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1. 发明公开

EP2800531A1 MEDICAL DEVICE FOR CONTROLLED NAIL PENETRATION 审中-公开
标题翻译：医疗器械VORRICHTUNGFÜRKONTROLLIERTE NAGELPENETRATION
公开(公告)号：EP2800531A1
公开(公告)日：2014-11-12
申请号：EP12812700.8
申请日：2012-12-18
申请人： Thomas, Rolf Lewis
发明人： Thomas, Rolf Lewis
IPC分类号： A61B17/54 , A61B17/16
CPC分类号： A61B17/1626 , A61B17/1662 , A61B17/54 , A61B90/03 , A61B2090/064
摘要： The present invention relates to a device for penetrating human nails (1) as a part of a treatment for Onychomycosis, commonly known as fungal nail. The device comprises a reusable electromechanical system and a single use cutting component. The electromechanical system incorporates an electric motor (5,11) and drive train (6) to advance the cutting component (2) through the nail (1). The electromechanical system also incorporates sensors (7-10,12) for measuring the cutting resistance for the purpose of preventing the cutting device (2) from overrunning into the nail bed. The device can be used to penetrate the nail (1) in a controlled manner which will create a portal through the nail without penetrating the nail bed below the nail (1).
摘要翻译：本发明涉及一种用于穿透人指甲作为甲癣治疗的一部分的装置，通常称为真菌指甲。该装置包括可重复使用的机电系统和单次使用的切割部件。机电系统包括电动马达和传动系，以使切割部件通过指甲推进。机电系统还包括用于测量切割阻力的传感器，以便防止切割装置超过甲床。该装置可用于以受控的方式穿透指甲，这将通过钉子产生通过钉子的入口，而不穿透指甲下方的甲床。

2. 发明公开

EP0664724A1 VERFAHREN FÜR DIE GEWINNUNG UND DIE UMPUFFERUNG UND/ODER EINENGUNG VON GELÖSTEN MAKROMOLEKÜLEN EINES MAKROMOLEKÜLGEMISCHES 失效
标题翻译：程序获得和停顿和/或供电中溶解性大分子一大分子混合物组成。
公开(公告)号：EP0664724A1
公开(公告)日：1995-08-02
申请号：EP93923461.0
申请日：1993-10-13
申请人： BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas Rolf
发明人： BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas Rolf
IPC分类号： G01N30 , A61K9 , B01D11 , B01D15 , B01D61
CPC分类号： B01D61/243 , B01D15/08 , G01N30/96 , G01N2030/8435
摘要： The invention pertains to a process for extracting and buffering and/or concentrating dissolved macromolecules of a macromolecular mixture using a liquid chromatography apparatus, wherein buffer solutions that promote the separation process are added to the macromolecular mixture to be separated prior to its entering into the liquid chromatography apparatus or during the separation process in the liquid chromatography apparatus, said buffer solutions then being entirely or partially withdrawn and/or exchanged after the separation for purposes of concentrating or purifying the kind of molecules extracted. To be able to carry out such a process of buffering and/or concentrating more quickly and continuously with less outlay for equipment, the invention proposes that the buffer solution be withdrawn and/or exchanged by means of countercurrent dialysis, which is carried out continuously with the eluate of the liquid chromatography apparatus. The countercurrent dialysis proposed as per the invention makes it possible to supply the eluate with specific low-molecular substrates for the enzymatic detection.

