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1. 发明申请

US20210038730A1 PEPTIDE NANOFIBERS 有权
公开(公告)号：US20210038730A1
公开(公告)日：2021-02-11
申请号：US17045085
申请日：2019-04-02
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： Aikaterini LALATSA , Diane LEITE
IPC分类号： A61K47/42 , A61K47/64 , C07K7/06 , A61K31/337 , A61K31/495 , A61K31/704
摘要： a nanofiber comprising a peptide GPCR modulator conjugated to a lipophilic moiety where in the peptide-lipophilic moiety conjugate comprises a poly(proline) type II helix structure.

2. 发明申请

US20220099685A1 METHOD 有权
公开(公告)号：US20220099685A1
公开(公告)日：2022-03-31
申请号：US17426058
申请日：2020-01-28
申请人： University of Portsmouth Higher Education Corporation
发明人： John Young , Sepinoud Firouzmand
IPC分类号： G01N33/68 , G01N33/573 , G01N33/94 , G01N33/50 , A61K31/4025 , A61K31/216 , A61K31/137 , A61K31/4725 , A61K31/46 , A61K31/453 , A61K31/445 , A61K31/222 , A61K31/426 , A61P13/10
摘要： The invention provides a method of diagnosing overactive bladder disorder (OAB), the method comprising: measuring the concentrations of one or more of adenosine triphosphate (ATP), acetylcholine (ACh), nitric oxide (NO) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP/Cr to 0.000001; ACh/Cr to 0.1; NO to 20000; IL-5/Cr to 100; wherein the likelihood of having OAB (pOAB)=1/1+e−x, where X=one or more of the following: (a) (−2.688±1.050)+5.472±2.098×subject's age+1.356±0.559×Gender (Female=1, Male=0)+(−7.998±40.273)×[IL-5/Cr]; (b) (−2.141±0.966)+4.506±1.902×subject's age+1.034±0.519×Gender (Female=1, Male=0)+(−5294.063±9075.456)×[ACh/Cr]; (c) (−2.825±1.072)+5.964±2.167×subject's age+1.312±0.562×Gender (Female=1, Male=0)+17.790±58.762×[IL-5/Cr]+(−9180.821±12700.057)×[ACh/Cr]; (d) (−2.993±1.197)+5.580±2.309×subject's age+1.724±0.719×Gender (Female=1, Male=0)+63.571±73.444×[IL-5/Cr]+(−0908.523±13606.752)×[ACh/Cr]+(−566.991±636.589)×[ATP/Cr]; (e) (−3.090±1.200)+5.393±2.256×subject's age+1.797±0.717×Gender (Female=1, Male=0)+34.767±56.331×[IL-5/Cr]+(−562.743±629.316)×[ATP/Cr]; or (f) (−2.650±1.067)+5.516±2.120×subject's age+1.389±0.583×Gender (Female=1, Male=0)+(−4.060±45.238)×[IL-5/Cr]+(−1.456±6.833)×[NO/Cr]; and wherein a pOAB above a threshold indicates that the subject has a high likelihood of having or developing OAB and a pOAB below a threshold indicates that the subject does not have OAB.

3. 发明申请

US20170349946A1 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：US20170349946A1
公开(公告)日：2017-12-07
申请号：US15527235
申请日：2015-10-23
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： Qian AN , Helen FILLMORE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6806 , C12Q2600/16
摘要： The application describes a cell line identification assay kit comprising: (a) one or more genotyping agents; (b) one or more rodent-specific agents; (c) one or more mycoplasma-specific markers; and optionally (d) one or more gender-specific markers.

4. 发明申请

US20210130894A1 Cell Assay Kit and Method 有权
公开(公告)号：US20210130894A1
公开(公告)日：2021-05-06
申请号：US17141828
申请日：2021-01-05
申请人： University of Portsmouth Higher Education Corporation
发明人： Qian An , Helen Fillmore
IPC分类号： C12Q1/6881 , C12Q1/6806
摘要： The application describes a cell line identification assay kit comprising: (a) one or more genotyping agents; (b) one or more rodent-specific agents; (c) one or more mycoplasma-specific markers; and optionally (d) one or more gender-specific markers.

