专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007144327A3 PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS 审中-公开
标题翻译：苯基吡唑衍生物作为非固定葡萄糖激素受体配体
公开(公告)号：WO2007144327A3
公开(公告)日：2008-04-10
申请号：PCT/EP2007055724
申请日：2007-06-11
申请人： GLAXO GROUP LTD , BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
发明人： BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
IPC分类号： C07D231/38 , A61K31/415
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.
摘要翻译：本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗药物的化合物，特别是用于治疗炎症，过敏和/或自身免疫状况。

2. 发明申请

WO2008000777A2 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2008000777A2
公开(公告)日：2008-01-03
申请号：PCT/EP2007/056448
申请日：2007-06-27
申请人： GLAXO GROUP LIMITED , BARNETT, Heather, Anne , CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad , WOOLVEN, James, Michael
发明人： BARNETT, Heather, Anne , CAMPBELL, Ian, Baxter , COE, Diane, Mary , COOPER, Anthony, William, James , INGLIS, Graham, George, Adam , JONES, Haydn, Terence , KEELING, Steven, Philip , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad , WOOLVEN, James, Michael
IPC分类号： C07D231/38 , A61K31/415 , A61P19/02 , A61P29/00 , A61P37/08
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供式（I）化合物，其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是治疗炎症和/或过敏症状。

3. 发明申请

WO2005028495A1 ANTI-INFLAMMATORY GLUCOCORTICOIDS 审中-公开
标题翻译：抗炎药物葡萄球菌
公开(公告)号：WO2005028495A1
公开(公告)日：2005-03-31
申请号：PCT/EP2004/010779
申请日：2004-09-22
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , WEINGARTEN, Gordon, Gad
发明人： BIGGADIKE, Keith , WEINGARTEN, Gordon, Gad
IPC分类号： C07J71/00
CPC分类号： C07J71/0031 , C07J71/00
摘要： A compound of formula (I) wherein R 1 and R 2 are the same or different and each represents hydrogen, halogen or a methyl group; R 3 represents H, Cl, F, OH OR OC(O)R 6 ; R 4 represents hydrogen or methyl, R 5 represents -(CH 2 ) n -CH=CH) m -Cycl or -(CH 2 ) n -(CH=CH) m -Ar or cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl; n represents 0, 1 or 2; m represents 0 or 1; R 6 represents H, C 1-8 alkyl; and formula (b) represents a single or a double bond; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.
摘要翻译：式（I）的化合物，其中R 1和R 2相同或不同，各自表示氢，卤素或甲基; R 3表示H，Cl，F，OH或OC（O）R 6; R 4表示氢或甲基，R 5表示 - （CH 2）n -CH = CH）m- Cycl或 - （CH 2）n - （CH = CH）m-Ar或环丙基，环丁基，环戊基，环己基，环庚基或环辛基; n表示0,1或2; m表示0或1; R 6表示H，C 1-8烷基; 式（b）表示单键或双键; 包括其药学上可接受的酯，酰胺和氨基甲酸酯，其盐，溶剂合物和这些药学上可接受的酯，酰胺，氨基甲酸酯和盐的溶剂合物。

4. 发明申请

WO2009050244A1 INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS 审中-公开
标题翻译： INDAZOLES作为糖皮质激素受体配体
公开(公告)号：WO2009050244A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063986
申请日：2008-10-16
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , COOPER, Anthony, William, James , HOUSE, David , MCLAY, Iain, McFarlane , ROBINSON, John, Edward , WEINGARTEN, Gordon, Gad
发明人： BIGGADIKE, Keith , COOPER, Anthony, William, James , HOUSE, David , MCLAY, Iain, McFarlane , ROBINSON, John, Edward , WEINGARTEN, Gordon, Gad
IPC分类号： C07D231/56 , C07D401/12 , A61K31/416 , A61P11/06
CPC分类号： C07D231/56 , C07D401/12
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供了式（I）的化合物，其制备方法，包含所述化合物和所述组合物的制备的药物组合物，中间体以及所述化合物用于制造用于治疗性治疗的药物，特别是用于治疗炎症和/或过敏性疾病。

