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1. 发明公开

EP4025702A1 ALPHA-SYNUCLEIN DETECTION USING BEADS 审中-实审
公开(公告)号：EP4025702A1
公开(公告)日：2022-07-13
申请号：EP20860102.1
申请日：2020-09-03
申请人： Amprion, Inc. , Concha, Luis , Farris, Carly , Holguin, Bret , Lebovitz, Russell , Vollrath, Benedikt K. , Espin, Frank, G.
发明人： CONCHA, Luis , FARRIS, Carly , HOLGUIN, Bret , LEBOVITZ, Russell , VOLLRATH, Benedikt , ESPIN, Frank, G.
IPC分类号： C12Q1/00 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/58 , G01N33/68

2. 发明公开

EP4292654A2 DETECTION OF MISFOLDED PROTEINS 审中-实审
公开(公告)号：EP4292654A2
公开(公告)日：2023-12-20
申请号：EP23189057.5
申请日：2015-09-11
申请人： Board of Regents of the University of Texas System , Amprion, Inc. , Jara, Claudio Soto , Shahnawaz, Mohammad , Lebovitz, Russell M. , Vollrath, Benedikt K.
发明人： JARA, Claudio, Soto , SHAHNAWAZ, Mohammad , LEBOVITZ, Russell M. , VOLLRATH, Benedikt, K.
IPC分类号： A61P25/28
摘要： Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer s Disease, Parkinson s Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.

3. 发明公开

EP2344151A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR 审中-公开
标题翻译：治疗和/或内耳患上化防治与调制METABO谷氨酸受体
公开(公告)号：EP2344151A2
公开(公告)日：2011-07-20
申请号：EP09822509.7
申请日：2009-10-19
申请人： HOUSE EAR INSTITUTE , Otonomy, Inc. , Friedman, Rick , Vollrath, Benedikt
发明人： FRIEDMAN, Rick , VOLLRATH, Benedikt
IPC分类号： A61K31/198 , A61K9/06 , A61K31/4545 , A61K31/4523 , A61P27/16
CPC分类号： A61K31/198 , A61K9/0046 , A61K9/06 , A61K31/4192 , A61K31/44 , A61K31/4523 , A61K31/4545
摘要： Described herein are compositions and methods of treating and/or preventing inner ear conditions by administering to a patient in need thereof a modulator of a metabotropic glutamate receptor.

4. 发明公开

EP4292654A3 DETECTION OF MISFOLDED PROTEINS 审中-实审
公开(公告)号：EP4292654A3
公开(公告)日：2024-01-03
申请号：EP23189057.5
申请日：2015-09-11
申请人： Board of Regents of the University of Texas System , Amprion, Inc. , Jara, Claudio Soto , Shahnawaz, Mohammad , Lebovitz, Russell M. , Vollrath, Benedikt K.
发明人： JARA, Claudio, Soto , SHAHNAWAZ, Mohammad , LEBOVITZ, Russell M. , VOLLRATH, Benedikt, K.
IPC分类号： C12Q1/00 , G01N33/00 , A61K38/00
摘要： Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer s Disease, Parkinson s Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.

5. 发明公开

EP4232072A1 ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS 审中-实审
公开(公告)号：EP4232072A1
公开(公告)日：2023-08-30
申请号：EP21887255.4
申请日：2021-10-25
申请人： Neptune Biosciences LLC , Killeen, Nigel , Beske, Oren , Vollrath, Benedikt K. , Govindarajan, Sridhar
发明人： KILLEEN, Nigel , BESKE, Oren , VOLLRATH, Benedikt, K. , GOVINDARAJAN, Sridhar
IPC分类号： A61K38/20 , C07K14/54

7. 发明公开

EP3191599A4 DETECTION OF MISFOLDED PROTEINS 有权转让
公开(公告)号：EP3191599A4
公开(公告)日：2018-03-14
申请号：EP15839278
申请日：2015-09-11
申请人： UNIV TEXAS , AMPRION INC , JARA CLAUDIO SOTO , SHAHNAWAZ MOHAMMAD , LEBOVITZ RUSSELL M , VOLLRATH BENEDIKT K
发明人： JARA CLAUDIO SOTO , SHAHNAWAZ MOHAMMAD , LEBOVITZ RUSSELL M , VOLLRATH BENEDIKT K
IPC分类号： C12Q1/00 , A61K38/00 , G01N33/00
CPC分类号： G01N33/6896 , G01N2800/52
摘要： Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer's Disease, Parkinson's Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.