5. 发明申请

WO2011104134A1 SACCHARIDE DERIVATIVES 审中-公开
标题翻译： SACCHARIDE衍生物
公开(公告)号：WO2011104134A1
公开(公告)日：2011-09-01
申请号：PCT/EP2011/052067
申请日：2011-02-11
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION , BARBU, Eugen , MOLNAR, Eva , TSIBOUKLIS, John , GORECKI, Darek , LIEN, Chun Fu
发明人： BARBU, Eugen , MOLNAR, Eva , TSIBOUKLIS, John , GORECKI, Darek , LIEN, Chun Fu
IPC分类号： C08B37/00 , A61K47/36 , C07H5/06 , C08J3/075 , C08J3/12
CPC分类号： C08B37/003 , C08J3/12 , C08J2301/00 , C08J2303/00 , C08J2305/00 , C08L5/08
摘要： The invention relates to a saccharide or polysaccharide substituted at one or more -OH functionalities with an alkyl glycerol; wherein the polysaccharide is selected from chitosan, chitin, polyglucosamine and derivatives and combinations thereof, and wherein the saccharide is selected from glucosamine and derivatives thereof. Particles formed from these saccharides or polysaccharides, and methods of preparation of the particles are also disclosed.
摘要翻译：本发明涉及用一种或多种-OH官能团与烷基甘油取代的糖或多糖; 其中所述多糖选自壳聚糖，几丁质，多葡糖胺及其衍生物及其组合，并且其中所述糖选自葡糖胺及其衍生物。还公开了由这些糖或多糖形成的颗粒，以及颗粒的制备方法。

6. 发明申请

US20210080473A1 URINE MARKERS AND FORMULA FOR DIAGNOSING OVERACTIVE BLADDER DISORDER 有权
公开(公告)号：US20210080473A1
公开(公告)日：2021-03-18
申请号：US16970327
申请日：2019-02-18
申请人： University of Portsmouth Higher Education Corporation
发明人： John S. Young , Sepinoud Firouzmand
IPC分类号： G01N33/68 , G16B40/00
摘要： The present invention relates to a method of diagnosing over active bladder disorder (OAB), the method comprising: measuring the concentrations of adenosine triphosphate (ATP), acetylcholine (ACh), nitrite, monocyte chemoattractant protein 1 (MCP-1) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP/Cr to 0.000001 mole/mgxdl−1; ACh/Cr to 0.1 mole/mgxdl−1; Nitrite to 200 nM/mgxdl−1; MCP-1/Cr to 100 pgxml−1/mgxdl−1; IL-5/Cr 100 pgxml-mgxdl−1; applying the normalised and range standardised concentrations to the following formula: Logit (p)=−1.738±1.404±4.985±2.914×subject's age+3315.959±5435.254×[ATP]/[Cr]+(−25204.194±20268.337)×[ACh]/[Cr]+26.799±32.967×[nitrite]/[Cr]+6.755±25.132 [MCP-1]/[Cr]+(−61.838±148.740) [IL-5]/[Cr] and calculating Logit; wherein a Logit value above a predetermined threshold indicates that the subject has OAB. Methods for monitoring the progression of OAB using the method, kits for use in the method and computer systems and programs configured to execute the method are also provided.

7. 发明申请

WO2019158937A1 URINE MARKERS AND FORMULA FOR DIAGNOSING OVERACTIVE BLADDER DISORDER 审中-公开
公开(公告)号：WO2019158937A1
公开(公告)日：2019-08-22
申请号：PCT/GB2019/050416
申请日：2019-02-18
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： YOUNG, John S. , FIROUZMAND, Sepinoud
IPC分类号： G01N33/68
摘要： The present invention relates to a method of diagnosing over active bladder disorder (OAB), the method comprising : measuring the concentrations of adenosine triphosphate (ATP), acetylcholine (ACh), nitrite, monocyte chemoattractant protein 1 (MCP-1) and interleukin 5 (IL-5) in a sample obtained from a subject; normalising the concentrations to the concentration of creatinine (Cr) in the sample; range standardising the normalised concentrations and subject's age to the following values: Age to 120 years old; ATP/Cr to 0.000001 mole/mgxdl -1 ; ACh/Cr to 0.1 mole/ mgxdl -1 ; Nitrite to 200 nM/mgxdl -1 ; MCP-l/Cr to 100 pgxml -1 /mgxdl -1 ; IL-5/Cr 100 pgxml-mgxdl -1 ; applying the normalised and range standardised concentrations to the following formula : Logit (p) = -1.738± 1.404 + 4.985±2.914 x subject's age + 3315.959± 5435.254 x [ATP]/[Cr] + (-25204.194±20268.337) x [ACh]/[Cr] + 26.799±32.967 x [nitrite ]/[Cr] + 6.755±25.132 [MCP-l]/[Cr] + (-61.838± 148.740) [IL-5]/[Cr] and calculating Logit; wherein a Logit value above a predetermined threshold indicates that the subject has OAB. Methods for monitoring the progression of OAB using the method, kits for use in the method and computer systems and programs configured to execute the method are also provided.

