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    • 9. 发明公开
    • Fluorescent silica-based nanoparticles
    • 荧光二氧化硅基纳米粒子
    • EP2369342A2
    • 2011-09-28
    • EP11156074.4
    • 2003-11-26
    • CORNELL RESEARCH FOUNDATION, INC.Wiesner, Ulrich B.Ow, Hooisweng
    • Wiesner, Ulrich B.Ow, Hooisweng
    • G01N33/50G01N33/58C09K11/02C09K11/06C01B33/14
    • C09K11/025B82Y30/00C01B33/18C01P2002/80C01P2004/03C01P2004/64C07K16/00C07K2317/52C09K11/06G01N33/5005G01N33/54346G01N33/582G01N33/587Y10T428/2438Y10T428/31663
    • The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.
    • 本发明提供纳米粒子组合物,其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。 还提供了用于制备纳米颗粒组合物的方法,所述纳米颗粒组合物包括荧光纳米颗粒,连接荧光纳米颗粒,具有治疗剂的连接荧光纳米颗粒和与分析物偶联或缔合的连接荧光纳米颗粒。 还提供了方法:用于检测连接的荧光纳米颗粒; 用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分相关联并且记录或监测所述细胞组分的移动; 用于通过将治疗剂与连接荧光纳米颗粒组合并且将所述组合与细胞或生物体接触或施用来改善治疗剂的治疗特性; 用于在例如用于检测各种分析物的诊断剂和类似应用中制造和使用荧光纳米颗粒。