5. 发明申请

WO1993001174A1 THIAZOLIDINE DERIVATIVES AND THEIR USE AS ANTI-VIRAL COMPOUNDS 审中-公开
标题翻译：噻唑烷衍生物及其作为抗病毒化合物的用途
公开(公告)号：WO1993001174A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001494
申请日：1992-07-03
申请人： GLAXO GROUP LIMITED , KITCHIN, John , HOLMES, Duncan, Stuart , HUMBER, David, Cedric , STORER, Richard , DOLAN, Simon, Charles , HANN, Michael, Menteith , MCMEEKIN, Peter , MURRAY-RUST, Peter , PATEL, Binakumari , WEINGARTEN, Gordon, Gad
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D217/06
CPC分类号： C07D417/12 , C07D277/06 , C07D417/14
摘要： The present invention provides compounds of formula (I), wherein R is hydrogen, alkyl or CH2alkyl where the alkyl portion is substituted by OH; A represents either a group CHR CHR OH or a group (II), where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen, alkyl, cycloalkylalkyl, aralkyl, CHR CONR R (where R is hydrogen, alkyl, cycloalkylalkyl or Aralkyl, R is hydrogen or methyl and R is hydrogen, alkyl optionnally substituted by one or two hydroxyl groups, aryl, heteroaryl, cycloalkylalkyl, Aralkyl wherein the alkyl portion is optionnally substituted by hydroxymethyl, or Hetalkyl) or CHR NHCOR (where R is alkyl, cycloalkylalkyl or an aralkyl), R is alkoxy or NR R (where R is hydrogen or methyl and R is hydrogen, alkyl, aryl, aralkyl or cycloalkylalkyl); X is a group -CHR (CHR )r(CHR )sCHR -, where R and R are hydrogen, r is 1, s is zero and R is hydroxyl or hydroxymethyl, or R and R are hydrogen, r and s are 1 and R and R are each hydrogen or hydroxyl provided that at least one of R and R is hydroxyl, or one of R and R is hydrogen and the other is hydroxymethyl and r and s are zero; useful in chemotherapy, particularly of viral infections.
摘要翻译：本发明提供式（I）化合物，其中R 1是氢，烷基或C 2烷基，其中烷基部分被OH取代; A代表基团CHR 21 CHR 22 OH或基团（II），其中R 21是氢，烷基，环烷基烷基或芳烷基，R 22是氢，烷基，环烷基烷基，芳烷基，CHR 24 R CONR 25 R 26（其中R 24是氢，烷基，环烷基烷基或芳烷基，R 25是氢或甲基，R 26是氢，烷基选择性地被一个或两个羟基取代，芳基，杂芳基，环烷基烷基，芳烷基，其中烷基部分选择性地被羟甲基或Hetalkyl取代）或CHR 24 NHCOR 27（其中R 27是烷基，环烷基烷基或芳烷基），R 23是烷氧基或NR 28 R 29（其中R 28是氢或甲基，R 29是氢，烷基，芳基，芳烷基或环烷基烷基）; X是基团-CHR 30（CHR 31）r（CHR 32）s CHR 33，其中R 30和R 33是氢，r是1，s是0，R 31是羟基或羟甲基，或R 30和R 33是氢，r和s是1，R 31和R 32各自是氢或羟基，条件是R 31中至少有一个且R 32为羟基，R 30和R 33之一为氢，另一个为羟甲基，r和s为0; 可用于化疗，特别是病毒感染。