8. 发明申请

WO2016063076A1 CELL ASSAY KIT AND METHOD 审中-公开
标题翻译：细胞测定试剂盒和方法
公开(公告)号：WO2016063076A1
公开(公告)日：2016-04-28
申请号：PCT/GB2015/053178
申请日：2015-10-23
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： AN, Qian , FILMORE, Helen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6806 , C12Q2600/16
摘要： The application describes a cell line identification assay kit comprising: (a) one or more genotyping agents; (b) one or more rodent-specific agents; (c) one or more mycoplasma-specific markers; and optionally (d) one or more gender-specific markers.
摘要翻译：该应用描述了细胞系鉴定测定试剂盒，其包含：（a）一种或多种基因分型试剂; （b）一种或多种啮齿动物特异性试剂; （c）一种或多种支原体特异性标记; 和（d）一个或多个性别特异性标记。

9. 发明申请

WO2018178194A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF BRAIN INJURIES OR DEMYELINATING DISORDERS 审中-公开
公开(公告)号：WO2018178194A1
公开(公告)日：2018-10-04
申请号：PCT/EP2018/058002
申请日：2018-03-28
申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , UNIVERSITE CLAUDE BERNARD LYON 1 , UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION , HEINRICH-HEINE-UNIVERSITÄT DÜSSELDORF
发明人： RAINETEAU, Olivier, Luc, Denis , BUTT, Morgan , AZIM, Kasum
IPC分类号： A61K31/165 , A61K31/216 , A61K31/426 , A61K31/506 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/426 , A61K31/165 , A61K31/216 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The invention is in the field of neuroregenerative medicine. Controlling the fate of neural stem cells represents a key therapeutic strategy in neuroregenerative medicine. The inventors used in silico genomic approaches, searchable platform-independent expression database/connectivity map (SPIED/CMAP) strategy, to identify small molecules that are predicted to regulate transcriptional changes associated with neurogenesis in the subventricular zone (SVZ) neurogenic niche. The approach was validated by demonstrating that two of the identified small molecules, inhibiting PI3K/Akt and GSK3β respectively, were able to differentially direct the fate of NSCs in vivo, to promote oligodendrogenesis and neurogenesis, in the postnatal and adult SVZ. The present invention thus relates to methods and pharmaceutical composition for use in the treatment of brain injuries or demyelinating disorders, and in particular to PI3K or GSK3β inhibitors for use in treating brain injuries, such as perinatal hypoxia/ischemia, or demyelinating disorders such as periventricular leukomalacias or multiple sclerosis.

10. 发明申请

WO2018146484A1 SCREENING METHOD AND KIT TO DETECT RECEPTOR ACTIVATION 审中-公开
公开(公告)号：WO2018146484A1
公开(公告)日：2018-08-16
申请号：PCT/GB2018/050367
申请日：2018-02-09
申请人： UNIVERSITY OF PORTSMOUTH HIGHER EDUCATION CORPORATION
发明人： DRAHEIM, Roger
IPC分类号： C12N15/62 , C12N9/12 , C07K14/245
CPC分类号： C12Y207/13001 , C07K14/245 , C07K2319/00 , C07K2319/03 , C12N9/12
摘要： The invention comprises a plasmid comprising: (i) a nucleotide sequence encoding a part of a sensor histidine kinase (SHK) comprising the intracellular domain of the SHK wherein the SHK intracellular domain comprises one or more C-terminus aromatic amino acid, and/or one or more positively charged amino acid substitutions or sequence rearrangements compared to the native SHK intracellular domain sequence and the part of the SHK does not comprise at least a portion of the extracellular or periplasmic domain of the SHK. (ii) a cloning site for the insertion of a nucleotide sequence encoding at least a part of an extracellular or periplasmic domain of a heterologous SHK inframe with the nucleotide sequence encoding the SHK intracellular domain.

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