一触摸模式或第二触摸模式。

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