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1. 发明专利

JP2006517985A Fluorescent nanoparticles of silica-based 有权
公开(公告)号：JP2006517985A
公开(公告)日：2006-08-03
申请号：JP2004566499
申请日：2003-11-26
申请人：ウィーズナー,ウルリッヒ,ビー.WIESNER,Ulrich,B. , オウ,フーイスウェングOW,Hooisweng , コーネルリサーチファウンデーション,インコーポレーティッド
发明人：ウィーズナー，ウルリッヒ，ビー． , オウ，フーイスウェング
IPC分类号： C09B67/08 , A61K9/14 , A61K31/352 , A61K31/4745 , A61K47/04 , A61K47/24 , A61K47/48 , A61K49/00 , A61P35/00 , B82B1/00 , B82B3/00 , C09B11/28 , C12Q1/02 , G01N33/50 , G01N33/58
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要：【解決すべき課題】
新規なシリカ系のナノ粒子を発見すること。
【解決手段】
本発明は、例えば蛍光シラン化合物を含むコア、及びコアにシリカ殻を含むナノ粒子組成物を提供する。また、蛍光ナノ粒子、リガンド結合蛍光ナノ粒子、治療薬を有するリガンド結合蛍光ナノ粒子、及び検体に結合したリガンド結合蛍光ナノ粒子を含むナノ粒子組成物の調製法も提供する。また、リガンド結合蛍光ナノ粒子を検出する方法、連結した蛍光ナノ粒子を目的の細胞成分と結合させ、その細胞成分の運動を記録又は監視する方法、治療薬と連結した蛍光ナノ粒子を結合させ、その結合物を細胞又は生体に接触若しくは投与することにより治療薬の治療特性を向上させる方法、例えば、様々な検体の検出のための診断薬に蛍光ナノ粒子を製造し、使用する方法、及び類似の適用も提供する。

2. 发明专利

JP2006514708A Silica-based fluorescent nanoparticles 审中-公开
公开(公告)号：JP2006514708A
公开(公告)日：2006-05-11
申请号：JP2004568576
申请日：2003-11-26
申请人：ウィーズナー,ウルリッヒWIESNER,Ulrich , ウエッブ,ワット,ダブリュー.WEBB,Watt,W. , オウ,フーイスウェングOW,Hooisweng , コーネルリサーチファウンデーション,インコーポレーティッド , ラーソン,ダニエル,アール.LARSON,Daniel,R.
发明人：ウィーズナー，ウルリッヒ , ウェッブ，ワット，ダブリュー． , オウ，フーイスウェング , ラーソン，ダニエル，アール．
IPC分类号： C09K11/08 , B82B1/00 , B82B3/00 , C09K11/59 , G01N33/50 , G01N33/58
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要：【解決すべき課題】
新規なシリカ系の蛍光ナノ粒子を発明すること。
【解決手段】
本発明は一般的に、蛍光ナノ粒子に関するものであり、より具体的には、有機色素が共有結合している３０ｎｍより小さいシリカ系の蛍光ナノ粒子に関する。本発明は、発蛍光団中心コア、及びシリカ殻を含む蛍光単分散シリカナノ粒子を提供する。このナノ粒子の放射特性は、コアの化学的性質（組成）とシリカ殻の存在に依存する。本発明は概して、３０ｎｍまで又はそれ以下の大きさのシリカ粒子内に包埋された色素分子の光物理的特性の制御を提供する。この制御はシリカの化学的性質と粒子構造をナノメートル規模で変えることにより達成されるものであり、その結果、遊離色素と比べて顕著な輝度の向上が得られる。

4. 发明授权

EP1572445B1 FLUORESCENT SILICA-BASED NANOPARTICLES 失效转让
公开(公告)号：EP1572445B1
公开(公告)日：2019-01-09
申请号：EP03815995.0
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng , Larson, Daniel E. , Webb, Watt W.
发明人： WIESNER, Ulrich , OW, Hooisweng , LARSON, Daniel, R. , WEBB, Watt, W.
IPC分类号： B32B5/16 , G01N33/553 , C09K11/02 , H01L33/00

5. 发明公开

EP2364840A1 Fluorescent silica-based nanoparticles 审中-公开
标题翻译：荧光素酶Nanoteilchen auf Siliciumdioxidbasis
公开(公告)号：EP2364840A1
公开(公告)日：2011-09-14
申请号：EP11162895.4
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng , Larson, Daniel E. , Webb, Watt W.
发明人： Wiesner, Ulrich B. , Ow, Hooisweng , Larsen, Daniel E. , Webb, Watt W.
IPC分类号： B32B5/16 , G01N33/553 , C09K11/02 , H01L33/00 , C09K11/06 , C01B33/14
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.
摘要翻译：本发明一般涉及荧光纳米颗粒，更具体地涉及具有共价连接的有机染料的小于30nm的二氧化硅基荧光纳米颗粒。本发明提供了包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米颗粒，其中纳米颗粒的辐射性质取决于芯的化学（组成）和二氧化硅壳的存在。在本发明的一个方面，核 - 壳结构提供了荧光量子效率的增强。本发明通常提供了封装在尺寸低至30nm及以下的二氧化硅颗粒内的染料分子的光物理性质的控制。这种控制是通过二氧化硅化学和粒子结构在纳米尺度尺度上的变化来实现的，并且与游离染料相比导致显着的亮度增强。