8. 发明公开

EP3191599A1 DETECTION OF MISFOLDED PROTEINS 有权转让
标题翻译：检测错误的蛋白质
公开(公告)号：EP3191599A1
公开(公告)日：2017-07-19
申请号：EP15839278.7
申请日：2015-09-11
申请人： Board Of Regents Of the University Of Texas System , Amprion Inc. , Jara, Claudio Soto , Shahnawaz, Mohammad , Lebovitz, Russell M. , Vollrath, Benedikt K.
发明人： JARA, Claudio Soto , SHAHNAWAZ, Mohammad , LEBOVITZ, Russell M. , VOLLRATH, Benedikt K.
IPC分类号： C12Q1/00 , G01N33/00 , A61K38/00
CPC分类号： G01N33/6896 , G01N2800/52
摘要： Methods and kits are provided for amplifying and detecting misfolded proteins from samples, for example, from patients having Alzheimer's Disease, Parkinson's Disease, and the like. For example, a method for determining a presence of soluble, misfolded protein in a sample may include contacting the sample with a monomeric, folded protein to form an incubation mixture; conducting an incubation cycle two or more times effective to form an amplified portion of misfolded protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded protein; physically disrupting the incubation mixture effective to break up at least a portion of any protein aggregate present; and determining the presence of the soluble, misfolded protein in the sample by detecting at least a portion of the soluble, misfolded protein. The monomeric, folded protein and the soluble, misfolded protein may exclude prion protein (PrP) and isoforms thereof.
摘要翻译：提供了用于扩增和检测来自样品的错折叠蛋白质的方法和试剂盒，所述样品例如来自患有阿尔茨海默病，帕金森氏病等的患者。例如，用于确定样品中可溶性错误折叠蛋白质存在的方法可以包括使样品与单体折叠蛋白质接触以形成温育混合物; 进行孵育循环两次或更多次，以形成错误折叠蛋白质的扩增部分; 温育有效引起至少一部分单体折叠蛋白质的错误折叠和/或聚集的温育混合物; 物理破坏温育混合物有效破碎存在的任何蛋白质聚集体的至少一部分; 并通过检测至少一部分可溶性错误折叠蛋白质来确定样品中可溶性错误折叠蛋白质的存在。单体折叠蛋白和可溶性错折叠蛋白可能不包括朊病毒蛋白（PrP）及其同种型。

9. 发明申请

WO2022093683A1 ORTHOGONAL IL-21 RECEPTOR/CYTOKINE SYSTEMS 审中-公开
公开(公告)号：WO2022093683A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056439
申请日：2021-10-25
申请人： NEPTUNE BIOSCIENCES LLC , KILLEEN, Nigel , BESKE, Oren , VOLLRATH, Benedikt, K. , GOVINDARAJAN, Sridhar
发明人： KILLEEN, Nigel , BESKE, Oren , VOLLRATH, Benedikt, K. , GOVINDARAJAN, Sridhar
IPC分类号： A61K38/20 , C07K14/54
摘要： Orthogonal IL-21 receptors and orthogonal IL-21 cytokines are described. The IL-21 receptor-cytokine pairs may include an orthogonal interleukin-21 receptor a chain ("ortho-IL- 21Rα") that has impaired binding to native interleukin-21 cytokine ("IL-21") and an orthogonal IL-21 cytokine ("ortho-IL-21") that has impaired binding to native IL-21Ra, wherein the ortho- IL-21 Ra binds to the ortho-IL-21. The IL-21 receptor-cytokine pair may activate IL-21 signaling. Cells engineered to express the orthogonal IL-21 receptors are also described, as well as methods for using such cells for treatment of various diseases and disorders.

10. 发明申请

WO2016040903A1 DETECTION OF MISFOLDED AMYLOID BETA PROTEIN 审中-公开
标题翻译：检测失败的AMYLOID BET蛋白
公开(公告)号：WO2016040903A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049840
申请日：2015-09-11
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , AMPRION, INC. , JARA, Claudio Soto , SHAHNAWAZ, Mohammad , LEBOVITZ, Russell M. , VOLLRATH, Benedikt K.
发明人： JARA, Claudio Soto , SHAHNAWAZ, Mohammad , LEBOVITZ, Russell M. , VOLLRATH, Benedikt K.
IPC分类号： G01N33/50 , G01N33/53 , C12Q1/00
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： Methods and kits are provided for amplifying and detecting Aβ proteins from samples, for example, from patients having Alzheimers Disease. For example, a method for determining a presence of a soluble, misfolded Aβ protein may include contacting the sample with a monomeric, folded Aβ protein to form an incubation mixture; conducting an incubation cycle two or more times on the incubation mixture effective to form an amplified portion of misfolded Aβ protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded Aβ protein; physically disrupting the incubation mixture effective to at least partly de-aggregate at least a portion of a misfolded Aβ aggregate present; and determining the presence of the soluble, misfolded Aβ protein in the sample by detecting at least a portion of the amplified portion of misfolded Aβ protein.
摘要翻译：提供了用于从样品中扩增和检测Aβ蛋白的方法和试剂盒，例如来自患有阿尔茨海默病的患者。例如，用于测定可溶性的错误折叠的Aβ蛋白质的存在的方法可以包括使样品与单体的折叠的Aβ蛋白质接触以形成孵育混合物; 在孵育混合物上进行两次或更多次的温育循环，有效形成错误折叠的Aβ蛋白质的扩增部分; 孵育孵育混合物有效地引起至少一部分单体折叠Aβ蛋白的错误折叠和/或聚集; 物理地破坏温育混合物，其有效地至少部分地使至少一部分错误折叠的Aβ聚集体存在; 并通过检测错误折叠的Aβ蛋白的扩增部分的至少一部分来确定样品中可溶性的错误折叠的Aβ蛋白的存在。

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