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1. 发明申请

WO1995029148A1 O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM 审中-公开
标题翻译： O-酰基-4-苯基 - 环己醇，它们的盐，药物含有它们的使用和用于生产
公开(公告)号：WO1995029148A1
公开(公告)日：1995-11-02
申请号：PCT/EP1994001276
申请日：1994-04-25
申请人： DR. KARL THOMAE GMBH , WOITUN, Eberhard , MAIER, Roland , MÜLLER, Peter , HURNAUS, Rudolf , MARK, Michael , EISELE, Bernhard , BUDZINSKI, Ralph-Michael , HALLERMAYER, Gerhard
发明人： DR. KARL THOMAE GMBH
IPC分类号： C07C219/24
CPC分类号： C07D295/096 , C07C219/24 , C07C237/06 , C07C2601/14
摘要： The invention concerns O-acyl-4-phenyl-cyclohexanols of the general formula (I) in which n stands for the numbers 0 or 1, m stands for the numbers 1 or 2, p stands for the numbers 0 or 1, R and R each stand for hydrogen, lower alkyl, alkenyl or alkinyl, these groups possibly being further substituted or, together with the intermediate nitrogen atom, forming 5 to 7-member saturated, monocyclic, heterocyclic rings which may possibly be further interrupted by an oxygen or sulphur atom or an imino group, R , R , R and R stand for hydrogen or lower alkyl, R additionally also stands for lower alkoxy, R stands for hydrogen, cycloalkyl, phenyl or substituted phenyl, naphthyl, tetrahydronaphthyl, thienyl, furyl or pyridyl and A stands for a chemical bond or alkyl, alkenyl or alkinyl having up to 17 carbon atoms. The invention further concerns a method of preparing said compounds, medicaments containing said compounds and the use of said medicaments which are effective in cholesterol biosynthesis. The anti-hypercholesterolemic substances are used for the treatment and prevention of atherosclerosis and inhibit the enzyme 2,3-epoxysqualene-lanosterol-cyclase.
摘要翻译：描述了O-酰基-4-苯基 - 环己醇的通式（I），其中n为数字0或1，m是1或2，p个数字0或1，R <1>和R <2> 形成各氢，低级烷基，烯基或炔基，这些基团任选地可以与处于中间的氮原子上被取代，或者一起表示5至7元饱和的单环，杂环还任选被氧或硫原子或亚氨基可以被中断，R <3>，R <4>，R <5>和R <6>是氢或低级烷基，R <5>除，低级烷氧基，R <7>为氢，环烷基，苯基或取代的苯基基，萘基，四氢萘基，噻吩基，呋喃基或吡啶基，且a是最多17个C原子的化学键或烷基，烯基或炔基，还涉及它们的制备方法，含有这些化合物的药物组合物，并且其在使用这些药物的胆囊从事甾醇生物合成。用于治疗动脉粥样硬化和预防的物质antihypercholesterolämischen，它可以抑制酶2,3-环氧角鲨烯 - 羊毛甾醇环化酶。

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