3. 发明授权

EP0664724B1 VERFAHREN FÜR DIE GEWINNUNG UND DIE UMPUFFERUNG UND/ODER EINENGUNG VON GELÖSTEN MAKROMOLEKÜLEN EINES MAKROMOLEKÜLGEMISCHES 失效
标题翻译：程序获得和停顿和/或供电中溶解性大分子一大分子合剂
公开(公告)号：EP0664724B1
公开(公告)日：1996-03-13
申请号：EP93923461.3
申请日：1993-10-13
申请人： BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas Rolf
发明人： BARTHOLMES, Peter , KAUFMANN, Michael , SCHWARZ, Thomas Rolf
IPC分类号： B01D15/08 , G01N30/96 , B01D61/24
CPC分类号： B01D61/243 , B01D15/08 , G01N30/96 , G01N2030/8435
摘要： The invention pertains to a process for extracting and buffering and/or concentrating dissolved macromolecules of a macromolecular mixture using a liquid chromatography apparatus, wherein buffer solutions that promote the separation process are added to the macromolecular mixture to be separated prior to its entering into the liquid chromatography apparatus or during the separation process in the liquid chromatography apparatus, said buffer solutions then being entirely or partially withdrawn and/or exchanged after the separation for purposes of concentrating or purifying the kind of molecules extracted. To be able to carry out such a process of buffering and/or concentrating more quickly and continuously with less outlay for equipment, the invention proposes that the buffer solution be withdrawn and/or exchanged by means of countercurrent dialysis, which is carried out continuously with the eluate of the liquid chromatography apparatus. The countercurrent dialysis proposed as per the invention makes it possible to supply the eluate with specific low-molecular substrates for the enzymatic detection.

4. 发明专利

AT135248T 未知
公开(公告)号：AT135248T
公开(公告)日：1996-03-15
申请号：AT93923461
申请日：1993-10-13
申请人： BARTHOLMES PETER , KAUFMANN MICHAEL , SCHWARZ THOMAS ROLF
发明人： BARTHOLMES PETER , KAUFMANN MICHAEL , SCHWARZ THOMAS ROLF
IPC分类号： G01N30/02 , A61K9/08 , B01D11/04 , B01D15/08 , B01D61/24 , G01N30/84 , G01N30/96
摘要： PCT No. PCT/EP93/02827 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Oct. 13, 1993 PCT Pub. No. WO94/08684 PCT Pub. Date Apr. 28, 1994The invention relates to an apparatus for recovery and buffer exchange and/or concentration of dissolved macromolecules from a mixture of macromolecules. The apparatus includes a liquid chromatography unit and at least one hollow fiber membrane cartridge connected downstream of the liquid chromatography unit.

5. 发明专利

CA2147134A1 PROCESS FOR EXTRACTING AND REBUFFERING AND/OR CONCENTRATING DISSOLVED MACRO-MOLECULES OF A MACROMOLECULAR MIXTURE 未知
公开(公告)号：CA2147134A1
公开(公告)日：1994-04-28
申请号：CA2147134
申请日：1993-10-13
申请人： BARTHOLMES PETER , KAUFMANN MICHAEL , SCHWARZ THOMAS ROLF
发明人： BARTHOLMES PETER , KAUFMANN MICHAEL , SCHWARZ THOMAS ROLF
IPC分类号： G01N30/02 , A61K9/08 , B01D11/04 , B01D15/08 , B01D61/24 , G01N30/84 , G01N30/96
摘要： The invention pertains to a process for extracting and buffering and/or concentrating dissolved macromolecules of a macromolecular mixture using a liquid chromatography apparatus, wherein buffer solutions that promote the separation process are added to the macromolecular mixture to be separated prior to its entering into the liquid chromatography apparatus or during the separation process in the liquid chromatography apparatus, said buffer solutions then being entirely or partially withdrawn and/ or exchanged after the separation for purposes of concentrating or purifying the kind of molecules extracted. To be able to carry out such a process of buffering and/or concentrating more quickly and continuously with less outlay for equipment, the invention proposes that the buffer solution be withdrawn and/or exchanged by means of countercurent dialysis, which is carried out continuously with the eluate of the liquid chromatography apparatus. The countercurrent dialysis proposed as per the invention makes it possible to supply the eluate with specific low-molecular substrates for the enzymatic detection.