6. 发明公开

EP1572445A4 FLUORESCENT SILICA-BASED NANOPARTICLES 失效转让
标题翻译： FLUORESZIERENDE NANOTEILCHEN AUF SILICIUMDIOXIDBASIS
公开(公告)号：EP1572445A4
公开(公告)日：2008-10-22
申请号：EP03815995
申请日：2003-11-26
申请人： CORNELL RES FOUNDATION INC , WIESNER ULRICH B , OW HOOISWENG , LARSON DANIEL E , WEBB WATT W
发明人： WIESNER ULRICH , OW HOOISWENG , LARSON DANIEL R , WEBB WATT W
IPC分类号： G01N33/50 , G01N33/58 , B32B5/16 , C09K11/02 , G01N33/553 , H01L33/00
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.
摘要翻译：本发明提供纳米颗粒组合物，其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。还提供了制备纳米颗粒组合物的方法，包括荧光纳米颗粒，连接荧光纳米颗粒，具有治疗剂的连接荧光纳米颗粒，以及与分析物偶联或结合的连接荧光纳米颗粒。还提供了用于检测连接的荧光纳米颗粒的方法：用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分结合并记录或监测细胞组分的移动; 用于通过将治疗剂与连接的荧光纳米颗粒组合并将组合接触或施用于细胞或生物体来改善治疗剂的治疗性质; 用于制造和使用例如用于检测各种分析物的诊断剂的荧光纳米颗粒和类似应用。

7. 发明公开

EP1572445A2 FLUORESCENT SILICA-BASED NANOPARTICLES 失效转让
标题翻译：荧光纳米粒子基于二氧化硅的
公开(公告)号：EP1572445A2
公开(公告)日：2005-09-14
申请号：EP03815995.0
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng , Larson, Daniel E. , Webb, Watt W.
发明人： WIESNER, Ulrich , OW, Hooisweng , LARSON, Daniel, R. , WEBB, Watt, W.
IPC分类号： B32B5/16 , G01N33/553 , C09K11/02 , H01L33/00
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.

8. 发明公开

EP2369342A3 Fluorescent silica-based nanoparticles 失效转让
标题翻译：基于二氧化硅荧光纳米粒子
公开(公告)号：EP2369342A3
公开(公告)日：2011-10-19
申请号：EP11156074.4
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng
发明人： Wiesner, Ulrich B. , Ow, Hooisweng
IPC分类号： G01N33/50 , G01N33/58 , C07K16/00 , C01B33/18 , C09K11/02 , C09K11/06 , C01B33/14
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.

9. 发明公开

EP2369342A2 Fluorescent silica-based nanoparticles 失效转让
标题翻译：荧光二氧化硅基纳米粒子
公开(公告)号：EP2369342A2
公开(公告)日：2011-09-28
申请号：EP11156074.4
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng
发明人： Wiesner, Ulrich B. , Ow, Hooisweng
IPC分类号： G01N33/50 , G01N33/58 , C09K11/02 , C09K11/06 , C01B33/14
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.
摘要翻译：本发明提供纳米粒子组合物，其包含例如包含荧光硅烷化合物的核心; 和核心上的二氧化硅壳。还提供了用于制备纳米颗粒组合物的方法，所述纳米颗粒组合物包括荧光纳米颗粒，连接荧光纳米颗粒，具有治疗剂的连接荧光纳米颗粒和与分析物偶联或缔合的连接荧光纳米颗粒。还提供了方法：用于检测连接的荧光纳米颗粒; 用于将所述连接的荧光纳米颗粒与感兴趣的细胞组分相关联并且记录或监测所述细胞组分的移动; 用于通过将治疗剂与连接荧光纳米颗粒组合并且将所述组合与细胞或生物体接触或施用来改善治疗剂的治疗特性; 用于在例如用于检测各种分析物的诊断剂和类似应用中制造和使用荧光纳米颗粒。

10. 发明公开

EP1604031A2 FLUORESCENT SILICA-BASED NANOPARTICLES 失效转让
标题翻译：荧光纳米粒子基于二氧化硅的
公开(公告)号：EP1604031A2
公开(公告)日：2005-12-14
申请号：EP03815190.8
申请日：2003-11-26
申请人： CORNELL RESEARCH FOUNDATION, INC. , Wiesner, Ulrich B. , Ow, Hooisweng
发明人： WIESNER, Ulrich, B. , OW, Hooisweng
IPC分类号： C12Q1/00
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The present invention provides nanoparticle compositions comprising, for example, a core comprising a fluorescent silane compound; and a silica shell on the core. Also provided are methods for the preparation of nanoparticle compositions including fluorescent nanoparticles, ligated-fluorescent nanoparticles, ligated-fluorescent nanoparticles having therapeutic agents, and ligated-fluorescent nanoparticles coupled or associated with an analyte. Also provided are methods: for the detection of the ligated-fluorescent nanoparticles; for associating the linked-fluorescent nanoparticles with a cellular component of interest and recording or monitoring the movement of the cellular component; for improving the therapeutic properties of the therapeutic agent by combining the therapeutic agent with linked-fluorescent nanoparticles and contacting or administering the combination to a cell or organism; for making and using the fluorescent nanoparticles in, for example, diagnostic agents for the detection of various analytes, and like applications.

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