6. 发明申请

WO1992020665A1 THIAZOLIDINE DERIVATIVES AND THEIR USE IN THERAPY 审中-公开
标题翻译：噻唑啶衍生物及其在治疗中的应用
公开(公告)号：WO1992020665A1
公开(公告)日：1992-11-26
申请号：PCT/GB1992000840
申请日：1992-05-08
申请人： GLAXO GROUP LIMITED , HUMBER, Dai, Cedric , WEINGARTEN, Gordon, Gad , STORER, Richard , KITCHIN, John , HANN, Michael, Menteith
发明人： GLAXO GROUP LIMITED
IPC分类号： C07D277/06
CPC分类号： C07D417/14 , C07D277/06 , C07D499/00
摘要： The present invention provides compounds of formula (I), wherein x is zero, 1 or 2; R and R are each independently hydrogen, C1-4alkyl or CH2C1-3alkyl where the C1-3alkyl portion is substituted by OH; R , R , R and R are each independently hydrogen, methyl, ethyl, CH2OH,CH2NH2 or COOH when x is zero, or R , R , R and R are each independently hydrogen, methyl or CH2OH when x is 1 or 2; R and R are each independently hydrogen, C1-10alkyl, C3-8cycloalkyl, ArC1-4alkyl, HetC1-4alkyl, COAr, COHet, COCH2R , COCH(OH)Ar, COCH(OH)Het, COCH=CHPh, COR , CO2CH2Ar, CO2CH2Het, SO2Ar, SO2Het,SO2CH2R , SO2CH=CHPh or SO2R [where R and R each independently represent hydrogen, C1-6alkyl, aryl, heteroaryl, ArC1-4alkyl, HetC1-4alkyl, aryloxy, heteroaryloxy, C3-8cycloalkyl, C3-8cycloalkylC1-4alkyl, (CH2)nCO2R (where n is zero or 1 and R is hydrogen or C1-6alkyl), (CH2)mNR R (where m is zero, 1, 2, 3, 4 or 5 and R are each independently hydrogen or C1-4alkyl or together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group), and R and R each independently represent C3-8cycloalkyl substituted by phenyl]; R and R are each independently hydrogen, C1-6alkyl, COOR (where R is hydrogen, C1-6alkyl or ArC1-4alkyl) or CONR R [where R is hydrogen or C1-4alkyl and R is hydrogen, OH, aryl, heteroaryl, ArC1-4alkyl (wherein the C1-4alkyl portion is optionally substituted by hydroxymethyl), HetC1-4alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-4alkyl, (CH2pR (where p is zero or 1 and R is CF3 or CO2R where R is hydrogen or C1-6alkyl), (CH2)qNR R (where q is zero, 1, 2, 3, 4, or 5 and R and R are each independently hydrogen, C1-4alkyl or aryl or together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group), CHArCO2R , CHHet CO2R (where R and R are each independently hydrogen or C1-6alkyl) or C1-6alkyl optionally substituted by OH, or R and R together with the nitrogen atom to which they are attached form a saturated heterocyclic amino group]; R and R are each independently hydrogen, hydroxy or acetoxy; and physiologically acceptable salts and solvates thereof. Also described are the use of the compounds as antiviral agents, pharmaceutical compositions containing them and methods for their preparation.
摘要翻译：本发明提供式（I）化合物，其中x为0,1或2; R 1和R 6各自独立地为氢，C 1-4烷基或C 2 -C 1-3烷基，其中C 1-3烷基部分被OH取代; 当x为零时，R 2，R 3，R 4和R 5各自独立地为氢，甲基，乙基，CH 2 OH，CH 2 NH 2或COOH，或R 2，R 3，R 当x为1或2时，R 4和R 5各自独立地为氢，甲基或CH 2 OH; R 7和R 9各自独立地为氢，C 1-10烷基，C 3-8环烷基，Ar C 1-4烷基，Het C 1-4烷基，COAr，COHet，COCH 2 R 13，COCH（OH）Ar，COCH（OH）Het ，COCH = CHPh，COR 14，CO 2 CH 2 Ar，CO 2 CH 2 Het，SO 2 Ar，SO 2 Het，SO 2 CH 2 R 15，SO 2 CH = CHPh或SO 2 R 16 [其中R 13和R 15各自独立地表示氢，C 1-6烷基，芳基，杂芳基，ArC 1-4烷基，HetC 1-4烷基，芳氧基，杂芳氧基，C 3-8环烷基，C 3-8环烷基C 1-4烷基，（CH 2）n CO 2 R 17（其中n为0或1，R 17为氢或C 1 烷基），（CH 2）m NR R 18 R（其中m为0,1,2,3,4或5，R 19各自独立地为氢或C 1-4烷基或与氮原子一起它们连接形成饱和杂环氨基），R 14和R 16各自独立地表示被苯基取代的C 3-8环烷基; R 8和R 10各自独立地为氢，C 1-6烷基，COOR 20（其中R 20为氢，C 1-6烷基或ArC 1-4烷基）或CONR 21 R 22 [其中 R 21是氢或C 1-4烷基，R 22是氢，OH，芳基，杂芳基，ArC 1-4烷基（其中C 1-4烷基部分任选被羟甲基取代），HetC 1-4烷基，C 3-8环烷基，C 3 -8环烷基C 1-4烷基，（CH 2 p R 23）（其中p为0或1，R 23为CF 3或CO 2 R 24，其中R 24为氢或C 1-6烷基），（CH 2）q NR R R <26>（其中q为零，1,2,3,4或5，R 25和R 26各自独立地为氢，C 1-4烷基或芳基，或与它们相连的氮原子一起形成饱和杂环氨基），CHArCO 2 R 27，CHHet CO 2 R 28（其中R 27和R 28各自独立地为氢或C 1-6烷基）或任选被OH取代的C 1-6烷基， 21>和R 22与它们所连接的氮原子一起形成饱和杂环氨基]; R 11和R 12各自独立地为氢羟基或乙酰氧基; 及其生理上可接受的盐和溶剂合物。还描述了化合物作为抗病毒剂的用途，含有它们的药物组合物及其制备方法。