6. 发明专利

GB201200005D0 Medical device for controlled tissue penetration and uses thereof 未知
公开(公告)号：GB201200005D0
公开(公告)日：2012-02-15
申请号：GB201200005
申请日：2012-01-01
申请人： THOMAS ROLF L , MEDICAL DEVICE TREAT LTD

7. 发明专利

DE2813215B2 未知
公开(公告)号：DE2813215B2
公开(公告)日：1981-05-27
申请号：DE2813215
申请日：1978-03-25
申请人： THOMAS, ROLF, 3500 KASSEL, DE
发明人： THOMAS, ROLF, 3500 KASSEL, DE
IPC分类号： A61B1/24 , A61B1/32 , A61M23/00 , A61M29/02 , A61B1/00 , A61D7/00

8. 发明专利

DE59301915D1 未知
公开(公告)号：DE59301915D1
公开(公告)日：1996-04-18
申请号：DE59301915
申请日：1993-10-13
申请人： BARTHOLMES PETER PROF DR , KAUFMANN MICHAEL DR , SCHWARZ THOMAS ROLF DIPL BIOCH
发明人： BARTHOLMES PETER PROF DR , KAUFMANN MICHAEL DR , SCHWARZ THOMAS ROLF
IPC分类号： G01N30/02 , A61K9/08 , B01D11/04 , B01D15/08 , B01D61/24 , G01N30/84 , G01N30/96
摘要： PCT No. PCT/EP93/02827 Sec. 371 Date Jun. 6, 1995 Sec. 102(e) Date Jun. 6, 1995 PCT Filed Oct. 13, 1993 PCT Pub. No. WO94/08684 PCT Pub. Date Apr. 28, 1994The invention relates to an apparatus for recovery and buffer exchange and/or concentration of dissolved macromolecules from a mixture of macromolecules. The apparatus includes a liquid chromatography unit and at least one hollow fiber membrane cartridge connected downstream of the liquid chromatography unit.

9. 发明专利

DE4234728A1 未知
公开(公告)号：DE4234728A1
公开(公告)日：1994-04-21
申请号：DE4234728
申请日：1992-10-15
申请人： BARTHOLMES PETER PROF DR , KAUFMANN MICHAEL DR , SCHWARZ THOMAS ROLF DIPL BIOCH
发明人： BARTHOLMES PETER PROF DR , KAUFMANN MICHAEL DR , SCHWARZ THOMAS ROLF DIPL BIOL
IPC分类号： G01N30/02 , A61K9/08 , B01D11/04 , B01D15/08 , B01D61/24 , G01N30/84 , G01N30/96
摘要： The invention pertains to a process for extracting and buffering and/or concentrating dissolved macromolecules of a macromolecular mixture using a liquid chromatography apparatus, wherein buffer solutions that promote the separation process are added to the macromolecular mixture to be separated prior to its entering into the liquid chromatography apparatus or during the separation process in the liquid chromatography apparatus, said buffer solutions then being entirely or partially withdrawn and/or exchanged after the separation for purposes of concentrating or purifying the kind of molecules extracted. To be able to carry out such a process of buffering and/or concentrating more quickly and continuously with less outlay for equipment, the invention proposes that the buffer solution be withdrawn and/or exchanged by means of countercurrent dialysis, which is carried out continuously with the eluate of the liquid chromatography apparatus. The countercurrent dialysis proposed as per the invention makes it possible to supply the eluate with specific low-molecular substrates for the enzymatic detection.

10. 发明专利

DE2813215C3 未知
公开(公告)号：DE2813215C3
公开(公告)日：1982-01-28
申请号：DE2813215
申请日：1978-03-25
申请人： THOMAS, ROLF, 3500 KASSEL, DE
发明人： THOMAS, ROLF, 3500 KASSEL, DE
IPC分类号： A61B1/24 , A61B1/32 , A61M23/00 , A61M29/02 , A61B1/00 , A61D7/00

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