7. 发明申请

WO2009050218A1 INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS 审中-公开
标题翻译： INDAZOLES作为糖皮质激素受体配体
公开(公告)号：WO2009050218A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063922
申请日：2008-10-16
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , COE, Diane, Mary , COOPER, Anthony, William, James , HOUSE, David , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , WEINGARTEN, Gordon, Gad
发明人： BIGGADIKE, Keith , COE, Diane, Mary , COOPER, Anthony, William, James , HOUSE, David , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , WEINGARTEN, Gordon, Gad
IPC分类号： C07D231/56 , C07D403/10 , A61K31/416 , A61P11/06
CPC分类号： C07D231/56 , C07D403/10
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供了式（I）的化合物：其制备方法，包含所述化合物和所述组合物的制备的药物组合物，中间体，以及所述化合物用于制造用于治疗性治疗的药物，特别是用于治疗炎症和/或过敏性疾病。

8. 发明申请

WO2008043789A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO2008043789A1
公开(公告)日：2008-04-17
申请号：PCT/EP2007/060777
申请日：2007-10-10
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , COOPER, Anthony, William, James , HOUSE, David , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
发明人： BIGGADIKE, Keith , COOPER, Anthony, William, James , HOUSE, David , MACDONALD, Simon, John, Fawcett , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
IPC分类号： C07D231/56 , C07D409/12 , A61K31/416 , A61P5/40
CPC分类号： C07D231/56 , C07C251/86 , C07D405/12 , C07D409/12 , Y10S514/885
摘要： The present invention provides glucocorticoid receptor agonists of formula (I), a process for their preparation, pharmaceutical compositions comprising the compounds and the preparation of said compositions, intermediates and use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or skin disease.
摘要翻译：本发明提供式（I）的糖皮质激素受体激动剂，其制备方法，包含所述化合物的药物组合物和所述组合物的制备，所述化合物的中间体和用途，用于制备用于治疗性治疗的药物，特别是用于治疗炎症，过敏和/或皮肤疾病。

9. 发明申请

WO2008000777A3 PHENYL- PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE 审中-公开
标题翻译：苯并吡唑衍生物及其制备方法及其药物应用
公开(公告)号：WO2008000777A3
公开(公告)日：2008-02-07
申请号：PCT/EP2007056448
申请日：2007-06-27
申请人： GLAXO GROUP LTD , BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
发明人： BARNETT HEATHER ANNE , CAMPBELL IAN BAXTER , COE DIANE MARY , COOPER ANTHONY WILLIAM JAMES , INGLIS GRAHAM GEORGE ADAM , JONES HAYDN TERENCE , KEELING STEVEN PHILIP , MACDONALD SIMON JOHN FAWCETT , MCLAY IAIN MCFARLANE , SKONE PHILIP ALAN , WEINGARTEN GORDON GAD , WOOLVEN JAMES MICHAEL
IPC分类号： C07D231/38 , A61K31/415 , A61P19/02 , A61P29/00 , A61P37/08
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供式（I）化合物，其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是治疗炎症和/或过敏症状。

10. 发明申请

WO2009050243A1 INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS 审中-公开
标题翻译： INDAZOLES作为GLUCOCORTICOID受体配体
公开(公告)号：WO2009050243A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063984
申请日：2008-10-16
申请人： GLAXO GROUP LIMITED , BIGGADIKE, Keith , COOPER, Anthony, William, James , DIALLO, Hawa , HOUSE, David , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
发明人： BIGGADIKE, Keith , COOPER, Anthony, William, James , DIALLO, Hawa , HOUSE, David , MACDONALD, Simon, John, Fawcett , MCLAY, Iain, McFarlane , SKONE, Philip, Alan , WEINGARTEN, Gordon, Gad
IPC分类号： C07D231/56 , C07D403/10 , A61K31/416 , A61P11/06
CPC分类号： C07D231/56 , C07D403/10
摘要： The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation and/or allergic conditions.
摘要翻译：本发明提供式（I）化合物，其制备方法，包含所述化合物的药物组合物，所述组合物的制备，中间体和用途，用于制备用于治疗性治疗的药物，特别是用于治疗炎症和/或过敏症状。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式